sevoflurane has been researched along with Postoperative Cognitive Complications in 30 studies
Sevoflurane: A non-explosive inhalation anesthetic used in the induction and maintenance of general anesthesia. It does not cause respiratory irritation and may also prevent PLATELET AGGREGATION.
sevoflurane : An ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups.
Postoperative Cognitive Complications: COGNITIVE IMPAIRMENT or functional decline after a surgical procedure.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Postoperative cognitive dysfunction (POCD) is regularly observed in patients postsurgery due to the usage of anesthetics, including Sevoflurane." | 8.31 | Effects of miR-190a-3p on Sevoflurane-induced postoperative cognitive dysfunction (POCD). ( Guo, LL; Song, S; Wang, HY; Wang, Y; Zhang, J, 2023) |
| "The objective of this study was to discuss the possible mechanism and effect of miR-182-5p delivered by plasma exosomes on sevoflurane-induced neuroinflammation and cognitive disorder in aged rats with postoperative cognitive dysfunction (POCD)." | 8.12 | miR-182-5p Delivered by Plasma Exosomes Promotes Sevoflurane-Induced Neuroinflammation and Cognitive Dysfunction in Aged Rats with Postoperative Cognitive Dysfunction by Targeting Brain-Derived Neurotrophic Factor and Activating NF-κB Pathway. ( Chen, SB; Huang, YL; Rao, MW; Wei, FS; Wu, YQ; Yang, L, 2022) |
| "The involvement of Dexmedetomidine (Dex) has been indicated in postoperative cognitive dysfunction (POCD), while the mechanism is not well characterized." | 8.02 | Protective role of dexmedetomidine against sevoflurane-induced postoperative cognitive dysfunction via the microRNA-129/TLR4 axis. ( Chen, S; He, S; Sun, Z; Wei, W; Zhang, W, 2021) |
| " Sevoflurane anesthesia has been found to lead to CD and microRNAs (miRNAs) were reported to affect cognitive function." | 7.91 | Neuroprotective effect of miR-410-3p against sevoflurane anesthesia-induced cognitive dysfunction in rats through PI3K/Akt signaling pathway via targeting C-X-C motif chemokine receptor 5. ( Feng, C; Su, R; Sun, P; Xiao, W; Zhang, D; Zhong, L, 2019) |
| "Although preoperative sleep deprivation is known to be an independent risk factor for postoperative cognitive dysfunction (POCD) after inhalation anesthesia, the circadian mechanisms involved are currently unclear." | 5.51 | REM sleep deprivation-induced circadian clock gene abnormalities participate in hippocampal-dependent memory impairment by enhancing inflammation in rats undergoing sevoflurane inhalation. ( Hou, J; Shen, Q; Wan, X; Wu, Y; Xia, Z; Zhao, B, 2019) |
| " Here we found that chronic pain (7 days, but not 1 day acute pain) induced by Complete Freund's Adjuvant (CFA) injected in the hind paw of rats could easily induce spatial cognition and memory impairment after being exposed to sevoflurane anesthesia." | 4.31 | Preoperative Pain Facilitates Postoperative Cognitive Dysfunction via Periaqueductal Gray Matter-Dorsal Raphe Circuit. ( Deng, H; Gao, P; Jiao, Y; Kong, D; Pan, C; Tang, D; Wen, D; Wu, Y; Xu, S; Yu, W, 2023) |
