shu-9119 has been researched along with Diabetes-Mellitus--Type-2* in 1 studies
1 other study(ies) available for shu-9119 and Diabetes-Mellitus--Type-2
| Article | Year |
|---|---|
Transcriptomic analysis links diverse hypothalamic cell types to fibroblast growth factor 1-induced sustained diabetes remission.
In rodent models of type 2 diabetes (T2D), sustained remission of hyperglycemia can be induced by a single intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1), and the mediobasal hypothalamus (MBH) was recently implicated as the brain area responsible for this effect. To better understand the cellular response to FGF1 in the MBH, we sequenced >79,000 single-cell transcriptomes from the hypothalamus of diabetic Lep Topics: Agouti-Related Protein; Animals; Astrocytes; Blood Glucose; Cell Communication; Cell Nucleus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Dietary Sucrose; Fibroblast Growth Factor 1; Humans; Hypoglycemic Agents; Hypothalamus; Injections, Intraventricular; Leptin; Male; Melanocortins; Melanocyte-Stimulating Hormones; Mice; Mice, Knockout; Neurons; Oligodendroglia; Receptor, Melanocortin, Type 4; Receptors, Melanocortin; Recombinant Proteins; Remission Induction; RNA-Seq; Signal Transduction; Single-Cell Analysis; Stereotaxic Techniques; Transcriptome | 2020 |