silicon and Graft-vs-Host-Disease

silicon has been researched along with Graft-vs-Host-Disease* in 2 studies

Other Studies

2 other study(ies) available for silicon and Graft-vs-Host-Disease

Article	Year
Superporous agarose scaffolds for encapsulation of adult human islets and human stem-cell-derived β cells for intravascular bioartificial pancreas applications. Journal of biomedical materials research. Part A, 2021, Volume: 109, Issue:12 Type 1 diabetic patients with severe hypoglycemia unawareness have benefitted from cellular therapies, such as pancreas or islet transplantation; however, donor shortage and the need for immunosuppression limits widespread clinical application. We previously developed an intravascular bioartificial pancreas (iBAP) using silicon nanopore membranes (SNM) for immunoprotection. To ensure ample nutrient delivery, the iBAP will need a cell scaffold with high hydraulic permeability to provide mechanical support and maintain islet viability and function. Here, we examine the feasibility of superporous agarose (SPA) as a potential cell scaffold in the iBAP. SPA exhibits 66-fold greater hydraulic permeability than the SNM along with a short (<10 μm) diffusion distance to the nearest islet. SPA also supports short-term functionality of both encapsulated human islets and stem-cell-derived enriched β-clusters in a convection-based system, demonstrated by high viability (>95%) and biphasic insulin responses to dynamic glucose stimulus. These findings suggest that the SPA scaffold will not limit nutrient delivery in a convection-based bioartificial pancreas and merits continued investigation. Topics: Adult; Diabetes Mellitus, Type 1; Glucose; Graft vs Host Disease; Humans; Insulin-Secreting Cells; Islets of Langerhans; Islets of Langerhans Transplantation; Membranes, Artificial; Nanopores; Pancreas, Artificial; Sepharose; Silicon; Stem Cell Transplantation; Tissue Scaffolds	2021
Elevated blood drug levels obtained from indwelling silicon catheters during oral cyclosporine A administration. Bone marrow transplantation, 2002, Volume: 29, Issue:6 Cyclosporine A (CsA) may be bound to and released from the inner surface of central venous catheters resulting in spuriously elevated blood drug levels. We observed this phenomenon in a boy transplanted because of aplastic anemia up to 9 weeks after CsA had been switched from intravenous to oral administration. In comparison to phlebotomy, simultaneous blood sampling from the double lumen catheter resulted in a greater than 10-fold, or two-fold increase in drug levels, respectively, depending on whether or not the line used for prior CsA infusion was selected. Thus, prolonged binding of CsA to the inner surface of venous catheters should also be considered during oral administration. Topics: Administration, Oral; Anemia, Aplastic; Catheters, Indwelling; Child; Cyclosporine; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Infusions, Intra-Arterial; Male; Monitoring, Immunologic; Silicon	2002

Article

Year

Superporous agarose scaffolds for encapsulation of adult human islets and human stem-cell-derived β cells for intravascular bioartificial pancreas applications.

Journal of biomedical materials research. Part A, 2021, Volume: 109, Issue:12

Type 1 diabetic patients with severe hypoglycemia unawareness have benefitted from cellular therapies, such as pancreas or islet transplantation; however, donor shortage and the need for immunosuppression limits widespread clinical application. We previously developed an intravascular bioartificial pancreas (iBAP) using silicon nanopore membranes (SNM) for immunoprotection. To ensure ample nutrient delivery, the iBAP will need a cell scaffold with high hydraulic permeability to provide mechanical support and maintain islet viability and function. Here, we examine the feasibility of superporous agarose (SPA) as a potential cell scaffold in the iBAP. SPA exhibits 66-fold greater hydraulic permeability than the SNM along with a short (<10 μm) diffusion distance to the nearest islet. SPA also supports short-term functionality of both encapsulated human islets and stem-cell-derived enriched β-clusters in a convection-based system, demonstrated by high viability (>95%) and biphasic insulin responses to dynamic glucose stimulus. These findings suggest that the SPA scaffold will not limit nutrient delivery in a convection-based bioartificial pancreas and merits continued investigation.

Topics: Adult; Diabetes Mellitus, Type 1; Glucose; Graft vs Host Disease; Humans; Insulin-Secreting Cells; Islets of Langerhans; Islets of Langerhans Transplantation; Membranes, Artificial; Nanopores; Pancreas, Artificial; Sepharose; Silicon; Stem Cell Transplantation; Tissue Scaffolds

2021

Elevated blood drug levels obtained from indwelling silicon catheters during oral cyclosporine A administration.

Bone marrow transplantation, 2002, Volume: 29, Issue:6

Cyclosporine A (CsA) may be bound to and released from the inner surface of central venous catheters resulting in spuriously elevated blood drug levels. We observed this phenomenon in a boy transplanted because of aplastic anemia up to 9 weeks after CsA had been switched from intravenous to oral administration. In comparison to phlebotomy, simultaneous blood sampling from the double lumen catheter resulted in a greater than 10-fold, or two-fold increase in drug levels, respectively, depending on whether or not the line used for prior CsA infusion was selected. Thus, prolonged binding of CsA to the inner surface of venous catheters should also be considered during oral administration.

Topics: Administration, Oral; Anemia, Aplastic; Catheters, Indwelling; Child; Cyclosporine; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Infusions, Intra-Arterial; Male; Monitoring, Immunologic; Silicon

2002