| "Postoperative cognitive dysfunction (POCD) is regularly observed in patients postsurgery due to the usage of anesthetics, including Sevoflurane." | 4.31 | Effects of miR-190a-3p on Sevoflurane-induced postoperative cognitive dysfunction (POCD). ( Guo, LL; Song, S; Wang, HY; Wang, Y; Zhang, J, 2023) |
| "Inhibition of C/EBPα promotes the M2 polarization of microglia and reduces the production of pro-inflammatory cytokines to alleviate the cognitive dysfunction of sevoflurane-induced elderly rats by HDAC1/STAT3 pathway." | 4.31 | C/EBPα involvement in microglial polarization via HDAC1/STAT3 pathway aggravated sevoflurane-induced cognitive impairment in aged rats. ( Xu, Z; Yao, B; Yao, X; Zhao, Y, 2023) |
| "Sevoflurane is one of the most widely used anesthetics in surgery which is the main cause of postoperative cognitive dysfunction (POCD)." | 4.31 | The m ( Huang, Y; Liu, Z; Wei, F; Yang, Y; Ye, C, 2023) |
| "The objective of this study was to discuss the possible mechanism and effect of miR-182-5p delivered by plasma exosomes on sevoflurane-induced neuroinflammation and cognitive disorder in aged rats with postoperative cognitive dysfunction (POCD)." | 4.12 | miR-182-5p Delivered by Plasma Exosomes Promotes Sevoflurane-Induced Neuroinflammation and Cognitive Dysfunction in Aged Rats with Postoperative Cognitive Dysfunction by Targeting Brain-Derived Neurotrophic Factor and Activating NF-κB Pathway. ( Chen, SB; Huang, YL; Rao, MW; Wei, FS; Wu, YQ; Yang, L, 2022) |
| "The involvement of Dexmedetomidine (Dex) has been indicated in postoperative cognitive dysfunction (POCD), while the mechanism is not well characterized." | 4.02 | Protective role of dexmedetomidine against sevoflurane-induced postoperative cognitive dysfunction via the microRNA-129/TLR4 axis. ( Chen, S; He, S; Sun, Z; Wei, W; Zhang, W, 2021) |
| "Our results demonstrated that GA, induced by intravenous ketamine or inhalational sevoflurane, disturbed iron homeostasis and caused iron overload in both in vitro hippocampal neuron culture and in vivo hippocampus." | 3.96 | Iron overload contributes to general anaesthesia-induced neurotoxicity and cognitive deficits. ( Cao, Y; Li, H; Li, K; Wu, J; Yang, JJ; Yang, S; Zhao, H, 2020) |
| " Sevoflurane, a clinical anesthetic, could stimulate neuro-inflammation and lead to POCD." | 3.96 | Silencing SP1 Alleviated Sevoflurane-Induced POCD Development via Cholinergic Anti-inflammatory Pathway. ( Li, C; Li, N; Lv, G; Wang, K; Wang, W, 2020) |
| " Sevoflurane anesthesia has been found to lead to CD and microRNAs (miRNAs) were reported to affect cognitive function." | 3.91 | Neuroprotective effect of miR-410-3p against sevoflurane anesthesia-induced cognitive dysfunction in rats through PI3K/Akt signaling pathway via targeting C-X-C motif chemokine receptor 5. ( Feng, C; Su, R; Sun, P; Xiao, W; Zhang, D; Zhong, L, 2019) |
| "Sevoflurane (Sev) is a commonly used anesthetic in hospitals that can cause neurotoxicity." | 1.62 | A new mechanism of POCD caused by sevoflurane in mice: cognitive impairment induced by cross-dysfunction of iron and glucose metabolism. ( Chang, Y; Gao, G; Ge, X; Li, X; Li, Y; Shi, Z; Thirupathi, A; Xie, J; Yu, P; Zhou, C; Zuo, Y, 2021) |
