sildenafil-citrate has been researched along with Cataract* in 2 studies
2 other study(ies) available for sildenafil-citrate and Cataract
Article | Year |
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The Effect of Sildenafil on Selenite-Induced Cataract in Rats.
To investigate the effect of sildenafil on an experimental sodium selenite-induced cataract model in rats.. Twenty-six young Wistar rats were separated into four groups. On postpartum day 10, six rats received only selenite (group 1, selenite-induced cataract), seven rats received selenite and high dose oral sildenafil (group 2, high-dose sildenafil-treated), seven rats received selenite and low dose oral sildenafil (group 3, low-dose sildenafil-treated), and six rats received only saline (group 4, controls). On postpartum day 30, cataract formation was graded and recorded using an operating microscope. The rats were sacrificed, lens tissues were isolated, and serum samples were collected. Nitrite oxide metabolites (NOx), advanced oxidative protein products (AOPP), and total sulfhydryl (TSH) levels were assessed in both serum and lenticular samples.. The rats treated with low-dose sildenafil showed lower levels of AOPP and NOx, and the higher levels of TSH than the rats in other experimental groups. Otherwise, the rats treated with high-dose sildenafil, similar to the selenite-induced cataract group, showed higher levels of AOPP and serum NOx than rats in the low-dose sildenafil-treated group. The rats treated with low-dose sildenafil also showed less cataract development than rats in the other experimental groups.. Low doses (0.7 mg/kg) of oral sildenafil might show a protective effect on cataract development by lowering oxidative stress. Topics: Administration, Oral; Advanced Oxidation Protein Products; Animals; Cataract; Disease Models, Animal; Lens, Crystalline; Nitric Oxide; Phosphodiesterase 5 Inhibitors; Rats; Rats, Wistar; Sildenafil Citrate; Slit Lamp Microscopy; Sodium Selenite; Sulfhydryl Compounds; Trace Elements | 2020 |
[Visual disturbance].
Topics: Antimetabolites, Antineoplastic; Antitubercular Agents; Cataract; Central Serous Chorioretinopathy; Corneal Opacity; Ethambutol; Glaucoma; Humans; Interferons; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Sildenafil Citrate; Steroids; Stevens-Johnson Syndrome; Sulfones; Tegafur; Vision Disorders | 2012 |