sevoflurane has been researched along with Neuromuscular Blockade in 83 studies
Sevoflurane: A non-explosive inhalation anesthetic used in the induction and maintenance of general anesthesia. It does not cause respiratory irritation and may also prevent PLATELET AGGREGATION.
sevoflurane : An ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups.
Neuromuscular Blockade: The intentional interruption of transmission at the NEUROMUSCULAR JUNCTION by external agents, usually neuromuscular blocking agents. It is distinguished from NERVE BLOCK in which nerve conduction (NEURAL CONDUCTION) is interrupted rather than neuromuscular transmission. Neuromuscular blockade is commonly used to produce MUSCLE RELAXATION as an adjunct to anesthesia during surgery and other medical procedures. It is also often used as an experimental manipulation in basic research. It is not strictly speaking anesthesia but is grouped here with anesthetic techniques. The failure of neuromuscular transmission as a result of pathological processes is not included here.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the effects of sevoflurane, propofol and alfaxalone on the neuromuscular blockade induced by a single intravenous bolus of rocuronium in dogs." | 9.51 | Effects of sevoflurane, propofol or alfaxalone on neuromuscular blockade produced by a single intravenous bolus of rocuronium in dogs. ( Chen, IY; Itami, T; Kato, K; Sano, T; Tamogi, H; Wei, Y; Yamashita, K, 2022) |
| " The present study investigated the effect of preoperative consumption of potatoes on succinylcholine-induced block and recovery from anesthesia." | 9.17 | The effect of preoperative consumption of potatoes on succinylcholine-induced block and recovery from anesthesia. ( Bestas, A; Erhan, OL; Goksu, H, 2013) |
| "The aim of our study was to compare the effects of fentanyl, remifentanil, and dexmedetomidine on neuromuscular blockade under sevoflurane anesthesia." | 9.16 | Comparison of the effects of fentanyl, remifentanil, and dexmedetomidine on neuromuscular blockade. ( Basar, H; Gulec, H; Ozcan, A; Ozcan, N; Yalcin, F, 2012) |
| "5 mg/kg could improve intubating conditions for tracheal intubation without neuromuscular blockade and preserve hemodynamic stability during sevoflurane inhalation induction with alfentanil in children." | 9.15 | The effect of ketamine on tracheal intubating conditions without neuromuscular blockade during sevoflurane induction in children. ( Kim, JY; Kim, KM; Kim, KS; Kwak, HJ; Lee, SY; Min, SK, 2011) |
| " In this study, to estimate the safe interval to avoid residual paralysis, we retrospectively selected patients in whom the TOF ratio was measured during remifentanil administration before extubation, and we studied the characteristics of recovery from the neuromuscular blockade produced by the empirical use of rocuronium." | 9.15 | Retrospective analysis of spontaneous recovery from neuromuscular blockade produced by empirical use of rocuronium. ( Ito, Y; Makita, K; Uchida, T; Yamamoto, H; Yamamoto, Y, 2011) |
| "This randomized trial investigated whether 5% sevoflurane potentiated neuromuscular blockade by vecuronium." | 9.14 | Neuromuscular blockade by vecuronium during induction with 5% sevoflurane or propofol. ( Higa, K; Iwashita, K; Kusumoto, G; Nitahara, K; Shono, S; Sugi, Y, 2010) |
| " This study compared the efficacy of sugammadex and neostigmine for reversal of neuromuscular blockade induced by rocuronium for facilitating elective surgery." | 9.14 | Reversal of rocuronium-induced neuromuscular blockade with sugammadex compared with neostigmine during sevoflurane anaesthesia: results of a randomised, controlled trial. ( Blobner, M; Della Rocca, G; Eriksson, LI; Motsch, J; Prins, ME; Scholz, J, 2010) |
| "Single-dose sugammadex (4 mg/kg) after continuous rocuronium infusion is equally effective and well tolerated during maintenance anesthesia with sevoflurane or propofol." | 9.14 | Reversal of neuromuscular blockade by sugammadex after continuous infusion of rocuronium in patients randomized to sevoflurane or propofol maintenance anesthesia. ( Heeringa, M; Rex, C; Rietbergen, H; Scholz, J; Spies, C; Wagner, S; Wulf, H, 2009) |
| "We designed this randomized, open-label, dose-response trial to explore the dose-response relationship of sugammadex for the reversal of deep neuromuscular blockade induced by rocuronium or vecuronium under propofol-induced and sevoflurane-maintained anesthesia." | 9.14 | A randomized, dose-response study of sugammadex given for the reversal of deep rocuronium- or vecuronium-induced neuromuscular blockade under sevoflurane anesthesia. ( Claudius, C; Debaene, B; Duvaldestin, P; Heeringa, M; Klein, J; Kuizenga, K; Saldien, V; Servin, F, 2010) |
| "The purpose of this study was to determine the optimal bolus dose of alfentanil required to provide successful intubating conditions following inhalation induction of anaesthesia using 5% sevoflurane and 60% nitrous oxide without neuromuscular blockade in adult day-case anaesthesia." | 9.13 | The optimal bolus dose of alfentanil for tracheal intubation during sevoflurane induction without neuromuscular blockade in day-case anaesthesia. ( Chang, YJ; Kim, JY; Kwak, HJ; Kwak, YL; Lee, KC, 2008) |
| "The aim of the present study was to compare the influence of volatile anesthetics on transcranial motor-evoked potentials (tcMEP) in humans anesthetized with propofol/fentanyl/nitrous oxide and on partial neuromuscular blockade (NMB)." | 9.12 | The effects of volatile anesthetics on intraoperative monitoring of myogenic motor-evoked potentials to transcranial electrical stimulation and on partial neuromuscular blockade during propofol/fentanyl/nitrous oxide anesthesia in humans. ( Goto, F; Ishizeki, J; Kubo, K; Nishikawa, K; Saito, S; Sekimoto, K, 2006) |
| "In this prospective case-series study, a balanced anesthetic scheme of sevoflurane in nitrous oxide supplemented with remifentanil and sustained neuromuscular block was applied in nine patients scheduled for laparoscopic adrenalectomy for pheochromocytoma." | 9.12 | Remifentanil preventing hemodynamic changes during laparoscopic adrenalectomy for pheochromocytoma. ( Atsalakis, J; Chantzi, C; Dimitriou, V; Malefaki, A; Stranomiti, J; Varveri, M; Zogogiannis, I, 2006) |
| "In young children during steady state anaesthesia onset of action of rocuronium is halved and the degree of neuromuscular blockade is markedly augmented during sevoflurane/N(2)O anaesthesia compared to propofol." | 9.09 | [Sevoflurane augments the degree and speeds the onset of rocuronium evoked neuromuscular blockade in children]. ( Eikermann, M; Peters, J; Renzing-Köhler, K, 2001) |
| " We hypothesised that there was a difference in the rate of reversal of rocuronium-induced neuromuscular blockade based on the selection of inhalation agent." | 9.09 | A comparison of antagonism of rocuronium-induced neuromuscular blockade during sevoflurane and isoflurane anaesthesia. ( Maslow, A; Murphy, CM; Shorten, GD; Sutcliffe, DG; Uppington, J, 2000) |
| "To compare acceleromyography (AMG) and electromyography (EMG) with xenon or sevoflurane anesthesia during vecuronium-induced neuromuscular blockade." | 9.08 | Comparison of acceleromyography and electromyography in vecuronium-induced neuromuscular blockade with xenon or sevoflurane anesthesia. ( Goto, T; Ichinose, F; Morita, S; Nakata, Y; Saito, H; Suwa, K; Uezono, S, 1998) |
| " We compared the changes in BIS and PSI values caused by the sugammadex reversal of NMB during steady-state sevoflurane anesthesia." | 8.31 | Changes in bispectral index and patient state index during sugammadex reversal of neuromuscular blockade under steady-state sevoflurane anesthesia. ( Jeong, JS; Kim, D; Kim, I; Kim, J, 2023) |
| "We examined the effects of preoperatively administered phenytoin and carbamazepine on rocuronium-induced neuromuscular block under sevoflurane anesthesia in this retrospective clinical study." | 7.80 | Effects of preoperatively administered carbamazepine and phenytoin on rocuronium-induced neuromuscular block under sevoflurane anesthesia: a retrospective clinical study. ( Araki, Y; Inoue, R; Kawamura, G; Kitamura, T; Mori, Y; Sato, K; Yamada, Y, 2014) |
| "The purpose of this study was to determine the optimum bolus dose of propofol required to provide excellent conditions for tracheal intubation following inhalational induction of anaesthesia using 5% sevoflurane without neuromuscular blockade." | 7.77 | Optimum bolus dose of propofol for tracheal intubation during sevoflurane induction without neuromuscular blockade in children. ( Hong, JY; Jeong, SM; Kim, SH; Park, PH; Suk, EH, 2011) |
| "Inhaling sevoflurane combined with continuous intravenous anesthesia during the operation effectively reduces the dosage of muscle relaxant required to achieve the same deep neuromuscular block (dNMB) effect." | 7.30 | Effect of Sevoflurane on the Deep Neuromuscular Blockade in Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy: A Single Center Prospective Randomized Controlled Study. ( Hao, J; Li, J; Liu, Y; Shao, L; Song, B; Wan, L; Wang, H; Xue, FS, 2023) |
| "Cisatracurium 0." | 5.56 | Incidence of residual neuromuscular blockade in children below 3 years after a single bolus of cisatracurium 0.1 mg/kg: A quality assurance study. ( Eriksen, K; Rasmussen, LS; Tarpgaard, M; Vested, M, 2020) |
| "To compare the effects of sevoflurane, propofol and alfaxalone on the neuromuscular blockade induced by a single intravenous bolus of rocuronium in dogs." | 5.51 | Effects of sevoflurane, propofol or alfaxalone on neuromuscular blockade produced by a single intravenous bolus of rocuronium in dogs. ( Chen, IY; Itami, T; Kato, K; Sano, T; Tamogi, H; Wei, Y; Yamashita, K, 2022) |
| " The present study investigated the effect of preoperative consumption of potatoes on succinylcholine-induced block and recovery from anesthesia." | 5.17 | The effect of preoperative consumption of potatoes on succinylcholine-induced block and recovery from anesthesia. ( Bestas, A; Erhan, OL; Goksu, H, 2013) |
