sildenafil-citrate and Aortic-Dissection

This report deals with a 28-year-old male patient, admitted with a type A aortic dissection, potentially related to the use of sildenafil. In the literature, we found only two other potentially sildenafil-related cases of aortic dissections, one type A and one type B. In our patient, a bicuspid aortic valve and an ascending aortic aneurysm were other underlying anomalies that could have led to the aortic dissection.

Topics: Adult; Aortic Aneurysm; Aortic Dissection; Aortic Valve; Aortography; Heart Defects, Congenital; Humans; Male; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Substance-Related Disorders; Sulfones; Tomography, X-Ray Computed; Treatment Outcome; Vascular Surgical Procedures

Topics: Adult; Aortic Aneurysm; Aortic Dissection; Child; Humans; Phosphodiesterase Inhibitors; Piperazines; Purines; Risk Assessment; Risk Factors; Sildenafil Citrate; Sulfones

Topics: Aortic Aneurysm, Thoracic; Aortic Dissection; Blood Vessel Prosthesis Implantation; Erectile Dysfunction; Fatal Outcome; Humans; Male; Middle Aged; Penile Erection; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones

We report the rare subchronic clinical course of a giant, dissecting pulmonary artery aneurysm in an oligosymptomatic middle-aged woman who had idiopathic pulmonary hypertension. Diagnosis was simple with the use of echocardiography and multislice computed tomography. Conversely, deciding on the treatment was difficult, because prominent surgeons declined to perform surgical repair of the aneurysm and recommended heart-lung transplantation. Therefore, we were forced to treat our patient medically. She survived for 1 year, including 8 months of treatment with sildenafil, and then died suddenly while awaiting transplantation. Our patient, who had a dissecting, high-pressure pulmonary artery aneurysm, had an unexpectedly stable and uneventful clinical course for 1 year, which, under more favorable circumstances, might have provided enough time for heart-lung transplantation to be performed.

Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Adult; Aortic Dissection; Echocardiography; Fatal Outcome; Female; Follow-Up Studies; Humans; Hypertension, Pulmonary; Piperazines; Pulmonary Artery; Pulmonary Wedge Pressure; Purines; Severity of Illness Index; Sildenafil Citrate; Sulfones; Tomography, X-Ray Computed; Vasodilator Agents

Topics: Adult; Aortic Aneurysm, Thoracic; Aortic Dissection; Cocaine; Drug Interactions; Humans; Male; Piperazines; Purines; Sildenafil Citrate; Sulfones