shu-508 and Coronary-Stenosis

shu-508 has been researched along with Coronary-Stenosis* in 4 studies

Other Studies

4 other study(ies) available for shu-508 and Coronary-Stenosis

ArticleYear
Which is the better method in detecting significant left anterior descending coronary artery stenosis during contrast-enhanced dobutamine stress echocardiography: coronary flow velocity reserve or wall-motion assessment?
    Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 2003, Volume: 16, Issue:6

    The diagnostic accuracy of dobutamine stress echocardiography (DSE) depends on wall-motion assessment. Coronary flow velocity reserve (CFVR) during DSE can be measured by transthoracic Doppler echocardiography. To investigate comparative diagnostic accuracy between wall-motion and CFVR assessment in the detection of significant left anterior descending coronary artery (LAD) stenosis, 274 patients underwent both contrast-enhanced DSE and coronary angiography. Intravenous contrast agent, Levovist, was injected to enhance left ventricular endocardial border delineation and coronary flow velocity in the LAD. Wall motion was assessed by standard technique, and CFVR was calculated as coronary flow velocity at peak dobutamine stress divided by baseline coronary flow velocity by transthoracic Doppler echocardiography. CFVR could be successfully obtained in 232 patients (feasibility, 85%). After excluding 14 patients with isolated diagonal stenosis, CFVR was significantly lower in 65 patients with significant LAD stenosis than it was in 153 patients without stenosis (1.62 +/- 0.56 vs 2.72 +/- 0.94, P <.001). CFVR < or = 2.0 had a 75% sensitivity, a 81% specificity, and a 79% diagnostic accuracy for detecting significant LAD stenosis, and these values were comparable with those by wall-motion analysis (sensitivity, 78%; specificity, 89%; and diagnostic accuracy, 86%). The measurement of CFVR in the LAD during DSE was feasible and the diagnostic accuracy of CFVR was equivalent to wall-motion assessment in the detection of LAD stenosis.

    Topics: Blood Flow Velocity; Contrast Media; Coronary Angiography; Coronary Circulation; Coronary Stenosis; Echocardiography; Echocardiography, Stress; Female; Humans; Male; Middle Aged; Myocardial Contraction; Polysaccharides; Prospective Studies; Sensitivity and Specificity

2003
Physiologic assessment of left anterior descending coronary artery stenosis by quantitative intravenous myocardial contrast echocardiography in humans: comparison with exercise single-photon emission computed tomography.
    Echocardiography (Mount Kisco, N.Y.), 2003, Volume: 20, Issue:6

    To clarify the potential of quantitative intravenous myocardial contrast echocardiography (MCE) for physiologic assessment of the left anterior descending artery (LAD) stenosis.. We studied 38 patients with suspected coronary artery disease. MCE was performed by continuous infusion of Levovist and intermittent ultrasonic exposure. Images were obtained from the apical four-chamber view at rest and after dipyridamole infusion. The background-subtracted intensity versus pulsing interval plots were fitted to an exponential function,Y=A(1 e-ss), to obtain the plateau level (A) and rate of rise (ss) of background-subtracted intensity both at rest and after dipyridamole infusion. We compared the results with those of exercise thallium-201 single-photon emission computed tomography (SPECT).. Of the 38 patients, 18 patients exhibited redistribution in the LAD territories with SPECT (group A), although 20 did not (group B). The ss reserve (DIP/rest) in group A was significantly lower than those in group B (0.8 +/- 0.5 versus 2.0 +/- 1.1, P < 0.001), while the A reserve did not differ between the two groups (1.2 +/- 0.6 versus 1.0 +/- 0.5, P = NS). The ss reserve <1.1, which was the optimal cutoff value, provided sensitivity of 79% and specificity of 84% for the presence of redistribution in SPECT.. Quantitative intravenous MCE allows us to estimate physiologic severity of the LAD stenosis in the clinical setting.