| "The aim of our study was to compare the effects of fentanyl, remifentanil, and dexmedetomidine on neuromuscular blockade under sevoflurane anesthesia." | 5.16 | Comparison of the effects of fentanyl, remifentanil, and dexmedetomidine on neuromuscular blockade. ( Basar, H; Gulec, H; Ozcan, A; Ozcan, N; Yalcin, F, 2012) |
| " In this study, to estimate the safe interval to avoid residual paralysis, we retrospectively selected patients in whom the TOF ratio was measured during remifentanil administration before extubation, and we studied the characteristics of recovery from the neuromuscular blockade produced by the empirical use of rocuronium." | 5.15 | Retrospective analysis of spontaneous recovery from neuromuscular blockade produced by empirical use of rocuronium. ( Ito, Y; Makita, K; Uchida, T; Yamamoto, H; Yamamoto, Y, 2011) |
| "We designed this randomized, open-label, dose-response trial to explore the dose-response relationship of sugammadex for the reversal of deep neuromuscular blockade induced by rocuronium or vecuronium under propofol-induced and sevoflurane-maintained anesthesia." | 5.14 | A randomized, dose-response study of sugammadex given for the reversal of deep rocuronium- or vecuronium-induced neuromuscular blockade under sevoflurane anesthesia. ( Claudius, C; Debaene, B; Duvaldestin, P; Heeringa, M; Klein, J; Kuizenga, K; Saldien, V; Servin, F, 2010) |
| "This randomized trial investigated whether 5% sevoflurane potentiated neuromuscular blockade by vecuronium." | 5.14 | Neuromuscular blockade by vecuronium during induction with 5% sevoflurane or propofol. ( Higa, K; Iwashita, K; Kusumoto, G; Nitahara, K; Shono, S; Sugi, Y, 2010) |
| "Two hundred and eighty children, 1 to 9 years old, undergoing elective strabismus surgery, were randomly assigned to eight groups; ketamine-sevoflurane (KS), ketamine-desflurane (KD), ketamine-propofol (KP), ketamine-remifentanil (KR), midazolam-sevoflurane (MS), midazolam-desflurane (MD), midazolam-propofol (MP), and midazolam-remifentanil (MR)." | 5.14 | Effect of different anesthetic agents on oculocardiac reflex in pediatric strabismus surgery. ( Choi, SR; Chung, CJ; Lee, JH; Lee, SC; Park, SW, 2009) |
| "The purpose of this study was to determine the optimal bolus dose of alfentanil required to provide successful intubating conditions following inhalation induction of anaesthesia using 5% sevoflurane and 60% nitrous oxide without neuromuscular blockade in adult day-case anaesthesia." | 5.13 | The optimal bolus dose of alfentanil for tracheal intubation during sevoflurane induction without neuromuscular blockade in day-case anaesthesia. ( Chang, YJ; Kim, JY; Kwak, HJ; Kwak, YL; Lee, KC, 2008) |
| "The aim of the present study was to compare the influence of volatile anesthetics on transcranial motor-evoked potentials (tcMEP) in humans anesthetized with propofol/fentanyl/nitrous oxide and on partial neuromuscular blockade (NMB)." | 5.12 | The effects of volatile anesthetics on intraoperative monitoring of myogenic motor-evoked potentials to transcranial electrical stimulation and on partial neuromuscular blockade during propofol/fentanyl/nitrous oxide anesthesia in humans. ( Goto, F; Ishizeki, J; Kubo, K; Nishikawa, K; Saito, S; Sekimoto, K, 2006) |
| "In this prospective case-series study, a balanced anesthetic scheme of sevoflurane in nitrous oxide supplemented with remifentanil and sustained neuromuscular block was applied in nine patients scheduled for laparoscopic adrenalectomy for pheochromocytoma." | 5.12 | Remifentanil preventing hemodynamic changes during laparoscopic adrenalectomy for pheochromocytoma. ( Atsalakis, J; Chantzi, C; Dimitriou, V; Malefaki, A; Stranomiti, J; Varveri, M; Zogogiannis, I, 2006) |
| "To quantify the neuromuscular blockade (NMB) produced by atracurium in either sevoflurane or propofol-anaesthetized dogs." | 5.11 | Neuromuscular blocking properties of atracurium during sevoflurane or propofol anaesthesia in dogs. ( Ascoli, FO; Becker, T; Gomez de Segura, IA; Kastrup, MR; Marsico, FF; Soares, JH, 2005) |
| " Anesthesia was induced with thiamylal and sevoflurane, and the trachea was intubated following vecuronium neuromuscular blockade." | 5.10 | The ED(95) of end-tidal sevoflurane concentration for the smooth exchange of the tracheal tube for a laryngeal mask airway is 2.97%. ( Kemmotsu, O; Morimoto, Y; Takita, K; Yamane, M, 2003) |
| "In young children during steady state anaesthesia onset of action of rocuronium is halved and the degree of neuromuscular blockade is markedly augmented during sevoflurane/N(2)O anaesthesia compared to propofol." | 5.09 | [Sevoflurane augments the degree and speeds the onset of rocuronium evoked neuromuscular blockade in children]. ( Eikermann, M; Peters, J; Renzing-Köhler, K, 2001) |
| "To compare acceleromyography (AMG) and electromyography (EMG) with xenon or sevoflurane anesthesia during vecuronium-induced neuromuscular blockade." | 5.08 | Comparison of acceleromyography and electromyography in vecuronium-induced neuromuscular blockade with xenon or sevoflurane anesthesia. ( Goto, T; Ichinose, F; Morita, S; Nakata, Y; Saito, H; Suwa, K; Uezono, S, 1998) |
| " Sugammadex is a A-cyclodextrin designed to encapsulate rocuronium bromide, providing a rapid reversal of neuromuscular blockade." | 4.85 | A novel approach to reversal of neuromuscular blockade. ( Della Rocca, G; Pompei, L, 2009) |
| " We performed a clinical study to establish the influence of moderate and deep neuromuscular blockade (NMB) on the abdominal working space, measured by Magnetic Resonance Imaging (MRI), during laparoscopic donor nephrectomy with standard pressure (12 mmHg) pneumoperitoneum under sevoflurane anaesthesia." | 4.31 | MRI measurement of the effects of moderate and deep neuromuscular blockade on the abdominal working space during laparoscopic surgery, a clinical study. ( Bruintjes, MHD; d'Ancona, F; Fütterer, JJ; Keijzer, C; Krijtenburg, P; Scheffer, GJ; van de Steeg, G; Warlé, MC, 2023) |
| "BACKGROUND There are no data available on the effects of different degrees of neuromuscular blockade on spectral entropy during sevoflurane anesthesia." | 3.91 | Effects of Neuromuscular Blockages on Entropy Monitoring During Sevoflurane Anesthesia. ( Chen, L; Li, S; Wang, H; Xing, Y; Xu, D; Xu, Y, 2019) |
| "We examined the effects of preoperatively administered phenytoin and carbamazepine on rocuronium-induced neuromuscular block under sevoflurane anesthesia in this retrospective clinical study." | 3.80 | Effects of preoperatively administered carbamazepine and phenytoin on rocuronium-induced neuromuscular block under sevoflurane anesthesia: a retrospective clinical study. ( Araki, Y; Inoue, R; Kawamura, G; Kitamura, T; Mori, Y; Sato, K; Yamada, Y, 2014) |
| "The purpose of this study was to determine the optimum bolus dose of propofol required to provide excellent conditions for tracheal intubation following inhalational induction of anaesthesia using 5% sevoflurane without neuromuscular blockade." | 3.77 | Optimum bolus dose of propofol for tracheal intubation during sevoflurane induction without neuromuscular blockade in children. ( Hong, JY; Jeong, SM; Kim, SH; Park, PH; Suk, EH, 2011) |
| "30 diabetic patients were assigned to diabetes mellitus (DM)-total iv anesthesia (TIVA); (n = 15) or DM-sevoflurane (S) groups (n = 15)." | 3.73 | Delayed recovery of vecuronium neuromuscular block in diabetic patients during sevoflurane anesthesia. ( Akatu, M; Hattori, H; Murakawa, M; Nakajima, H; Saitoh, Y; Sanbe, N, 2005) |
| " Anaesthetic technique included inhalation induction using sevoflurane/O2/air and neuromuscular blockade." | 3.72 | The effect of insufflation pressure on pulmonary mechanics in infants during laparoscopic surgical procedures. ( Bannister, CF; Brosius, KK; Wulkan, M, 2003) |
| "Inhaling sevoflurane combined with continuous intravenous anesthesia during the operation effectively reduces the dosage of muscle relaxant required to achieve the same deep neuromuscular block (dNMB) effect." | 3.30 | Effect of Sevoflurane on the Deep Neuromuscular Blockade in Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy: A Single Center Prospective Randomized Controlled Study. ( Hao, J; Li, J; Liu, Y; Shao, L; Song, B; Wan, L; Wang, H; Xue, FS, 2023) |
| "Pipecuronium is a steroidal neuromuscular blocking agent." | 2.80 | Reversal of Pipecuronium-Induced Moderate Neuromuscular Block with Sugammadex in the Presence of a Sevoflurane Anesthetic: A Randomized Trial. ( Asztalos, L; Fülesdi, B; Lengyel, S; Nemes, R; Pongrácz, A; Tassonyi, E, 2015) |
| "Rocuronium 0." | 2.73 | Reversal of rocuronium-induced neuromuscular block with the novel drug sugammadex is equally effective under maintenance anesthesia with propofol or sevoflurane. ( Kalmar, AF; Prins, ME; Rietbergen, H; Saldien, V; Struys, MM; Vanacker, BF; Vandermeersch, E; Vermeyen, KM, 2007) |
| "Rocuronium was administered in increments of 100 micrograms." | 2.69 | Neuromuscular blocking effects of rocuronium during desflurane, isoflurane, and sevoflurane anaesthesia. ( Ledowski, T; Linstedt, U; Proppe, D; Sitzlack, D; Wulf, H, 1998) |
| "Neuromuscular blockade was monitored by train-of-four (TOF) stimulation every 10 s and adductor pollicis electromyography." | 2.69 | Decreased mivacurium requirements and delayed neuromuscular recovery during sevoflurane anesthesia in children and adults. ( Bevan, DR; Bevan, JC; Bridge, HS; Martin, GR; Reimer, EJ; Smith, MF, 1998) |
| "Cisatracurium 0." | 1.56 | Incidence of residual neuromuscular blockade in children below 3 years after a single bolus of cisatracurium 0.1 mg/kg: A quality assurance study. ( Eriksen, K; Rasmussen, LS; Tarpgaard, M; Vested, M, 2020) |
| "When rocuronium was applied at higher concentrations (IC25 and IC50), sevoflurane had an effect similar to that of isoflurane." | 1.39 | Synergistic effect of sevoflurane and isoflurane on inhibition of the adult-type muscle nicotinic acetylcholine receptor by rocuronium. ( Cao, J; Li, W; Liu, L; Luo, J; Min, S; Wang, B; Wei, K, 2013) |
