sevoflurane has been researched along with Kidney Diseases in 45 studies
Sevoflurane: A non-explosive inhalation anesthetic used in the induction and maintenance of general anesthesia. It does not cause respiratory irritation and may also prevent PLATELET AGGREGATION.
sevoflurane : An ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups.
Kidney Diseases: Pathological processes of the KIDNEY or its component tissues.
Excerpt | Relevance | Reference |
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"To investigate the influence of intravenous nonselective cyclooxygenase inhibitor, ketoprofen (keto), on kidney histological changes and kidney cytokines, tumor necrosis factor-α (TNF-α) and interleukin-1 (IL-1), levels after hemorrhage of 30% of volemia (three times 10%, intervals of 10 min) in rats." | 7.78 | Renal histology and immunohistochemistry after acute hemorrhage in rats under sevoflurane and ketoprofen effect. ( Amorim, RL; Castiglia, YM; Cruz, DS; Guedes, FS; Rodrigues, MM; Silva, LM; Vianna, PT, 2012) |
"Low-flow sevoflurane anesthesia was associated with mild and transient proteinuria." | 5.08 | Effects of sevoflurane and isoflurane on renal function and on possible markers of nephrotoxicity. ( Higuchi, H; Ikemoto, T; Kanno, M; Nakai, T; Satoh, T; Sumita, S; Ura, T; Wada, H, 1998) |
"To investigate the influence of intravenous nonselective cyclooxygenase inhibitor, ketoprofen (keto), on kidney histological changes and kidney cytokines, tumor necrosis factor-α (TNF-α) and interleukin-1 (IL-1), levels after hemorrhage of 30% of volemia (three times 10%, intervals of 10 min) in rats." | 3.78 | Renal histology and immunohistochemistry after acute hemorrhage in rats under sevoflurane and ketoprofen effect. ( Amorim, RL; Castiglia, YM; Cruz, DS; Guedes, FS; Rodrigues, MM; Silva, LM; Vianna, PT, 2012) |
" However, no consensus has been reached whether sevoflurane could have adverse effects on renal function in cirrhotic patients." | 2.78 | Sevoflurane has no adverse effects on renal function in cirrhotic patients: a comparison with propofol. ( Lu, ZJ; Song, JC; Sun, YM; Wu, QC; Yang, LQ; Yu, WF; Zhang, MZ, 2013) |
"Ketorolac, which may cause renal vasoconstriction by cyclooxygenase inhibition, is often administered to patients anesthetized with sevoflurane that is metabolized to inorganic fluoride (F(-)), another potential nephrotoxin." | 2.70 | Ketorolac is not nephrotoxic in connection with sevoflurane anesthesia in patients undergoing breast surgery. ( Eriksson, H; Koivusalo, AM; Laisalmi, M; Lindgren, L; Pere, P; Rosenberg, P, 2001) |
" Until recently, inorganic fluoride has been thought to be the aetiological agent responsible for fluorinated anaesthetic nephrotoxicity, with a toxic concentration threshold of 50 micromol/L in serum." | 2.41 | Renal toxicity with sevoflurane: a storm in a teacup? ( Gentz, BA; Malan, TP, 2001) |
