silatrane and Breast-Neoplasms

silatrane has been researched along with Breast-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for silatrane and Breast-Neoplasms

Article	Year
Stereoselective and improved syntheses and anticancer testing of 3'-O-silatranylthymidines. Bioorganic & medicinal chemistry letters, 2002, Dec-16, Volume: 12, Issue:24 A stereoselective synthesis of 3'-O-((R,R,R)-trimethylsilatranyl)thymidine (R,R,R-1) and synthesis of 3'-O-silatranylthymidine (5) via an improved silatranylation procedure using tetrakis(dimethylamino)silane are reported. Diastereomeric mixture 1 showed more activity than R,R,R-1 or 5 in a primary anticancer screen against breast, CNS, and lung cell lines; demonstrating the import of the configuration and presence, respectively, of the silatrane methyl groups for growth inhibition. Topics: Antineoplastic Agents; Brain Neoplasms; Breast Neoplasms; Bridged Bicyclo Compounds, Heterocyclic; Cell Division; Drug Screening Assays, Antitumor; Humans; Lung Neoplasms; Organosilicon Compounds; Sensitivity and Specificity; Stereoisomerism; Thymidine; Tumor Cells, Cultured	2002

Article

Year

Stereoselective and improved syntheses and anticancer testing of 3'-O-silatranylthymidines.

Bioorganic & medicinal chemistry letters, 2002, Dec-16, Volume: 12, Issue:24

A stereoselective synthesis of 3'-O-((R,R,R)-trimethylsilatranyl)thymidine (R,R,R-1) and synthesis of 3'-O-silatranylthymidine (5) via an improved silatranylation procedure using tetrakis(dimethylamino)silane are reported. Diastereomeric mixture 1 showed more activity than R,R,R-1 or 5 in a primary anticancer screen against breast, CNS, and lung cell lines; demonstrating the import of the configuration and presence, respectively, of the silatrane methyl groups for growth inhibition.

Topics: Antineoplastic Agents; Brain Neoplasms; Breast Neoplasms; Bridged Bicyclo Compounds, Heterocyclic; Cell Division; Drug Screening Assays, Antitumor; Humans; Lung Neoplasms; Organosilicon Compounds; Sensitivity and Specificity; Stereoisomerism; Thymidine; Tumor Cells, Cultured

2002