| "Atracurium was administered via a continuous infusion in order to obtain 85% twitch depression of the control value assessed by repeated accelerometric stimulation at the adductor pollicis." | 1.33 | Acute desflurane or sevoflurane exposure on a previously stabilized atracurium-induced neuromuscular block. ( Beaussier, M; Boughaba, A; d'Hollander, A; Debaene, B; Lienhart, A; Schiffer, E, 2006) |
| "kg-1 and construction of dose-response curves (n = 72)." | 1.30 | Potency and time course of mivacurium block during sevoflurane, isoflurane and intravenous anesthesia. ( Carroll, MT; Hughes, DA; Lowry, DW; McCarthy, GJ; Mirakhur, RK; O'Hare, RA, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 14 (16.87) | 18.2507 |
| 2000's | 28 (33.73) | 29.6817 |
| 2010's | 32 (38.55) | 24.3611 |
| 2020's | 9 (10.84) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, IY | 1 |
| Tamogi, H | 1 |
| Wei, Y | 1 |
| Kato, K | 1 |
| Itami, T | 1 |
| Sano, T | 1 |
| Yamashita, K | 1 |
| Ebert, TJ | 1 |
| Cumming, CE | 1 |
| Roberts, CJ | 1 |
| Anglin, MF | 1 |
| Gandhi, S | 1 |
| Anderson, CJ | 1 |
| Stekiel, TA | 1 |
| Gliniecki, R | 1 |
| Dugan, SM | 1 |
| Abdelrahim, MT | 1 |
| Klinewski, VB | 1 |
| Sherman, K | 1 |
| Kim, J | 1 |
| Kim, D | 1 |
| Kim, I | 1 |
| Jeong, JS | 1 |
| Krijtenburg, P | 1 |
| Bruintjes, MHD | 1 |
| Fütterer, JJ | 1 |
| van de Steeg, G | 1 |
| d'Ancona, F | 1 |
| Scheffer, GJ | 1 |
| Keijzer, C | 1 |
| Warlé, MC | 1 |
| Shao, L | 1 |
| Liu, Y | 1 |
| Hao, J | 1 |
| Li, J | 1 |
| Wang, H | 2 |
| Xue, FS | 1 |
| Song, B | 1 |
| Wan, L | 1 |
| Matsui, M | 2 |
| Konishi, J | 1 |
| Suzuki, T | 2 |
| Sekijima, C | 1 |
| Miyazawa, N | 1 |
| Yamamoto, S | 1 |
| Vested, M | 1 |
| Tarpgaard, M | 1 |
| Eriksen, K | 1 |
| Rasmussen, LS | 1 |
| Xing, Y | 1 |
| Xu, D | 1 |
| Xu, Y | 1 |
| Chen, L | 1 |
| Li, S | 1 |
| Takagi, S | 1 |
| Kitajima, O | 1 |
| Yamamoto, M | 1 |
| Honing, GHM | 1 |
| Martini, CH | 1 |
| Olofsen, E | 1 |
| Bevers, RFM | 1 |
| Huurman, VAL | 1 |
| Alwayn, IPJ | 1 |
| van Velzen, M | 1 |
| Niesters, M | 1 |
| Aarts, LPHJ | 1 |
| Dahan, A | 1 |
| Boon, M | 1 |
| Kim, YB | 1 |
| Choi, JM | 1 |
| Park, C | 1 |
| Choi, HR | 1 |
| In, J | 1 |
| Yang, HS | 2 |
| Ye, L | 1 |
| Yang, P | 1 |
| Koo, BW | 1 |
| Jung, KW | 1 |
| Oh, AY | 1 |
| Kim, EY | 1 |
| Na, HS | 1 |
| Choi, ES | 1 |
| Seo, KS | 1 |
| Tassonyi, E | 2 |
| Asztalos, L | 2 |
| Szabó-Maák, Z | 1 |
| Nemes, R | 2 |
| Pongrácz, A | 2 |
| Lengyel, S | 2 |
| Fülesdi, B | 2 |
| Salik, I | 1 |
| Awad, M | 1 |
| Barst, S | 1 |
| Fuchs-Buder, T | 1 |
| Bestas, A | 1 |
| Goksu, H | 1 |
| Erhan, OL | 1 |
| Iwasaki, H | 2 |
| Takahoko, K | 1 |
| Otomo, S | 1 |
| Sasakawa, T | 1 |
| Kunisawa, T | 1 |
| Chung, YH | 1 |
| Kim, WH | 1 |
| Lee, JJ | 1 |
| Yang, SI | 1 |
| Lim, SH | 1 |
| Seo, DW | 1 |
| Park, K | 1 |
| Chung, IS | 1 |
| Gupta, B | 1 |
| Ayub, A | 1 |
| Bindra, A | 1 |
| Gupta, S | 1 |
| Mishra, B | 1 |
| Kawamura, G | 1 |
| Inoue, R | 1 |
| Araki, Y | 1 |
| Mori, Y | 1 |
| Sato, K | 1 |
| Yamada, Y | 1 |
| Kitamura, T | 1 |
| Tiwari, AK | 1 |
| Wong, DT | 1 |
| Venkatraghaven, L | 1 |
| Cornelius, B | 1 |
| Sakai, T | 1 |
| McKay, RE | 1 |
| Hall, KT | 1 |
| Hills, N | 1 |
| Preault, A | 1 |
| Capron, F | 1 |
| Chantereau, C | 1 |
| Donati, F | 1 |
| Dimet, J | 1 |
| Cassavaugh, JM | 1 |
| Oravitz, TM | 1 |
| Lee, S | 1 |
| Ro, YJ | 1 |
| Koh, WU | 1 |
| Nishiyama, T | 1 |
| Hayashi, K | 1 |
| Kumar, N | 1 |
| Sardana, R | 1 |
| Kaur, R | 1 |
| Jain, A | 1 |
| Passariello, M | 1 |
| Almenrader, N | 1 |
| Pietropaoli, P | 1 |
| Amin, AM | 1 |
| Mohammad, MY | 1 |
| Ibrahim, MF | 1 |
| Soulard, A | 1 |
| Babre, F | 1 |
| Bordes, M | 1 |
| Meymat, Y | 1 |
| Sztark, F | 1 |
| Cros, AM | 1 |
| Della Rocca, G | 2 |
| Pompei, L | 1 |
| Rex, C | 1 |
| Wagner, S | 1 |
| Spies, C | 1 |
| Scholz, J | 2 |
| Rietbergen, H | 2 |
| Heeringa, M | 2 |
| Wulf, H | 2 |
| Choi, SR | 1 |
| Park, SW | 1 |
| Lee, JH | 1 |
| Lee, SC | 1 |
| Chung, CJ | 1 |
| Duvaldestin, P | 1 |
| Kuizenga, K | 1 |
| Saldien, V | 2 |
| Claudius, C | 1 |
| Servin, F | 1 |
| Klein, J | 1 |
| Debaene, B | 2 |
| Lee, KH | 1 |
| Nam, SH | 1 |
| Yoo, SY | 1 |
| Jung, CW | 1 |
| Bae, SS | 1 |
| Lee, JR | 1 |
| Blobner, M | 1 |
| Eriksson, LI | 1 |
| Motsch, J | 1 |
| Prins, ME | 2 |
| Nitahara, K | 1 |
| Sugi, Y | 1 |
| Kusumoto, G | 1 |
| Shono, S | 1 |
| Iwashita, K | 1 |
| Higa, K | 1 |
| Kim, KS | 1 |
| Kwak, HJ | 2 |
| Min, SK | 2 |
| Lee, SY | 1 |
| Kim, KM | 1 |
| Kim, JY | 3 |
| Sakai, Y | 1 |
| Tsutsumi, YM | 1 |
| Wakamatsu, N | 1 |
| Soga, T | 1 |
| Tanaka, K | 1 |
| Oshita, S | 1 |
| Messieha, ZS | 1 |
| Guirguis, S | 1 |
| Hanna, S | 1 |
| Yamamoto, H | 1 |
| Uchida, T | 1 |
| Yamamoto, Y | 1 |
| Ito, Y | 1 |
| Makita, K | 2 |
| Kim, SH | 1 |
| Hong, JY | 1 |
| Suk, EH | 1 |
| Jeong, SM | 1 |
| Park, PH | 1 |
| Ozcan, A | 1 |
| Ozcan, N | 1 |
| Gulec, H | 1 |
| Yalcin, F | 1 |
| Basar, H | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective Randomized Blinded Controlled Trial Comparing Clinical Outcomes in Cardiac Surgical Patients Who Receive Sugammadex vs. Placebo[NCT05801679] | Phase 3 | 175 participants (Anticipated) | Interventional | 2023-07-03 | Recruiting | ||
| Effect of Atracurium and Rocuronium on the State and Response Entropy During Isoflurane Anesthesia[NCT05097508] | Early Phase 1 | 40 participants (Actual) | Interventional | 2020-06-20 | Completed | ||
| Optimal Dose of Combination of Rocuronium and Cisatracurium: A Randomized Double-blinded Clinical Trial[NCT02495038] | 81 participants (Actual) | Interventional | 2014-03-31 | Completed | |||
| A Multi -Center, Randomized, Parallel Group, Safety Assessor Blinded Trial Comparing Efficacy and Safety of 4.0 mg.Kg-1 Sugammadex , Administered at T1 3-10% After Continuous Infusion of Rocuronium, and Pharmacokinetics of Rocuronium, Between Subjects Rec[NCT00559468] | Phase 3 | 52 participants (Actual) | Interventional | 2006-12-07 | Completed | ||
| A Multi -Center, Randomized, Open -Label, Prospective Bridging, Parallel Dose-Finding Trial Comparing Efficacy, Safety and Pharmacokinetics of 5 Doses of Org 25969 Administered at 1-2 PTC After Rocuronium or Vecuronium in Japanese and Caucasian Subjects. [NCT00552929] | Phase 2 | 102 participants (Actual) | Interventional | 2005-10-04 | Completed | ||
| Comparison of AMG (Acceleromyography) and EMG (Electromyography) to Avoid Postoperative Residual Paralysis After General Anesthesia[NCT02126852] | 214 participants (Actual) | Interventional | 2014-04-30 | Completed | |||
| Comparison of Sugammadex Dosages to Reverse the Effect of Rocuronium for Continuous Intraoperative Neuromonitoring in Thyroid Surgery[NCT03689413] | 102 participants (Actual) | Interventional | 2018-10-01 | Completed | |||
| The Reversal of Residual Neuromuscular Blockade After Neostigmine and Half-dose Sugammadex: A Comparison With Standard Reversal of Full-dose Neostigmine[NCT05066035] | Phase 4 | 113 participants (Actual) | Interventional | 2013-05-01 | Completed | ||
| Deep Neuromuscular Block During General Anaesthesia in Laparoscopic (and Robotic Laparoscopic) Surgery and Its Potential Benefits for Certain Physiological Parameters in Perioperative Period[NCT03420937] | Phase 4 | 138 participants (Actual) | Interventional | 2016-06-30 | Completed | ||
| A Multi -Center Randomized Parallel Group Comparative Active Controlled Safety Assessor Blinded Phase 3a Pivotal Trial in Adult Subjects Comparing Org 25969 With Neostigmine as Reversal Agents of a Neuromuscular Block Induced by Rocuronium or Vecuronium a[NCT00451217] | Phase 3 | 198 participants (Actual) | Interventional | 2005-11-17 | Completed | ||
| Comparison Between the Efficacy of Neostigmine Versus Sugammadex Reversal of Rocuronium Induced Neuromuscular Blockade In Paediatric Patients.[NCT03137290] | 80 participants (Actual) | Interventional | 2014-12-01 | Completed | |||
| Sugammadex Versus Neostigmine for Antagonism of Rocuronium-induced Neuromuscular Blockade in Patients With Liver Cirrhosis Undergoing Liver Resection: A Controlled Randomized Study[NCT02414880] | Phase 4 | 60 participants (Actual) | Interventional | 2014-12-31 | Completed | ||
| Evaluation of Duration of Curarisation (Surgical Efficacy) and Pharmacokinetics of Neuromuscular Block After a Single Dose of Rocuronium in Geriatric Patients (Age ≥ 80 Years ) Compared to a Younger Population (Age < 50 Years).[NCT03551652] | 28 participants (Anticipated) | Observational | 2020-05-15 | Recruiting | |||
| Optimal Control of Muscle Strength for Electroconvulsive Therapy: A Comparison of Succinylcholine Versus Rocuronium-induced Neuromuscular Blockade[NCT01441960] | 45 participants (Actual) | Interventional | 2011-05-31 | Completed | |||
| Propofol for Pediatric Tracheal Intubation With Deep Anesthesia During Sevoflurane Induction: Dosing According to Elapsed Time for Two Age Groups,IRB-HSR# 13666[NCT01150838] | Phase 4 | 106 participants (Actual) | Interventional | 2008-07-31 | Completed | ||
| Study to Evaluate the Optimal Dose of Remifentanil Required to Ensure Apnoea During Magnetic Resonance Imaging of the Heart Under General Anaesthesia[NCT02481791] | Phase 3 | 35 participants (Anticipated) | Interventional | 2015-07-31 | Recruiting | ||
| Optimal Sevoflurane Concentration for Intubation Without Using Muscle Relaxants in Combination of Different Clinical Bolus Doses of Remifentanil[NCT02440204] | 68 participants (Actual) | Interventional | 2015-05-31 | Completed | |||
| Pressure Support Ventilation Versus Continuous Positive Air Way Pressure (CPAP) Using I Gel Laryngeal Mask for Minor Surgery in Adult Patients, a Prospective cross_over Study[NCT05116839] | 38 participants (Anticipated) | Interventional | 2019-03-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Additional Rescue Doses Per Hour Ratio is the number per hour of addition of rescue dose administrated with 10% of initial NMBAs dose. The formula is {(Addition number + 1 / Anesthetic time) x 60}. (NCT02495038)
Timeframe: Intraoperative, an average of 3 hours.
