Page last updated: 2024-11-04

sibutramine and Weight Gain

sibutramine has been researched along with Weight Gain in 31 studies

sibutramine: serotonin and norepinephrine transporter inhibitor; Meridia is tradename for sibutramine hydrochloride

Weight Gain: Increase in BODY WEIGHT over existing weight.

Research Excerpts

ExcerptRelevanceReference
" The current trial investigated the effect of add-on treatment with sibutramine in schizophrenia outpatients who had gained more than 7% of weight during the course of treatment."9.19Sibutramine in the treatment of antipsychotic-induced weight gain: a pilot study in patients with schizophrenia. ( Biedermann, F; Ebenbichler, CF; Fleischhacker, WW; Hofer, A; Kemmler, G; Lechleitner, M, 2014)
"Combination therapy with sibutramine and varenicline for weight gain prevention and smoking cessation as an intervention for smokers at risk for relapse to smoking because of weight gain may warrant further investigation."9.14Sibutramine for weight gain attenuation during smoking cessation with varenicline: a pilot study. ( Clark, MM; Croghan, IT; Ebbert, JO; Hays, JT; Schroeder, DR; Sood, A, 2009)
"Metformin (850-1700 mg) plus sibutramine (10-20 mg, n=13) or placebo (n=15) was administered for 12 weeks in olanzapine-treated chronic schizophrenia patients."9.13Metformin plus sibutramine for olanzapine-associated weight gain and metabolic dysfunction in schizophrenia: a 12-week double-blind, placebo-controlled pilot study. ( Baptista, T; Beaulieu, S; de Baptista, EA; El Fakih, Y; Galeazzi, T; Rangel, N; Uzcátegui, E, 2008)
"This was a 12-week double-blind, placebo controlled, randomized trial of sibutramine for weight loss in obese clozapine-treated schizophrenia or schizoaffective disorder subjects."9.12A double-blind, placebo-controlled trial of sibutramine for clozapine-associated weight gain. ( Borba, CP; Cather, C; Copeland, PM; Daley, TB; Evins, AE; Fan, X; Freudenreich, O; Goff, DC; Hayden, D; Henderson, DC; Nguyen, DD; Zhang, H, 2007)
"To describe the comparative efficacy of orlistat and sibutramine in an obesity management program, with specific attention to compliance and weight regains after noncompliance."9.12Comparison of orlistat and sibutramine in an obesity management program: efficacy, compliance, and weight regain after noncompliance. ( Baskal, N; Cesur, M; Cin, MO; Erdogan, MF; Gursoy, A, 2006)
"In this 24-week, open-label, flexible-dose, comparison trial, 46 outpatients with bipolar disorders who had a body mass index (BMI) > or =30 kg/m(2), or > or =27 kg/m(2) with obesity-related comorbidities, and psychotropic-associated weight gain were randomly assigned to receive sibutramine (n = 18; 5-15 mg/day) or topiramate (n = 28; 25-600 mg/day)."9.12A 24-week, randomized, controlled trial of adjunctive sibutramine versus topiramate in the treatment of weight gain in overweight or obese patients with bipolar disorders. ( Altshuler, LL; Black, D; Denicoff, KD; Frye, MA; Hellemann, G; Keck, PE; Kupka, R; Leverich, GS; McElroy, SL; Mintz, J; Nolen, W; Post, RM; Suppes, T, 2007)
"Each subject had a DSM-IV diagnosis of schizophrenia or schizoaffective disorder, had been taking a stable dose of olanzapine for at least 4 months, and had a body mass index of >/=30 kg/m(2) or >/=27 kg/m(2) plus at least one cardiovascular risk factor."9.11A double-blind, placebo-controlled trial of sibutramine for olanzapine-associated weight gain. ( Borba, CP; Cather, C; Copeland, PM; Daley, TB; Evins, AE; Freudenreich, O; Goff, DC; Hayden, D; Henderson, DC; Louie, PM; Nguyen, DD, 2005)
"After Sibutramine discontinuation patients had weight gain but they did not reach the baseline body weight."9.09Second phase of a double-blind study clinical trial on Sibutramine for the treatment of patients suffering essential obesity: 6 months after treatment cross-over. ( Berber, A; Cortinas, L; Fanghänel, G; Sánchez-Reyes, L, 2001)
"Orlistat and sibutramine had early effects on weight loss, not sustained over 3 years."7.81The effectiveness of pharmaceutical interventions for obesity: weight loss with orlistat and sibutramine in a United Kingdom population-based cohort. ( Batterham, RL; Bhaskaran, K; Douglas, IJ; Smeeth, L, 2015)