| "Postoperative cognitive dysfunction is a well-recognized complication after major surgery in the elderly, but its pathophysiological mechanism is not fully understood." | 1.56 | Hippocampal complement C3 might contribute to cognitive impairment induced by anesthesia and surgery. ( Ji, MH; Mao, MJ; Qiu, LL; Yang, JJ; Zhang, L, 2020) |
| "Cardiopulmonary bypass (CPB) caused postoperative cognitive dysfunction (POCD) was characterized by hippocampus apoptosis, which seriously limited the therapeutic efficacy and utilization of CPB in clinic." | 1.56 | Low-dose Sevoflurane Attenuates Cardiopulmonary Bypass (CPB)- induced Postoperative Cognitive Dysfunction (POCD) by Regulating Hippocampus Apoptosis via PI3K/AKT Pathway. ( Ma, D; Ma, Q; Qin, J, 2020) |
| "Although preoperative sleep deprivation is known to be an independent risk factor for postoperative cognitive dysfunction (POCD) after inhalation anesthesia, the circadian mechanisms involved are currently unclear." | 1.51 | REM sleep deprivation-induced circadian clock gene abnormalities participate in hippocampal-dependent memory impairment by enhancing inflammation in rats undergoing sevoflurane inhalation. ( Hou, J; Shen, Q; Wan, X; Wu, Y; Xia, Z; Zhao, B, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (6.67) | 24.3611 |
| 2020's | 28 (93.33) | 2.80 |
| Authors | Studies |
|---|---|
| Wei, W | 1 |
| Sun, Z | 1 |
| He, S | 1 |
| Zhang, W | 5 |
| Chen, S | 1 |
| Ge, X | 1 |
| Zuo, Y | 1 |
| Xie, J | 1 |
| Li, X | 1 |
| Li, Y | 3 |
| Thirupathi, A | 1 |
| Yu, P | 1 |
| Gao, G | 1 |
| Zhou, C | 1 |
| Chang, Y | 1 |
| Shi, Z | 1 |
| He, B | 1 |
| Wang, J | 1 |
| Wei, FS | 1 |
| Rao, MW | 1 |
| Huang, YL | 1 |
| Chen, SB | 1 |
| Wu, YQ | 1 |
| Yang, L | 1 |
| Zhao, J | 3 |
| Wang, S | 4 |
| Li, Z | 4 |
| Huang, Y | 4 |
| Li, L | 3 |
| Lu, J | 1 |
| Liu, Z | 2 |
| Zhao, Y | 2 |
| Liu, X | 1 |
| He, W | 1 |
| Zhang, L | 2 |
| Zhou, Q | 2 |
| Zheng, Z | 1 |
| Wang, X | 1 |
| Li, W | 2 |
| Wang, L | 1 |
| Yin, C | 1 |
| Zhang, Q | 1 |
| Wang, Q | 2 |
| Zhang, X | 1 |
| Li, M | 1 |
| Yue, Y | 1 |
| Zhang, Y | 2 |
| Wu, A | 1 |
| Zeng, K | 1 |
| Long, J | 1 |
| Hu, J | 1 |
| Deng, H | 1 |
| Wu, Y | 2 |
| Gao, P | 1 |
| Kong, D | 1 |
| Pan, C | 1 |
| Xu, S | 1 |
| Tang, D | 1 |
| Jiao, Y | 1 |
| Wen, D | 1 |
| Yu, W | 1 |
| Guo, LL | 1 |
| Wang, Y | 1 |
| Wang, HY | 1 |
| Song, S | 1 |
| Zhang, J | 2 |
| Kuzminskaite, V | 1 |
| Kontrimaviciute, E | 1 |
| Kauzonas, E | 1 |
| Slauzgalvyte, I | 1 |
| Bukelyte, G | 1 |
| Bruzyte-Narkiene, G | 1 |
| Jatuzis, D | 1 |
| Li, S | 1 |
| Hou, Q | 1 |
| Wang, R | 1 |
| Hou, Y | 1 |
| Zhang, B | 1 |
| Ni, C | 1 |
| Zheng, H | 1 |
| Xu, Z | 1 |
| Yao, X | 1 |
| Yao, B | 1 |
| Yang, Y | 1 |
| Ye, C | 1 |
| Wei, F | 2 |
| Jiang, Y | 1 |
| Zhou, Y | 1 |
| Ma, H | 1 |
| Cao, X | 1 |
| Chen, F | 1 |
| Wang, H | 3 |
| Liu, C | 1 |
| Zha, X | 1 |
| Liu, H | 1 |
| Zhang, F | 1 |
| Fu, JB | 1 |
| Wang, ZH | 1 |
| Ren, YY | 1 |
| Guo, L | 1 |
| Lin, F | 1 |
| Dai, H | 1 |
| Du, X | 1 |
| Yu, M | 1 |
| Huang, H | 1 |