| Intervention | ratio (Mean) |
|---|---|
| Intubating Dose, Group I | 1.43455 |
| 10% Reduction of Combination of Esmeron® and Nimbex®, Group S | 1.21014 |
| 20% Reduction of Combination of Esmeron® and Nimbex®, Group L | 0.82128 |
Time from induction to recovery of anesthesia, asessed up to 3 hours. (NCT02495038)
Timeframe: Intraoperative, an average 4 hours.
| Intervention | Minute (Mean) |
|---|---|
| Intubating Dose, Group I | 163.0 |
| 10% Reduction of Combination of Esmeron® and Nimbex®, Group S | 159.9 |
| 20% Reduction of Combination of Esmeron® and Nimbex®, Group L | 161.4 |
"The BIS monitor provides a single dimensionless number, which ranges from 0 (equivalent to EEG silence) to 100. A BIS value between 40 and 60 indicates an appropriate level for general anesthesia, as recommended by the manufacturer.~Before induction of anesthesia, bispectral index was measured for baseline. And after injection of NMBAs, bispectral index was measured at 10 min." (NCT02495038)
Timeframe: Before and after induction of anesthesia, an average 10 min.
| Intervention | BIS score (Mean) |
|---|---|
| Intubating Dose, Group I | 46.0 |
| 10% Reduction of Combination of Esmeron® and Nimbex®, Group S | 46.1 |
| 20% Reduction of Combination of Esmeron® and Nimbex®, Group L | 44.3 |
"Before induction of anesthesia, body temperature was measured for baseline by oral temperature probe.~And after injection of NMBAs, non invasive blood pressure was measured at 10 min by esophageal temperature probe." (NCT02495038)
Timeframe: Before and after induction of anesthesia, an average 10 min.
| Intervention | Celcius degree (Mean) |
|---|---|
| Intubating Dose, Group I | 36.3 |
| 10% Reduction of Combination of Esmeron® and Nimbex®, Group S | 36.3 |
| 20% Reduction of Combination of Esmeron® and Nimbex®, Group L | 36.3 |
Time from administration of initial NMBAs to Train-of-four (TOF) ratio >25%, assessed up to 2 hours during general anesthesia. (NCT02495038)
Timeframe: Intraoperative, an average of 1 hours
| Intervention | Minute (Mean) |
|---|---|
| Intubating Dose, Group I | 51.3 |
| 10% Reduction of Combination of Esmeron® and Nimbex®, Group S | 47.9 |
| 20% Reduction of Combination of Esmeron® and Nimbex®, Group L | 39.4 |
Time from administration of initial NMBAs to Train-of-four (TOF) ratio=0, assessed up to 15 minutes during general anesthesia. (NCT02495038)
Timeframe: Intraoperative, an average of 5 minutes
| Intervention | Second (Mean) |
|---|---|
| Intubating Dose, Group I | 212.8 |
| 10% Reduction of Combination of Esmeron® and Nimbex®, Group S | 230.1 |
| 20% Reduction of Combination of Esmeron® and Nimbex®, Group L | 399.3 |
Time from skin incision to wound dressing assessed up to 8 hours. (NCT02495038)
Timeframe: Intraoperative, an average of 3 hours.
| Intervention | Minute (Mean) |
|---|---|
| Intubating Dose, Group I | 151.8 |
| 10% Reduction of Combination of Esmeron® and Nimbex®, Group S | 147.0 |
| 20% Reduction of Combination of Esmeron® and Nimbex®, Group L | 145.9 |
"Before induction of anesthesia, peripheral oxygen saturation was measured for baseline.~And after injection of NMBAs, peripheral oxygen saturation was measured at 10 min." (NCT02495038)
Timeframe: Before and after induction of anesthesia, an average 10 min.
| Intervention | Percentage (Mean) |
|---|---|
| Intubating Dose, Group I | 100 |
| 10% Reduction of Combination of Esmeron® and Nimbex®, Group S | 99.9 |
| 20% Reduction of Combination of Esmeron® and Nimbex®, Group L | 100 |
Time from TOF ratio 25% to 75%, assessed up to 1 hour during general anesthesia. (NCT02495038)
Timeframe: Intraoperative, an average of 20 minutes
| Intervention | Minute (Mean) |
|---|---|
| Intubating Dose, Group I | 15.9 |
| 10% Reduction of Combination of Esmeron® and Nimbex®, Group S | 16.2 |
| 20% Reduction of Combination of Esmeron® and Nimbex®, Group L | 14.1 |
"Before induction of anesthesia, non invasive blood pressure was measured for baseline.~And after injection of NMBAs, non invasive blood pressure was measured at 10 min." (NCT02495038)
Timeframe: Before and after induction of anesthesia, an average 10 min.
| Intervention | mmHg (Mean) | |
|---|---|---|
| Systolic pressure | Diastolic pressure | |
| 10% Reduction of Combination of Esmeron® and Nimbex®, Group S | 128.3 | 76.7 |
| 20% Reduction of Combination of Esmeron® and Nimbex®, Group L | 128.4 | 74.8 |
| Intubating Dose, Group I | 128.3 | 75.6 |
Neuromuscular functioning was monitored by applying repetitive Train of Four (TOF) electrical stimulations to the ulnar nerve every 15 seconds and assessing twitch response at the adductor pollicis muscle. T1 and T4 refer to the amplitudes (heights) of the first and fourth twitches, respectively, after TOF nerve stimulation. The T4/T1 ratio (expressed as a decimal from 0 [loss of T4] up to 1.0 [no NMB]) indicates the extent of recovery from NMB. In this study, twitch responses were recorded until the T4/T1 Ratio reached >= 0.9, the minimum acceptable ratio that indicated recovery from NMB. A faster time to recovery of the T4/T1 ratio to 0.9 indicates a faster recovery from NMB. (NCT00559468)
Timeframe: Up to 3 minutes after sugammadex administration
| Intervention | minutes (Mean) |
|---|---|
| Sugammadex + Sevoflurane | 1.45 |
| Sugammadex + Propofol | 1.32 |
Neuromuscular functioning was monitored by applying repetitive TOF electrical stimulations to the ulnar nerve every 15 seconds and assessing twitch response at the adductor pollicis muscle. T1 and T4 refer to the amplitudes (heights) of the first and fourth twitches, respectively, after TOF nerve stimulation. The T4/T1 ratio (expressed as a decimal from 0 [loss of T4] up to 1.0 [no NMB]) indicates the extent of recovery from NMB. A faster time to recovery of the T4/T1 ratio to 0.7 indicates a faster recovery from NMB. (NCT00559468)
Timeframe: Up to 3 minutes after sugammadex administration
| Intervention | minutes (Mean) |
|---|---|
| Sugammadex + Sevoflurane | 1.07 |
| Sugammadex + Propofol | 1.02 |
Neuromuscular functioning was monitored by applying repetitive TOF electrical stimulations to the ulnar nerve every 15 seconds and assessing twitch response at the adductor pollicis muscle. T1 and T4 refer to the amplitudes (heights) of the first and fourth twitches, respectively, after TOF nerve stimulation. The T4/T1 ratio (expressed as a decimal from 0 [loss of T4] up to 1.0 [no NMB]) indicates the extent of recovery from NMB. A faster time to recovery of the T4/T1 ratio to 0.8 indicates a faster recovery from NMB. (NCT00559468)
Timeframe: Up to 3 minutes after sugammadex administration
| Intervention | minutes (Mean) |
|---|---|
| Sugammadex + Sevoflurane | 1.20 |
| Sugammadex + Propofol | 1.12 |
The number of participants who had at least one AE during treatment and follow-up was assessed. An AE is any untoward medical occurrence in a participant or clinical investigation participant administered a pharmaceutical product and which does not necessarily have to have a causal relationship with this treatment. (NCT00552929)
Timeframe: From Screening to 7 post-operative days
| Intervention | Participants (Count of Participants) |
|---|---|
| Sugammadex 0.5 mg/kg (Rocuronium) | 6 |
| Sugammadex 1.0 mg/kg (Rocuroniium) | 8 |
| Sugammadex 2.0 mg/kg (Rocuronium) | 8 |
| Sugammadex 4.0 mg/kg (Rocuronium) | 10 |
| Sugammadex 8.0 mg/kg (Rocuronium) | 8 |
| Sugammadex 0.5 mg/kg (Vecuronium) | 6 |
| Sugammadex 1.0 mg/kg (Vecuronium) | 6 |
| Sugammadex 2.0 mg/kg (Vecuronium) | 7 |
| Sugammadex 4.0 mg/kg (Vecuronium) | 6 |
| Sugammadex 8.0 mg/kg (Vecuronium) | 8 |
Neuromuscular functioning was monitored by applying repetitive TOF electrical stimulations to the ulnar nerve every 15 seconds and assessing twitch response at the adductor pollicis muscle. T1 and T4 refer to the amplitudes (heights) of the first and fourth twitches, respectively, after TOF nerve stimulation. The T4/T1 Ratio (expressed as a decimal of up to 1.0) indicates the extent of recovery from NMB. A faster time to recovery of the T4/T1 Ratio to 0.7 indicates a faster recovery from NMB. (NCT00552929)
Timeframe: Up to 96:24 (min:sec)
| Intervention | Minutes (Mean) |
|---|---|
| Sugammadex 0.5 mg/kg (Rocuronium) | 47.72 |
| Sugammadex 1.0 mg/kg (Rocuroniium) | 4.47 |
| Sugammadex 2.0 mg/kg (Rocuronium) | 2.17 |
| Sugammadex 4.0 mg/kg (Rocuronium) | 1.25 |
| Sugammadex 8.0 mg/kg (Rocuronium) | 0.93 |
| Sugammadex 0.5 mg/kg (Vecuronium) | 30.22 |
| Sugammadex 1.0 mg/kg (Vecuronium) | 4.07 |
| Sugammadex 2.0 mg/kg (Vecuronium) | 2.32 |
| Sugammadex 4.0 mg/kg (Vecuronium) | 1.65 |
| Sugammadex 8.0 mg/kg (Vecuronium) | 1.33 |
Neuromuscular functioning was monitored by applying repetitive TOF electrical stimulations to the ulnar nerve every 15 seconds and assessing twitch response at the adductor pollicis muscle. T1 and T4 refer to the amplitudes (heights) of the first and fourth twitches, respectively, after TOF nerve stimulation. The T4/T1 Ratio (expressed as a decimal of up to 1.0) indicates the extent of recovery from NMB. A faster time to recovery of the T4/T1 Ratio to 0.8 indicates a faster recovery from NMB. (NCT00552929)
Timeframe: Up to 102:25 (min:sec)
| Intervention | Minutes (Mean) |
|---|---|
| Sugammadex 0.5 mg/kg (Rocuronium) | 57.00 |
| Sugammadex 1.0 mg/kg (Rocuroniium) | 14.22 |
| Sugammadex 2.0 mg/kg (Rocuronium) | 2.45 |
| Sugammadex 4.0 mg/kg (Rocuronium) | 1.35 |
| Sugammadex 8.0 mg/kg (Rocuronium) | 0.98 |
| Sugammadex 0.5 mg/kg (Vecuronium) | 45.93 |
