sevoflurane has been researched along with Innate Inflammatory Response in 96 studies
Sevoflurane: A non-explosive inhalation anesthetic used in the induction and maintenance of general anesthesia. It does not cause respiratory irritation and may also prevent PLATELET AGGREGATION.
sevoflurane : An ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study assessed, for the first time, the expression of the genes hOGG1, TP53, and IL-6 in leukocytes by real-time quantitative polymerase chain reaction in surgical patients before (baseline), during (2 h of anesthesia) and 1 day after sevoflurane anesthesia." | 8.31 | Modulation of gene expression and inflammation but not DNA damage after sevoflurane anesthesia. ( Braz, JRC; Braz, LG; Braz, MG; Silva, MAP, 2023) |
| "Postoperative cognitive dysfunction (POCD) is regularly observed in patients postsurgery due to the usage of anesthetics, including Sevoflurane." | 8.31 | Effects of miR-190a-3p on Sevoflurane-induced postoperative cognitive dysfunction (POCD). ( Guo, LL; Song, S; Wang, HY; Wang, Y; Zhang, J, 2023) |
| "We aimed to explore the effects of hypercholesterolemia on sevoflurane-induced cognitive impairment in aged rats and the underlying mechanism(s)." | 8.12 | Hypercholesterolemia aggravates sevoflurane-induced cognitive impairment in aged rats by inducing neurological inflammation and apoptosis. ( Liu, L; Long, B; Wang, C; Wu, X; Zhang, X, 2022) |
| "Sevoflurane reduced inflammation, recovered cell division so as to suppress cell apoptosis and maintain cell survival, and activated autophagic flux in LPS-induced ALI models in vivo and in vitro." | 8.12 | Activation of the AMPK-ULK1 pathway mediated protective autophagy by sevoflurane anesthesia restrains LPS-induced acute lung injury (ALI). ( Fu, Z; Wu, X; Zhang, Y; Zheng, F, 2022) |
| "Sevoflurane or LPS treatment increased activated caspase-3 and caspase-9 expression in the hippocampal subiculum and CA1, which was greater when sevoflurane was administered in the setting of LPS-induced inflammation." | 8.12 | Systemic inflammation exacerbates developmental neurotoxicity induced by sevoflurane in neonatal rats. ( Cabrera, OH; Jevtovic-Todorovic, V; Liechty, C; Maksimovic, S; Quillinan, N; Useinovic, N, 2022) |
| " To elucidate the POCD molecular mechanism, sevoflurane was employed in the present study to generate neuroinflammation mice model." | 8.02 | Sevoflurane induces inflammation in primary hippocampal neurons by regulating Hoxa5/Gm5106/miR-27b-3p positive feedback loop. ( Ma, L; Zhu, Z, 2021) |
| "Sevoflurane induces inflammation of microglia in hippocampus of neonatal rats by inhibiting Wnt/β-Catenin/CaMKIV pathway." | 8.02 | Sevoflurane induces inflammation of microglia in hippocampus of neonatal rats by inhibiting Wnt/β-Catenin/CaMKIV pathway. ( Li, C; Ma, J; Shao, J; Wang, F, 2021) |
| "Our findings imply that apoptosis, inflammation, and oxidative stress in the hippocampal region of neonatal mouse brain were significantly reduced by pre-treatment with PCA before sevoflurane exposure." | 7.96 | Protective role of protocatechuic acid in sevoflurane-induced neuron apoptosis, inflammation and oxidative stress in mice. ( Gao, Y; Han, T; Ma, L; Wang, M; Wang, Y; Zhang, D, 2020) |
| "To investigate the expression of miR-203 by sevoflurane treatment and its effect on neuroinflammation induced by cerebral ischemia-reperfusion." | 7.96 | Sevoflurane Post-treatment Upregulated miR-203 Expression to Attenuate Cerebral Ischemia-Reperfusion-Induced Neuroinflammation by Targeting MyD88. ( Chen, H; Gu, C; Zhong, H, 2020) |
| " Sevoflurane (SEV), a widely used inhalational anesthetic, can exaggerate neuroinflammation and cause cognitive dysfunction under chronic intermittent hypoxia (CIH) conditions by downregulating hippocampal peroxisome proliferator‑activated receptor‑γ (PPAR‑γ)." | 7.91 | Pioglitazone prevents sevoflurane‑induced neuroinflammation and cognitive decline in a rat model of chronic intermittent hypoxia by upregulating hippocampal PPAR‑γ. ( Dong, P; Fei, J; Li, D; Li, L; Li, N; Lin, Q; Lu, L; Yang, B; Zhang, X, 2019) |
