sildenafil-citrate and Antiphospholipid-Syndrome

To perform a review and update of the antiphospholipid syndrome summarizing its urological presentations.. A complete bibliographic search was performed through PubMed MEDLINE and articles were reviewed with special attention to those bibliographic references about urological presentations. We document the unique and unpublished case of a patient with neurogenic bladder secondary to antiphospholipid syndrome.. The antiphospholipid syndrome is an acquired autoimmune systemic disease generating a permanent hypercoagulability status with recurrent multiorgan thrombotic events due to circulating antiphospholipid antibodies. It may be secondary to a heterogeneous group of diseases (mainly lupus) and drugs, or primary if it appears isolated without any demonstrable systemic disease or concomitant medication. It is mainly characterized by venous or arterial recurrent thrombosis, recurrent abortion, thrombocytopenia, and circulating antiphospholipid auto-antibodies. Treatment with anticoagulants and correction of the hypercoagulable status contributing factors, arterial or venous thrombosis, and vascular risk aim to avoid new thrombosis episodes. Genitourynary system may be affected in any of its parts, generally by arterial or venous thrombosis. Kidney is the most frequently affected organ, in addition to transplanted kidney grafts, adrenal glands, bladder and testicles. There is a relationship between antiphospholipid syndrome and infertility. For the first time, we describe bladder involvement presenting as hyperreflexic neurogenic bladder with detrusor-sphincter dyssynergia after spontaneous spinal cord thrombosis in an asymptomatic adolescent with primary antiphospholipid syndrome which was unknown before.

Topics: Abortion, Spontaneous; Adolescent; Antiphospholipid Syndrome; Female; Humans; Male; Piperazines; Pregnancy; Purines; Sildenafil Citrate; Skin Diseases; Sulfones; Testicular Diseases; Urinary Bladder, Neurogenic; Urologic Diseases

Topics: Adolescent; Antiphospholipid Syndrome; Female; Foot Diseases; Gangrene; Humans; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Purpura; Sildenafil Citrate; Sulfones; Toes; Treatment Outcome

Nonhealing skin ulceration is a cutaneous manifestation of the antiphospholipid syndrome (APS) and is associated with thrombosis of small dermal vessels. Numerous therapies have been described but are either ineffective or require a prolonged course of treatment with potential complications. We describe the efficacy of sildenafil, a phosphodiesterase inhibitor, in the treatments of such ulcers.

Topics: Antiphospholipid Syndrome; Humans; Male; Middle Aged; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Skin Ulcer; Sulfones; Wound Healing