| Sugammadex 1.0 mg/kg (Vecuronium) | 5.10 |
| Sugammadex 2.0 mg/kg (Vecuronium) | 2.92 |
| Sugammadex 4.0 mg/kg (Vecuronium) | 2.87 |
| Sugammadex 8.0 mg/kg (Vecuronium) | 1.43 |
Neuromuscular functioning was monitored by applying repetitive Train-Of-Four (TOF) electrical stimulations to the ulnar nerve every 15 seconds and assessing twitch response at the adductor pollicis muscle. T1 and T4 refer to the amplitudes (heights) of the first and fourth twitches, respectively, after TOF nerve stimulation. The T4/T1 Ratio (expressed as a decimal of up to 1.0) indicates the extent of recovery from neuromuscular blockade (NMB). In this study, twitch responses were recorded until the T4/T1 Ratio reached >= 0.9, the minimum acceptable ratio that indicated recovery from NMB. A faster time to recovery of the T4/T1 Ratio to 0.9 indicates a faster recovery from NMB. (NCT00552929)
Timeframe: Up to 131:40 (min:sec)
| Intervention | Minutes (Mean) |
|---|---|
| Sugammadex 0.5 mg/kg (Rocuronium) | 79.78 |
| Sugammadex 1.0 mg/kg (Rocuroniium) | 28.00 |
| Sugammadex 2.0 mg/kg (Rocuronium) | 3.17 |
| Sugammadex 4.0 mg/kg (Rocuronium) | 1.65 |
| Sugammadex 8.0 mg/kg (Rocuronium) | 1.13 |
| Sugammadex 0.5 mg/kg (Vecuronium) | 68.40 |
| Sugammadex 1.0 mg/kg (Vecuronium) | 25.12 |
| Sugammadex 2.0 mg/kg (Vecuronium) | 9.08 |
| Sugammadex 4.0 mg/kg (Vecuronium) | 3.30 |
| Sugammadex 8.0 mg/kg (Vecuronium) | 1.65 |
Neuromuscular functioning was monitored by applying repetitive Train-Of-Four (TOF) electrical stimulations to the ulnar nerve every 15 seconds and assessing twitch response at the adductor pollicis muscle. T1 and T4 refer to the amplitudes (heights) of the first and fourth twitches, respectively, after TOF nerve stimulation. The T4/T1 Ratio (expressed as a decimal of up to 1.0) indicates the extent of recovery from neuromuscular blockade (NMB). In this study, twitch responses were recorded until the T4/T1 Ratio reached >= 0.9, the minimum acceptable ratio that indicated recovery from NMB. A faster time to recovery of the T4/T1 Ratio to 0.9 indicates a faster recovery from NMB. (NCT00451217)
Timeframe: Day 1: From start of sugammadex or neostigmine administration to recovery of T4/T1 ratio to 0.9
| Intervention | Minutes (Mean) |
|---|---|
| Rocuronium + Sugammadex | 1.62 |
| Rocuronium + Neostigmine | 26.78 |
| Vecuronium + Sugammadex | 4.47 |
| Vecuronium + Neostigmine | 23.43 |
Neuromuscular functioning was monitored by applying repetitive TOF electrical stimulations to the ulnar nerve every 15 seconds and assessing twitch response at the adductor pollicis muscle. T1 and T4 refer to the amplitudes (heights) of the first and fourth twitches, respectively, after TOF nerve stimulation. The T4/T1 Ratio (expressed as a decimal of up to 1.0) indicates the extent of recovery from NMB. A faster time to recovery of the T4/T1 Ratio to 0.7 indicates a faster recovery from NMB. (NCT00451217)
Timeframe: Day 1: From start of sugammadex or neostigmine administration to recovery of T4/T1 ratio to 0.7
| Intervention | Minutes (Mean) |
|---|---|
| Rocuronium + Sugammadex | 1.17 |
| Rocuronium + Neostigmine | 9.60 |
| Vecuronium + Sugammadex | 1.68 |
| Vecuronium + Neostigmine | 9.52 |
Neuromuscular functioning was monitored by applying repetitive TOF electrical stimulations to the ulnar nerve every 15 seconds and assessing twitch response at the adductor pollicis muscle. T1 and T4 refer to the amplitudes (heights) of the first and fourth twitches, respectively, after TOF nerve stimulation. The T4/T1 Ratio (expressed as a decimal of up to 1.0) indicates the extent of recovery from NMB. A faster time to recovery of the T4/T1 Ratio to 0.8 indicates a faster recovery from NMB. (NCT00451217)
Timeframe: Day 1: From start of sugammadex or neostigmine administration to recovery of T4/T1 ratio to 0.8
| Intervention | Minutes (Mean) |
|---|---|
| Rocuronium + Sugammadex | 1.32 |
| Rocuronium + Neostigmine | 15.32 |
| Vecuronium + Sugammadex | 2.12 |
| Vecuronium + Neostigmine | 15.33 |
Just prior to discharge from the recovery room, neuromuscular recovery was assessed by monitoring every 15 minutes the following clinical signs of recovery: level of consciousness (i.e., awake and oriented, arousable with minimal stimulation, responsive only to tactile stimulation); 5-second head lift test (ability to lift the head for 5 seconds); and general muscle weakness (NCT00451217)
Timeframe: Day 1
| Intervention | Participants (Count of Participants) | ||||
|---|---|---|---|---|---|
| Consciousness: Awake and oriented | Consciousness: Arousable with minimal stimulation | Consciousness: Responsive only to tactile stimuli | Able to perform the 5 second head lift | Has general muscle weakness | |
| Rocuronium + Neostigmine | 48 | 0 | 0 | 48 | 0 |
| Rocuronium + Sugammadex | 46 | 1 | 0 | 47 | 0 |
| Vecuronium + Neostigmine | 43 | 1 | 0 | 44 | 0 |
| Vecuronium + Sugammadex | 48 | 0 | 0 | 48 | 0 |
After anesthesia and prior to transfer to the recovery room after extubation, neuromuscular recovery was assessed by monitoring every 15 minutes the following clinical signs of recovery: level of consciousness (i.e., awake and oriented, arousable with minimal stimulation, responsive only to tactile stimulation); 5-second head lift test (ability to lift the head for 5 seconds); and general muscle weakness (NCT00451217)
Timeframe: Day 1
| Intervention | Participants (Count of Participants) | ||||
|---|---|---|---|---|---|
| Consciousness: Awake and oriented | Consciousness: Arousable with minimal stimulation | Consciousness: Responsive only to tactile stimuli | Able to perform the 5 second head lift | Has general muscle weakness | |
| Rocuronium + Neostigmine | 35 | 13 | 0 | 37 | 9 |
| Rocuronium + Sugammadex | 30 | 16 | 2 | 38 | 3 |
| Vecuronium + Neostigmine | 26 | 14 | 5 | 32 | 6 |
| Vecuronium + Sugammadex | 29 | 17 | 2 | 40 | 4 |
The investigators defined the compound specific differences in time to recovery from neuromuscular blockade - i.e., recovery of spontaneous breathing and recovery of the twitch height to baseline. (NCT01441960)
Timeframe: Up to six weeks following inclusion
| Intervention | minutes (Mean) |
|---|---|
| Succinylchline | 9.7 |
| Rocuronium | 19.5 |
Observational reports suggest that differences in seizure duration might exist depending on the neuromuscular blocking agents used to accomplish muscle strength control during ECT. (NCT01441960)
Timeframe: Up to six weeks following inclusion
| Intervention | Seconds (Mean) |
|---|---|
| Succinylcholine | 27 |
| Rocuronium | 31 |
The optimal dose of muscle neuromuscular blocking is defined as the lowest dose of either compound that predicts 'acceptable' control of muscle strength during ECT. Assessment of the primary end point is based on a dichotomous scale 'acceptable' and 'not acceptable' control of muscle strength during ECT, and the two assessors will be blinded to the dose of neuromuscular blocking agent. The optimal dose was identified for each subject, and results were reported as the average of all lowest doses collected in the study. (NCT01441960)
Timeframe: Up to six weeks following inclusion
| Intervention | mg.kg-1 (Mean) |
|---|---|
| NMBA: Sux | 0.85 |
| NMBA- Rocuronium | 0.41 |
"Logistic regression utilized to measure the amount of propofol to obtain 50% excellent intubation conditions for each age/time group.~The quality of tracheal intubation will be graded according to the Steyn modification of the Helbo-Hansen scoring system for tracheal intubation, which includes evaluation of ease of laryngoscopy, position of the vocal cords, coughing, jaw relaxation and movement of limbs, each evaluated on a 1-4 scale, with 1 being the best possible condition and 4 the worst. The intubation conditions will be classified as either excellent or not-excellent. Excellent will be defined as a total score of 5, a score of 1 for each category, and not-excellent will be a total score of 6-20, meaning a score of >1 in any category. While the outcome measure of each intubation is excellent or not excellent, the overall outcome being generated is the amount of propofol in mg/kg required for 50% excellent intubation score." (NCT01150838)
Timeframe: Amount of time it takes to intubate each patient; approximate time is 15-45 seconds
| Intervention | mg/kg (Mean) |
|---|---|
| Age 1-6 Years, Time 2-4 Minutes of Sevoflurane Until Propofol Administration | 1.48 |
| Age 1-6 Years, Time 4-6 Minutes of Sevoflurane Until Propofol Administration | 0.00 |
| Age 1-6 Years, Time 6-8 Minutes of Sevoflurane Until Propofol Administration | 0.07 |
| Age 6-11 Years, Time 2-4 Minutes of Sevoflurane Until Propofol Administration | 2.35 |
| Age 6-11 Years, Time 4-6 Minutes of Sevoflurane Until Propofol Administration | 2.33 |
Sevoflurane concentration used to perform intubation (For ED50 finding) (NCT02440204)
Timeframe: During the induction of anesthesia
| Intervention | vol% (Mean) |
|---|---|
| Remifentanil 1.0 mcg/kg | 3.00 |
| Remifentanil 1.5 mcg/kg | 2.00 |
| Remifentanil 2.0 mcg/kg | 1.29 |
Sevoflurane concentration used to perform intubation (For ED95 finding) (NCT02440204)
Timeframe: During the induction of anesthesia
| Intervention | vol% (Mean) |
|---|---|
| Remifentanil 1.0 mcg/kg | 3.45 |
| Remifentanil 1.5 mcg/kg | 2.91 |
| Remifentanil 2.0 mcg/kg | 1.89 |
3 reviews available for sevoflurane and Neuromuscular Blockade
| Article | Year |
|---|---|
Anesthetic considerations and airway management in a professional singer: case report and brief review.
