shu-508 and Colonic-Neoplasms

Topics: Colonic Neoplasms; Contrast Media; Digestive System; Gastrointestinal Hemorrhage; Humans; Ileal Neoplasms; Image Enhancement; Polysaccharides; Ultrasonography

To evaluate the capability of contrast-enhanced wideband harmonic imaging (WHI) to detect liver metastases in comparison with fundamental B-mode US and postcontrast CT.. We studied 27 patients with hepatic metastases from different malignancies with conventional B-mode sonography, WHI 3 min after injection of contrast agent (Levovist(R) 2.5 g, 300 mg/ml) and postcontrast helical CT (HCT). The number and location of the lesions and the smallest lesion for each patient were noted by two different observers and compared.. Both readers recorded an increase in the number of lesions in harmonic mode compared with conventional B-mode in all 27 patients with hepatic metastases with a mean increase in both observers from 9.3 lesions with B-mode to 18.8 lesions with WHI. The smallest lesions were detected with WHI when compared with conventional US and HCT (2 mm with WHI, 5 mm with B-mode and 5 mm with CT). WHI detected more lesions than conventional US or HCT.. Contrast-enhanced WHI seems superior to conventional US and HCT for the detection of hepatic metastases, specially for those nodules under 1 cm of diameter.

Topics: Adult; Aged; Breast Neoplasms; Colonic Neoplasms; Contrast Media; Female; Humans; Image Enhancement; Liver Neoplasms; Male; Middle Aged; Polysaccharides; Sensitivity and Specificity; Tomography, Spiral Computed; Ultrasonography

To evaluate contrast-enhanced color Doppler ultrasonography (CDUS) aimed at quantifying angiogenesis in vivo.. Eight colon tumors xenografted into mice were studied with CDUS both without and after injection of SHU 508A. The number of intratumor vessels and pedicles visualized with CDUS and the value of the acoustic intensity quantified by computer were compared with the evaluation of angiogenesis by study of digitized histological slides.. SHU 508A increased the number of intratumor vessels and pedicles depicted by CDUS, which could also be quantified by acoustic intensity. The comparison of CDUS and digitized histological slide studies showed that the detection threshold after SHU 508A administration allowed visualization of small vessels (40 microm in diameter). The "hot spots" seen on histology were superimposable onto vessels seen with CDUS. Regions in which no vessels were detected by CDUS corresponded to regions in which vascularization was absent by histological analysis.. Injection of SHU 508A significantly increased vessel detection with CDUS.

Topics: Animals; Colonic Neoplasms; Contrast Media; Humans; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Polysaccharides; Ultrasonography, Doppler, Color