" She started sibutramine treatment and presented with amenogalactorrhea."7.77A case of sibutramine-induced hyperprolactinemia. ( da Costa Oliveira, M; Pereira-Lima, JF; Soares Leaes, CG, 2011)
"Sibutramine treatment decreased body weight gain by 12% without a significant overall change in daily food intake."7.70Effect of the antiobesity agent sibutramine in obese-diabetic ob/ob mice. ( Bailey, CJ; Day, C, 1998)
" Single dosing with sibutramine (3."5.35Sibutramine-induced anorexia: potent, dose-dependent and behaviourally-selective profile in male rats. ( Blundell, JE; Rodgers, RJ; Tallett, AJ, 2009)
" The current trial investigated the effect of add-on treatment with sibutramine in schizophrenia outpatients who had gained more than 7% of weight during the course of treatment."5.19Sibutramine in the treatment of antipsychotic-induced weight gain: a pilot study in patients with schizophrenia. ( Biedermann, F; Ebenbichler, CF; Fleischhacker, WW; Hofer, A; Kemmler, G; Lechleitner, M, 2014)
"To develop statistical models for predicting weight loss and regain, we analyzed the phenotypic responses in an outpatient study of 60 obese subjects randomized to one of three 12-week interventions, diet (-600 kcal) alone, diet with exercise, and diet with sibutramine."5.16Prediction of weight loss and regain following dietary, lifestyle, and pharmacologic intervention. ( Brooke, A; Delafont, B; Elkhawad, M; Miller, SR; Murgatroyd, PR; Napolitano, A; Nunez, DJ; Tan, CY; Vidal-Puig, A; Virtue, S, 2012)
"Combination therapy with sibutramine and varenicline for weight gain prevention and smoking cessation as an intervention for smokers at risk for relapse to smoking because of weight gain may warrant further investigation."5.14Sibutramine for weight gain attenuation during smoking cessation with varenicline: a pilot study. ( Clark, MM; Croghan, IT; Ebbert, JO; Hays, JT; Schroeder, DR; Sood, A, 2009)
"Metformin (850-1700 mg) plus sibutramine (10-20 mg, n=13) or placebo (n=15) was administered for 12 weeks in olanzapine-treated chronic schizophrenia patients."5.13Metformin plus sibutramine for olanzapine-associated weight gain and metabolic dysfunction in schizophrenia: a 12-week double-blind, placebo-controlled pilot study. ( Baptista, T; Beaulieu, S; de Baptista, EA; El Fakih, Y; Galeazzi, T; Rangel, N; Uzcátegui, E, 2008)
"This was a 12-week double-blind, placebo controlled, randomized trial of sibutramine for weight loss in obese clozapine-treated schizophrenia or schizoaffective disorder subjects."5.12A double-blind, placebo-controlled trial of sibutramine for clozapine-associated weight gain. ( Borba, CP; Cather, C; Copeland, PM; Daley, TB; Evins, AE; Fan, X; Freudenreich, O; Goff, DC; Hayden, D; Henderson, DC; Nguyen, DD; Zhang, H, 2007)
"To describe the comparative efficacy of orlistat and sibutramine in an obesity management program, with specific attention to compliance and weight regains after noncompliance."5.12Comparison of orlistat and sibutramine in an obesity management program: efficacy, compliance, and weight regain after noncompliance. ( Baskal, N; Cesur, M; Cin, MO; Erdogan, MF; Gursoy, A, 2006)
"In this 24-week, open-label, flexible-dose, comparison trial, 46 outpatients with bipolar disorders who had a body mass index (BMI) > or =30 kg/m(2), or > or =27 kg/m(2) with obesity-related comorbidities, and psychotropic-associated weight gain were randomly assigned to receive sibutramine (n = 18; 5-15 mg/day) or topiramate (n = 28; 25-600 mg/day)."5.12A 24-week, randomized, controlled trial of adjunctive sibutramine versus topiramate in the treatment of weight gain in overweight or obese patients with bipolar disorders. ( Altshuler, LL; Black, D; Denicoff, KD; Frye, MA; Hellemann, G; Keck, PE; Kupka, R; Leverich, GS; McElroy, SL; Mintz, J; Nolen, W; Post, RM; Suppes, T, 2007)
"Each subject had a DSM-IV diagnosis of schizophrenia or schizoaffective disorder, had been taking a stable dose of olanzapine for at least 4 months, and had a body mass index of >/=30 kg/m(2) or >/=27 kg/m(2) plus at least one cardiovascular risk factor."5.11A double-blind, placebo-controlled trial of sibutramine for olanzapine-associated weight gain. ( Borba, CP; Cather, C; Copeland, PM; Daley, TB; Evins, AE; Freudenreich, O; Goff, DC; Hayden, D; Henderson, DC; Louie, PM; Nguyen, DD, 2005)
