silicate-cement and Inflammation

The purpose of this study was to determine the level of periodontal tissue regeneration in a canine model following post-extraction placement of an implant molded from a composite material made from extracted tooth dentin and a calcium silicate cement (CSC) material. The investigation used autologous dentin in conjunction with a CSC material to form a composite implant designed for immediate tooth replacement.. Two (2) beagles had a periodontal and radiographic examination performed to rule out any pre-treatment inflammation, significant periodontal disease, or mobility. Then, ination eleven (11) teeth were extracted and polyvinyl siloxane molds were made to fabricate three different types of implants: Particulate Implant (Test Group 1, n = 4), Shell Implant Alone (Test Group 2, n = 2), Shell Implant with Emdogain® (Test Group 3, n = 3). Teeth in the control group were extracted, scaled (n = 2), and then re-implanted into their respective fresh extraction sockets. At 4 weeks, a clinical, radiographic, and histologic assessment was performed.. Clinical evaluation revealed no mobility in any of the test or control implants and no radiographic evidence of significant bone loss or active disease. Based on the MicroCT analysis, direct bone to implant contact was observed in some areas with an apparent periodontal ligament space. Implant-related inflammation, on average, was similar among all groups, with low numbers of infiltrates. Implant-related inflammatory reaction was generally minimal and not interpreted to be adverse.. The proposed novel composite materials revealed that not only do these materials demonstrate high biocompatibility, but also their successful integration in the alveolus is likely secondary to a partial ligamentous attachment. The current investigation may lead to the use of calcium silicate-based materials as custom dental implants. Further research on this novel composite's biomechanical properties is necessary to develop the optimal material composition for use as a load-bearing dental implant.

Topics: Animals; Biomechanical Phenomena; Calcium Compounds; Dental Implants; Dentin; Dogs; Imaging, Three-Dimensional; Inflammation; Male; Osseointegration; Periodontal Ligament; Pilot Projects; Silicate Cement; Silicates; Tooth Extraction; Tooth Socket; X-Ray Microtomography

Topics: Animals; Composite Resins; Connective Tissue; Dental Implantation; Female; Foreign-Body Reaction; Inflammation; Male; Rats; Silicate Cement

Topics: Abdominal Muscles; Acrylic Resins; Animals; Edema; Guinea Pigs; Inflammation; Necrosis; Polymers; Silicate Cement; Stainless Steel; Wound Healing; Zinc Oxide-Eugenol Cement

Topics: Acrylic Resins; Animals; Connective Tissue; Dental Amalgam; Dental Materials; Dental Restoration, Permanent; Dental Restoration, Temporary; Gold; Hydroxyapatites; Inflammation; Metals; Photomicrography; Rats; Silicate Cement; Silver; Skin; Stainless Steel; Zinc Phosphate Cement