"Sevoflurane is a comparatively recent addition to the range of inhalational anaesthetics which has been recently released for clinical use." | 2.40 | Clinical pharmacokinetics of sevoflurane. ( Behne, M; Harder, S; Wilke, HJ, 1999) |
"Sevoflurane does not suppress compound A nephrotoxicity in rats in vivo." | 1.33 | Influence of sevoflurane on the metabolism and renal effects of compound A in rats. ( Kharasch, ED; Liggitt, HD; Schroeder, JL; Sheffels, P, 2005) |
" FDVE-mercapturic acid sulfoxides were more toxic than other FDVE conjugates to renal proximal tubular cells in culture." | 1.32 | Role of cytochrome P4503A in cysteine S-conjugates sulfoxidation and the nephrotoxicity of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in rats. ( Altuntas, TG; Kharasch, ED; Liggitt, HD; Schroeder, JL; Sheffels, P, 2004) |
"Carbon dioxide absorbents degrade both halothane and sevoflurane to toxic unsaturated compounds (CF2=CBrCl and CH2F-O-C[=CF2][CF3] [i." | 1.30 | Quantitative differences in the production and toxicity of CF2=BrCl versus CH2F-O-C(=CF2)(CF3) (compound A): the safety of halothane does not indicate the safety of sevoflurane. ( Eger, EI; Gong, D; Ionescu, P; Kerschmann, RL; Laster, MJ; Weiskopf, RB, 1997) |
"Methoxyflurane nephrotoxicity is mediated by cytochrome P450-catalyzed metabolism to toxic metabolites." | 1.29 | Human kidney methoxyflurane and sevoflurane metabolism. Intrarenal fluoride production as a possible mechanism of methoxyflurane nephrotoxicity. ( Hankins, DC; Kharasch, ED; Thummel, KE, 1995) |
" Although dose-related, neither the lethal nor the toxic effects are simply a function of cumulative dose (concentration-time)." | 1.29 | Toxicity of compound A in rats. Effect of increasing duration of administration. ( Eger, EI; Ferrell, LD; Gonsowski, CT; Kerschmann, RL; Laster, MJ, 1994) |
"Soda lime converts sevoflurane to CF2 = C(CF3)OCH2F, an olefin called compound A, whose toxicity raises concerns regarding the safe administration of sevoflurane via rebreathing circuits." | 1.29 | Toxicity of compound A in rats. Effect of a 3-hour administration. ( Eger, EI; Ferrell, LD; Gonsowski, CT; Kerschmann, RL; Laster, MJ, 1994) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 25 (55.56) | 18.2507 |
2000's | 15 (33.33) | 29.6817 |
2010's | 5 (11.11) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Song, JC | 1 |
Zhang, MZ | 1 |
Wu, QC | 1 |
Lu, ZJ | 1 |
Sun, YM | 1 |
Yang, LQ | 1 |
Yu, WF | 1 |
Xing, N | 1 |
Wei, X | 1 |
Chang, Y | 1 |
Du, Y | 1 |
Zhang, W | 1 |
Röhm, KD | 1 |
Mengistu, A | 1 |
Boldt, J | 1 |
Mayer, J | 1 |
Beck, G | 1 |
Piper, SN | 1 |
Wang, JM | 1 |
Hu, ZY | 1 |
Gu, WZ | 1 |
Stucchi, R | 1 |
Fumagalli, R | 1 |
Guedes, FS | 1 |
Cruz, DS | 1 |
Rodrigues, MM | 1 |
Silva, LM | 1 |
Amorim, RL | 1 |
Vianna, PT | 1 |
Castiglia, YM | 1 |
Orhan, H | 1 |
Sahin, A | 1 |
Sahin, G | 1 |
Aypar, U | 1 |
Vermeulen, NP | 1 |
Julier, K | 1 |
da Silva, R | 1 |
Garcia, C | 1 |
Bestmann, L | 1 |
Frascarolo, P | 1 |
Zollinger, A | 1 |
Chassot, PG | 1 |
Schmid, ER | 1 |
Turina, MI | 1 |
von Segesser, LK | 1 |
