sevoflurane has been researched along with Learning Disabilities in 12 studies
Sevoflurane: A non-explosive inhalation anesthetic used in the induction and maintenance of general anesthesia. It does not cause respiratory irritation and may also prevent PLATELET AGGREGATION.
sevoflurane : An ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups.
Learning Disabilities: Conditions characterized by a significant discrepancy between an individual's perceived level of intellect and their ability to acquire new language and other cognitive skills. These may result from organic or psychological conditions. Relatively common subtypes include DYSLEXIA, DYSCALCULIA, and DYSGRAPHIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Therefore, the authors set out to assess the effects of sevoflurane, the most commonly used inhalation anesthetic, on caspase activation, apoptosis, beta-amyloid protein levels, and neuroinflammation in the brain tissues of neonatal naïve and Alzheimer disease (AD) transgenic mice." | 7.76 | Anesthetic sevoflurane causes neurotoxicity differently in neonatal naïve and Alzheimer disease transgenic mice. ( Dong, Y; Lu, Y; Wu, X; Xie, Z; Xu, Z; Zhang, Y, 2010) |
| "Sevoflurane has been shown to stimulate or depress memory in adult rats; however, the cellular mechanism of this bidirectional effect has not been fully investigated." | 5.48 | Different doses of sevoflurane facilitate and impair learning and memory function through activation of the ERK pathway and synthesis of ARC protein in the rat hippocampus. ( Luo, Y; Xue, QS; Yu, BW; Zhang, FJ; Zhu, QL, 2018) |
| " Therefore, the authors set out to assess the effects of sevoflurane, the most commonly used inhalation anesthetic, on caspase activation, apoptosis, beta-amyloid protein levels, and neuroinflammation in the brain tissues of neonatal naïve and Alzheimer disease (AD) transgenic mice." | 3.76 | Anesthetic sevoflurane causes neurotoxicity differently in neonatal naïve and Alzheimer disease transgenic mice. ( Dong, Y; Lu, Y; Wu, X; Xie, Z; Xu, Z; Zhang, Y, 2010) |
| " The authors investigated whether exposure of neonatal mice to inhaled sevoflurane causes deficits in social behavior as well as learning disabilities." | 3.75 | Neonatal exposure to sevoflurane induces abnormal social behaviors and deficits in fear conditioning in mice. ( Imaki, J; Ito, M; Miyao, H; Satoh, Y; Satomoto, M; Takishima, K; Terui, K, 2009) |
| "Sevoflurane has been shown to stimulate or depress memory in adult rats; however, the cellular mechanism of this bidirectional effect has not been fully investigated." | 1.48 | Different doses of sevoflurane facilitate and impair learning and memory function through activation of the ERK pathway and synthesis of ARC protein in the rat hippocampus. ( Luo, Y; Xue, QS; Yu, BW; Zhang, FJ; Zhu, QL, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 10 (83.33) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, Z | 1 |
| Zhang, Y | 4 |
| Zhao, P | 2 |
| Shi, Y | 1 |
| Wang, G | 1 |
| Li, J | 1 |
| Yu, W | 1 |
| Zhu, QL | 1 |
| Luo, Y | 1 |
| Xue, QS | 1 |
| Zhang, FJ | 1 |
| Yu, BW | 1 |
| Guo, S | 1 |
| Liu, L | 1 |
| Wang, C | 1 |
| Jiang, Q | 1 |
| Dong, Y | 2 |
| Tian, Y | 1 |
| Wang, Y | 1 |
| Yin, S | 1 |
| Xue, H | 1 |
| Yang, Y | 1 |
| Zhang, N | 1 |
| Wang, WY | 2 |
| Yang, R | 1 |
| Hu, SF | 2 |
| Wang, H | 1 |
| Ma, ZW | 1 |
| Lu, Y | 2 |
| Wu, XM | 1 |
| Jia, LJ | 1 |
| Zhang, HH | 1 |
| Cai, F | 1 |
| Mao, H | 1 |
| Xu, WC | 1 |
| Chen, L | 1 |
| Zhang, J | 1 |
| Satomoto, M | 2 |
| Sun, Z | 1 |
| Adachi, YU | 1 |
| Makita, K | 1 |
| Hu, X | 1 |
| Wang, J | 1 |