"After Sibutramine discontinuation patients had weight gain but they did not reach the baseline body weight."5.09Second phase of a double-blind study clinical trial on Sibutramine for the treatment of patients suffering essential obesity: 6 months after treatment cross-over. ( Berber, A; Cortinas, L; Fanghänel, G; Sánchez-Reyes, L, 2001)
"Topiramate (alone or associated with sibutramine) and orlistat (alone or in combination) promoted significant weight loss after 2 years of use in patients submitted to bariatric surgery with weight regain."4.31Treatment with Antiobesity Drugs in Weight Regain After Bariatric Surgery: a Retrospective Cohort Study. ( Boger, BS; Canuto, MC; Cercato, C; de Melo, ME; Mancini, MC; Noriega, PEP; Queiroz, NL; Stumpf, MAM, 2023)
"Orlistat and sibutramine had early effects on weight loss, not sustained over 3 years."3.81The effectiveness of pharmaceutical interventions for obesity: weight loss with orlistat and sibutramine in a United Kingdom population-based cohort. ( Batterham, RL; Bhaskaran, K; Douglas, IJ; Smeeth, L, 2015)
" She started sibutramine treatment and presented with amenogalactorrhea."3.77A case of sibutramine-induced hyperprolactinemia. ( da Costa Oliveira, M; Pereira-Lima, JF; Soares Leaes, CG, 2011)
" Included were 158 patients with schizophrenia or bipolar disorder and a body mass index (BMI) > or = 25 kg/m2 who had received olanzapine treatment in combination with nizatidine (n = 68), sibutramine (n = 42), or amantadine (n = 48)."3.75Predictors and correlates for weight changes in patients co-treated with olanzapine and weight mitigating agents; a post-hoc analysis. ( Heinloth, AN; Hoffmann, VP; Kinon, BJ; Lipkovich, I; McGregor, HS; Stauffer, VL, 2009)
" Sibutramine treatment did not affect the dietary behaviour of high-protein- or high-carbohydrate-fed rats, while it significantly attenuated the daily food intake and body weight gain rate in the high-fat group, at the dose of 10 mg/kg."3.74Effect of isocaloric diets and sibutramine on food intake, body mass variation and serum TNF-alpha levels in rats. ( Couvari, E; Dontas, I; Galanopoulou, P; Liapi, C; Mavri, M; Perelas, A; Perrea, D; Stroubini, T; Trapali, M, 2008)
"Dexfenfluramine (DEX) and sibutramine (SIB) are effective antiobesity agents."3.73Chronic treatment with either dexfenfluramine or sibutramine in diet-switched diet-induced obese mice. ( Brune, ME; Bush, EN; Droz, BA; Fey, T; Jacobson, PB; Knourek-Segel, VE; Lin, E; Shapiro, R, 2006)
"Sibutramine treatment decreased body weight gain by 12% without a significant overall change in daily food intake."3.70Effect of the antiobesity agent sibutramine in obese-diabetic ob/ob mice. ( Bailey, CJ; Day, C, 1998)
"Obesity is associated with considerable morbidity and decreased life expectancy."2.41Options for pharmacological management of obesity in patients treated with atypical antipsychotics. ( Sanders, TA; Taylor, D; Werneke, U, 2002)
" Single dosing with sibutramine (3."1.35Sibutramine-induced anorexia: potent, dose-dependent and behaviourally-selective profile in male rats. ( Blundell, JE; Rodgers, RJ; Tallett, AJ, 2009)
"Lean and obese Zucker rats were orally dosed with SR 141716 (3, 10, 30 mg/kg PO), sibutramine (5 mg/kg PO) or vehicle for one week."1.32Preferential effects of the cannabinoid CB1 receptor antagonist, SR 141716, on food intake and body weight gain of obese (fa/fa) compared to lean Zucker rats. ( Dourish, CT; Kennett, GA; Vickers, SP; Webster, LJ; Wyatt, A, 2003)
"To determine the effect of acute and chronic administration of a new food intake-reducing compound (HMR1426) with novel mode of action (retardation of gastric emptying) on body weight development, food intake, and energy metabolism in rats."1.32The novel antiobesic HMR1426 reduces food intake without affecting energy expenditure in rats. ( Bickel, M; Geisen, K; Gossel, M; Jähne, G; Kampe, J; Klaus, S; Lang, HJ; Ortmann, S, 2004)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (12.90)18.2507
2000's20 (64.52)29.6817
2010's6 (19.35)24.3611
2020's1 (3.23)2.80