Pasch, T | 1 |
Spahn, DR | 1 |
Zaugg, M | 1 |
Trevisan, A | 1 |
Venturini, MB | 1 |
Carrieri, M | 1 |
Giraldo, M | 1 |
Maccà, I | 1 |
Perini, M | 1 |
Scapellato, ML | 1 |
Virgili, A | 1 |
Bartolucci, GB | 1 |
Altuntas, TG | 2 |
Zager, RA | 1 |
Kharasch, ED | 6 |
Ziegeler, S | 1 |
Sheffels, P | 2 |
Schroeder, JL | 3 |
Liggitt, HD | 2 |
Bammler, T | 1 |
Beyer, R | 1 |
Srinouanprachanh, S | 1 |
Khalil, S | 1 |
Glorimar, M | 1 |
Tabrizi, HK | 1 |
Lorsomradee, S | 2 |
Cromheecke, S | 1 |
De Hert, SG | 1 |
Lee, HT | 1 |
Chen, SW | 1 |
Doetschman, TC | 1 |
Deng, C | 1 |
D'Agati, VD | 1 |
Kim, M | 1 |
Hankins, DC | 1 |
Thummel, KE | 1 |
Gonsowski, CT | 2 |
Laster, MJ | 5 |
Eger, EI | 6 |
Ferrell, LD | 2 |
Kerschmann, RL | 4 |
Keller, KA | 1 |
Callan, C | 1 |
Prokocimer, P | 1 |
Delgado-Herrera, L | 1 |
Friedman, MB | 1 |
Hoffman, GM | 1 |
Wooding, WL | 1 |
Cusick, PK | 1 |
Krasula, RW | 1 |
Blanco, E | 1 |
Vidal, MI | 1 |
Blanco, J | 1 |
Fagundo, S | 1 |
Campaña, O | 1 |
Alvarez, J | 1 |
Tsukamoto, N | 1 |
Hirabayashi, Y | 1 |
Shimizu, R | 1 |
Mitsuhata, H | 1 |
Martin, JL | 1 |
Kandel, L | 1 |
Reed, GF | 1 |
Bito, H | 2 |
Ikeda, K | 1 |
Martínez, A | 1 |
Aguirre, I | 1 |
Aguilera, L | 1 |
Daniel, M | 1 |
DeSouza, GJ | 1 |
Gold, MI | 1 |
Epstein, RH | 1 |
Gong, D | 2 |
Koblin, DD | 1 |
Bowland, T | 1 |
Ionescu, P | 2 |
Weiskopf, RB | 2 |
Staacke, T | 1 |
Ebert, TJ | 1 |
Frink, EJ | 1 |
Mazze, RI | 1 |
Higuchi, H | 1 |
Sumita, S | 1 |
Wada, H | 1 |
Ura, T | 1 |
Ikemoto, T | 1 |
Nakai, T | 1 |
Kanno, M | 1 |
Satoh, T | 1 |
Artru, AA | 1 |
Hara, T | 1 |
Fukusaki, M | 1 |
Nakamura, T | 2 |
Sumikawa, K | 1 |
Uttamsingh, V | 1 |
Iyer, RA | 1 |
Baggs, RB | 1 |
Anders, MW | 1 |
Saidman, LJ | 1 |
Behne, M | 1 |
Wilke, HJ | 1 |
Harder, S | 1 |
Hase, K | 1 |
Meguro, K | 1 |
Laisalmi, M | 1 |
Eriksson, H | 1 |
Koivusalo, AM | 1 |
Pere, P | 1 |
Rosenberg, P | 1 |
Lindgren, L | 1 |
Gentz, BA | 1 |
Malan, TP | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
A Comparison of Myocardial Protection Using Preconditioning With Sevoflurane Against High Thoracic Epidural Analgesia for CABG Surgery[NCT00244283] | Phase 4 | 150 participants | Interventional | 2006-01-31 | Not yet recruiting | ||
Optimierung Der Kardioprotektion Durch Inhalative Anästhetika Eine Untersuchung Bei Patienten Mit Diabetes Mellitus während Off-pump Herzchirurgie[NCT02407626] | 2 participants (Actual) | Interventional | 2015-09-30 | Terminated (stopped due to Very low patient recruitment, changed insurance requirements) | |||
Determination Effective Dose 95 (ED95) of Intravenous Cannulation With the Induction of Sevoflurane 8 Vol% in Patients Aged 1-3 Years Using Dixon up and Down Method[NCT04284579] | 22 participants (Actual) | Interventional | 2019-05-27 | Completed | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
4 reviews available for sevoflurane and Kidney Diseases
Article | Year |
---|---|
Renal effects of sevoflurane during conditions of possible increased risk.
