Page last updated: 2024-11-04

sevoflurane and Kidney Diseases

sevoflurane has been researched along with Kidney Diseases in 45 studies

Sevoflurane: A non-explosive inhalation anesthetic used in the induction and maintenance of general anesthesia. It does not cause respiratory irritation and may also prevent PLATELET AGGREGATION.
sevoflurane : An ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups.

Kidney Diseases: Pathological processes of the KIDNEY or its component tissues.

Research Excerpts

ExcerptRelevanceReference
"To investigate the influence of intravenous nonselective cyclooxygenase inhibitor, ketoprofen (keto), on kidney histological changes and kidney cytokines, tumor necrosis factor-α (TNF-α) and interleukin-1 (IL-1), levels after hemorrhage of 30% of volemia (three times 10%, intervals of 10 min) in rats."7.78Renal histology and immunohistochemistry after acute hemorrhage in rats under sevoflurane and ketoprofen effect. ( Amorim, RL; Castiglia, YM; Cruz, DS; Guedes, FS; Rodrigues, MM; Silva, LM; Vianna, PT, 2012)
"Low-flow sevoflurane anesthesia was associated with mild and transient proteinuria."5.08Effects of sevoflurane and isoflurane on renal function and on possible markers of nephrotoxicity. ( Higuchi, H; Ikemoto, T; Kanno, M; Nakai, T; Satoh, T; Sumita, S; Ura, T; Wada, H, 1998)
"To investigate the influence of intravenous nonselective cyclooxygenase inhibitor, ketoprofen (keto), on kidney histological changes and kidney cytokines, tumor necrosis factor-α (TNF-α) and interleukin-1 (IL-1), levels after hemorrhage of 30% of volemia (three times 10%, intervals of 10 min) in rats."3.78Renal histology and immunohistochemistry after acute hemorrhage in rats under sevoflurane and ketoprofen effect. ( Amorim, RL; Castiglia, YM; Cruz, DS; Guedes, FS; Rodrigues, MM; Silva, LM; Vianna, PT, 2012)
" However, no consensus has been reached whether sevoflurane could have adverse effects on renal function in cirrhotic patients."2.78Sevoflurane has no adverse effects on renal function in cirrhotic patients: a comparison with propofol. ( Lu, ZJ; Song, JC; Sun, YM; Wu, QC; Yang, LQ; Yu, WF; Zhang, MZ, 2013)
"Ketorolac, which may cause renal vasoconstriction by cyclooxygenase inhibition, is often administered to patients anesthetized with sevoflurane that is metabolized to inorganic fluoride (F(-)), another potential nephrotoxin."2.70Ketorolac is not nephrotoxic in connection with sevoflurane anesthesia in patients undergoing breast surgery. ( Eriksson, H; Koivusalo, AM; Laisalmi, M; Lindgren, L; Pere, P; Rosenberg, P, 2001)
" Until recently, inorganic fluoride has been thought to be the aetiological agent responsible for fluorinated anaesthetic nephrotoxicity, with a toxic concentration threshold of 50 micromol/L in serum."2.41Renal toxicity with sevoflurane: a storm in a teacup? ( Gentz, BA; Malan, TP, 2001)
"Sevoflurane is a comparatively recent addition to the range of inhalational anaesthetics which has been recently released for clinical use."2.40Clinical pharmacokinetics of sevoflurane. ( Behne, M; Harder, S; Wilke, HJ, 1999)
"Sevoflurane does not suppress compound A nephrotoxicity in rats in vivo."1.33Influence of sevoflurane on the metabolism and renal effects of compound A in rats. ( Kharasch, ED; Liggitt, HD; Schroeder, JL; Sheffels, P, 2005)
" FDVE-mercapturic acid sulfoxides were more toxic than other FDVE conjugates to renal proximal tubular cells in culture."1.32Role of cytochrome P4503A in cysteine S-conjugates sulfoxidation and the nephrotoxicity of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in rats. ( Altuntas, TG; Kharasch, ED; Liggitt, HD; Schroeder, JL; Sheffels, P, 2004)
"Carbon dioxide absorbents degrade both halothane and sevoflurane to toxic unsaturated compounds (CF2=CBrCl and CH2F-O-C[=CF2][CF3] [i."1.30Quantitative differences in the production and toxicity of CF2=BrCl versus CH2F-O-C(=CF2)(CF3) (compound A): the safety of halothane does not indicate the safety of sevoflurane. ( Eger, EI; Gong, D; Ionescu, P; Kerschmann, RL; Laster, MJ; Weiskopf, RB, 1997)
"Methoxyflurane nephrotoxicity is mediated by cytochrome P450-catalyzed metabolism to toxic metabolites."1.29Human kidney methoxyflurane and sevoflurane metabolism. Intrarenal fluoride production as a possible mechanism of methoxyflurane nephrotoxicity. ( Hankins, DC; Kharasch, ED; Thummel, KE, 1995)
" Although dose-related, neither the lethal nor the toxic effects are simply a function of cumulative dose (concentration-time)."1.29Toxicity of compound A in rats. Effect of increasing duration of administration. ( Eger, EI; Ferrell, LD; Gonsowski, CT; Kerschmann, RL; Laster, MJ, 1994)
"Soda lime converts sevoflurane to CF2 = C(CF3)OCH2F, an olefin called compound A, whose toxicity raises concerns regarding the safe administration of sevoflurane via rebreathing circuits."1.29Toxicity of compound A in rats. Effect of a 3-hour administration. ( Eger, EI; Ferrell, LD; Gonsowski, CT; Kerschmann, RL; Laster, MJ, 1994)

