sibutramine has been researched along with Liver Cirrhosis in 2 studies
sibutramine: serotonin and norepinephrine transporter inhibitor; Meridia is tradename for sibutramine hydrochloride
Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sibutramine is widely used as a weight-loss substance in the treatment of obesity and is a selective inhibitor of the neuronal reuptake of serotonin and noradrenaline." | 3.79 | Rats on a high-energy diet showing no weight gain present with ultrastructural changes associated with liver fibrosis. ( Bester, MJ; Oberholzer, HM; van der Schoor, C, 2013) |
| "Sibutramine induces liver fibrosis with steatosis in female Sprague-Dawley rats fed a high-energy diet without significant weight gain." | 1.42 | Sibutramine, a serotonin-norepinephrine reuptake inhibitor, causes fibrosis in rats. ( Bester, MJ; Oberholzer, HM; van der Schoor, C, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Oberholzer, HM | 2 |
| Bester, MJ | 2 |
| van der Schoor, C | 2 |
2 other studies available for sibutramine and Liver Cirrhosis
| Article | Year |
|---|---|
Rats on a high-energy diet showing no weight gain present with ultrastructural changes associated with liver fibrosis.
Topics: Animals; Appetite Depressants; Body Mass Index; Cyclobutanes; Diet, High-Fat; Disease Models, Animal | 2013 |
Sibutramine, a serotonin-norepinephrine reuptake inhibitor, causes fibrosis in rats.
Topics: Animals; Appetite Depressants; Cyclobutanes; Female; Liver Cirrhosis; Neurotransmitter Uptake Inhibi | 2015 |