Authors

AuthorsStudies
Boger, BS1
Queiroz, NL1
Noriega, PEP1
Canuto, MC1
Stumpf, MAM1
Cercato, C1
Mancini, MC1
de Melo, ME1
Biedermann, F1
Fleischhacker, WW1
Kemmler, G1
Ebenbichler, CF1
Lechleitner, M1
Hofer, A1
Douglas, IJ1
Bhaskaran, K1
Batterham, RL1
Smeeth, L1
Tallett, AJ2
Blundell, JE2
Rodgers, RJ2
Rihmer, Z1
Purebl, G1
Faludi, G1
Halmy, L1
Stauffer, VL1
Lipkovich, I1
Hoffmann, VP1
Heinloth, AN1
McGregor, HS1
Kinon, BJ1
Sood, A1
Ebbert, JO1
Clark, MM1
Croghan, IT1
Schroeder, DR1
Hays, JT1
Kaplan, LM1
Soares Leaes, CG1
Pereira-Lima, JF1
da Costa Oliveira, M1
Napolitano, A1
Miller, SR1
Murgatroyd, PR1
Delafont, B1
Brooke, A1
Elkhawad, M1
Tan, CY1
Virtue, S1
Vidal-Puig, A1
Nunez, DJ1
Werneke, U1
Taylor, D1
Sanders, TA1
Vickers, SP1
Webster, LJ1
Wyatt, A1
Dourish, CT1
Kennett, GA1
Casado, A1
Rodríguez, VM1
Portillo, MP1
Macarulla, MT1
Abecia, LC1
Echevarría, E1
Casis, L1
Matsumoto, K1
Iijima, H1
Ortmann, S1
Kampe, J1
Gossel, M1
Bickel, M1
Geisen, K1
Jähne, G1
Lang, HJ1
Klaus, S1
Henderson, DC2
Copeland, PM2
Daley, TB2
Borba, CP2
Cather, C2
Nguyen, DD2
Louie, PM1
Evins, AE2
Freudenreich, O2
Hayden, D2
Goff, DC2
Bush, EN1
Shapiro, R1
Brune, ME1
Knourek-Segel, VE1
Droz, BA1
Fey, T1
Lin, E1
Jacobson, PB1
Alisky, JM1
Fan, X1
Zhang, H1
Gursoy, A1
Erdogan, MF1
Cin, MO1
Cesur, M1
Baskal, N1
McElroy, SL1
Frye, MA1
Altshuler, LL1
Suppes, T1
Hellemann, G1
Black, D1
Mintz, J1
Kupka, R1
Nolen, W1
Leverich, GS1
Denicoff, KD1
Post, RM1
Keck, PE1
Bahadori, B1
Uitz, E1
Tonninger-Bahadori, K1
Moghadasian, MH1
Baptista, T1
Uzcátegui, E1
Rangel, N1
El Fakih, Y1
Galeazzi, T1
Beaulieu, S1
de Baptista, EA1
Trapali, M1
Liapi, C1
Perelas, A1
Perrea, D1
Stroubini, T1
Dontas, I1
Couvari, E1
Mavri, M1
Galanopoulou, P1
Day, C1
Bailey, CJ1
Maughan, KL1
Lean, M1
Greenberg, I1
Chan, S1
Blackburn, GL1
Fanghänel, G1
Cortinas, L1
Sánchez-Reyes, L1
Berber, A1
Jakicic, JM1
Clark, K1
Coleman, E1
Donnelly, JE1
Foreyt, J1
Melanson, E1
Volek, J1
Volpe, SL1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Eat Well for Life: A Weight Loss Maintenance Study[NCT01849627]345 participants (Anticipated)Interventional2014-08-31Active, not recruiting
Feasibility of a Campaign Intervention Compared to a Standard Behavioral Weight Loss Intervention in Overweight and Obese Adults[NCT01803737]26 participants (Actual)Interventional2013-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Body Weight

