sildenafil-citrate and Hand-Dermatoses

sildenafil-citrate has been researched along with Hand-Dermatoses* in 3 studies

Trials

1 trial(s) available for sildenafil-citrate and Hand-Dermatoses

Article	Year
Effect of sildenafil on digital ulcers in systemic sclerosis: analysis from a single centre pilot study. Annals of the rheumatic diseases, 2010, Volume: 69, Issue:8 In this pilot study, the effect of sildenafil on digital ulcer (DU) healing and related clinical symptoms was analysed.. A total of 19 patients with systemic sclerosis (SSc) were treated with maximally tolerated sildenafil doses up to 6 months. Primary outcome was the healing of DUs. Changes in other clinical symptoms were also evaluated.. In all, 49 DUs were present at baseline; this decreased to 17 ulcers (p<0.001) at the end of sildenafil treatment. Furthermore, the visual analogue scale (VAS) score for Raynaud's phenomenon (RP), pain and activity improved (p=0.003, p=0.002 and p=0.05, respectively). A total of 9 patients developed 12 new DUs during sildenafil treatment.. This study indicates an effect of sildenafil on DU healing in patients with SSc and an improvement of RP and associated symptoms that should be validated in controlled studies. Topics: Adult; Aged; Dermatologic Agents; Fingers; Hand Dermatoses; Humans; Middle Aged; Phosphodiesterase Inhibitors; Pilot Projects; Piperazines; Purines; Scleroderma, Systemic; Sildenafil Citrate; Skin Ulcer; Sulfones; Treatment Outcome	2010

Article

Year

Effect of sildenafil on digital ulcers in systemic sclerosis: analysis from a single centre pilot study.

Annals of the rheumatic diseases, 2010, Volume: 69, Issue:8

In this pilot study, the effect of sildenafil on digital ulcer (DU) healing and related clinical symptoms was analysed.. A total of 19 patients with systemic sclerosis (SSc) were treated with maximally tolerated sildenafil doses up to 6 months. Primary outcome was the healing of DUs. Changes in other clinical symptoms were also evaluated.. In all, 49 DUs were present at baseline; this decreased to 17 ulcers (p<0.001) at the end of sildenafil treatment. Furthermore, the visual analogue scale (VAS) score for Raynaud's phenomenon (RP), pain and activity improved (p=0.003, p=0.002 and p=0.05, respectively). A total of 9 patients developed 12 new DUs during sildenafil treatment.. This study indicates an effect of sildenafil on DU healing in patients with SSc and an improvement of RP and associated symptoms that should be validated in controlled studies.

Topics: Adult; Aged; Dermatologic Agents; Fingers; Hand Dermatoses; Humans; Middle Aged; Phosphodiesterase Inhibitors; Pilot Projects; Piperazines; Purines; Scleroderma, Systemic; Sildenafil Citrate; Skin Ulcer; Sulfones; Treatment Outcome

2010

Other Studies

2 other study(ies) available for sildenafil-citrate and Hand-Dermatoses

Article	Year
Low-dose combination therapy of severe digital ulcers in diffuse progressive systemic sclerosis with the endothelin-1 receptor antagonist bosentan and the phosphodiesterase V inhibitor sildenafil. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2009, Volume: 7, Issue:10 Digital ulcers in progressive systemic sclerosis (PSS) are often refractory to therapy. A frequently chronic aggressive course can lead to the loss of acral limbs involved. A 73-year-old woman developed a dramatic worsening of her ulcerations despite maximum conventional therapy. Switching therapy to bosentan and sildenafil, both in low-dose regimens, resulted for the first time in ten years in a complete healing of the ulcers. If substantiated in a series of patients, the additive and perhaps synergistic clinical benefits of combining bosentan and sildenafil may be a valuable option for the treatment of acral ulcers in PSS. Topics: Aged; Bosentan; Drug Therapy, Combination; Endothelin Receptor Antagonists; Female; Fingers; Hand Dermatoses; Humans; Phosphodiesterase Inhibitors; Piperazines; Purines; Scleroderma, Diffuse; Sildenafil Citrate; Sulfonamides; Sulfones; Treatment Outcome; Ulcer	2009
[Sildenafil in the treatment of digital ulcers in patients with systemic sclerosis]. Actas dermo-sifiliograficas, 2009, Volume: 100, Issue:9 Topics: Amputation, Surgical; Female; Fingers; Hand Dermatoses; Humans; Ischemia; Microcirculation; Middle Aged; Piperazines; Postoperative Complications; Purines; Scleroderma, Systemic; Sildenafil Citrate; Skin Ulcer; Sulfones; Vasodilator Agents	2009

Article

Year

Low-dose combination therapy of severe digital ulcers in diffuse progressive systemic sclerosis with the endothelin-1 receptor antagonist bosentan and the phosphodiesterase V inhibitor sildenafil.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2009, Volume: 7, Issue:10

Digital ulcers in progressive systemic sclerosis (PSS) are often refractory to therapy. A frequently chronic aggressive course can lead to the loss of acral limbs involved. A 73-year-old woman developed a dramatic worsening of her ulcerations despite maximum conventional therapy. Switching therapy to bosentan and sildenafil, both in low-dose regimens, resulted for the first time in ten years in a complete healing of the ulcers. If substantiated in a series of patients, the additive and perhaps synergistic clinical benefits of combining bosentan and sildenafil may be a valuable option for the treatment of acral ulcers in PSS.

Topics: Aged; Bosentan; Drug Therapy, Combination; Endothelin Receptor Antagonists; Female; Fingers; Hand Dermatoses; Humans; Phosphodiesterase Inhibitors; Piperazines; Purines; Scleroderma, Diffuse; Sildenafil Citrate; Sulfonamides; Sulfones; Treatment Outcome; Ulcer

2009

[Sildenafil in the treatment of digital ulcers in patients with systemic sclerosis].

Actas dermo-sifiliograficas, 2009, Volume: 100, Issue:9

Topics: Amputation, Surgical; Female; Fingers; Hand Dermatoses; Humans; Ischemia; Microcirculation; Middle Aged; Piperazines; Postoperative Complications; Purines; Scleroderma, Systemic; Sildenafil Citrate; Skin Ulcer; Sulfones; Vasodilator Agents

2009