Research

Studies (45)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's25 (55.56)18.2507
2000's15 (33.33)29.6817
2010's5 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Song, JC1
Zhang, MZ1
Wu, QC1
Lu, ZJ1
Sun, YM1
Yang, LQ1
Yu, WF1
Xing, N1
Wei, X1
Chang, Y1
Du, Y1
Zhang, W1
Röhm, KD1
Mengistu, A1
Boldt, J1
Mayer, J1
Beck, G1
Piper, SN1
Wang, JM1
Hu, ZY1
Gu, WZ1
Stucchi, R1
Fumagalli, R1
Guedes, FS1
Cruz, DS1
Rodrigues, MM1
Silva, LM1
Amorim, RL1
Vianna, PT1
Castiglia, YM1
Orhan, H1
Sahin, A1
Sahin, G1
Aypar, U1
Vermeulen, NP1
Julier, K1
da Silva, R1
Garcia, C1
Bestmann, L1
Frascarolo, P1
Zollinger, A1
Chassot, PG1
Schmid, ER1
Turina, MI1
von Segesser, LK1
Pasch, T1
Spahn, DR1
Zaugg, M1
Trevisan, A1
Venturini, MB1
Carrieri, M1
Giraldo, M1
Maccà, I1
Perini, M1
Scapellato, ML1
Virgili, A1
Bartolucci, GB1
Altuntas, TG2
Zager, RA1
Kharasch, ED6
Ziegeler, S1
Sheffels, P2
Schroeder, JL3
Liggitt, HD2
Bammler, T1
Beyer, R1
Srinouanprachanh, S1
Khalil, S1
Glorimar, M1
Tabrizi, HK1
Lorsomradee, S2
Cromheecke, S1
De Hert, SG1
Lee, HT1
Chen, SW1
Doetschman, TC1
Deng, C1
D'Agati, VD1
Kim, M1
Hankins, DC1
Thummel, KE1
Gonsowski, CT2
Laster, MJ5
Eger, EI6
Ferrell, LD2
Kerschmann, RL4
Keller, KA1
Callan, C1
Prokocimer, P1
Delgado-Herrera, L1
Friedman, MB1
Hoffman, GM1
Wooding, WL1
Cusick, PK1
Krasula, RW1
Blanco, E1
Vidal, MI1
Blanco, J1
Fagundo, S1
Campaña, O1
Alvarez, J1
Tsukamoto, N1
Hirabayashi, Y1
Shimizu, R1
Mitsuhata, H1
Martin, JL1
Kandel, L1
Reed, GF1
Bito, H2
Ikeda, K1
Martínez, A1
Aguirre, I1
Aguilera, L1
Daniel, M1
DeSouza, GJ1
Gold, MI1
Epstein, RH1
Gong, D2
Koblin, DD1
Bowland, T1
Ionescu, P2
Weiskopf, RB2
Staacke, T1
Ebert, TJ1
Frink, EJ1
Mazze, RI1
Higuchi, H1
Sumita, S1
Wada, H1
Ura, T1
Ikemoto, T1
Nakai, T1
Kanno, M1
Satoh, T1
Artru, AA1
Hara, T1
Fukusaki, M1
Nakamura, T2
Sumikawa, K1
Uttamsingh, V1
Iyer, RA1
Baggs, RB1
Anders, MW1
Saidman, LJ1
Behne, M1
Wilke, HJ1
Harder, S1
Hase, K1
Meguro, K1
Laisalmi, M1
Eriksson, H1
Koivusalo, AM1
Pere, P1
Rosenberg, P1
Lindgren, L1
Gentz, BA1
Malan, TP1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Comparison of Myocardial Protection Using Preconditioning With Sevoflurane Against High Thoracic Epidural Analgesia for CABG Surgery[NCT00244283]Phase 4150 participants Interventional2006-01-31Not yet recruiting
Optimierung Der Kardioprotektion Durch Inhalative Anästhetika Eine Untersuchung Bei Patienten Mit Diabetes Mellitus während Off-pump Herzchirurgie[NCT02407626]2 participants (Actual)Interventional2015-09-30Terminated (stopped due to Very low patient recruitment, changed insurance requirements)
Determination Effective Dose 95 (ED95) of Intravenous Cannulation With the Induction of Sevoflurane 8 Vol% in Patients Aged 1-3 Years Using Dixon up and Down Method[NCT04284579]22 participants (Actual)Interventional2019-05-27Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for sevoflurane and Kidney Diseases