Topics: Airway Management; Androstanols; Anesthetics, Inhalation; Anesthetics, Intravenous; Dysphonia; Fenta | 2015 |
A novel approach to reversal of neuromuscular blockade.
Topics: Adolescent; Adult; Androstanols; Child; Cholinesterase Inhibitors; Clinical Trials as Topic; Delayed | 2009 |
Newer drugs in pediatric anesthesia.
Topics: Anesthesiology; Anesthetics; Anesthetics, Inhalation; Child; Desflurane; Humans; Isoflurane; Methyl | 1999 |
49 trials available for sevoflurane and Neuromuscular Blockade
| Article | Year |
|---|---|
Effects of sevoflurane, propofol or alfaxalone on neuromuscular blockade produced by a single intravenous bolus of rocuronium in dogs.
Topics: Androstanols; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Dogs; Female; Male; Methyl | 2022 |
Effect of Sevoflurane on the Deep Neuromuscular Blockade in Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy: A Single Center Prospective Randomized Controlled Study.
Topics: Anesthetics, Inhalation; Gastrectomy; Humans; Hypoxia; Laparoscopy; Methyl Ethers; Neuromuscular Blo | 2023 |
Reversibility of Rocuronium-Induced Deep Neuromuscular Block with Sugammadex in Infants and Children-A Randomized Study.
Topics: Analgesics, Opioid; Anesthesia; Anesthesia Recovery Period; Child; Humans; Infant; Muscle Contractio | 2019 |
Potentiation by sevoflurane of rocuronium-induced neuromuscular block is greater in older than younger adult patients: a randomised controlled trial.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Drug Synergism; Humans; Middle Aged; Neuromuscular Bloc | 2020 |
Deep neuromuscular block does not improve surgical conditions in patients receiving sevoflurane anaesthesia for laparoscopic renal surgery.
Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Inhalation; Double-Blind Method; Female; Humans; Intrao | 2021 |
Is neuromuscular blocker needed in children undergoing inguinal herniorrhaphy?: A prospective, randomized, and controlled trial.
Topics: Androstanols; Anesthetics, Inhalation; Child; Child, Preschool; Female; Hernia, Inguinal; Herniorrha | 2017 |
Reversal of Deep Pipecuronium-Induced Neuromuscular Block With Moderate Versus Standard Dose of Sugammadex: A Randomized, Double-Blind, Noninferiority Trial.
Topics: Adolescent; Adult; Aged; Airway Extubation; Anesthesia Recovery Period; Anesthesia, General; Double- | 2018 |
The effect of preoperative consumption of potatoes on succinylcholine-induced block and recovery from anesthesia.
Topics: Adjuvants, Anesthesia; Adult; Alkaloids; Anesthesia; Anesthesia Recovery Period; Anesthetics, Inhala | 2013 |
Lateral spread response monitoring during microvascular decompression for hemifacial spasm. Comparison of two targets of partial neuromuscular blockade.
Topics: Adult; Aged; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Electric Stimul | 2014 |
Reversal of Pipecuronium-Induced Moderate Neuromuscular Block with Sugammadex in the Presence of a Sevoflurane Anesthetic: A Randomized Trial.
Topics: Adult; Aged; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Inhalation; Antidotes; Do | 2015 |
The Effect of Anesthetic Choice (Sevoflurane Versus Desflurane) and Neuromuscular Management on Speed of Airway Reflex Recovery.
Topics: Accelerometry; Adolescent; Adult; Aged; Ambulatory Surgical Procedures; Androstanols; Anesthesia Rec | 2016 |
Under sevoflurane anaesthesia, a reduced dose of neostigmine can antagonize a shallow neuromuscular block: A double-blind, randomised study.
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Inhalation; Anesthetics, Inhalation; Anesthetics, Intrav | 2016 |
The neuromuscular effects of rocuronium under sevoflurane-remifentanil or propofol-remifentanil anesthesia: a randomized clinical comparative study in an Asian population.
Topics: Adult; Aged; Androstanols; Anesthetics, Combined; Anesthetics, Inhalation; Anesthetics, Intravenous; | 2016 |
Comparative study of neuromuscular blocking and hemodynamic effects of rocuronium and cisatracurium under sevoflurane or total intravenous anesthesia.
Topics: Adult; Androstanols; Anesthesia Recovery Period; Anesthetics, Inhalation; Anesthetics, Intravenous; | 2009 |
Optimal dose of sufentanil in children for intubation after sevoflurane induction without neuromuscular block.
Topics: Analgesics, Opioid; Anesthetics, Inhalation; Blood Pressure; Child; Child, Preschool; Dose-Response | 2009 |
Reversal of neuromuscular blockade by sugammadex after continuous infusion of rocuronium in patients randomized to sevoflurane or propofol maintenance anesthesia.
Topics: Adult; Androstanols; Anesthesia; Anesthesia Recovery Period; Female; gamma-Cyclodextrins; Humans; In | 2009 |
Effect of different anesthetic agents on oculocardiac reflex in pediatric strabismus surgery.
Topics: Androstanols; Anesthesia; Anesthesia, General; Anesthetics; Anesthetics, Dissociative; Anesthetics, | 2009 |
A randomized, dose-response study of sugammadex given for the reversal of deep rocuronium- or vecuronium-induced neuromuscular blockade under sevoflurane anesthesia.
Topics: Adult; Androstanols; Anesthesia, Inhalation; Anesthetics, Inhalation; Dose-Response Relationship, Dr | 2010 |
A randomized, dose-response study of sugammadex given for the reversal of deep rocuronium- or vecuronium-induced neuromuscular blockade under sevoflurane anesthesia.
Topics: Adult; Androstanols; Anesthesia, Inhalation; Anesthetics, Inhalation; Dose-Response Relationship, Dr | 2010 |
A randomized, dose-response study of sugammadex given for the reversal of deep rocuronium- or vecuronium-induced neuromuscular blockade under sevoflurane anesthesia.
Topics: Adult; Androstanols; Anesthesia, Inhalation; Anesthetics, Inhalation; Dose-Response Relationship, Dr | 2010 |
A randomized, dose-response study of sugammadex given for the reversal of deep rocuronium- or vecuronium-induced neuromuscular blockade under sevoflurane anesthesia.
Topics: Adult; Androstanols; Anesthesia, Inhalation; Anesthetics, Inhalation; Dose-Response Relationship, Dr | 2010 |
A randomized, dose-response study of sugammadex given for the reversal of deep rocuronium- or vecuronium-induced neuromuscular blockade under sevoflurane anesthesia.
Topics: Adult; Androstanols; Anesthesia, Inhalation; Anesthetics, Inhalation; Dose-Response Relationship, Dr | 2010 |
A randomized, dose-response study of sugammadex given for the reversal of deep rocuronium- or vecuronium-induced neuromuscular blockade under sevoflurane anesthesia.
Topics: Adult; Androstanols; Anesthesia, Inhalation; Anesthetics, Inhalation; Dose-Response Relationship, Dr | 2010 |
A randomized, dose-response study of sugammadex given for the reversal of deep rocuronium- or vecuronium-induced neuromuscular blockade under sevoflurane anesthesia.
Topics: Adult; Androstanols; Anesthesia, Inhalation; Anesthetics, Inhalation; Dose-Response Relationship, Dr | 2010 |
A randomized, dose-response study of sugammadex given for the reversal of deep rocuronium- or vecuronium-induced neuromuscular blockade under sevoflurane anesthesia.
Topics: Adult; Androstanols; Anesthesia, Inhalation; Anesthetics, Inhalation; Dose-Response Relationship, Dr | 2010 |
A randomized, dose-response study of sugammadex given for the reversal of deep rocuronium- or vecuronium-induced neuromuscular blockade under sevoflurane anesthesia.
Topics: Adult; Androstanols; Anesthesia, Inhalation; Anesthetics, Inhalation; Dose-Response Relationship, Dr | 2010 |
A randomized, dose-response study of sugammadex given for the reversal of deep rocuronium- or vecuronium-induced neuromuscular blockade under sevoflurane anesthesia.
Topics: Adult; Androstanols; Anesthesia, Inhalation; Anesthetics, Inhalation; Dose-Response Relationship, Dr | 2010 |
A randomized, dose-response study of sugammadex given for the reversal of deep rocuronium- or vecuronium-induced neuromuscular blockade under sevoflurane anesthesia.
Topics: Adult; Androstanols; Anesthesia, Inhalation; Anesthetics, Inhalation; Dose-Response Relationship, Dr | 2010 |
A randomized, dose-response study of sugammadex given for the reversal of deep rocuronium- or vecuronium-induced neuromuscular blockade under sevoflurane anesthesia.
Topics: Adult; Androstanols; Anesthesia, Inhalation; Anesthetics, Inhalation; Dose-Response Relationship, Dr | 2010 |
A randomized, dose-response study of sugammadex given for the reversal of deep rocuronium- or vecuronium-induced neuromuscular blockade under sevoflurane anesthesia.
Topics: Adult; Androstanols; Anesthesia, Inhalation; Anesthetics, Inhalation; Dose-Response Relationship, Dr | 2010 |
A randomized, dose-response study of sugammadex given for the reversal of deep rocuronium- or vecuronium-induced neuromuscular blockade under sevoflurane anesthesia.
