silicon and Epilepsy

A controlled clinical trial of the anti-epileptic efficacy and toxic side effects of diphenylsilanediol was conducted on 24 client-owned epileptic dogs. Data obtained from an abbreviated procedural treatment program indicated that diphenylsilanediol compared favorably with primidone as an anti-epileptic compound, but had limiting toxic side effects to the liver, pancreas, and possibly to other tissues. There was a mean reduction of 60.7% in seizure frequency in 15 epileptic dogs treated with diphenylsilanediol when compared with their pretreatment frequency. There was a mean reduction of 55.6% in seizure frequency in 9 spileptic control dogs treated with primidone. Samples of blood obtained from the dogs in the program on the 4th, 8th, 12th, 24th, and 36th weeks of treatment were examined for complete blood cell count, blood urea nitrogen, liver function, and pancreatic function. Toxic side effects were not seen among the primidone-treated control dogs, with the exception of occasional dose-related drowsiness. Among the diphenylsilanediol-treated dogs, 3 developed liver disease, 2 developed definite pancreatic changes, and 2 showed evidence of bone marrow suppression. Four dogs died during treatment with diphenylsilanediol, whereas no deaths occurred during the same interval of primidone therapy.

Topics: Animals; Anticonvulsants; Bone Marrow; Clinical Trials as Topic; Dog Diseases; Dogs; Epilepsy; Heart; Liver; Pancreas; Primidone; Silanes; Silicon

Topics: Brain; Deep Brain Stimulation; Epilepsy; Humans; Seizures; Silicon

Surgical resection of epileptogenic foci is often a beneficial treatment for patients suffering debilitating seizures arising from intractable epilepsy [1], [2], [3]. Electrodes placed subdurally on the surface of the brain in the form of an ECoG array is one of the multiple methods for localizing epileptogenic zones for the purpose of defining the region for surgical resection. Currently, transcutaneous wires from ECoG grids limit the duration of time that implanted grids can be used for diagnosis. A wireless ECoG recording and stimulation system may be a solution to extend the diagnostic period. To avoid the transcutaneous connections, a 64-channel wireless silicon recording/stimulating ASIC was developed as the electronic component of a wireless ECoG array that uses SIROF electrodes on a polyimide substrate[4]. Here we describe two new ASIC devices that have been developed and tested as part of the on-going wireless ECoG system design.

Topics: Brain; Brain Mapping; Electrodes, Implanted; Electroencephalography; Epilepsy; Humans; Resins, Synthetic; Signal-To-Noise Ratio; Silicon; Wireless Technology

The implantable stimulator for epileptic seizure suppression with loading impedance adaptability was proposed in this work. The stimulator consisted of the high voltage generator, output driver, adaptor, and switches, can constantly provide the required 40-μA stimulus currents, as the loading impedance varied within 10 kΩ -300 kΩ. The performances of this design have been successfully verified in silicon chip fabricated by a 0.35- μm 3.3-V/24-V CMOS process. The power consumption of this work was only 1.1 mW-1.4 mW. The animal test results with the fabricated chip of proposed design have successfully verified in the Long-Evans rats with epileptic seizures.

Topics: Animals; Biomedical Engineering; Brain; Deep Brain Stimulation; Disease Models, Animal; Electric Impedance; Electric Power Supplies; Electrodes, Implanted; Electronics, Medical; Epilepsy; Equipment Design; Rats; Rats, Long-Evans; Signal Processing, Computer-Assisted; Silicon

Surgery for medically intractable epilepsy secondary to unihemispheric pathology has evolved from more aggressive hemispherectomy to less aggressive variations of hemispherotomy. The authors propose a novel minimally invasive endoscopic hemispherotomy that should give results comparable to conventional open craniotomy and microsurgery.. Endoscopic transventricular hemispherotomy was performed in 5 silicon-injected cadaveric heads in the authors' minimally invasive neurosurgery laboratory. The lateral ventricle was accessed endoscopically through a frontal and occipital bur hole. White matter disconnections were performed to unroof the temporal horn and to disconnect the frontobasal region, corpus callosum, and fornix.. Using an endoscopic transventricular approach, all white matter disconnections were successfully performed in all 5 cadavers.. The authors have demonstrated the feasibility of endoscopic transventricular hemispherotomy in a cadaveric model. The technique is simple and could be useful in a subgroup of patients with parenchymal volume loss and ventriculomegaly.

Topics: Cadaver; Cerebral Cortex; Cerebral Veins; Corpus Callosum; Endoscopy; Epilepsy; Feasibility Studies; Hemispherectomy; Humans; Lateral Ventricles; Minimally Invasive Surgical Procedures; Pia Mater; Postoperative Complications; Silicon

Polarizing microscopy (PM), scanning electron microscopy (SEM), x-ray dispersive analysis (EDAX), x-ray diffraction (XRD), and infrared spectrometry (IR) were used to study the following pathological mineralizations: calcifications and silicon(Si)-bearing mineralizations in cerebral tissue from an epileptic child; traces of Si-bearing particles in periprosthesic mammarian tissue, and calcifications in capsular mammarian tissue from a patient with a silicone gel mammarian implant, and 2 calcium-bearing compounds, a typical apatitic calcification, and a nonphosphorous-bearing calcification in arterial tissues. In this tissue we also found Si-bearing particles due to an artifact from glassware.

Topics: Aged; Apatites; Arteries; Artifacts; Brain Diseases; Breast; Breast Diseases; Breast Implants; Cadaver; Calcinosis; Child; Electron Probe Microanalysis; Epilepsy; Female; Foreign Bodies; Glass; Humans; Lymph Nodes; Microscopy, Electron, Scanning; Microscopy, Polarization; Middle Aged; Prostheses and Implants; Silicon; Silicone Gels; Spectrophotometry, Infrared; Vascular Diseases; X-Ray Diffraction