silicon and Anaphylaxis

silicon has been researched along with Anaphylaxis* in 1 studies

Other Studies

1 other study(ies) available for silicon and Anaphylaxis

Article	Year
Antiallergic activity profile in vitro RBL-2H3 and in vivo passive cutaneous anaphylaxis mouse model of new sila-substituted 1,3,4-oxadiazoles. Journal of medicinal chemistry, 2012, Jul-26, Volume: 55, Issue:14 A new class of sila-substituted 1,3,4-oxadiazoles was synthesized and evaluated for antiallergic activity using RBL-2H3 as the in vitro model and the in vivo anaphylactic mouse model. We observed that compound 5c effectively suppressed DNP-HSA-induced mast cell degranulation, compared to carbon analogue 9, and also suppressed the expression of TNF-α mRNA and Akt phosphorylation in antigen-stimulated RBL-2H3 cells. We also studied the effect of 5c in an in vivo passive cutaneous anaphylaxis (PCA) mouse model. The suppression by 5c was more effective than that by diphenylhydramine (DPH), a typical anti-histamine drug. Topics: Anaphylaxis; Animals; Anti-Allergic Agents; beta-N-Acetylhexosaminidases; Cell Line; Gene Expression Regulation; Immunoglobulin E; Male; Mice; Organometallic Compounds; Oxadiazoles; Passive Cutaneous Anaphylaxis; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; RNA, Messenger; Silicon; Silver; Tumor Necrosis Factor-alpha	2012

Article

Year

Antiallergic activity profile in vitro RBL-2H3 and in vivo passive cutaneous anaphylaxis mouse model of new sila-substituted 1,3,4-oxadiazoles.

Journal of medicinal chemistry, 2012, Jul-26, Volume: 55, Issue:14

A new class of sila-substituted 1,3,4-oxadiazoles was synthesized and evaluated for antiallergic activity using RBL-2H3 as the in vitro model and the in vivo anaphylactic mouse model. We observed that compound 5c effectively suppressed DNP-HSA-induced mast cell degranulation, compared to carbon analogue 9, and also suppressed the expression of TNF-α mRNA and Akt phosphorylation in antigen-stimulated RBL-2H3 cells. We also studied the effect of 5c in an in vivo passive cutaneous anaphylaxis (PCA) mouse model. The suppression by 5c was more effective than that by diphenylhydramine (DPH), a typical anti-histamine drug.

Topics: Anaphylaxis; Animals; Anti-Allergic Agents; beta-N-Acetylhexosaminidases; Cell Line; Gene Expression Regulation; Immunoglobulin E; Male; Mice; Organometallic Compounds; Oxadiazoles; Passive Cutaneous Anaphylaxis; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; RNA, Messenger; Silicon; Silver; Tumor Necrosis Factor-alpha

2012