ArticleYear
Renal effects of sevoflurane during conditions of possible increased risk.
    Journal of clinical anesthesia, 1998, Volume: 10, Issue:7

    Topics: Anesthetics, Inhalation; Animals; Clinical Trials as Topic; Humans; Hypotension, Controlled; Kidney

1998
Clinical pharmacokinetics of sevoflurane.
    Clinical pharmacokinetics, 1999, Volume: 36, Issue:1

    Topics: Age Factors; Anesthetics, Inhalation; Animals; Humans; Kidney Diseases; Methyl Ethers; Obesity; Sevo

1999
[Metabolism and toxicity of anesthetics].
    Masui. The Japanese journal of anesthesiology, 1999, Volume: 48 Suppl

    Topics: Anesthetics, Inhalation; Carbon Monoxide Poisoning; Chemical and Drug Induced Liver Injury; Enfluran

1999
Renal toxicity with sevoflurane: a storm in a teacup?
    Drugs, 2001, Volume: 61, Issue:15

    Topics: Air Movements; Anesthetics, Inhalation; Drug Interactions; Ethers; Gases; Humans; Hydrocarbons, Fluo

2001

Trials

15 trials available for sevoflurane and Kidney Diseases

ArticleYear
Sevoflurane has no adverse effects on renal function in cirrhotic patients: a comparison with propofol.
    Acta anaesthesiologica Scandinavica, 2013, Volume: 57, Issue:7

    Topics: Adult; Anesthetics, Inhalation; Anesthetics, Intravenous; Blood Urea Nitrogen; Creatinine; Diuresis;

2013
Renal integrity in sevoflurane sedation in the intensive care unit with the anesthetic-conserving device: a comparison with intravenous propofol sedation.
    Anesthesia and analgesia, 2009, Volume: 108, Issue:6

    Topics: Aged; Aged, 80 and over; Anesthetics, Inhalation; Blood Loss, Surgical; Conscious Sedation; Critical

2009
Urinary lipid and protein oxidation products upon halothane, isoflurane, or sevoflurane anesthesia in humans: potential biomarkers for a subclinical nephrotoxicity.
    Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2013, Volume: 18, Issue:1

    Topics: Acetone; Aldehydes; Anesthetics, Inhalation; Biomarkers; Female; Glycosuria; Halothane; Humans; Isof

2013
Preconditioning by sevoflurane decreases biochemical markers for myocardial and renal dysfunction in coronary artery bypass graft surgery: a double-blinded, placebo-controlled, multicenter study.
    Anesthesiology, 2003, Volume: 98, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Inhalation; Anesthetics, Inhalation; Biomarkers; Coronar

