sildenafil-citrate and Chylothorax

Congenital chylothorax (CC) can result from a congenital malformation or an acquired obstruction or disruption of the thoracic duct. Recently, oral administration of the phosphodiesterase-5 inhibitor, sildenafil, was reported to be effective in resolving non-pulmonary lymphatic malformations in infants and young children. We report a case of CC in a late preterm infant with congenital pulmonary lymphangiectasia where octreotide was not effective, but management with oral sildenafil was successful.

Topics: Chylothorax; Female; Humans; Infant, Newborn; Infant, Premature, Diseases; Lung; Lung Diseases; Lymphangiectasis; Phosphodiesterase 5 Inhibitors; Sildenafil Citrate; Tomography, X-Ray Computed