shikonin and Pregnancy--Tubal

shikonin has been researched along with Pregnancy--Tubal* in 1 studies

Other Studies

1 other study(ies) available for shikonin and Pregnancy--Tubal

Article	Year
Shikonin Could Be Used to Treat Tubal Pregnancy via Enhancing Ferroptosis Sensitivity. Drug design, development and therapy, 2022, Volume: 16 Albeit oxidative stress has been implied in the pathogenesis of tubal pregnancy (TP), there are scant data to suggest that ferroptosis occurs in TP. Shikonin plays a pivotal role in redox status, but whether it can regulate ferroptosis to treat TP remains unknown.. We collected and analyzed ferroptosis-related indices from the villous tissue (VT) of women suffering from TP and from women with a normal pregnancy. In vitro, we used shikonin and/or RAS-selective lethal 3 (RSL3) to intervene HTR-8/SVneo cells and further detected ferroptosis indices and cell functions. Finally, the expression of the nuclear factor erythroid 2-related factor 2 (Nrf2) is pharmacologically activated to explore the effect of Nrf2 on shikonin regulating ferroptosis.. This study firstly showed that ferroptosis may be involved in TP pathogenesis and shikonin potentially targeted ferroptosis to treat TP. Topics: Carbolines; Cell Death; Female; Ferroptosis; Humans; Naphthoquinones; NF-E2-Related Factor 2; Phospholipid Hydroperoxide Glutathione Peroxidase; Pregnancy, Tubal; Reactive Oxygen Species	2022

Article

Year

Shikonin Could Be Used to Treat Tubal Pregnancy via Enhancing Ferroptosis Sensitivity.

Drug design, development and therapy, 2022, Volume: 16

Albeit oxidative stress has been implied in the pathogenesis of tubal pregnancy (TP), there are scant data to suggest that ferroptosis occurs in TP. Shikonin plays a pivotal role in redox status, but whether it can regulate ferroptosis to treat TP remains unknown.. We collected and analyzed ferroptosis-related indices from the villous tissue (VT) of women suffering from TP and from women with a normal pregnancy. In vitro, we used shikonin and/or RAS-selective lethal 3 (RSL3) to intervene HTR-8/SVneo cells and further detected ferroptosis indices and cell functions. Finally, the expression of the nuclear factor erythroid 2-related factor 2 (Nrf2) is pharmacologically activated to explore the effect of Nrf2 on shikonin regulating ferroptosis.. This study firstly showed that ferroptosis may be involved in TP pathogenesis and shikonin potentially targeted ferroptosis to treat TP.

Topics: Carbolines; Cell Death; Female; Ferroptosis; Humans; Naphthoquinones; NF-E2-Related Factor 2; Phospholipid Hydroperoxide Glutathione Peroxidase; Pregnancy, Tubal; Reactive Oxygen Species

2022