| Ge, W | 1 |
| Tao, G | 1 |
| Pan, L | 1 |
| Ji, MH | 1 |
| Qiu, LL | 1 |
| Mao, MJ | 1 |
| Yang, JJ | 2 |
| Wu, J | 1 |
| Cao, Y | 1 |
| Li, H | 2 |
| Zhao, H | 1 |
| Yang, S | 1 |
| Li, K | 1 |
| Qin, J | 1 |
| Ma, Q | 1 |
| Ma, D | 1 |
| Lv, G | 1 |
| Li, C | 1 |
| Wang, W | 1 |
| Li, N | 1 |
| Wang, K | 1 |
| Feng, X | 1 |
| Chen, L | 1 |
| Zhou, R | 1 |
| Bao, X | 1 |
| Mou, H | 1 |
| Ye, L | 1 |
| Yang, P | 1 |
| Chen, D | 1 |
| Wang, Z | 1 |
| Song, F | 1 |
| Ling, L | 1 |
| Shen, Z | 1 |
| Hu, C | 1 |
| Peng, J | 1 |
| Xing, W | 1 |
| Pan, J | 1 |
| Liang, H | 1 |
| Cai, J | 1 |
| He, Z | 1 |
| Peng, S | 1 |
| Zeng, W | 1 |
| Zuo, Z | 1 |
| Yu, Y | 1 |
| Zhu, D | 1 |
| Shao, H | 1 |
| Tang, CY | 1 |
| Wang, VX | 1 |
| Lun, MY | 1 |
| Mincer, JS | 1 |
| Ng, JC | 1 |
| Brallier, JW | 1 |
| Schwartz, AE | 1 |
| Ahn, H | 1 |
| McCormick, PJ | 1 |
| Nir, T | 1 |
| Delman, B | 1 |
| Sano, M | 1 |
| Deiner, SG | 1 |
| Baxter, MG | 1 |
| Xie, L | 1 |
| Fang, Q | 1 |
| Wei, X | 1 |
| Zhou, L | 1 |
| Hou, J | 1 |
| Shen, Q | 1 |
| Wan, X | 1 |
| Zhao, B | 1 |
| Xia, Z | 1 |
| Su, R | 1 |
| Sun, P | 1 |
| Zhang, D | 1 |
| Xiao, W | 1 |
| Feng, C | 1 |
| Zhong, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Gut Microbiome and Blood Indices in Patients With AD and Their Spousal Caregivers[NCT05601856] | 104 participants (Anticipated) | Observational | 2022-12-15 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for sevoflurane and Postoperative Cognitive Complications
| Article | Year |
|---|---|
Preventing postoperative cognitive dysfunction using anesthetic drugs in elderly patients undergoing noncardiac surgery: a systematic review and meta-analysis.
Topics: Aged; Anesthetics, Inhalation; Dexmedetomidine; Humans; Postoperative Cognitive Complications; Posto | 2023 |
4 trials available for sevoflurane and Postoperative Cognitive Complications
| Article | Year |
|---|---|
Sevoflurane and desflurane effects on early cognitive function after low-risk surgery: A randomized clinical trial.
Topics: Anesthetics, Inhalation; Cognition; Desflurane; Humans; Isoflurane; Methyl Ethers; Postoperative Cog | 2023 |
Impact of Sevoflurane Versus Propofol Anesthesia on Post-Operative Cognitive Dysfunction in Elderly Cancer Patients: A Double-Blinded Randomized Controlled Trial.
Topics: Aged; Anesthesia, Intravenous; Anesthetics, Intravenous; Double-Blind Method; Female; Follow-Up Stud | 2020 |
Intravenous versus Volatile Anesthetic Effects on Postoperative Cognition in Elderly Patients Undergoing Laparoscopic Abdominal Surgery.
Topics: Abdomen; Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Biomarkers; China; Double-Blind Me | 2021 |
Transient changes in white matter microstructure during general anesthesia.
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, General; Anesthetics, Inhalation; Brain; Brain Mapping; | 2021 |
25 other studies available for sevoflurane and Postoperative Cognitive Complications
| Article | Year |
|---|---|
Protective role of dexmedetomidine against sevoflurane-induced postoperative cognitive dysfunction via the microRNA-129/TLR4 axis.