Topics: Anesthetics, Inhalation; Animals; Clinical Trials as Topic; Humans; Hypotension, Controlled; Kidney | 1998 |
Clinical pharmacokinetics of sevoflurane.
Topics: Age Factors; Anesthetics, Inhalation; Animals; Humans; Kidney Diseases; Methyl Ethers; Obesity; Sevo | 1999 |
[Metabolism and toxicity of anesthetics].
Topics: Anesthetics, Inhalation; Carbon Monoxide Poisoning; Chemical and Drug Induced Liver Injury; Enfluran | 1999 |
Renal toxicity with sevoflurane: a storm in a teacup?
Topics: Air Movements; Anesthetics, Inhalation; Drug Interactions; Ethers; Gases; Humans; Hydrocarbons, Fluo | 2001 |
15 trials available for sevoflurane and Kidney Diseases
Article | Year |
---|---|
Sevoflurane has no adverse effects on renal function in cirrhotic patients: a comparison with propofol.
Topics: Adult; Anesthetics, Inhalation; Anesthetics, Intravenous; Blood Urea Nitrogen; Creatinine; Diuresis; | 2013 |
Renal integrity in sevoflurane sedation in the intensive care unit with the anesthetic-conserving device: a comparison with intravenous propofol sedation.
Topics: Aged; Aged, 80 and over; Anesthetics, Inhalation; Blood Loss, Surgical; Conscious Sedation; Critical | 2009 |
Urinary lipid and protein oxidation products upon halothane, isoflurane, or sevoflurane anesthesia in humans: potential biomarkers for a subclinical nephrotoxicity.
Topics: Acetone; Aldehydes; Anesthetics, Inhalation; Biomarkers; Female; Glycosuria; Halothane; Humans; Isof | 2013 |
Preconditioning by sevoflurane decreases biochemical markers for myocardial and renal dysfunction in coronary artery bypass graft surgery: a double-blinded, placebo-controlled, multicenter study.
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Inhalation; Anesthetics, Inhalation; Biomarkers; Coronar | 2003 |
Preconditioning by sevoflurane decreases biochemical markers for myocardial and renal dysfunction in coronary artery bypass graft surgery: a double-blinded, placebo-controlled, multicenter study.
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Inhalation; Anesthetics, Inhalation; Biomarkers; Coronar | 2003 |
Preconditioning by sevoflurane decreases biochemical markers for myocardial and renal dysfunction in coronary artery bypass graft surgery: a double-blinded, placebo-controlled, multicenter study.
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Inhalation; Anesthetics, Inhalation; Biomarkers; Coronar | 2003 |
Preconditioning by sevoflurane decreases biochemical markers for myocardial and renal dysfunction in coronary artery bypass graft surgery: a double-blinded, placebo-controlled, multicenter study.
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Inhalation; Anesthetics, Inhalation; Biomarkers; Coronar | 2003 |
[Preconditioning with sevoflurane reduces biochemical markers for myocardial and renal dysfunction after aortocoronary procedures].
Topics: Anesthetics, Inhalation; Biomarkers; Cardiomyopathies; Coronary Artery Bypass; Double-Blind Method; | 2004 |
Effects of sevoflurane on biomechanical markers of hepatic and renal dysfunction after coronary artery surgery.
Topics: Administration, Inhalation; Aged; Alanine Transaminase; Anesthesia, General; Anesthetics, Inhalation | 2006 |
Comparison of maintenance and recovery characteristics of sevoflurane-nitrous oxide and enflurane-nitrous oxide anaesthesia.
Topics: Analgesics, Opioid; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Inhalation; Blood | 1995 |
The effects of sevoflurane and isoflurane anesthesia on renal tubular function in patients with moderately impaired renal function.
Topics: Acetylglucosaminidase; Adult; Aged; Aged, 80 and over; Anesthesia, Closed-Circuit; Anesthetics, Inha | 1996 |
Renal and hepatic function in surgical patients after low-flow sevoflurane or isoflurane anesthesia.
