sildenafil-citrate and Endocarditis

In recent years, there has been a rise in the number patients with CHD surviving into adulthood. Many have complications related to their CHD or its treatments, outside the heart, including ocular abnormalities. The objective of this review is to highlight the ocular abnormalities that occur in adults with CHD, either from their condition or related to the common drugs prescribed to manage it. In particular, we reviewed the effects of cyanosis, coarctation of the aorta, endocarditis, and the side effects of Sildenafil and Amiodarone. A change in the retinal vasculature is a common observation with cyanosis or coarctation of the aorta. Occlusion of the retinal vessels may also be observed in cyanotic patients, as well as those with infectious endocarditis. Sildenafil has established ocular side effects; here they are explored in the context of therapy for pulmonary hypertension. Similarly, Amiodarone has established ocular risks, which are summarised. The high prevalence of ocular consequences in adult CHD patients reinforces the need for knowledge of the risks involved and for frequent ophthalmological screening where appropriate.

Topics: Adult; Amiodarone; Aortic Coarctation; Cyanosis; Endocarditis; Eye Diseases; Heart Defects, Congenital; Humans; Retinal Vessels; Sildenafil Citrate

We report on the management of Candida endocarditis in a 5-month old infant. The orifice of the tricuspid valve was totally obstructed, and the tension apparatus of the valve destroyed. Excision of the valve led to severe failure of the right heart. The combined use of anti-failure treatment, and reduction of right ventricular afterload with oxygen, nitric oxide and sildenafil, proved successful.

Topics: Antifungal Agents; Candidiasis; Endocarditis; Female; Fluconazole; Heart Failure; Humans; Infant; Nitric Oxide; Oxygen Inhalation Therapy; Piperazines; Postoperative Complications; Purines; Sildenafil Citrate; Sulfones; Tricuspid Valve; Vasodilator Agents