Topics: Animals; Cognitive Dysfunction; Dexmedetomidine; MicroRNAs; Postoperative Cognitive Complications; R | 2021 |
A new mechanism of POCD caused by sevoflurane in mice: cognitive impairment induced by cross-dysfunction of iron and glucose metabolism.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Brain; Cognitive Dysfunction; Endothelial Cells; Glucos | 2021 |
METTL3 regulates hippocampal gene transcription via N6-methyladenosine methylation in sevoflurane-induced postoperative cognitive dysfunction mouse.
Topics: Adenosine; Animals; Disease Models, Animal; DNA Methylation; Female; Hippocampus; MAP Kinase Signali | 2021 |
miR-182-5p Delivered by Plasma Exosomes Promotes Sevoflurane-Induced Neuroinflammation and Cognitive Dysfunction in Aged Rats with Postoperative Cognitive Dysfunction by Targeting Brain-Derived Neurotrophic Factor and Activating NF-κB Pathway.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cognitive Dysfunction; Exosomes; Interleukin-6; MicroRNA | 2022 |
Sevoflurane-induced POCD-associated exosomes delivered miR-584-5p regulates the growth of human microglia HMC3 cells through targeting BDNF.
Topics: Brain-Derived Neurotrophic Factor; Exosomes; Humans; Microglia; MicroRNAs; Postoperative Cognitive C | 2022 |
Sevoflurane-induced POCD-associated exosomes delivered miR-584-5p regulates the growth of human microglia HMC3 cells through targeting BDNF.
Topics: Brain-Derived Neurotrophic Factor; Exosomes; Humans; Microglia; MicroRNAs; Postoperative Cognitive C | 2022 |
Sevoflurane-induced POCD-associated exosomes delivered miR-584-5p regulates the growth of human microglia HMC3 cells through targeting BDNF.
Topics: Brain-Derived Neurotrophic Factor; Exosomes; Humans; Microglia; MicroRNAs; Postoperative Cognitive C | 2022 |
Sevoflurane-induced POCD-associated exosomes delivered miR-584-5p regulates the growth of human microglia HMC3 cells through targeting BDNF.
Topics: Brain-Derived Neurotrophic Factor; Exosomes; Humans; Microglia; MicroRNAs; Postoperative Cognitive C | 2022 |
FGF19 improves sevoflurane-induced cognitive dysfunction in rats through the PGC-1α/BDNF/FNDC5 pathway.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cognitive Dysfunction; Fibroblast Growth Factors; Hippoc | 2023 |
taVNS Alleviates Sevoflurane-Induced Cognitive Dysfunction in Aged Rats Via Activating Basal Forebrain Cholinergic Neurons.
Topics: Animals; Basal Forebrain; Cholinergic Agents; Cholinergic Neurons; Cognitive Dysfunction; Hippocampu | 2023 |
Luteoloside Prevents Sevoflurane-induced Cognitive Dysfunction in Aged Rats via Maintaining Mitochondrial Function and Dynamics in Hippocampal Neurons.
Topics: Animals; Cognitive Dysfunction; Hippocampus; Male; Mitochondria; Mitochondrial Dynamics; Neurons; Po | 2023 |
Preoperative Pain Facilitates Postoperative Cognitive Dysfunction via Periaqueductal Gray Matter-Dorsal Raphe Circuit.
Topics: Aged; Animals; Chronic Pain; Dorsal Raphe Nucleus; Humans; Periaqueductal Gray; Postoperative Cognit | 2023 |
Effects of miR-190a-3p on Sevoflurane-induced postoperative cognitive dysfunction (POCD).
Topics: Animals; Cognitive Dysfunction; Inflammation; MicroRNAs; NF-E2-Related Factor 2; Postoperative Cogni | 2023 |
Sevoflurane upregulates neuron death process-related Ddit4 expression by NMDAR in the hippocampus.