Body weight will be measured on a digital scale to assess change in body weight over the 12-week intervention period. (NCT01803737)
Timeframe: Week 0 and 12

Interventionkg (Mean)
Standard Behavioral Weight Loss Intervention (SBWL)-5.6
Campaign Intervention (CI)-3.1

Change in Dietary Intake: % Carbohydrate

A questionnaire will be used to assess self-reported food intake. This will be used to estimate calories, dietary fat, protein, and carbohydrates consumed. (NCT01803737)
Timeframe: Week 0 and 12

Interventionpercentage of carbohydrate intake (Mean)
Standard Behavioral Weight Loss Intervention (SBWL)0.64
Campaign Intervention (CI)0.90

Change in Dietary Intake: % Fat

A questionnaire will be used to assess self-reported food intake. This will be used to estimate calories, dietary fat, protein, and carbohydrates consumed. (NCT01803737)
Timeframe: Week 0 and 12

Interventionpercentage of fat intake (Mean)
Standard Behavioral Weight Loss Intervention (SBWL)-3.26
Campaign Intervention (CI)-0.00

Change in Dietary Intake: % Protein

A questionnaire will be used to assess self-reported food intake. This will be used to estimate calories, dietary fat, protein, and carbohydrates consumed. (NCT01803737)
Timeframe: Week 0 and 12

Interventionpercentage of protein intake (Mean)
Standard Behavioral Weight Loss Intervention (SBWL)0.73
Campaign Intervention (CI)0.44

Change in Dietary Intake: Kcals/Day

A questionnaire will be used to assess self-reported food intake. This will be used to estimate calories, dietary fat, protein, and carbohydrates consumed. (NCT01803737)
Timeframe: Week 0 and 12

Interventionkcals/day (Mean)
Standard Behavioral Weight Loss Intervention (SBWL)474.8
Campaign Intervention (CI)242.5

Change in Physical Activity

A questionnaire will be used to measure and quantify energy expenditure from physical activity. (NCT01803737)
Timeframe: Week 0 and 12

Interventionkcals/wk (Mean)
Standard Behavioral Weight Loss Intervention (SBWL)983.3
Campaign Intervention (CI)776.3

Change in Weight Loss Self-efficacy

Self-efficacy for weight loss was assessed at week 0 and 12 using a 20-item Weight Efficacy Lifestyle Questionnaire (WEL). The total score ranges from 0-180. Higher values represent greater beliefs toward the completion of weight management behaviors. (NCT01803737)
Timeframe: Week 0 and 12

Interventionunits on a scale (Mean)
Standard Behavioral Weight Loss Intervention (SBWL)28.3
Campaign Intervention (CI)16.3