    Topics: Contrast Media; Coronary Angiography; Coronary Stenosis; Dipyridamole; Echocardiography; Exercise Test; Female; Humans; Male; Microbubbles; Middle Aged; Polysaccharides; Sensitivity and Specificity; Thallium Radioisotopes; Tomography, Emission-Computed, Single-Photon; Vasodilator Agents

2003
Myocardial contrast echocardiography for assessment of myocardial perfusion at rest in a patient with left main coronary artery stenosis.
    Zeitschrift fur Kardiologie, 2003, Volume: 92, Issue:10

    The present case will focus on the potential of hypoperfusion detection with myocardial contrast echocardiography (MCE) using power Doppler harmonic imaging (PDHI). PDHI is normally performed in a triggered mode. Microbubbles were destroyed by the ultrasound energy in the myocardium, and myocardium has to be refilled with microbubbles within the time interval between the ultrasound pulses to obtain repetitive information about perfusion. Using the contrast agent Levovist, however, real-time PDHI also results in myocardial opacification presumably due to perfusion signals of the arteriolar microbubble passage. A 45-year-old woman with typical stress-induced angina was admitted to our department for cardiac catheterization. Prior to the angiography a conventional echocardiogram showed normal left ventricular function. Tissue Doppler, however, demonstrated postsystolic longitudinal shortening of the septal, anterior, and lateral wall regions. Myocardial contrast echocardiography with triggered PDHI showed complete opacification of the myocardium at rest. Using real-time PDHI with Levovist, the septum could not be opacified. The consecutive angiography documented a severe unprotected main coronary artery stenosis. After angioplasty and stent implantation, MCE measurements were repeated. Repetitive intravenous bolus injections of Optison during triggered PDHI showed no differences to the investigation prior to the angioplasty. Using real-time PDHI with Levovist, however, there was a marked difference in comparison to the pre-interventional analysis. A complete opacification of the apical septum was observed. The present case suggests that different MCE techniques can analyze different compartments of the myocardial vasculature in clinical practice. This methodological comparison between triggered and real-time PDHI shows obviously differences in the DI signal detection due to the different microbubble behavior. Clinicians should be aware of the potentials of MCE to improve noninvasive diagnostic procedures in patients with ischemic heart disease.

    Topics: Albumins; Angioplasty, Balloon, Coronary; Contrast Media; Coronary Angiography; Coronary Circulation; Coronary Stenosis; Echocardiography, Doppler, Color; Echocardiography, Doppler, Pulsed; Female; Fluorocarbons; Humans; Image Enhancement; Image Processing, Computer-Assisted; Microbubbles; Middle Aged; Myocardial Contraction; Polysaccharides; Reference Values; Rest; Sensitivity and Specificity; Stents; Stroke Volume

2003
Changes in transmural distribution of myocardial perfusion assessed by quantitative intravenous myocardial contrast echocardiography in humans.
    Heart (British Cardiac Society), 2002, Volume: 88, Issue:4

    To clarify whether changes in transmural distribution of myocardial perfusion under significant coronary artery stenosis can be assessed by quantitative intravenous myocardial contrast echocardiography (MCE) in humans.. 31 patients underwent dipyridamole stress MCE and quantitative coronary angiography. Intravenous MCE was performed by continuous infusion of Levovist. Images were obtained from the apical four chamber view with alternating pulsing intervals both at rest and after dipyridamole infusion. Images were analysed offline by placing regions of interest over both endocardial and epicardial sides of the mid-septum. The background subtracted intensity versus pulsing interval plots were fitted to an exponential function, y = A (1 - e(-betat)), where A is plateau level and beta is rate of rise.. Of the 31 patients, 16 had significant stenosis (> 70%) in the left anterior descending artery (group A) and 15 did not (group B). At rest, there were no differences in the A endocardial to epicardial ratio (A-EER) and beta-EER between the two groups (mean (SD) 1.2 (0.6) v 1.2 (0.8) and 1.2 (0.7) v 1.1 (0.6), respectively, NS). During hyperaemia, beta-EER in group A was significantly lower than that in group B (1.0 (0.5) v 1.4 (0.5), p < 0.05) and A-EER did not differ between the two groups (1.0 (0.5) v 1.2 (0.4), NS).. Changes in transmural distribution of myocardial perfusion under significant coronary artery stenosis can be assessed by quantitative intravenous MCE in humans.

    Topics: Contrast Media; Coronary Angiography; Coronary Stenosis; Dipyridamole; Echocardiography; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Myocardial Reperfusion; Observer Variation; Polysaccharides; Vasodilator Agents

2002
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