silicon and Nephritis--Interstitial

To clarify the time course of toxicological effects of tetraethoxysaline [Si(OC2H5)4, TEOS] on the kidney and the relationship between blood silicon levels (Si-B) and the effects, 250 mg/kg or 500 mg/kg TEOS was intraperitoneally administered to ten 5-week-old male ICR mice (SPF grade) in each group, and morphological and functional changes of the kidney were assessed at 12 h, 24 h, 3 days and 2 weeks after administration of TEOS. Injury to tubular epithelial cells was observed in mice killed 12 and 24 h after administration, and its severity increased with increasing dosage. The mean values of blood urea nitrogen exhibited dose-related increase in mice sacrificed 24 h after the administration. The concentrations of Si-B increased in order of the administered doses of TEOS, and then decreased steadily. The results of Si-B were consistent with the concept that renal toxicity of TEOS is mediated by siliceous compounds. The kidney was recovering from injury 3 days after administration, and had developed tubulointerstitial nephritis, which could be regarded as repaired lesion of acute injury, by 2 weeks after administration.

Topics: Animals; Blood Urea Nitrogen; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Kidney; Kidney Function Tests; Kidney Tubules; Male; Mice; Mice, Inbred ICR; Microscopy, Electron; Nephritis, Interstitial; Silanes; Silicon; Specific Pathogen-Free Organisms

Topics: Animals; Chemical Phenomena; Chemistry; Guinea Pigs; Mice; Nephritis; Nephritis, Interstitial; Pathology; Research; Silicates; Silicon; Toxicology; Water Supply; Yugoslavia