2003
Preconditioning by sevoflurane decreases biochemical markers for myocardial and renal dysfunction in coronary artery bypass graft surgery: a double-blinded, placebo-controlled, multicenter study.
    Anesthesiology, 2003, Volume: 98, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Inhalation; Anesthetics, Inhalation; Biomarkers; Coronar

2003
Preconditioning by sevoflurane decreases biochemical markers for myocardial and renal dysfunction in coronary artery bypass graft surgery: a double-blinded, placebo-controlled, multicenter study.
    Anesthesiology, 2003, Volume: 98, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Inhalation; Anesthetics, Inhalation; Biomarkers; Coronar

2003
Preconditioning by sevoflurane decreases biochemical markers for myocardial and renal dysfunction in coronary artery bypass graft surgery: a double-blinded, placebo-controlled, multicenter study.
    Anesthesiology, 2003, Volume: 98, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Inhalation; Anesthetics, Inhalation; Biomarkers; Coronar

2003
[Preconditioning with sevoflurane reduces biochemical markers for myocardial and renal dysfunction after aortocoronary procedures].
    Der Anaesthesist, 2004, Volume: 53, Issue:9

    Topics: Anesthetics, Inhalation; Biomarkers; Cardiomyopathies; Coronary Artery Bypass; Double-Blind Method;

2004
Effects of sevoflurane on biomechanical markers of hepatic and renal dysfunction after coronary artery surgery.
    Journal of cardiothoracic and vascular anesthesia, 2006, Volume: 20, Issue:5

    Topics: Administration, Inhalation; Aged; Alanine Transaminase; Anesthesia, General; Anesthetics, Inhalation

2006
Comparison of maintenance and recovery characteristics of sevoflurane-nitrous oxide and enflurane-nitrous oxide anaesthesia.
    European journal of anaesthesiology, 1995, Volume: 12, Issue:5

    Topics: Analgesics, Opioid; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Inhalation; Blood

1995
The effects of sevoflurane and isoflurane anesthesia on renal tubular function in patients with moderately impaired renal function.
    Anesthesia and analgesia, 1996, Volume: 82, Issue:5

    Topics: Acetylglucosaminidase; Adult; Aged; Aged, 80 and over; Anesthesia, Closed-Circuit; Anesthetics, Inha

1996
Renal and hepatic function in surgical patients after low-flow sevoflurane or isoflurane anesthesia.
    Anesthesia and analgesia, 1996, Volume: 82, Issue:1

    Topics: Adult; Aged; Alanine Transaminase; Anesthesia, General; Anesthetics, Inhalation; Aspartate Aminotran

1996
There is no evidence of sevoflurane nephrotoxicity.
    Anesthesia and analgesia, 1997, Volume: 84, Issue:3

    Topics: Anesthetics, Inhalation; Ethers; Humans; Kidney Diseases; Methyl Ethers; Sevoflurane

1997
Sevoflurane and postoperative renal function: are omitted clinical data of concern?
    Anesthesia and analgesia, 1997, Volume: 84, Issue:3

    Topics: Ethers; Humans; Kidney Diseases; Methyl Ethers; Sevoflurane

1997
Effects of sevoflurane and isoflurane on renal function and on possible markers of nephrotoxicity.
    Anesthesiology, 1998, Volume: 89, Issue:2

    Topics: Acetylglucosaminidase; Adolescent; Adult; Anesthetics, Inhalation; beta 2-Microglobulin; Biomarkers;

1998
Renal function in patients during and after hypotensive anesthesia with sevoflurane.
    Journal of clinical anesthesia, 1998, Volume: 10, Issue:7

    Topics: Adult; Aged; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Gas Analysis; Creatinine; Female

1998
Assessment of renal effects of sevoflurane in elderly patients using urinary markers.
    Anesthesia and analgesia, 1999, Volume: 88, Issue:6

    Topics: Aged; Anesthesia, Epidural; Anesthetics, Inhalation; Biomarkers; Gastrectomy; Humans; Isoflurane; Ki

1999
Ketorolac is not nephrotoxic in connection with sevoflurane anesthesia in patients undergoing breast surgery.
    Anesthesia and analgesia, 2001, Volume: 92, Issue:4

