silatrane and Wounds-and-Injuries

Experiments on rats were performed to study the effect of I-/chlormethyl/silatrane and I-/ethoxy/silatrane as well as that of triethanolamine and /chlormethyl/triethoxysilane on the biochemical characteristics of granular-fibrous tissue. The drugs were applied to the wound in the form of liniments. Silatranes stimulated cell proliferation and raised biosynthetic activity of the cells. They also favoured collagen and non-collagenous protein accumulation and reduced the inflammatory manifestations. The silicon-containing fragment of the silatrane molecule, /chlormethyl/triethoxysilane, produced an analogous but less pronounced action. Triethanolamine containing no silicon appeared to be far less active. These data indicate that the presence of silicon in the silatrane grouping is of great importance for its effective biological function.

Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Granulation Tissue; Liniments; Organosilicon Compounds; Rats; Silicon; Wound Healing; Wounds and Injuries