Topics: Animals; Apoptosis; Hippocampus; Mice; Neurons; Postoperative Cognitive Complications; Rats; Sevoflu | 2023 |
C/EBPα involvement in microglial polarization via HDAC1/STAT3 pathway aggravated sevoflurane-induced cognitive impairment in aged rats.
Topics: Animals; CCAAT-Enhancer-Binding Proteins; Cognitive Dysfunction; Microglia; Postoperative Cognitive | 2023 |
The m
Topics: Animals; Brain-Derived Neurotrophic Factor; Cognitive Dysfunction; Hippocampus; Neurons; Postoperati | 2023 |
Autophagy Dysfunction and mTOR Hyperactivation Is Involved in Surgery: Induced Behavioral Deficits in Aged C57BL/6J Mice.
Topics: Age Factors; Animals; Autophagy; Hepatectomy; Hippocampus; Liver; Male; Maze Learning; Mice, Inbred | 2020 |
Ampelopsin alleviates sevoflurane-induced cognitive dysfunction by mediating NF-κB pathway in aged rats.
Topics: Anesthetics, Inhalation; Animals; Flavonoids; HMGB1 Protein; Male; MicroRNAs; NF-kappa B; Postoperat | 2020 |
Forkhead Box O1-p21 Mediates Macrophage Polarization in Postoperative Cognitive Dysfunction Induced by Sevoflurane.
Topics: Anesthetics, Inhalation; Animals; Cell Polarity; Cytokines; Forkhead Box Protein O1; Hippocampus; Ma | 2020 |
Hippocampal complement C3 might contribute to cognitive impairment induced by anesthesia and surgery.
Topics: Aged; Anesthesia; Anesthetics, Inhalation; Animals; Complement C3; Dendritic Spines; Gastrointestina | 2020 |
Iron overload contributes to general anaesthesia-induced neurotoxicity and cognitive deficits.
Topics: Anesthesia, General; Anesthetics, General; Animals; Hippocampus; Iron; Iron Overload; Ketamine; Male | 2020 |
Low-dose Sevoflurane Attenuates Cardiopulmonary Bypass (CPB)- induced Postoperative Cognitive Dysfunction (POCD) by Regulating Hippocampus Apoptosis via PI3K/AKT Pathway.
Topics: Animals; Apoptosis; Cardiopulmonary Bypass; Dose-Response Relationship, Drug; Hippocampus; Male; Pho | 2020 |
Silencing SP1 Alleviated Sevoflurane-Induced POCD Development via Cholinergic Anti-inflammatory Pathway.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Anesthetics, Inhalation; Animals; Apoptosis; Gene Knockdown | 2020 |
Blocking the Mineralocorticoid Receptor Improves Cognitive Impairment after Anesthesia/Splenectomy in Rats.
Topics: Administration, Inhalation; Administration, Oral; Anesthesia, Inhalation; Animals; Disease Models, A | 2021 |
LncRNA Rian ameliorates sevoflurane anesthesia-induced cognitive dysfunction through regulation of miR-143-3p/LIMK1 axis.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Cell Survival; Gene Expression; Hippocampus; L-Lactate | 2021 |
Exogenous insulin-like growth factor 1 attenuates sevoflurane anesthesia-induced cognitive dysfunction in aged rats.
Topics: Aging; Anesthetics, Inhalation; Animals; Behavior, Animal; Disease Models, Animal; Down-Regulation; | 2021 |
REM sleep deprivation-induced circadian clock gene abnormalities participate in hippocampal-dependent memory impairment by enhancing inflammation in rats undergoing sevoflurane inhalation.
Topics: Animals; Circadian Clocks; Cognition Disorders; Gene Expression; Gene Expression Regulation; Hippoca | 2019 |
Neuroprotective effect of miR-410-3p against sevoflurane anesthesia-induced cognitive dysfunction in rats through PI3K/Akt signaling pathway via targeting C-X-C motif chemokine receptor 5.
Topics: Anesthesia; Animals; Apoptosis; Cognitive Dysfunction; Disease Models, Animal; Down-Regulation; Hipp | 2019 |