sevoflurane and Muscle Relaxation studies

Sevoflurane: A non-explosive inhalation anesthetic used in the induction and maintenance of general anesthesia. It does not cause respiratory irritation and may also prevent PLATELET AGGREGATION.
sevoflurane : An ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups.

Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.

Research Excerpts

Excerpt	Relevance	Reference
"In adults, sevoflurane augments the intensity of rocuronium evoked neuromuscular blockade."	9.09	[Sevoflurane augments the degree and speeds the onset of rocuronium evoked neuromuscular blockade in children]. ( Eikermann, M; Peters, J; Renzing-Köhler, K, 2001)
" Furthermore, we found evidence that primarily the spinal cord mediated the skeletal muscle relaxation action of sevoflurane."	7.85	Spinal Cord is the Primary Site of Action for Skeletal Muscle Relaxation by Sevoflurane. ( Yang, P; Ye, L; Zhang, P; Zhu, T, 2017)
"The purpose of this study was to determine the optimum bolus dose of propofol required to provide excellent conditions for tracheal intubation following inhalational induction of anaesthesia using 5% sevoflurane without neuromuscular blockade."	7.77	Optimum bolus dose of propofol for tracheal intubation during sevoflurane induction without neuromuscular blockade in children. ( Hong, JY; Jeong, SM; Kim, SH; Park, PH; Suk, EH, 2011)
"Both sevoflurane and propofol at low dosages combined with remifentanil under comparable BIS values and partial muscle relaxation can be used when monitoring of TceMEPs and SSEPs is required for brainstem surgery."	5.20	Comparison of the Effects of Propofol and Sevoflurane Combined With Remifentanil on Transcranial Electric Motor-evoked and Somatosensory-evoked Potential Monitoring During Brainstem Surgery. ( Doménech-Asensi, P; Falcón-Araña, L; Fuentes-García, D; Hernández-Palazón, J; Izura, V; Piqueras-Pérez, C, 2015)
"Neuromuscular block times, quality of muscle relaxation for tracheal tube insertion, and the haemodynamic effects after cisatracurium and vecuronium under sevoflurane-remifentanil anaesthesia were compared in elderly patients."	5.11	Assessment of neuromuscular and haemodynamic effects of cisatracurium and vecuronium under sevoflurane-remifentanil anaesthesia in elderly patients. ( Cavuş, Z; Keleş, GT; Sakarya, M; Yentür, A, 2004)
"In adults, sevoflurane augments the intensity of rocuronium evoked neuromuscular blockade."	5.09	[Sevoflurane augments the degree and speeds the onset of rocuronium evoked neuromuscular blockade in children]. ( Eikermann, M; Peters, J; Renzing-Köhler, K, 2001)
"The purpose of this study was to determine the optimum bolus dose of propofol required to provide excellent conditions for tracheal intubation following inhalational induction of anaesthesia using 5% sevoflurane without neuromuscular blockade."	3.77	Optimum bolus dose of propofol for tracheal intubation during sevoflurane induction without neuromuscular blockade in children. ( Hong, JY; Jeong, SM; Kim, SH; Park, PH; Suk, EH, 2011)
"Mivacurium was administered in increments of 25 micrograms kg-1 until a depression of T1 > 95% was reached."	2.69	[Augmentation of the neuromuscular blocking effect of mivacurium during inhalation anesthesia with desflurane, sevoflorane and isoflurane in comparison with total intravenous anesthesia]. ( Hauschild, S; Ledowski, T; Proppe, D; Wulf, H, 1998)
"Sevoflurane responses were repeated at concentrations with no effect on spontaneous contractility of TEA, a Ca(2+)-activated K(+) channel blocker, and glibenclamide, an adenosine triphosphate-sensitive K(+) channel blocker, in myometrial strips."	1.31	The role of K(+) channels on the inhibitor effect of sevoflurane in pregnant rat myometrium. ( Bagcivan, I; Gürsoy, S; Kafali, H; Karadas, B; Kaya, T; Sarioglu, Y, 2002)

Research

Studies (22)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Number of Participants Experiencing Side Effects (Nausea, Dizziness)

