sibutramine has been researched along with Binge-Eating Disorder in 2 studies
sibutramine: serotonin and norepinephrine transporter inhibitor; Meridia is tradename for sibutramine hydrochloride
Binge-Eating Disorder: A disorder associated with three or more of the following: eating until feeling uncomfortably full; eating large amounts of food when not physically hungry; eating much more rapidly than normal; eating alone due to embarrassment; feeling of disgust, DEPRESSION, or guilt after overeating. Criteria includes occurrence on average, at least 2 days a week for 6 months. The binge eating is not associated with the regular use of inappropriate compensatory behavior (i.e. purging, excessive exercise, etc.) and does not co-occur exclusively with BULIMIA NERVOSA or ANOREXIA NERVOSA. (From DSM-IV, 1994)
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study compared the effectiveness of self-help cognitive-behavioral therapy (shCBT) and an anti-obesity medication (sibutramine), alone and in combination, and it is only the second placebo-controlled trial of any medication for BED to evaluate longer-term effects after treatment discontinuation." | 5.19 | Treatment of binge eating disorder in racially and ethnically diverse obese patients in primary care: randomized placebo-controlled clinical trial of self-help and medication. ( Barnes, RD; Garcia, R; Genao, I; Grilo, CM; Gueorguieva, R; Masheb, RM; McKenzie, KC; Walsh, BT; White, MA, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Grilo, CM | 2 |
| Masheb, RM | 2 |
| White, MA | 2 |
| Gueorguieva, R | 2 |
| Barnes, RD | 1 |
| Walsh, BT | 1 |
| McKenzie, KC | 1 |
| Genao, I | 1 |
| Garcia, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Treatment of Binge Eating in Obese Patients in Primary Care[NCT00537810] | Phase 4 | 104 participants (Actual) | Interventional | 2007-09-30 | Completed | ||
| Do Visuals of Symptom Change Increase Rates of Rapid Response in First Weeks of CBT for Eating Disorders?[NCT02940613] | 80 participants (Anticipated) | Interventional | 2016-12-31 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
BMI (kg/m^2) was measured 4 months after treatment. (NCT00537810)
Timeframe: 4 months
| Intervention | BMI (kg/m^2) (Mean) |
|---|---|
| Sibutramine | 38.4 |
| Placebo | 39.6 |
| Placebo/CBTsh | 35.9 |
| Sibutramine/CBTsh | 35.6 |
Remission from binge eating (zero binge episodes during previous 28 days) (NCT00537810)
Timeframe: 4 months treatment; 6 and 12 month follow up post treatment
| Intervention | participants (Number) | ||
|---|---|---|---|
| Remission at Post-treatment | Remission at 6 month follow up | Remission at 12 month follow up | |
| Placebo | 8 | 11 | 10 |
| Placebo/CBTsh | 6 | 10 | 10 |
| Sibutramine | 10 | 5 | 5 |
| Sibutramine/CBTsh | 6 | 13 | 11 |
2 trials available for sibutramine and Binge-Eating Disorder
| Article | Year |
|---|---|
Treatment of binge eating disorder in racially and ethnically diverse obese patients in primary care: randomized placebo-controlled clinical trial of self-help and medication.
Topics: Adolescent; Adult; Aged; Anti-Obesity Agents; Binge-Eating Disorder; Black or African American; Body | 2014 |
Predicting meaningful outcomes to medication and self-help treatments for binge-eating disorder in primary care: The significance of early rapid response.
Topics: Adult; Anti-Obesity Agents; Binge-Eating Disorder; Cognitive Behavioral Therapy; Combined Modality T | 2015 |
Predicting meaningful outcomes to medication and self-help treatments for binge-eating disorder in primary care: The significance of early rapid response.
Topics: Adult; Anti-Obesity Agents; Binge-Eating Disorder; Cognitive Behavioral Therapy; Combined Modality T | 2015 |
Predicting meaningful outcomes to medication and self-help treatments for binge-eating disorder in primary care: The significance of early rapid response.
Topics: Adult; Anti-Obesity Agents; Binge-Eating Disorder; Cognitive Behavioral Therapy; Combined Modality T | 2015 |
Predicting meaningful outcomes to medication and self-help treatments for binge-eating disorder in primary care: The significance of early rapid response.
Topics: Adult; Anti-Obesity Agents; Binge-Eating Disorder; Cognitive Behavioral Therapy; Combined Modality T | 2015 |