Topics: Adult; Aged; Alanine Transaminase; Anesthesia, General; Anesthetics, Inhalation; Aspartate Aminotran | 1996 |
There is no evidence of sevoflurane nephrotoxicity.
Topics: Anesthetics, Inhalation; Ethers; Humans; Kidney Diseases; Methyl Ethers; Sevoflurane | 1997 |
Sevoflurane and postoperative renal function: are omitted clinical data of concern?
Topics: Ethers; Humans; Kidney Diseases; Methyl Ethers; Sevoflurane | 1997 |
Effects of sevoflurane and isoflurane on renal function and on possible markers of nephrotoxicity.
Topics: Acetylglucosaminidase; Adolescent; Adult; Anesthetics, Inhalation; beta 2-Microglobulin; Biomarkers; | 1998 |
Renal function in patients during and after hypotensive anesthesia with sevoflurane.
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Gas Analysis; Creatinine; Female | 1998 |
Assessment of renal effects of sevoflurane in elderly patients using urinary markers.
Topics: Aged; Anesthesia, Epidural; Anesthetics, Inhalation; Biomarkers; Gastrectomy; Humans; Isoflurane; Ki | 1999 |
Ketorolac is not nephrotoxic in connection with sevoflurane anesthesia in patients undergoing breast surgery.
Topics: Acetylglucosaminidase; Adult; Anesthetics, Inhalation; Anti-Inflammatory Agents, Non-Steroidal; Biom | 2001 |
26 other studies available for sevoflurane and Kidney Diseases
Article | Year |
---|---|
Effects of low-flow sevoflurane anesthesia on renal function in low birth weight infants.
Topics: Acetylglucosaminidase; Anesthetics, Inhalation; Blood Urea Nitrogen; Creatinine; Female; Humans; Inf | 2015 |
[Effects of sevoflurane postconditioning on renal ischemia-reperfusion injury: experiment with rats].
Topics: Animals; Disease Models, Animal; Kidney Diseases; Male; Methyl Ethers; Rats; Rats, Sprague-Dawley; R | 2009 |
Treatment of Tetani infection using sevoflurane and AnaConDa: cases of transient renal impairment.
Topics: Administration, Inhalation; Adult; Anesthetics, Inhalation; Blood Urea Nitrogen; Creatinine; Female; | 2011 |
Renal histology and immunohistochemistry after acute hemorrhage in rats under sevoflurane and ketoprofen effect.
Topics: Acute Disease; Acute Kidney Injury; Anesthetics, Inhalation; Animals; Anti-Inflammatory Agents, Non- | 2012 |
Biological indices of kidney involvement in personnel exposed to sevoflurane in surgical areas.
Topics: Adult; Anesthetics, Inhalation; Female; Health Personnel; Humans; Kidney Diseases; Male; Methyl Ethe | 2003 |
Cytotoxicity of S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl) vinyl ether (Compound A) in a human proximal tubular cell line.
Topics: Anesthetics, Inhalation; Cell Line; Cysteine; Ethers; Formazans; Glutathione; Humans; Hydrocarbons, | 2003 |
Role of cytochrome P4503A in cysteine S-conjugates sulfoxidation and the nephrotoxicity of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in rats.
Topics: Anesthetics, Inhalation; Animals; Aryl Hydrocarbon Hydroxylases; Cysteine; Cytochrome P-450 CYP3A; D | 2004 |
Influence of sevoflurane on the metabolism and renal effects of compound A in rats.
Topics: Anesthetics, Inhalation; Animals; Biotransformation; Ethers; Hydrocarbons, Fluorinated; Kidney; Kidn | 2005 |
Gene expression profiling of nephrotoxicity from the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether ("compound A") in rats.
Topics: Anesthetics, Inhalation; Animals; Ethers; Gene Expression Profiling; Hydrocarbons, Fluorinated; Kidn | 2006 |
Sevoflurane-induced hepatotoxicity?
