sf-837 and Dermatitis--Atopic

sf-837 has been researched along with Dermatitis--Atopic* in 1 studies

Other Studies

1 other study(ies) available for sf-837 and Dermatitis--Atopic

ArticleYear
Effects of the macrolide antibiotic, midecamycin, on Staphylococcus aureus product-induced Th2 cytokine response in patients with atopic dermatitis.
    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2004, Volume: 24, Issue:3

    In the present study, the effects of the macrolide antibiotic, midecamycin (MDM), on the Th2 cytokine response induced by the Staphylococcus aureus products, staphylococcal enterotoxin B (SEB), lipoteichoic acid (LTA), and peptidoglycan (PEG), was investigated in human peripheral blood mononuclear cells (PBMCs) from patients with atopic dermatitis (AD). MDM inhibited SEB-induced mRNA expression of the Th2 cytokines interleukin-4 (IL-4) and IL-5 in PBMCs from patients with AD. Furthermore, MDM also suppressed LTA-induced or PEG-induced IL-5 mRNA expression in these patients. Inhibition of mRNA expression by MDM correlated with the synthesis of cytokines in PBMCs, indicating that MDM controls Th2 cytokine production. In addition, S. aureus strains isolated from skin lesions of patients with AD were particularly susceptible to MDM compared with gentamicin, which is used widely in Japan as an antibiotic ointment combined with steroid for topical application in AD. These results suggest that topical administration of MDM might be beneficial in AD lesions infected with S. aureus.

    Topics: Adult; Anti-Bacterial Agents; Cytokines; Dermatitis, Atopic; Enterotoxins; Gene Expression Regulation; Gentamicins; Humans; Interleukin-4; Interleukin-5; Leucomycins; Lipopolysaccharides; Macrolides; Peptidoglycan; RNA, Messenger; Staphylococcus aureus; Teichoic Acids; Th2 Cells

2004