    Topics: Acetylglucosaminidase; Adult; Anesthetics, Inhalation; Anti-Inflammatory Agents, Non-Steroidal; Biom

2001

Other Studies

26 other studies available for sevoflurane and Kidney Diseases

ArticleYear
Effects of low-flow sevoflurane anesthesia on renal function in low birth weight infants.
    BMC anesthesiology, 2015, Jan-21, Volume: 15

    Topics: Acetylglucosaminidase; Anesthetics, Inhalation; Blood Urea Nitrogen; Creatinine; Female; Humans; Inf

2015
[Effects of sevoflurane postconditioning on renal ischemia-reperfusion injury: experiment with rats].
    Zhonghua yi xue za zhi, 2009, Apr-21, Volume: 89, Issue:15

    Topics: Animals; Disease Models, Animal; Kidney Diseases; Male; Methyl Ethers; Rats; Rats, Sprague-Dawley; R

2009
Treatment of Tetani infection using sevoflurane and AnaConDa: cases of transient renal impairment.
    Minerva anestesiologica, 2011, Volume: 77, Issue:7

    Topics: Administration, Inhalation; Adult; Anesthetics, Inhalation; Blood Urea Nitrogen; Creatinine; Female;

2011
Renal histology and immunohistochemistry after acute hemorrhage in rats under sevoflurane and ketoprofen effect.
    Acta cirurgica brasileira, 2012, Volume: 27, Issue:1

    Topics: Acute Disease; Acute Kidney Injury; Anesthetics, Inhalation; Animals; Anti-Inflammatory Agents, Non-

2012
Biological indices of kidney involvement in personnel exposed to sevoflurane in surgical areas.
    American journal of industrial medicine, 2003, Volume: 44, Issue:5

    Topics: Adult; Anesthetics, Inhalation; Female; Health Personnel; Humans; Kidney Diseases; Male; Methyl Ethe

2003
Cytotoxicity of S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl) vinyl ether (Compound A) in a human proximal tubular cell line.
    Toxicology and applied pharmacology, 2003, Nov-15, Volume: 193, Issue:1

    Topics: Anesthetics, Inhalation; Cell Line; Cysteine; Ethers; Formazans; Glutathione; Humans; Hydrocarbons,

2003
Role of cytochrome P4503A in cysteine S-conjugates sulfoxidation and the nephrotoxicity of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in rats.
    Chemical research in toxicology, 2004, Volume: 17, Issue:9

    Topics: Anesthetics, Inhalation; Animals; Aryl Hydrocarbon Hydroxylases; Cysteine; Cytochrome P-450 CYP3A; D

2004
Influence of sevoflurane on the metabolism and renal effects of compound A in rats.
    Anesthesiology, 2005, Volume: 103, Issue:6

    Topics: Anesthetics, Inhalation; Animals; Biotransformation; Ethers; Hydrocarbons, Fluorinated; Kidney; Kidn

2005
Gene expression profiling of nephrotoxicity from the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether ("compound A") in rats.
    Toxicological sciences : an official journal of the Society of Toxicology, 2006, Volume: 90, Issue:2

    Topics: Anesthetics, Inhalation; Animals; Ethers; Gene Expression Profiling; Hydrocarbons, Fluorinated; Kidn

2006
Sevoflurane-induced hepatotoxicity?
    Paediatric anaesthesia, 2006, Volume: 16, Issue:7

    Topics: Anesthetics, Inhalation; Chemical and Drug Induced Liver Injury; Dilatation; Down Syndrome; Esophagu

2006
Sevoflurane protects against renal ischemia and reperfusion injury in mice via the transforming growth factor-beta1 pathway.
    American journal of physiology. Renal physiology, 2008, Volume: 295, Issue:1

    Topics: Anesthetics, Inhalation; Animals; Cells, Cultured; Kidney Diseases; Kidney Medulla; Methyl Ethers; M

2008
Human kidney methoxyflurane and sevoflurane metabolism. Intrarenal fluoride production as a possible mechanism of methoxyflurane nephrotoxicity.
    Anesthesiology, 1995, Volume: 82, Issue:3

    Topics: Cytochrome P-450 Enzyme System; Ethers; Fluorides; Humans; In Vitro Techniques; Isoenzymes; Kidney;