| "These results suggested that activation of SIRT3 by honokiol may attenuate surgery/anesthesia-induced cognitive impairment in mice through regulation of oxidative stress and neuroinflammatory in hippocampus." | 7.91 | SIRT3 activator honokiol ameliorates surgery/anesthesia-induced cognitive decline in mice through anti-oxidative stress and anti-inflammatory in hippocampus. ( Chen, L; Lei, SQ; Lu, YY; Peng, M; Xia, ZY; Ye, JS, 2019) |
| "These data indicated that miR-410-3p exhibited its neuroprotective effect on sevoflurane anesthesia-induced CD by targeting CXCR5 via PI3K/Akt signaling pathway." | 7.91 | Neuroprotective effect of miR-410-3p against sevoflurane anesthesia-induced cognitive dysfunction in rats through PI3K/Akt signaling pathway via targeting C-X-C motif chemokine receptor 5. ( Feng, C; Su, R; Sun, P; Xiao, W; Zhang, D; Zhong, L, 2019) |
| "These data suggest that the PI3K/Akt/mTOR pathway contributes to sevoflurane-induced neuroinflammation and that activation of PI3K/Akt/mTOR signaling by DEX could help reduce the neuroinflammatory effects of sevoflurane." | 7.91 | Dexmedetomidine suppresses sevoflurane anesthesia-induced neuroinflammation through activation of the PI3K/Akt/mTOR pathway. ( Wang, M; Wang, N, 2019) |
| "Sevoflurane was found to show protective roles in mice with asthma, however, the mechanism of which needs further exploring." | 7.91 | Sevoflurane modulates AQPs (1,5) expression and endoplasmic reticulum stress in mice lung with allergic airway inflammation. ( Lv, CM; Shen, QY; Wu, HM; Wu, L; Xu, GH; Yang, ZL, 2019) |
| "Our colleagues have demonstrated an impressive therapeutic role of sevoflurane in a murine allergic airway inflammation model, but the mechanisms underlying this effect remain undefined." | 7.88 | Sevoflurane Inhibits the Th2 Response and NLRP3 Expression in Murine Allergic Airway Inflammation. ( Cheng, C; Liu, R; Shen, Q; Wang, L; Wu, H; Zha, B; Zou, H, 2018) |
| "Anti-IL-17A may alleviate neuroinflammation and oxidative stress via inhibiting NF-κB pathway, thereby attenuating post-operative cognitive dysfunction (POCD) in aged rats anaesthetized with sevoflurane." | 7.88 | IL-17A promotes the neuroinflammation and cognitive function in sevoflurane anesthetized aged rats via activation of NF-κB signaling pathway. ( Yang, ZY; Yuan, CX, 2018) |
| "We have shown that systemic attenuation of inflammation by the volatile anaesthetic sevoflurane did not translate into attenuated neuro-inflammation in this LPS-induced inflammation model." | 7.85 | Sevoflurane attenuates systemic inflammation compared with propofol, but does not modulate neuro-inflammation: A laboratory rat study. ( Baumann, L; Beck-Schimmer, B; Booy, C; Eugster, P; Hasler, M; Restin, T; Schläpfer, M, 2017) |
| "Compared with isoflurane, sevoflurane did not affect lung inflammation in ARDSexp, but it did reduce lung inflammation in ARDSp." | 7.85 | Sevoflurane, Compared With Isoflurane, Minimizes Lung Damage in Pulmonary but Not in Extrapulmonary Acute Respiratory Distress Syndrome in Rats. ( Araújo, MN; Cavalcanti, VCM; Cruz, FF; Felix, NS; Fernandes, FC; Heil, LBB; Morales, MM; Pelosi, P; Rocco, PRM; Samary, CS; Santos, CL; Silva, JD; Silva, PL; Villela, NR, 2017) |
| "Toll like receptor 2 involved in the anti-inflammatory effect of sevoflurane on asthmatic airway inflammation in mice." | 7.83 | [Effect of Toll-like receptor 2 on the inhibition role of sevoflurane on airway inflammation in asthmatic mice]. ( Fang, L; He, F; Liu, RY; Shen, QY; Wu, HM; Wu, L, 2016) |
| " The aim of this study was to evaluate the effect of propofol on the apoptosis, Aβ accumulation, and inflammation induced by sevoflurane in human neuroglioma cells." | 7.81 | Anesthetic Propofol Attenuates Apoptosis, Aβ Accumulation, and Inflammation Induced by Sevoflurane Through NF-κB Pathway in Human Neuroglioma Cells. ( Guo, S; Guo, Y; Jian, L; Tian, Y, 2015) |