Completion of Self-monitoring of Dietary Intake and Physical Activity

The frequency that participants engaged in the self-monitoring of dietary intake and physical activity was assessed at week 12. The diaries were completed weekly throughout the study. (NCT01803737)
Timeframe: Week 0 and 12

Interventionpercentage of diaries completed (Mean)
Standard Behavioral Weight Loss Intervention (SBWL)91.6
Campaign Intervention (CI)60.1

Autonomous and Controlled Motivation

At week 12, participants completed the 13-item TSRQ to assess motivation to continue to participate in the program if given the opportunity. The TSRQ represents participants' reasons for continuing participation in a weight loss program via participants' endorsement of statements of autonomous and controlled motivation. Responses were given using a 7-point Likert scale (1 = not at all true to 7 = very true). The responses on the autonomous items (5) and controlled items (8) were averaged. (NCT01803737)
Timeframe: Week 12

,
Interventionunits on a scale (Mean)
Autonomous MotivationControlled Motivation
Campaign Intervention (CI)5.32.9
Standard Behavioral Weight Loss Intervention (SBWL)6.32.9

Reviews

6 reviews available for sibutramine and Weight Gain

ArticleYear
[Association of obesity and depression].
    Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, 2008, Volume: 10, Issue:4

    Topics: Anti-Obesity Agents; Antidepressive Agents; Appetite Depressants; Appetite Regulation; Bipolar Disor

2008
Pharmacologic therapies for obesity.
    Gastroenterology clinics of North America, 2010, Volume: 39, Issue:1

    Topics: Anti-Obesity Agents; Appetite Depressants; Bariatric Surgery; Benzazepines; Bupropion; Cyclobutanes;

2010
Options for pharmacological management of obesity in patients treated with atypical antipsychotics.
    International clinical psychopharmacology, 2002, Volume: 17, Issue:4

    Topics: Amantadine; Antipsychotic Agents; Cimetidine; Cyclobutanes; Fluoxetine; Fructose; Humans; Lactones;

2002
Cutting fat absorption to halt weight gain.
    The Practitioner, 1998, Volume: 242, Issue:1593

    Topics: Anti-Obesity Agents; Cyclobutanes; Diet, Fat-Restricted; Family Practice; Humans; Intestinal Absorpt

1998
Nonpharmacologic and pharmacologic management of weight gain.
    The Journal of clinical psychiatry, 1999, Volume: 60 Suppl 21

    Topics: Anti-Obesity Agents; Appetite Depressants; Behavior Therapy; Cyclobutanes; Diet, Reducing; Energy In

1999
American College of Sports Medicine position stand. Appropriate intervention strategies for weight loss and prevention of weight regain for adults.
    Medicine and science in sports and exercise, 2001, Volume: 33, Issue:12

    Topics: Adult; Body Mass Index; Cyclobutanes; Diet Therapy; Dietary Fats; Energy Intake; Exercise Therapy; H

2001
American College of Sports Medicine position stand. Appropriate intervention strategies for weight loss and prevention of weight regain for adults.
    Medicine and science in sports and exercise, 2001, Volume: 33, Issue:12

    Topics: Adult; Body Mass Index; Cyclobutanes; Diet Therapy; Dietary Fats; Energy Intake; Exercise Therapy; H

2001
American College of Sports Medicine position stand. Appropriate intervention strategies for weight loss and prevention of weight regain for adults.
    Medicine and science in sports and exercise, 2001, Volume: 33, Issue:12

    Topics: Adult; Body Mass Index; Cyclobutanes; Diet Therapy; Dietary Fats; Energy Intake; Exercise Therapy; H

2001
American College of Sports Medicine position stand. Appropriate intervention strategies for weight loss and prevention of weight regain for adults.
    Medicine and science in sports and exercise, 2001, Volume: 33, Issue:12

    Topics: Adult; Body Mass Index; Cyclobutanes; Diet Therapy; Dietary Fats; Energy Intake; Exercise Therapy; H