1995
Toxicity of compound A in rats. Effect of increasing duration of administration.
    Anesthesiology, 1994, Volume: 80, Issue:3

    Topics: Anesthetics; Animals; Body Weight; Cell Division; Dose-Response Relationship, Drug; Drug Administrat

1994
Toxicity of compound A in rats. Effect of a 3-hour administration.
    Anesthesiology, 1994, Volume: 80, Issue:3

    Topics: Anesthetics; Animals; Brain; Brain Diseases; Dose-Response Relationship, Drug; Drug Administration S

1994
Inhalation toxicity study of a haloalkene degradant of sevoflurane, Compound A (PIFE), in Sprague-Dawley rats.
    Anesthesiology, 1995, Volume: 83, Issue:6

    Topics: Anesthetics, Inhalation; Animals; Blood Chemical Analysis; Blood Coagulation; Dose-Response Relation

1995
Metabolism of compound A by renal cysteine-S-conjugate beta-lyase is not the mechanism of compound A-induced renal injury in the rat.
    Anesthesia and analgesia, 1996, Volume: 82, Issue:4

    Topics: Aminooxyacetic Acid; Anesthetics, Inhalation; Animals; Buthionine Sulfoximine; Carbon-Sulfur Lyases;

1996
[Safety of sevoflurane in humans].
    Revista espanola de anestesiologia y reanimacion, 1996, Volume: 43, Issue:2

    Topics: Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intravenous;

1996
Sevoflurane.
    British journal of anaesthesia, 1996, Volume: 77, Issue:2

    Topics: Anesthetics, Inhalation; Conflict of Interest; Ethers; Kidney Diseases; Methyl Ethers; Sevoflurane

1996
Dose-related biochemical markers of renal injury after sevoflurane versus desflurane anesthesia in volunteers.
    Anesthesia and analgesia, 1997, Volume: 85, Issue:5

    Topics: Adult; Anesthesia, General; Anesthetics, Inhalation; Biomarkers; Chemical and Drug Induced Liver Inj

1997
Quantitative differences in the production and toxicity of CF2=BrCl versus CH2F-O-C(=CF2)(CF3) (compound A): the safety of halothane does not indicate the safety of sevoflurane.
    Anesthesia and analgesia, 1997, Volume: 85, Issue:5

    Topics: Absorption; Aminooxyacetic Acid; Anesthetics, Inhalation; Animals; Chemical Phenomena; Chemistry, Ph

1997
Ethics of human toxicity study questioned.
    Anesthesia and analgesia, 1998, Volume: 86, Issue:2

    Topics: Anesthetics, Inhalation; Clinical Trials as Topic; Desflurane; Ethers; Ethics, Medical; Humans; Isof

1998
Absence of biochemical evidence for renal and hepatic dysfunction after 8 hours of 1.25 minimum alveolar concentration sevoflurane anesthesia in volunteers.
    Anesthesiology, 1998, Volume: 88, Issue:3

    Topics: Adult; Alanine Transaminase; Anesthetics, Inhalation; Body Temperature; Chemical and Drug Induced Li

1998
No evidence of sevoflurane-induced renal injury in volunteers.
    Anesthesia and analgesia, 1998, Volume: 87, Issue:1

    Topics: Albuminuria; Anesthetics, Inhalation; Creatinine; Humans; Kidney Diseases; Methyl Ethers; Sevofluran

1998
Fate and toxicity of 2-(fluoromethoxy)-1,1,3,3,3-pentafluoro-1-propene (compound A)-derived mercapturates in male, Fischer 344 rats.
    Anesthesiology, 1998, Volume: 89, Issue:5

    Topics: Acetylcysteine; Acyltransferases; Anesthetics, Inhalation; Animals; Biotransformation; Chemical and

1998
Studies' divergent results.
    Anesthesiology, 1999, Volume: 90, Issue:1

    Topics: Anesthetics, Inhalation; Clinical Trials as Topic; Ethics, Medical; Humans; Kidney Diseases; Methyl

1999
Compound A: does it matter?
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2001, Volume: 48, Issue:5

    Topics: Adsorption; Anesthetics, Inhalation; Canada; Carbon Dioxide; Ethers; Humans; Hydrocarbons, Fluorinat

2001