Topics: Anesthetics, Inhalation; Chemical and Drug Induced Liver Injury; Dilatation; Down Syndrome; Esophagu | 2006 |
Sevoflurane protects against renal ischemia and reperfusion injury in mice via the transforming growth factor-beta1 pathway.
Topics: Anesthetics, Inhalation; Animals; Cells, Cultured; Kidney Diseases; Kidney Medulla; Methyl Ethers; M | 2008 |
Human kidney methoxyflurane and sevoflurane metabolism. Intrarenal fluoride production as a possible mechanism of methoxyflurane nephrotoxicity.
Topics: Cytochrome P-450 Enzyme System; Ethers; Fluorides; Humans; In Vitro Techniques; Isoenzymes; Kidney; | 1995 |
Toxicity of compound A in rats. Effect of increasing duration of administration.
Topics: Anesthetics; Animals; Body Weight; Cell Division; Dose-Response Relationship, Drug; Drug Administrat | 1994 |
Toxicity of compound A in rats. Effect of a 3-hour administration.
Topics: Anesthetics; Animals; Brain; Brain Diseases; Dose-Response Relationship, Drug; Drug Administration S | 1994 |
Inhalation toxicity study of a haloalkene degradant of sevoflurane, Compound A (PIFE), in Sprague-Dawley rats.
Topics: Anesthetics, Inhalation; Animals; Blood Chemical Analysis; Blood Coagulation; Dose-Response Relation | 1995 |
Metabolism of compound A by renal cysteine-S-conjugate beta-lyase is not the mechanism of compound A-induced renal injury in the rat.
Topics: Aminooxyacetic Acid; Anesthetics, Inhalation; Animals; Buthionine Sulfoximine; Carbon-Sulfur Lyases; | 1996 |
[Safety of sevoflurane in humans].
Topics: Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intravenous; | 1996 |
Sevoflurane.
Topics: Anesthetics, Inhalation; Conflict of Interest; Ethers; Kidney Diseases; Methyl Ethers; Sevoflurane | 1996 |
Dose-related biochemical markers of renal injury after sevoflurane versus desflurane anesthesia in volunteers.
Topics: Adult; Anesthesia, General; Anesthetics, Inhalation; Biomarkers; Chemical and Drug Induced Liver Inj | 1997 |
Quantitative differences in the production and toxicity of CF2=BrCl versus CH2F-O-C(=CF2)(CF3) (compound A): the safety of halothane does not indicate the safety of sevoflurane.
Topics: Absorption; Aminooxyacetic Acid; Anesthetics, Inhalation; Animals; Chemical Phenomena; Chemistry, Ph | 1997 |
Ethics of human toxicity study questioned.
Topics: Anesthetics, Inhalation; Clinical Trials as Topic; Desflurane; Ethers; Ethics, Medical; Humans; Isof | 1998 |
Absence of biochemical evidence for renal and hepatic dysfunction after 8 hours of 1.25 minimum alveolar concentration sevoflurane anesthesia in volunteers.
Topics: Adult; Alanine Transaminase; Anesthetics, Inhalation; Body Temperature; Chemical and Drug Induced Li | 1998 |
No evidence of sevoflurane-induced renal injury in volunteers.
Topics: Albuminuria; Anesthetics, Inhalation; Creatinine; Humans; Kidney Diseases; Methyl Ethers; Sevofluran | 1998 |
Fate and toxicity of 2-(fluoromethoxy)-1,1,3,3,3-pentafluoro-1-propene (compound A)-derived mercapturates in male, Fischer 344 rats.
Topics: Acetylcysteine; Acyltransferases; Anesthetics, Inhalation; Animals; Biotransformation; Chemical and | 1998 |
Studies' divergent results.
Topics: Anesthetics, Inhalation; Clinical Trials as Topic; Ethics, Medical; Humans; Kidney Diseases; Methyl | 1999 |
Compound A: does it matter?
Topics: Adsorption; Anesthetics, Inhalation; Canada; Carbon Dioxide; Ethers; Humans; Hydrocarbons, Fluorinat | 2001 |