2001

Trials

9 trials available for sibutramine and Weight Gain

ArticleYear
Sibutramine in the treatment of antipsychotic-induced weight gain: a pilot study in patients with schizophrenia.
    International clinical psychopharmacology, 2014, Volume: 29, Issue:3

    Topics: Adult; Aged; Antipsychotic Agents; Appetite Depressants; Cyclobutanes; Female; Humans; Male; Middle

2014
Sibutramine for weight gain attenuation during smoking cessation with varenicline: a pilot study.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2009, Volume: 11, Issue:12

    Topics: Adult; Appetite Depressants; Benzazepines; Cyclobutanes; Drug Therapy, Combination; Female; Humans;

2009
Prediction of weight loss and regain following dietary, lifestyle, and pharmacologic intervention.
    Clinical pharmacology and therapeutics, 2012, Volume: 91, Issue:6

    Topics: Absorptiometry, Photon; Adult; Appetite Depressants; Body Composition; Body Weight; Calorimetry, Ind

2012
A double-blind, placebo-controlled trial of sibutramine for olanzapine-associated weight gain.
    The American journal of psychiatry, 2005, Volume: 162, Issue:5

    Topics: Adult; Antipsychotic Agents; Appetite Depressants; Behavior Therapy; Benzodiazepines; Combined Modal

2005
A double-blind, placebo-controlled trial of sibutramine for clozapine-associated weight gain.
    Acta psychiatrica Scandinavica, 2007, Volume: 115, Issue:2

    Topics: Adult; Anthropometry; Antipsychotic Agents; Appetite Depressants; Blood Glucose; Body Mass Index; Bo

2007
Comparison of orlistat and sibutramine in an obesity management program: efficacy, compliance, and weight regain after noncompliance.
    Eating and weight disorders : EWD, 2006, Volume: 11, Issue:4

    Topics: Adult; Anti-Obesity Agents; Appetite Depressants; Combined Modality Therapy; Cyclobutanes; Diet, Red

2006
A 24-week, randomized, controlled trial of adjunctive sibutramine versus topiramate in the treatment of weight gain in overweight or obese patients with bipolar disorders.
    Bipolar disorders, 2007, Volume: 9, Issue:4

    Topics: Adult; Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Appetite Depressants; Bipolar D

2007
Metformin plus sibutramine for olanzapine-associated weight gain and metabolic dysfunction in schizophrenia: a 12-week double-blind, placebo-controlled pilot study.
    Psychiatry research, 2008, May-30, Volume: 159, Issue:1-2

    Topics: Adult; Antipsychotic Agents; Appetite Depressants; Benzodiazepines; Body Mass Index; Chronic Disease

2008
Second phase of a double-blind study clinical trial on Sibutramine for the treatment of patients suffering essential obesity: 6 months after treatment cross-over.
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 2001, Volume: 25, Issue:5

    Topics: Adolescent; Adult; Aged; Anthropometry; Appetite Depressants; Body Mass Index; Body Weight; Cross-Ov

2001

Other Studies

16 other studies available for sibutramine and Weight Gain

ArticleYear
Treatment with Antiobesity Drugs in Weight Regain After Bariatric Surgery: a Retrospective Cohort Study.
    Obesity surgery, 2023, Volume: 33, Issue:9

    Topics: Aged; Anti-Obesity Agents; Bariatric Surgery; Female; Humans; Male; Middle Aged; Obesity, Morbid; Or

2023
The effectiveness of pharmaceutical interventions for obesity: weight loss with orlistat and sibutramine in a United Kingdom population-based cohort.
    British journal of clinical pharmacology, 2015, Volume: 79, Issue:6

    Topics: Adult; Anti-Obesity Agents; Appetite Depressants; Body Mass Index; Case-Control Studies; Cyclobutane

2015
Sibutramine-induced anorexia: potent, dose-dependent and behaviourally-selective profile in male rats.
    Behavioural brain research, 2009, Mar-17, Volume: 198, Issue:2

    Topics: Animals; Anorexia; Appetite Depressants; Cyclobutanes; Dose-Response Relationship, Drug; Eating; Fee

2009
Predictors and correlates for weight changes in patients co-treated with olanzapine and weight mitigating agents; a post-hoc analysis.
    BMC psychiatry, 2009, Mar-28, Volume: 9

