silicon and Laryngeal-Neoplasms

In vitro experiments showed that stem and cancer cells retained their viability on the surface of porous silicon with 10-100 nm nanostructures, but their proliferation was inhibited. Silicon nanoparticles of 100 nm in size obtained by mechanical grinding of porous silicon films or crystal silicon plates in a concentration below 1 mg/ml in solution did not modify viability and proliferation of mouse fibroblast and human laryngeal cancer cells. Additional ultrasonic exposure of cancer cells in the presence of 1 mg/ml silicon nanoparticles added to nutrient medium led to complete destruction of cells or to the appearance of membrane defects blocking their proliferation and initiating their apoptotic death.

Topics: Animals; Apoptosis; Cell Count; Cell Cycle; Cell Proliferation; Cell Survival; Electrochemical Techniques; Fetus; Humans; Laryngeal Neoplasms; Mice; Nanoparticles; NIH 3T3 Cells; Particle Size; Porosity; Silicon; Sonication; Stem Cells; Tumor Cells, Cultured

Total laryngectomy or laryngopharyngectomy are commonly performed for the treatment of laryngeal cancer or hypopharyngeal cancer. However pharyngocutaneous fistula and cervical esophageal stenosis have been reported as postoperative complications of these procedures. We used a silicon pharyngeal tube in cases that developed pharyngocutaneous fistula and cervical esophageal stenosis. The pharyngeal tube was useful for controlling aspiration pneumonia and for starting oral feeding in a case of pharyngocutaneous fistula after a total laryngectomy. It was also helpful for starting oral feeding in a case with cervical esophageal stenosis after total laryngopharyngectomy and free jejunum interposition. This patient was able to maintain a good quality of life until re-operation. Adverse effects from the insertion of the tube included a foreign body sensation and pharyngeal pain that was tolerable with the use of NSAIDs for a short time. Silicon pharyngeal tubes are useful for the treatment of pharyngocutaneous fistula and cervical esophageal stenosis.

Topics: Aged; Cutaneous Fistula; Digestive System Fistula; Esophageal Stenosis; Glottis; Humans; Intubation; Laryngeal Neoplasms; Male; Pharyngeal Diseases; Pharyngectomy; Pharynx; Postoperative Complications; Quality of Life; Silicon

The Growing importance of industrial noxae for carcinogenesis will, in the course of further progressive mechanization and industrialization, suggest an increasing confrontation with this problem. The above mentioned case, a patient working with insulating materials on industrial heating systems, impressevely demonstrates the transformation of chronic laryngitis into a carcinoma in the course of years, brought about by industrial influences and thus proving the exogenous origin of this genesis. Dust as well as strong effects of heat under conditions of variable atmospheric humidily are concerned to be principal damaging factors.

Topics: Asbestos; Carcinoma, Squamous Cell; Chronic Disease; Construction Materials; Dust; Heating; Humans; Humidity; Laryngeal Neoplasms; Laryngitis; Male; Middle Aged; Occupational Diseases; Occupations; Silicon