sf-2575 and Leukemia-P388

sf-2575 has been researched along with Leukemia-P388* in 2 studies

Other Studies

2 other study(ies) available for sf-2575 and Leukemia-P388

Article	Year
Crystal structure of SsfS6, the putative C-glycosyltransferase involved in SF2575 biosynthesis. Proteins, 2013, Volume: 81, Issue:7 The molecule known as SF2575 from Streptomyces sp. is a tetracycline polyketide natural product that displays antitumor activity against murine leukemia P388 in vivo. In the SF2575 biosynthetic pathway, SsfS6 has been implicated as the crucial C-glycosyltransferase (C-GT) that forms the C-C glycosidic bond between the sugar and the SF2575 tetracycline-like scaffold. Here, we report the crystal structure of SsfS6 in the free form and in complex with TDP, both at 2.4 Å resolution. The structures reveal SsfS6 to adopt a GT-B fold wherein the TDP and docked putative aglycon are consistent with the overall C-glycosylation reaction. As one of only a few existing structures for C-glycosyltransferases, the structures described herein may serve as a guide to better understand and engineer C-glycosylation. Topics: Animals; Anti-Bacterial Agents; Bacterial Proteins; Crystallography, X-Ray; Glycosylation; Glycosyltransferases; Leukemia P388; Mice; Streptomyces; Tetracyclines	2013
A new tetracycline antibiotic with antitumor activity. I. Taxonomy and fermentation of the producing strain, isolation and characterization of SF2575. The Journal of antibiotics, 1992, Volume: 45, Issue:3 A new antitumor antibiotic SF2575 has been isolated from a culture filtrate of Streptomyces sp. SF2575. The molecular formula was determined to be C40H43NO15 by elemental analysis, mass and 13C NMR spectral analyses. The spectral data revealed SF2575 to be a new tetracycline antibiotic. It was active against Gram-positive bacteria and exhibited antitumor activity against P388 leukemia in mice. Topics: Animals; Antibiotics, Antineoplastic; Fermentation; Leukemia P388; Mice; Streptomyces; Tetracyclines	1992

Article

Year

Crystal structure of SsfS6, the putative C-glycosyltransferase involved in SF2575 biosynthesis.

Proteins, 2013, Volume: 81, Issue:7

The molecule known as SF2575 from Streptomyces sp. is a tetracycline polyketide natural product that displays antitumor activity against murine leukemia P388 in vivo. In the SF2575 biosynthetic pathway, SsfS6 has been implicated as the crucial C-glycosyltransferase (C-GT) that forms the C-C glycosidic bond between the sugar and the SF2575 tetracycline-like scaffold. Here, we report the crystal structure of SsfS6 in the free form and in complex with TDP, both at 2.4 Å resolution. The structures reveal SsfS6 to adopt a GT-B fold wherein the TDP and docked putative aglycon are consistent with the overall C-glycosylation reaction. As one of only a few existing structures for C-glycosyltransferases, the structures described herein may serve as a guide to better understand and engineer C-glycosylation.

Topics: Animals; Anti-Bacterial Agents; Bacterial Proteins; Crystallography, X-Ray; Glycosylation; Glycosyltransferases; Leukemia P388; Mice; Streptomyces; Tetracyclines

2013

A new tetracycline antibiotic with antitumor activity. I. Taxonomy and fermentation of the producing strain, isolation and characterization of SF2575.

The Journal of antibiotics, 1992, Volume: 45, Issue:3

A new antitumor antibiotic SF2575 has been isolated from a culture filtrate of Streptomyces sp. SF2575. The molecular formula was determined to be C40H43NO15 by elemental analysis, mass and 13C NMR spectral analyses. The spectral data revealed SF2575 to be a new tetracycline antibiotic. It was active against Gram-positive bacteria and exhibited antitumor activity against P388 leukemia in mice.

Topics: Animals; Antibiotics, Antineoplastic; Fermentation; Leukemia P388; Mice; Streptomyces; Tetracyclines

1992