Topics: Adult; Androstanols; Anesthesia, Inhalation; Anesthetics, Inhalation; Dose-Response Relationship, Dr | 2010 |
A randomized, dose-response study of sugammadex given for the reversal of deep rocuronium- or vecuronium-induced neuromuscular blockade under sevoflurane anesthesia.
Topics: Adult; Androstanols; Anesthesia, Inhalation; Anesthetics, Inhalation; Dose-Response Relationship, Dr | 2010 |
A randomized, dose-response study of sugammadex given for the reversal of deep rocuronium- or vecuronium-induced neuromuscular blockade under sevoflurane anesthesia.
Topics: Adult; Androstanols; Anesthesia, Inhalation; Anesthetics, Inhalation; Dose-Response Relationship, Dr | 2010 |
Reversal of rocuronium-induced neuromuscular blockade with sugammadex compared with neostigmine during sevoflurane anaesthesia: results of a randomised, controlled trial.
Topics: Adult; Aged; Androstanols; Anesthetics, Inhalation; Cholinesterase Inhibitors; Female; gamma-Cyclode | 2010 |
Reversal of rocuronium-induced neuromuscular blockade with sugammadex compared with neostigmine during sevoflurane anaesthesia: results of a randomised, controlled trial.
Topics: Adult; Aged; Androstanols; Anesthetics, Inhalation; Cholinesterase Inhibitors; Female; gamma-Cyclode | 2010 |
Reversal of rocuronium-induced neuromuscular blockade with sugammadex compared with neostigmine during sevoflurane anaesthesia: results of a randomised, controlled trial.
Topics: Adult; Aged; Androstanols; Anesthetics, Inhalation; Cholinesterase Inhibitors; Female; gamma-Cyclode | 2010 |
Reversal of rocuronium-induced neuromuscular blockade with sugammadex compared with neostigmine during sevoflurane anaesthesia: results of a randomised, controlled trial.
Topics: Adult; Aged; Androstanols; Anesthetics, Inhalation; Cholinesterase Inhibitors; Female; gamma-Cyclode | 2010 |
Reversal of rocuronium-induced neuromuscular blockade with sugammadex compared with neostigmine during sevoflurane anaesthesia: results of a randomised, controlled trial.
Topics: Adult; Aged; Androstanols; Anesthetics, Inhalation; Cholinesterase Inhibitors; Female; gamma-Cyclode | 2010 |
Reversal of rocuronium-induced neuromuscular blockade with sugammadex compared with neostigmine during sevoflurane anaesthesia: results of a randomised, controlled trial.
Topics: Adult; Aged; Androstanols; Anesthetics, Inhalation; Cholinesterase Inhibitors; Female; gamma-Cyclode | 2010 |
Reversal of rocuronium-induced neuromuscular blockade with sugammadex compared with neostigmine during sevoflurane anaesthesia: results of a randomised, controlled trial.
Topics: Adult; Aged; Androstanols; Anesthetics, Inhalation; Cholinesterase Inhibitors; Female; gamma-Cyclode | 2010 |
Reversal of rocuronium-induced neuromuscular blockade with sugammadex compared with neostigmine during sevoflurane anaesthesia: results of a randomised, controlled trial.
Topics: Adult; Aged; Androstanols; Anesthetics, Inhalation; Cholinesterase Inhibitors; Female; gamma-Cyclode | 2010 |
Reversal of rocuronium-induced neuromuscular blockade with sugammadex compared with neostigmine during sevoflurane anaesthesia: results of a randomised, controlled trial.
Topics: Adult; Aged; Androstanols; Anesthetics, Inhalation; Cholinesterase Inhibitors; Female; gamma-Cyclode | 2010 |
Reversal of rocuronium-induced neuromuscular blockade with sugammadex compared with neostigmine during sevoflurane anaesthesia: results of a randomised, controlled trial.
Topics: Adult; Aged; Androstanols; Anesthetics, Inhalation; Cholinesterase Inhibitors; Female; gamma-Cyclode | 2010 |
Reversal of rocuronium-induced neuromuscular blockade with sugammadex compared with neostigmine during sevoflurane anaesthesia: results of a randomised, controlled trial.
Topics: Adult; Aged; Androstanols; Anesthetics, Inhalation; Cholinesterase Inhibitors; Female; gamma-Cyclode | 2010 |
Reversal of rocuronium-induced neuromuscular blockade with sugammadex compared with neostigmine during sevoflurane anaesthesia: results of a randomised, controlled trial.
Topics: Adult; Aged; Androstanols; Anesthetics, Inhalation; Cholinesterase Inhibitors; Female; gamma-Cyclode | 2010 |
Reversal of rocuronium-induced neuromuscular blockade with sugammadex compared with neostigmine during sevoflurane anaesthesia: results of a randomised, controlled trial.
Topics: Adult; Aged; Androstanols; Anesthetics, Inhalation; Cholinesterase Inhibitors; Female; gamma-Cyclode | 2010 |
Reversal of rocuronium-induced neuromuscular blockade with sugammadex compared with neostigmine during sevoflurane anaesthesia: results of a randomised, controlled trial.
Topics: Adult; Aged; Androstanols; Anesthetics, Inhalation; Cholinesterase Inhibitors; Female; gamma-Cyclode | 2010 |
Reversal of rocuronium-induced neuromuscular blockade with sugammadex compared with neostigmine during sevoflurane anaesthesia: results of a randomised, controlled trial.
Topics: Adult; Aged; Androstanols; Anesthetics, Inhalation; Cholinesterase Inhibitors; Female; gamma-Cyclode | 2010 |
Reversal of rocuronium-induced neuromuscular blockade with sugammadex compared with neostigmine during sevoflurane anaesthesia: results of a randomised, controlled trial.
Topics: Adult; Aged; Androstanols; Anesthetics, Inhalation; Cholinesterase Inhibitors; Female; gamma-Cyclode | 2010 |
Neuromuscular blockade by vecuronium during induction with 5% sevoflurane or propofol.
Topics: Adult; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Demography; Dose-Response Rela | 2010 |
The effect of ketamine on tracheal intubating conditions without neuromuscular blockade during sevoflurane induction in children.
Topics: Anesthetics, Inhalation; Blood Pressure; Child; Child, Preschool; Female; Heart Rate; Humans; Intuba | 2011 |
Retrospective analysis of spontaneous recovery from neuromuscular blockade produced by empirical use of rocuronium.
Topics: Adult; Aged; Aged, 80 and over; Androstanols; Anesthesia Recovery Period; Anesthesia, General; Femal | 2011 |
Comparison of the effects of fentanyl, remifentanil, and dexmedetomidine on neuromuscular blockade.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-2 Receptor Agonists; Adult; Anesthetics, Inhalation; Anesthe | 2012 |
Optimal rocuronium dose for intubation during inhalation induction with sevoflurane in children.
Topics: Androstanols; Anesthetics, Inhalation; Blood Pressure; Child; Child, Preschool; Drug Administration | 2002 |
The ED(95) of end-tidal sevoflurane concentration for the smooth exchange of the tracheal tube for a laryngeal mask airway is 2.97%.
Topics: Adult; Anesthetics, Inhalation; Dose-Response Relationship, Drug; Humans; Intubation, Intratracheal; | 2003 |
Recovery from neuromuscular block following infusion of cisatracurium using either sevoflurane or propofol for anaesthesia.
Topics: Adolescent; Adult; Aged; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Inhalation; A | 2004 |
Rocuronium duration of action under sevoflurane, desflurane or propofol anaesthesia.
Topics: Abdomen; Adult; Androstanols; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalati | 2004 |
Time course and train-of-four fade of mivacurium block during sevoflurane and intravenous anaesthesia.
Topics: Adult; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inh | 2005 |
Neuromuscular blocking properties of atracurium during sevoflurane or propofol anaesthesia in dogs.
Topics: Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Atracurium; Dogs; D | 2005 |
The comparative effect of single dose mivacurium during sevoflurane or propofol anesthesia in children.
Topics: Anesthetics, Combined; Anesthetics, Inhalation; Child; Child, Preschool; Dose-Response Relationship, | 2005 |
The effects of volatile anesthetics on intraoperative monitoring of myogenic motor-evoked potentials to transcranial electrical stimulation and on partial neuromuscular blockade during propofol/fentanyl/nitrous oxide anesthesia in humans.
Topics: Adult; Aged; Anesthesia, General; Anesthetics, Inhalation; Evoked Potentials, Motor; Female; Fentany | 2006 |
Bispectral index guided timing of intubation without neuromuscular blockade during sevoflurane induction of anaesthesia in adults.
Topics: Adjuvants, Anesthesia; Adolescent; Adult; Anesthesia, General; Anesthetics, Inhalation; Blood Pressu | 2006 |
Remifentanil preventing hemodynamic changes during laparoscopic adrenalectomy for pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adult; Anesthetics, Inhalation; Anesthetics, Intravenous; Bl | 2006 |
Reversal of rocuronium-induced neuromuscular block with the novel drug sugammadex is equally effective under maintenance anesthesia with propofol or sevoflurane.
Topics: Adolescent; Adult; Aged; Androstanols; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, In | 2007 |
The optimal dose of remifentanil for intubation during sevoflurane induction without neuromuscular blockade in children.
Topics: Analgesics, Opioid; Anesthetics, Inhalation; Blood Pressure; Child; Child, Preschool; Dose-Response | 2007 |
The optimal dose of remifentanil for intubation during sevoflurane induction without neuromuscular blockade in children.
Topics: Analgesics, Opioid; Anesthetics, Inhalation; Blood Pressure; Child; Child, Preschool; Dose-Response | 2007 |
The optimal dose of remifentanil for intubation during sevoflurane induction without neuromuscular blockade in children.
Topics: Analgesics, Opioid; Anesthetics, Inhalation; Blood Pressure; Child; Child, Preschool; Dose-Response | 2007 |
The optimal dose of remifentanil for intubation during sevoflurane induction without neuromuscular blockade in children.
Topics: Analgesics, Opioid; Anesthetics, Inhalation; Blood Pressure; Child; Child, Preschool; Dose-Response | 2007 |
The optimal dose of remifentanil for intubation during sevoflurane induction without neuromuscular blockade in children.
Topics: Analgesics, Opioid; Anesthetics, Inhalation; Blood Pressure; Child; Child, Preschool; Dose-Response | 2007 |
The optimal dose of remifentanil for intubation during sevoflurane induction without neuromuscular blockade in children.
Topics: Analgesics, Opioid; Anesthetics, Inhalation; Blood Pressure; Child; Child, Preschool; Dose-Response | 2007 |
The optimal dose of remifentanil for intubation during sevoflurane induction without neuromuscular blockade in children.
Topics: Analgesics, Opioid; Anesthetics, Inhalation; Blood Pressure; Child; Child, Preschool; Dose-Response | 2007 |
The optimal dose of remifentanil for intubation during sevoflurane induction without neuromuscular blockade in children.
