shu-508 and Infarction--Middle-Cerebral-Artery

Administration of microbubbles (MB) may augment the effect of ultrasound-enhanced systemic thrombolysis in acute stroke. Bubble structural characteristics may influence the effect of MB on sonothrombolysis. We aimed to compare the effects of galactose-based air-filled MB (Levovist) and sulphur hexafluoride-filled MB (Sonovue) on recanalization and clinical outcome. One hundred thirty-eight i.v. recombinant tissue plasminogen activator-(tPA-) treated patients with middle cerebral artery (MCA) occlusion were studied. Presence and location of arterial occlusion and recanalization (RE) were assessed using the thrombolysis in brain ischemia (TIBI) flow grading system. Patients underwent 2 h of continuous transcranial Doppler (TCD) monitoring and received three bolus of MB after 2, 20 and 40 min of tPA bolus. Ninety-one patients received Levovist (LV) and 47 received Sonovue (SV). NIHSS scores were obtained at baseline and after 24 h. Modified Rankin Scale (mRS) score was used to assess outcome at 3 mo. Median admission NIHSS was 17. On TCD, 96 (69.6%) patients had a proximal and 42 (30.4%) a distal MCA occlusion. Age, baseline NIHSS, clot location, stroke subtypes and time to treatment were similar between LV and SV groups. Recanalization rates after 1 h (32.2%/35.6%), 2 h (50.0%/46.7%) and 6 h (63.8%/54.5%) were similar in LV/SV groups (p > 0.3). Clinical improvement (NIHSS decrease >or= 4 points) at 24 h was similar in both groups (54.9%/51.1%, p = 0.400), as well as symptomatic intracranial haemorrhage rate (3.3%/2.1%, p = 0.580) and in-hospital mortality (8.1%/9.3%, p = 0.531). Similarly, the type of MB administered did not affect long-term outcome after sonothrombolysis. Forty-four percent of patients in the LV group and 48.5% in the SV group achieved functional independence (mRS

Topics: Aged; Aged, 80 and over; Combined Modality Therapy; Contrast Media; Female; Humans; Infarction, Middle Cerebral Artery; Male; Microbubbles; Middle Aged; Middle Cerebral Artery; Phospholipids; Polysaccharides; Recombinant Proteins; Stroke; Sulfur Hexafluoride; Thrombolytic Therapy; Tissue Plasminogen Activator; Treatment Outcome; Ultrasonic Therapy; Ultrasonography, Doppler, Transcranial; Ultrasonography, Interventional

Color-coded perfusion maps can be calculated from ultrasound harmonic gray-scale imaging data after ultrasound contrast agent bolus injection to analyze brain tissue perfusion. First reports indicate that this method can display cerebral perfusion deficits in acute ischemic stroke. We performed a prospective patient study to evaluate this approach.. Thirty consecutive patients suffering from acute middle cerebral artery infarction who presented to our department within 12 hours after symptom onset were investigated with ultrasound perfusion harmonic imaging (PHI) after Levovist bolus injection. Color-coded perfusion maps were calculated from the ultrasound data. In addition, the original gray-scale images were analyzed in cine mode. Findings were compared with those of cranial CT.. All 30 patients suffered from acute ischemic stroke of the middle cerebral artery territory (median National Institutes of Health Stroke Scale score, 16 points). Twenty-three of the 30 patients (76.7%) had sufficient PHI insonation conditions. In 19 of these 23 patients (82.6%), a marked deficit in contrast enhancement could be visualized by initial PHI with the color-coded parameter images and cine-mode images. In 17 of the 23 (73.9%), the perfusion deficit was found on the parameter images. The area of hypoperfusion in the initial PHI investigation corresponded to the definite area of infarction in follow-up cranial CT. In 3 of 23 patients (13.0%), a perfusion deficit could be demonstrated in PHI, although the supplying artery was found patent by transcranial color-coded duplex sonography.. With PHI, it is possible to display cerebral perfusion deficits in acute ischemic stroke. PHI yields additional information on the perfusion state of the human brain compared with extracranial and transcranial color-coded duplex sonography.

