sildenafil-citrate and Behcet-Syndrome

Behcet's disease (BD) is a multisystemic inflammatory disorder of unknown origin, presenting with mucocutaneous, ocular, articular, vascular, gastrointestinal and central nervous system manifestations. Coronary involvement is very rare in patients with BD. Sildenafil, an oral drug used to treat erectile dysfunction, was shown to cause significant cardiovascular problems including acute myocardial infarction (MI) and sudden cardiac death. Acute MI associated with BD and sildenafil has not been reported previously. We present a case of a 23-year-old male patient with an acute inferior MI associated with BD diagnosed after admission of sildenafil, who was successfully treated with thrombus aspiration and tirofiban administration.

Topics: Behcet Syndrome; Coronary Angiography; Electrocardiography; Follow-Up Studies; Humans; Male; Myocardial Infarction; Piperazines; Purines; Sildenafil Citrate; Sulfones; Vasodilator Agents; Young Adult

Behçet's disease (BD) may cause uveitis and retinal vasculitis in nearly half of the patients. Uveitis is one of the most serious complications that can lead to blindness. Sildenafil (Viagra(R)) and the other phosphodiesterase type 5 (PDE5) inhibitors are the first-line options for the treatment of erectile dysfunction, but transient visual symptoms and serious ocular side effects have been reported in PDE5 inhibitor users. Herein, we report a case with BD who applied to our outpatient unit with recurrent uveitis after sildenafil therapy.

Topics: Adult; Behcet Syndrome; Humans; Male; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Recurrence; Sildenafil Citrate; Sulfones; Uveitis