    Topics: Adult; Amantadine; Appetite; Benzodiazepines; Bipolar Disorder; Cognition Disorders; Cyclobutanes; D

2009
Effects of acute low-dose combined treatment with rimonabant and sibutramine on appetite and weight gain in rats.
    Pharmacology, biochemistry, and behavior, 2010, Volume: 97, Issue:1

    Topics: Animals; Appetite; Cyclobutanes; Drug Administration Schedule; Drug Therapy, Combination; Male; Pipe

2010
A case of sibutramine-induced hyperprolactinemia.
    Neuro endocrinology letters, 2011, Volume: 32, Issue:5

    Topics: Adult; Amenorrhea; Appetite Depressants; Cyclobutanes; Diagnosis, Differential; Female; Galactorrhea

2011
Preferential effects of the cannabinoid CB1 receptor antagonist, SR 141716, on food intake and body weight gain of obese (fa/fa) compared to lean Zucker rats.
    Psychopharmacology, 2003, Volume: 167, Issue:1

    Topics: Animals; Appetite Depressants; Cannabinoids; Cyclobutanes; Dose-Response Relationship, Drug; Eating;

2003
Sibutramine decreases body weight gain and increases energy expenditure in obese Zucker rats without changes in NPY and orexins.
    Nutritional neuroscience, 2003, Volume: 6, Issue:2

    Topics: Adipose Tissue; Animals; Appetite Depressants; Body Composition; Carrier Proteins; Cyclobutanes; Dri

2003
Sibutramine sensitivity assay revealed a unique phenotype of bombesin BB3 receptor-deficient mice.
    European journal of pharmacology, 2003, Jul-18, Volume: 473, Issue:1

    Topics: Animals; Appetite Depressants; Cyclobutanes; Disease Models, Animal; Feeding Behavior; Female; Hyper

2003
The novel antiobesic HMR1426 reduces food intake without affecting energy expenditure in rats.
    Obesity research, 2004, Volume: 12, Issue:8

    Topics: Animals; Anti-Obesity Agents; Cyclobutanes; Eating; Energy Metabolism; Heterocyclic Compounds, 3-Rin

2004
Chronic treatment with either dexfenfluramine or sibutramine in diet-switched diet-induced obese mice.
    Endocrine, 2006, Volume: 29, Issue:2

    Topics: Animals; Anti-Obesity Agents; Body Weight; Cyclobutanes; Dexfenfluramine; Diet, Fat-Restricted; Ghre

2006
Phentermine, sibutramine and metformin could be used for the prevention and treatment of steroid-induced weight gain.
    Medical hypotheses, 2007, Volume: 68, Issue:2

    Topics: Adrenergic Agents; Appetite Depressants; Cyclobutanes; Humans; Hypoglycemic Agents; Metformin; Phent

2007
Successful treatment of a morbidly obese and growth-retarded adolescent with Williams-Beuren Syndrome by combining the medication of growth hormone and sibutramine.
    Singapore medical journal, 2008, Volume: 49, Issue:1

    Topics: Adolescent; Appetite Depressants; Body Composition; Body Mass Index; Body Weight; Cyclobutanes; Huma

2008
Effect of isocaloric diets and sibutramine on food intake, body mass variation and serum TNF-alpha levels in rats.
    Pharmacology, 2008, Volume: 82, Issue:1

    Topics: Animals; Appetite Depressants; Body Weight; Cyclobutanes; Diet; Dietary Carbohydrates; Dietary Fats;

2008
Effect of the antiobesity agent sibutramine in obese-diabetic ob/ob mice.
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1998, Volume: 22, Issue:7

    Topics: Animals; Appetite Depressants; Blood Glucose; Cyclobutanes; Diabetes Mellitus; Fatty Acids, Nonester

1998
Does sibutramine keep the weight off?
    The Journal of family practice, 1999, Volume: 48, Issue:6

    Topics: Cyclobutanes; Diet, Reducing; Double-Blind Method; Energy Intake; Humans; Obesity; Randomized Contro

1999