Number of Participants Needing Intervention to Treat Blood Loss (a Composite of Use of Uterotonics, Re-aspiration, and Bimanual Massage)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	8 (36.36)	18.2507
2000's	10 (45.45)	29.6817
2010's	4 (18.18)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Zhang, P	1
Yang, P	1
Ye, L	1
Zhu, T	1
Hernández-Palazón, J	1
Izura, V	1
Fuentes-García, D	1
Piqueras-Pérez, C	1
Doménech-Asensi, P	1
Falcón-Araña, L	1
Sakai, Y	1
Tsutsumi, YM	1
Wakamatsu, N	1
Soga, T	1
Tanaka, K	1
Oshita, S	1
Kim, SH	1
Hong, JY	1
Suk, EH	1
Jeong, SM	1
Park, PH	1
Turner, RJ	1
Lambrost, M	1
Holmes, C	1
Katz, SG	1
Downs, CS	1
Collins, DW	1
Gatt, SP	1
Thorlacius, K	1
Bodelsson, M	1
Yu, J	1
Ogawa, K	1
Tokinaga, Y	1
Iwahashi, S	1
Hatano, Y	2
Keleş, GT	1
Yentür, A	1
Cavuş, Z	1
Sakarya, M	1
Nagahama, S	1
Nishimura, R	1
Mochizuki, M	1
Sasaki, N	1
Woloszczuk-Gebicka, B	1
Wyska, E	1
Grabowski, T	1
Ohashi, Y	1
Sumikura, H	1
Tateda, T	1
Yamaguchi, A	1
Okabe, E	2
Akata, T	1
Nakashima, M	1
Kodama, K	1
Boyle, WA	1
Takahashi, S	1
Nakamura, K	1
Toda, H	1
Mori, K	1
Young, CJ	1
Apfelbaum, JL	1
Wulf, H	1
Hauschild, S	1
Proppe, D	1
Ledowski, T	1
Xu, J	1
Cheng, Q	1
Niu, X	1
Wiklund, CU	1
Lim, S	1
Lindsten, U	1
Lindahl, SG	1
Eikermann, M	1
Renzing-Köhler, K	1
Peters, J	1
Kafali, H	1
Kaya, T	1
Gürsoy, S	1
Bagcivan, I	1
Karadas, B	1
Sarioglu, Y	1
Arriero, MM	1
Muñoz Alameda, L	1
López-Farré, A	1
Escribano Burgos, M	1
Carrasco, C	1
Millás, I	1
Celdrán, A	1
de la Pinta, JC	1
Yoshida, K	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Sevoflurane as an Anesthetic During Dilation and Evacuation Procedures: Does it Increase Blood Loss and Interventions for Blood Loss and Why Do Anesthesiologists Choose to Use It?[NCT01048658]	Phase 4	160 participants (Actual)	Interventional	2009-09-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	Participants (Count of Participants)
Sevoflurane	13
No Sevoflurane	11

Provider report for need to intervene due to blood loss (yes/no) (NCT01048658)
Timeframe: At time of uterine evacuation and immediately post-operatively, an average of 7.1 minutes

Number of Participants With Estimated Blood Loss Greater Than 300 mL (Yes/no)

Intervention	Participants (Count of Participants)
Sevoflurane	20
No Sevoflurane	13

Procedural blood loss greater than 300 mL. Blood loss was measured in a standardized fashion (amniotic fluid was discarded, blood was separated from tissue, and all gauze surgical drapes weighed). (NCT01048658)
Timeframe: At time of uterine evacuation, an average of 7.1 minutes

Procedure Time: T-test (Time of Speculum Placement to Time Speculum Removed)

Intervention	Participants (Count of Participants)
Sevoflurane	12
No Sevoflurane	6

Length of procedure from time of speculum placement to time of speculum removal, in minutes. (NCT01048658)
Timeframe: Time of speculum place to time of speculum removal, an average of 7.1 minutes

Patient and Provider Satisfaction With Anesthesia

Intervention	minutes (Mean)
Sevoflurane	7.0
No Sevoflurane	7.3

Scores reported on 10-cm Visual Analog Scale (VAS anchors: 0= not satisfied at all, 10= completely satisfied) . Reported as mean +/- standard deviation. Subjects and providers were blinded to anesthesia method. Subjects and providers completed post-operative questionnaire within 30 minutes of procedure completion. (NCT01048658)
Timeframe: Post-procedure, within 30 minutes

Article	Year
Comparison of the Effects of Propofol and Sevoflurane Combined With Remifentanil on Transcranial Electric Motor-evoked and Somatosensory-evoked Potential Monitoring During Brainstem Surgery. Journal of neurosurgical anesthesiology, 2015, Volume: 27, Issue:4 Topics: Adolescent; Adult; Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Brain Stem; Consciousnes	2015
Assessment of neuromuscular and haemodynamic effects of cisatracurium and vecuronium under sevoflurane-remifentanil anaesthesia in elderly patients. European journal of anaesthesiology, 2004, Volume: 21, Issue:11 Topics: Aged; Anesthesia Recovery Period; Anesthetics, Inhalation; Anesthetics, Intravenous; Atracurium; Blo	2004
The effects of propofol, isoflurane and sevoflurane on vecuronium infusion rates for surgical muscle relaxation in dogs. Veterinary anaesthesia and analgesia, 2006, Volume: 33, Issue:3 Topics: Anesthesia, General; Anesthetics, Combined; Anesthetics, Intravenous; Animals; Cross-Over Studies; D	2006
[Augmentation of the neuromuscular blocking effect of mivacurium during inhalation anesthesia with desflurane, sevoflorane and isoflurane in comparison with total intravenous anesthesia]. Anaesthesiologie und Reanimation, 1998, Volume: 23, Issue:4 Topics: Adolescent; Adult; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation; Desflur	1998
[Sevoflurane augments the degree and speeds the onset of rocuronium evoked neuromuscular blockade in children]. Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 2001, Volume: 36, Issue:12 Topics: Androstanols; Anesthetics, Inhalation; Child; Child, Preschool; Dose-Response Relationship, Drug; Dr	2001