| Zhang, Q | 1 |
| Duan, X | 1 |
| Chen, Z | 1 |
| Satoh, Y | 1 |
| Terui, K | 1 |
| Miyao, H | 1 |
| Takishima, K | 1 |
| Ito, M | 1 |
| Imaki, J | 1 |
| Wu, X | 1 |
| Xu, Z | 1 |
| Xie, Z | 1 |
| Hazarika, T | 1 |
| O'Donohoe, B | 1 |
| Turtle, M | 1 |
| Milne, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Sevoflurane on the Success of External Cephalic Version for Breech Presentation[NCT04346823] | Phase 4 | 40 participants (Anticipated) | Interventional | 2020-05-25 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
12 other studies available for sevoflurane and Learning Disabilities
| Article | Year |
|---|---|
Sirtuin 2 Inhibition Attenuates Sevoflurane-Induced Learning and Memory Deficits in Developing Rats via Modulating Microglial Activation.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Benzamides; Cognitive Dysfunction; Growth and De | 2020 |
Hydrogen gas attenuates sevoflurane neurotoxicity through inhibiting nuclear factor κ-light-chain-enhancer of activated B cells signaling and proinflammatory cytokine release in neonatal rats.
Topics: Active Transport, Cell Nucleus; Anesthetics, Inhalation; Animals; Animals, Newborn; B-Lymphocytes; C | 2017 |
Different doses of sevoflurane facilitate and impair learning and memory function through activation of the ERK pathway and synthesis of ARC protein in the rat hippocampus.
Topics: AIDS-Related Complex; Anesthetics, Inhalation; Animals; Butadienes; Disease Models, Animal; Dose-Res | 2018 |
Repeated exposure to sevoflurane impairs the learning and memory of older male rats.
Topics: Aging; Anesthetics, Inhalation; Animals; Apoptosis; Brain Chemistry; Brain-Derived Neurotrophic Fact | 2018 |
Mid-gestational sevoflurane exposure inhibits fetal neural stem cell proliferation and impairs postnatal learning and memory function in a dose-dependent manner.
Topics: Anesthetics, Inhalation; Animals; Cell Division; Cyclin D1; Dose-Response Relationship, Drug; Female | 2018 |
N-stearoyl-L-tyrosine ameliorates sevoflurane induced neuroapoptosis via MEK/ERK1/2 MAPK signaling pathway in the developing brain.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Brain; Cell Survival; Cells, Cultured; Embryo, Nonmamma | 2013 |
Beta-arrestin1 and 2 differently modulate metabotropic glutamate receptor 7 signaling in rat developmental sevoflurane-induced neuronal apoptosis.
Topics: Animals; Apoptosis; Arrestins; Benzhydryl Compounds; beta-Arrestin 1; beta-Arrestin 2; beta-Arrestin | 2016 |
Neonatal Sevoflurane Exposure Induces Adulthood Fear-induced Learning Disability and Decreases Glutamatergic Neurons in the Basolateral Amygdala.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Basolateral Nuclear Complex; Blood Gas Analysis; | 2018 |
Postconditioning with sevoflurane ameliorates spatial learning and memory deficit after hemorrhage shock and resuscitation in rats.
Topics: Animals; Biomarkers; Choline O-Acetyltransferase; Cholinergic Neurons; Hippocampus; Ischemic Postcon | 2016 |
Neonatal exposure to sevoflurane induces abnormal social behaviors and deficits in fear conditioning in mice.
Topics: Animals; Animals, Newborn; Conditioning, Psychological; Fear; Learning Disabilities; Male; Memory Di | 2009 |
Anesthetic sevoflurane causes neurotoxicity differently in neonatal naïve and Alzheimer disease transgenic mice.
Topics: Alzheimer Disease; Anesthetics, Inhalation; Animals; Animals, Newborn; Apoptosis; Brain; Caspase 3; | 2010 |
Sevoflurane, weaning and learning difficulty in the intensive care unit.
Topics: Adult; Anesthetics, Inhalation; Critical Care; Encephalitis; Epilepsy; Humans; Learning Disabilities | 2010 |