Topics: Analgesics, Opioid; Anesthetics, Inhalation; Blood Pressure; Child; Child, Preschool; Dose-Response | 2007 |
The optimal dose of remifentanil for intubation during sevoflurane induction without neuromuscular blockade in children.
Topics: Analgesics, Opioid; Anesthetics, Inhalation; Blood Pressure; Child; Child, Preschool; Dose-Response | 2007 |
The optimal bolus dose of alfentanil for tracheal intubation during sevoflurane induction without neuromuscular blockade in day-case anaesthesia.
Topics: Adolescent; Adult; Alfentanil; Ambulatory Surgical Procedures; Anesthesia, Inhalation; Anesthetics, | 2008 |
Vecuronium-induced neuromuscular block during xenon or sevoflurane anaesthesia in humans.
Topics: Adult; Anesthetics, Inhalation; Drug Interactions; Female; Humans; Male; Methyl Ethers; Middle Aged; | 1998 |
Comparison of acceleromyography and electromyography in vecuronium-induced neuromuscular blockade with xenon or sevoflurane anesthesia.
Topics: Acceleration; Adult; Analysis of Variance; Anesthesia Recovery Period; Anesthesia, Inhalation; Anest | 1998 |
Neuromuscular blocking effects of rocuronium during desflurane, isoflurane, and sevoflurane anaesthesia.
Topics: Adult; Androstanols; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; An | 1998 |
Patient outcomes with positive pressure versus spontaneous ventilation in non-paralysed adults with the laryngeal mask.
Topics: Adult; Anesthesia Recovery Period; Anesthetics, Inhalation; Anesthetics, Intravenous; Carbon Dioxide | 1998 |
Decreased mivacurium requirements and delayed neuromuscular recovery during sevoflurane anesthesia in children and adults.
Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Inhalation; Anesthetics, Intravenous; Child; Child, Pr | 1998 |
Neuromuscular effects of rocuronium during sevoflurane, isoflurane, and intravenous anesthesia.
Topics: Adult; Androstanols; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intravenous; Dru | 1998 |
Post-tetanic burst count and train-of-four during recovery from vecuronium-induced intense neuromuscular block under different types of anaesthesia.
Topics: Adult; Anesthesia Recovery Period; Anesthesia, General; Anesthesia, Inhalation; Anesthetics, Inhalat | 1998 |
Teaching the use of fiberoptic intubation in anesthetized, spontaneously breathing patients.
Topics: Adult; Anesthesia, General; Anesthesia, Intravenous; Anesthesiology; Anesthetics, Inhalation; Female | 1999 |
A comparison of antagonism of rocuronium-induced neuromuscular blockade during sevoflurane and isoflurane anaesthesia.
Topics: Adult; Androstanols; Anesthesia Recovery Period; Anesthetics, Inhalation; Female; Humans; Isoflurane | 2000 |
Prolonged duration of neuromuscular block with rapacuronium in the presence of sevoflurane.
Topics: Anesthesia, General; Anesthetics, Inhalation; Child; Child, Preschool; Drug Interactions; Humans; Me | 2000 |
High concentration sevoflurane induction of anesthesia accelerates onset of vecuronium neuromuscular blockade.
Topics: Adjuvants, Anesthesia; Adult; Anesthesia, General; Anesthetics, Inhalation; Electric Stimulation; Fe | 2001 |
[The effect of anesthetic technique on recovery from neuromuscular blockade with cisatracurium].
Topics: Adult; Aged; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Atracurium | 2001 |
[Sevoflurane augments the degree and speeds the onset of rocuronium evoked neuromuscular blockade in children].
Topics: Androstanols; Anesthetics, Inhalation; Child; Child, Preschool; Dose-Response Relationship, Drug; Dr | 2001 |
31 other studies available for sevoflurane and Neuromuscular Blockade
| Article | Year |
|---|---|
Characterizing the Heart Rate Effects From Administration of Sugammadex to Reverse Neuromuscular Blockade: An Observational Study in Patients.
Topics: Adjuvants, Anesthesia; Androstanols; Anesthetics; gamma-Cyclodextrins; Heart Rate; Humans; Neuromusc | 2022 |
Changes in bispectral index and patient state index during sugammadex reversal of neuromuscular blockade under steady-state sevoflurane anesthesia.
Topics: Adult; Anesthesia; Female; Humans; Male; Middle Aged; Neuromuscular Blockade; Sevoflurane; Sugammade | 2023 |
MRI measurement of the effects of moderate and deep neuromuscular blockade on the abdominal working space during laparoscopic surgery, a clinical study.
Topics: Abdomen; Humans; Laparoscopy; Neuromuscular Blockade; Pneumoperitoneum; Sevoflurane | 2023 |
Incidence of residual neuromuscular blockade in children below 3 years after a single bolus of cisatracurium 0.1 mg/kg: A quality assurance study.
Topics: Atracurium; Child, Preschool; Cleft Lip; Cleft Palate; Female; Humans; Infant; Male; Neuromuscular B | 2020 |
Effects of Neuromuscular Blockages on Entropy Monitoring During Sevoflurane Anesthesia.
Topics: Adult; Anesthesia, Inhalation; Anesthesiology; China; Electric Stimulation; Entropy; Female; Humans; | 2019 |
Effects of sevoflurane and adenosine receptor antagonist on the sugammadex-induced recovery from rocuronium-induced neuromuscular blockade in rodent phrenic nerve-hemidiaphragm tissue specimens.
Topics: 2-Chloroadenosine; Adenosine A1 Receptor Agonists; Animals; Cyclohexanes; Diaphragm; Heterocyclic Co | 2021 |
A preferential delivery method to investigate direct neuromuscular blockade effect of inhaled anesthetics on skeletal muscle.
Topics: Anesthetics, Inhalation; Dose-Response Relationship, Drug; Humans; Methyl Ethers; Models, Theoretica | 2017 |
Anesthetic management of small bowel obstruction in a pediatric patient with heterotaxy syndrome and Fontan physiology.
Topics: Anesthesia, Epidural; Anesthesia, Inhalation; Child, Preschool; Contrast Media; Digestive System Abn | 2019 |
[43-year-old female with laparoscopic hysterectomy : Preparation for the medical specialist examination: Part 8].
Topics: Adult; Anesthesia, General; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics; Female; Hu | 2019 |
A temporary decrease in twitch response following reversal of rocuronium-induced neuromuscular block with a small dose of sugammadex in a pediatric patient.
Topics: Androstanols; Anesthesia Recovery Period; Anesthetics, Inhalation; Elective Surgical Procedures; Fem | 2014 |
Distal tracheoesophageal fistula in pediatric patient - an anesthetic challenge.
Topics: Accidental Falls; Adjuvants, Anesthesia; Airway Management; Androstanols; Anesthesia, Inhalation; An | 2014 |
Effects of preoperatively administered carbamazepine and phenytoin on rocuronium-induced neuromuscular block under sevoflurane anesthesia: a retrospective clinical study.
Topics: Adult; Aged; Androstanols; Anesthesia; Anesthesia Recovery Period; Anticonvulsants; Carbamazepine; F | 2014 |
Inadvertent Endobronchial Intubation in a Patient With a Short Neck Length.
Topics: Anesthetics, Intravenous; Bronchi; Cholecystectomy, Laparoscopic; Fentanyl; Humans; Hypercapnia; Int | 2015 |
Multiple anesthetics for a patient with stiff-person syndrome.
Topics: Androstanols; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Female; Fentan | 2016 |
Inappropriately low bispectral index of the elderly during emergence from sevoflurane anesthesia.
Topics: Age Factors; Aged, 80 and over; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inh | 2016 |
Intraoperative mandibular nerve block with peripheral nerve stimulator for temporomandibular joint ankylosis.
Topics: Androstanols; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Anesthetics, L | 2016 |
Anesthesia for a child with Menkes disease.
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Fever; Gastrostomy; Humans; Infant; Male; Menkes Ki | 2008 |
Vecuronium requirement during liver transplantation under sevoflurane anesthesia.
Topics: Aged; Analysis of Variance; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; | 2010 |
A case where rocuronium was unable to achieve neuromuscular block immediately after sugammadex administration.
Topics: Aged; Analgesics, Opioid; Androstanols; Anesthetics, Inhalation; Female; gamma-Cyclodextrins; Humans | 2011 |
Bispectral index monitoring (BIS) as a guide for intubation without neuromuscular blockade in office-based pediatric general anesthesia: a retrospective evaluation.
Topics: Administration, Oral; Adolescent; Ambulatory Care; Anesthesia, Dental; Anesthesia, General; Anesthet | 2011 |
Optimum bolus dose of propofol for tracheal intubation during sevoflurane induction without neuromuscular blockade in children.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Blood Pressure; Child; Child, Preschool; Dose-Res | 2011 |
Synergistic effect of sevoflurane and isoflurane on inhibition of the adult-type muscle nicotinic acetylcholine receptor by rocuronium.
Topics: Acetylcholine; Androstanols; Anesthetics, Inhalation; Cell Line; Drug Synergism; HEK293 Cells; Human | 2013 |
Comparison of the effects of neuroleptanesthesia and enflurane or sevoflurane anesthesia on neuromuscular blockade by rocuronium.
Topics: Androstanols; Anesthesia, Inhalation; Anesthetics, Inhalation; Drug Synergism; Enflurane; Female; Hu | 2003 |
The effect of insufflation pressure on pulmonary mechanics in infants during laparoscopic surgical procedures.
Topics: Anesthesia, General; Anesthetics, Inhalation; Humans; Infant; Infant, Newborn; Insufflation; Laparos | 2003 |
Delayed recovery of vecuronium neuromuscular block in diabetic patients during sevoflurane anesthesia.
Topics: Adult; Aged; Anesthesia, Intravenous; Anesthetics, Inhalation; Diabetes Mellitus; Female; Humans; Ma | 2005 |
Acute desflurane or sevoflurane exposure on a previously stabilized atracurium-induced neuromuscular block.
Topics: Adult; Anesthetics, Inhalation; Atracurium; Calibration; Desflurane; Female; Humans; Isoflurane; Mal | 2006 |
[Effects of halothane and sevoflurane on reversal of neuromuscular blockade induced by vecuronium in man].
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthetics, Inhalation; Drug Residues; Ethers; Female; Halotha | 1997 |
Sevoflurane for predicted difficult tracheal intubation.
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Inhalation; Anesthetics, Inhalation; Female; Forecasting | 1998 |
Potency and time course of mivacurium block during sevoflurane, isoflurane and intravenous anesthesia.
Topics: Adolescent; Adult; Anesthesia Recovery Period; Anesthesia, Intravenous; Anesthetics, Inhalation; Ane | 1999 |
Sevoflurane for dental extraction in children with Tetralogy of Fallot.
Topics: Anesthesia Recovery Period; Anesthesia, Dental; Anesthesia, Inhalation; Anesthetics, Inhalation; Atr | 1999 |
Intraarterial atracurium followed by difficult intubation in a child with congenital muscular dystrophy.
Topics: Anesthetics, Inhalation; Atracurium; Brachial Artery; Female; Hip Dislocation, Congenital; Humans; I | 1999 |