shishijimicin-a and Leukemia-P388

shishijimicin-a has been researched along with Leukemia-P388* in 1 studies

Other Studies

1 other study(ies) available for shishijimicin-a and Leukemia-P388

Article	Year
Shishijimicins A-C, novel enediyne antitumor antibiotics from the ascidian Didemnum proliferum(1). Journal of the American Chemical Society, 2003, Feb-26, Volume: 125, Issue:8 Three new compounds of the enediyne antibiotics, shishijimicins A-C (1-3), have been isolated from the ascidian Didemnum proliferum. They encompass a novel sugar component, which is a conjugation product of a hexose and a beta-carboline, attached to the calicheamicinone aglycone. Their structures have been determined by interpretation of spectral data. Shishijimicins showed extremely potent cytotoxicity against HeLa cells with IC(50) values of 1.8-6.9 pM. Topics: Animals; Antibiotics, Antineoplastic; Carbolines; Disaccharides; Drug Screening Assays, Antitumor; Enediynes; HeLa Cells; Humans; Leukemia P388; Urochordata	2003

Article

Year

Shishijimicins A-C, novel enediyne antitumor antibiotics from the ascidian Didemnum proliferum(1).

Journal of the American Chemical Society, 2003, Feb-26, Volume: 125, Issue:8

Three new compounds of the enediyne antibiotics, shishijimicins A-C (1-3), have been isolated from the ascidian Didemnum proliferum. They encompass a novel sugar component, which is a conjugation product of a hexose and a beta-carboline, attached to the calicheamicinone aglycone. Their structures have been determined by interpretation of spectral data. Shishijimicins showed extremely potent cytotoxicity against HeLa cells with IC(50) values of 1.8-6.9 pM.

Topics: Animals; Antibiotics, Antineoplastic; Carbolines; Disaccharides; Drug Screening Assays, Antitumor; Enediynes; HeLa Cells; Humans; Leukemia P388; Urochordata

2003