Topics: Acute Disease; Adult; Aged; Brain; Brain Ischemia; Contrast Media; Echoencephalography; Female; Humans; Image Processing, Computer-Assisted; Infarction, Middle Cerebral Artery; Male; Middle Aged; Polysaccharides; Predictive Value of Tests; Prospective Studies; Sensitivity and Specificity; Severity of Illness Index; Stroke; Tomography, X-Ray Computed

Some patients with internal carotid artery (ICA) occlusion or stenosis are at risk of developing a hemodynamic stroke. Transcranial ultrasonography using an echo-contrast bolus technique might be able to assess the extent of hemodynamic compromise. We describe a transcranial Doppler sonographic method that analyzes the differences in echo-contrast bolus arrival between both middle cerebral arteries after intravenous echo-contrast application. Ten patients with 50%-79% ICA stenosis, 10 patients with 80%-99% ICA stenosis and 22 patients with ICA occlusion were studied and compared with 15 age-matched controls. There were significant increases in delayed filling of the middle cerebral artery in both 80%-99% stenoses and occlusions compared with controls. The extent of the observed delays did not correlate with vasomotor reactivity. Echo-contrast bolus arrival time can be used to gain additional information on the intracranial hemodynamic effects of extracranial carotid artery disease that seems to be independent of the established ultrasound indices.

Topics: Aged; Carotid Stenosis; Computer Simulation; Contrast Media; Female; Humans; Image Interpretation, Computer-Assisted; Infarction, Middle Cerebral Artery; Male; Middle Aged; Models, Cardiovascular; Polysaccharides; Reproducibility of Results; Sensitivity and Specificity; Ultrasonography, Doppler, Transcranial

Initial reports indicate that cerebral perfusion deficits in acute ischemic stroke might be detectable by means of transcranial harmonic imaging after an ultrasound contrast agent (UCA) bolus injection. Twenty-four patients with acute middle cerebral artery (MCA) infarction were investigated twice with perfusion harmonic imaging (PHI) after Levovist (Schering, Berlin, Germany) bolus injection no longer than 12 h after symptom onset. The findings were compared with those of cranial computed tomography (CCT). All 24 patients suffered from acute ischemic stroke of the MCA territory (median National Institutes of Health Stroke Scale score: 15 points). Corresponding to the area of infarction in follow-up CCT, a marked contrast deficit was visualized in 19 of 24 patients by initial PHI, which had a sensitivity and specificity of 86.4% and 96.2%, respectively, for predicting the occurrence and localization of a definite infarction in the midthalamic plane. The area of hypoperfusion in the initial PHI investigation correlated with the definite area of infarction in follow-up CCT (r=0.66, p<0.01). When time-intensity curves of both hemispheres were compared, the areas under the curve were significantly less in the symptomatic brain regions (p=0.01). With PHI and UCA bolus injection, it is possible to assess cerebral perfusion deficits that correlate with the definite area of infarction in acute ischemic stroke patients.

Topics: Acute Disease; Adult; Aged; Artifacts; Contrast Media; Female; Follow-Up Studies; Humans; Image Processing, Computer-Assisted; Infarction, Middle Cerebral Artery; Male; Microcirculation; Middle Aged; Polysaccharides; Sensitivity and Specificity; Tomography, X-Ray Computed; Ultrasonography, Doppler, Transcranial

Proper assessment of intracranial arteries by transcranial Doppler sonography (TCD) in patients with intracranial stenoses is occasionally made difficult by an insufficient temporal bone window, an unfavourable insonation angle, or low flow velocity or volume. This condition is frequently found in Chinese. In these cases, echocontrast could be helpful. We investigated 48 temporal windows of 24 acute Chinese stroke patients with insufficient native transtemporal insonation conditions before and after the application of the echo enhancer Levovist (galactose/palmitic acid) by an injection pump. We classified the signal quality from four segments of the main intracranial arteries: anterior cerebral artery (A1), main stem of the middle cerebral artery (MCA, M1), intracranial segment of the carotid artery (C1), and posterior cerebral artery (P1). The signal quality was classified as follows: 0 = no signal, 1 = poor, envelope curve does not follow spectrum, 2 = adequate, envelope curve follows spectrum. As compared to the pre-contrast scans, echocontrast allowed for more segments to be evaluated by pulsed Doppler sonography. Before Levovist, only 12% of the segments could be detected, after Levovist 63%. For all arteries, signal quality was better after Levovist, p between 0.0180 and 0.0003. In 3 patients, MCA stenoses with peak systolic Doppler flow velocities above 160 cm/s were found only after Levovist. In patients with poor pre-contrast detection, echocontrast-enhanced TCD allows for more arterial segments to be insonated and for the detection of stenoses unnoted during the non-enhanced investigation.

Topics: Aged; Aged, 80 and over; Asian People; Blood Flow Velocity; Carotid Stenosis; Contrast Media; Female; Humans; Image Enhancement; Infarction, Middle Cerebral Artery; Injections, Intravenous; Intracranial Arteriosclerosis; Male; Middle Aged; Polysaccharides; Signal Processing, Computer-Assisted; Ultrasonography, Doppler, Transcranial