sialosylparagloboside and Burkitt-Lymphoma

sialosylparagloboside has been researched along with Burkitt-Lymphoma* in 1 studies

Other Studies

1 other study(ies) available for sialosylparagloboside and Burkitt-Lymphoma

ArticleYear
A membrane-located glycosphingolipid of monocyte/granulocyte lineage cells induces growth arrest and triggers the lytic viral cycle in Epstein-Barr virus genome-positive Burkitt lymphoma lines.
    Medical microbiology and immunology, 1999, Volume: 188, Issue:1

    Gangliosides are known to influence cell growth and differentiation. The neolacto series ganglioside IV3NeuAc-nLc4 (2-->3-sialosylparagloboside) is present in members of the monocyte/granulocyte lineage, but is not found in cells that belong to the lymphocyte lineage. In this study we demonstrated that IV3NeuAc-nLc4 inhibits the proliferation of Epstein-Barr virus (EBV) genome-positive Burkitt lymphoma cells of the lines Raji and P3HR-1K. IV3NeuAc-nLc4-induced growth inhibition is associated with an increase in G0/G1 phase cells and a reduced expression of CD21 and HLA-DR antigens on Raji cells. These data suggest that IV3NeuAc-nLc4 may affect differentiation of lymphoma cells. Additionally, the increased expression of viral mRNA species which are characteristic for the lytic viral cycle in the non-producer line Raji and the enhanced release of virions from the producer line P3HR-1K demonstrate that IV3NeuAc-nLc4 activates the replication of EBV. Growth inhibition and termination of the viral latency suggest that IV3NeuAc-nLc4 present in monocyte/granulocyte lineage cells may be an effector of the natural defense against EBV persistency and transformation.

    Topics: Apoptosis; B-Lymphocytes; Burkitt Lymphoma; Cell Cycle; Cell Division; Cell Lineage; Cell Membrane; Flow Cytometry; Globosides; Granulocytes; Herpesvirus 4, Human; Humans; Monocytes; Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Viral Proteins; Virus Latency; Virus Replication

1999