Article	Year
Spinal Cord is the Primary Site of Action for Skeletal Muscle Relaxation by Sevoflurane. Spine, 2017, Nov-15, Volume: 42, Issue:22 Topics: Anesthetics, Inhalation; Animals; Brain; Male; Muscle Relaxation; Muscle, Skeletal; Organ Culture Te	2017
A case where rocuronium was unable to achieve neuromuscular block immediately after sugammadex administration. The journal of medical investigation : JMI, 2011, Volume: 58, Issue:1-2 Topics: Aged; Analgesics, Opioid; Androstanols; Anesthetics, Inhalation; Female; gamma-Cyclodextrins; Humans	2011
Optimum bolus dose of propofol for tracheal intubation during sevoflurane induction without neuromuscular blockade in children. Anaesthesia and intensive care, 2011, Volume: 39, Issue:5 Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Blood Pressure; Child; Child, Preschool; Dose-Res	2011
The effects of sevoflurane on isolated gravid human myometrium. Anaesthesia and intensive care, 2002, Volume: 30, Issue:5 Topics: Analysis of Variance; Anesthesia, Obstetrical; Culture Techniques; Dose-Response Relationship, Drug;	2002
Sevoflurane promotes endothelium-dependent smooth muscle relaxation in isolated human omental arteries and veins. Anesthesia and analgesia, 2004, Volume: 99, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Inhalation; Arteries; Cyclic GMP; Endothelium, Vascular	2004
The vascular relaxing effects of sevoflurane and isoflurane are more important in hypertensive than in normotensive rats. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2004, Volume: 51, Issue:10 Topics: Anesthetics, Inhalation; Angiotensin II; Animals; Aorta; Dose-Response Relationship, Drug; Endotheli	2004
Sevoflurane increases fade of neuromuscular response to TOF stimulation following rocuronium administration in children. A PK/PD analysis. Paediatric anaesthesia, 2007, Volume: 17, Issue:7 Topics: Androstanols; Anesthetics, Inhalation; Anesthetics, Intravenous; Blood Pressure; Body Temperature; C	2007
Inhibitory effect of alprostadil against sevoflurane-induced myometrial relaxation in rats. Journal of anesthesia, 2007, Volume: 21, Issue:3 Topics: Alprostadil; Anesthetics, Inhalation; Animals; Area Under Curve; Dose-Response Relationship, Drug; F	2007
Effect of sevoflurane on the vascular reactivity of rabbit mesenteric artery. British journal of anaesthesia, 1995, Volume: 74, Issue:5 Topics: Acetylcholine; Anesthetics; Animals; Dose-Response Relationship, Drug; Drug Synergism; Ethers; In Vi	1995
Effects of volatile anesthetics on acetylcholine-induced relaxation in the rabbit mesenteric resistance artery. Anesthesiology, 1995, Volume: 82, Issue:1 Topics: Acetylcholine; Anesthetics, Inhalation; Animals; Electrophysiology; Enflurane; Ethers; Isoflurane; M	1995
Comparison of the direct effects of sevoflurane, isoflurane and halothane on isolated canine coronary arteries. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1993, Volume: 40, Issue:3 Topics: Anesthetics; Animals; Coronary Vessels; Dogs; Dose-Response Relationship, Drug; Ethers; Halothane; I	1993
[Effects of sevoflurane on contractility of isolated thoracic aorta rings in rabbits]. Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University, 1997, Volume: 22, Issue:4 Topics: Anesthetics, Inhalation; Animals; Aorta, Thoracic; In Vitro Techniques; Methyl Ethers; Muscle Relaxa	1997
Relaxation by sevoflurane, desflurane and halothane in the isolated guinea-pig trachea via inhibition of cholinergic neurotransmission. British journal of anaesthesia, 1999, Volume: 83, Issue:3 Topics: Acetylcholine; Anesthetics, Inhalation; Animals; Cholinergic Fibers; Culture Techniques; Desflurane;	1999
The role of K(+) channels on the inhibitor effect of sevoflurane in pregnant rat myometrium. Anesthesia and analgesia, 2002, Volume: 94, Issue:1 Topics: Adenosine Triphosphate; Anesthetics, Inhalation; Animals; Dose-Response Relationship, Drug; Female;	2002
Sevoflurane reduces endothelium-dependent vasorelaxation: role of superoxide anion and endothelin. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2002, Volume: 49, Issue:5 Topics: Anesthetics, Inhalation; Animals; Aorta, Thoracic; Endothelins; Endothelium, Vascular; In Vitro Tech	2002
Selective impairment of endothelium-dependent relaxation by sevoflurane: oxygen free radicals participation. Anesthesiology, 1992, Volume: 76, Issue:3 Topics: Anesthetics; Animals; Dogs; Endothelium, Vascular; Ethers; Female; Free Radicals; In Vitro Technique	1992

sevoflurane and Muscle Relaxation