| "Repeated inhalation of sevoflurane (SVF) can benefit asthmatic patients by bronchodilation." | 7.81 | Repeated inhalation of sevoflurane inhibits airway inflammation in an OVA-induced mouse model of allergic airway inflammation. ( Ding, PS; Fang, L; He, F; Liu, RY; Shen, QY; Wu, HM, 2015) |
| "Sevoflurane, one of the most commonly used anesthetics in clinic, induced neuroinflammation and caused cognitive impairment." | 7.80 | 2-Deoxy-d-glucose attenuates sevoflurane-induced neuroinflammation through nuclear factor-kappa B pathway in vitro. ( Li, B; Liu, S; Sun, M; Wang, Q; Yang, L; Zhang, L; Zhao, Y, 2014) |
| "The goal of this study was to confirm whether or not sevoflurane is more effective than propofol in ameliorating the inflammatory response in an animal model of acute respiratory distress syndrome." | 7.79 | Sevoflurane, but not propofol, reduces the lung inflammatory response and improves oxygenation in an acute respiratory distress syndrome model: a randomised laboratory study. ( Aguilar, G; Belda, FJ; Ferrando, C; Moreno, J; Piqueras, L; Soro, M, 2013) |
| "Sevoflurane is an anesthetic agent which also participates in protective mechanisms in sepsis, likely due to anti-inflammatory properties." | 7.79 | Effects of sevoflurane postconditioning on cell death, inflammation and TLR expression in human endothelial cells exposed to LPS. ( Álvarez, J; Baluja, A; Brea, D; Rodríguez, A; Rodríguez, J; Rodríguez-González, R; Taboada, M; Veiras Del Río, S, 2013) |
| "Compared with sevoflurane, propofol administration during suprarenal aortic clamping and unclamping led to modulation of markers of inflammation and decreased NFkappaB expression." | 7.74 | The comparative abilities of propofol and sevoflurane to modulate inflammation and oxidative stress in the kidney after aortic cross-clamping. ( Cascajo, C; García-Criado, FJ; González-Sarmiento, R; Lozano, FS; Muriel, C; Nicolás, JL; Rodríguez-López, JM; Sánchez-Conde, P, 2008) |
| "Coenzyme Q10 (CoQ10) has been reported to reduce sevoflurane anesthesia‑induced cognitive deficiency in 6‑day‑old mice." | 5.56 | Coenzyme Q10 alleviates sevoflurane‑induced neuroinflammation by regulating the levels of apolipoprotein E and phosphorylated tau protein in mouse hippocampal neurons. ( Lian, N; Wang, Y; Xie, K; Yang, M; Yu, Y, 2020) |
| "Sevoflurane has been used to treat life-threatening asthma and our previous study shows that sevoflurane inhibits acute lung inflammation in ovalbumin (OVA)-induced allergic mice." | 5.51 | Sevoflurane Prevents Airway Remodeling via Downregulation of VEGF and TGF-β1 in Mice with OVA-Induced Chronic Airway Inflammation. ( Shen, QY; Wei, CS; Wu, HM; Wu, L; Zhou, YN, 2019) |
| "Although preoperative sleep deprivation is known to be an independent risk factor for postoperative cognitive dysfunction (POCD) after inhalation anesthesia, the circadian mechanisms involved are currently unclear." | 5.51 | REM sleep deprivation-induced circadian clock gene abnormalities participate in hippocampal-dependent memory impairment by enhancing inflammation in rats undergoing sevoflurane inhalation. ( Hou, J; Shen, Q; Wan, X; Wu, Y; Xia, Z; Zhao, B, 2019) |
| "Sevoflurane is a widely used volatile anesthetic in the clinical setting." | 5.48 | Sevoflurane exaggerates cognitive decline in a rat model of chronic intermittent hypoxia by aggravating microglia-mediated neuroinflammation via downregulation of PPAR-γ in the hippocampus. ( Dong, P; Li, D; Li, L; Li, N; Lu, L; Yang, B; Zhang, L; Zhang, X; Zhao, J, 2018) |
| "Tetrandrine is a bisbenzylisoquinoline alkaloid extracted from Stephania tetrandra, a traditional Chinese herbal medicine, which has been observed to exert anti‑inflammatory effects." | 5.43 | Tetrandrine ameliorates sevoflurane‑induced cognitive impairment via the suppression of inflammation and apoptosis in aged rats. ( Li, X; Ma, H; Pang, L; Yao, L; Yao, Q, 2016) |
| "To determine if isoflurane anesthesia without surgery causes systemic inflammation in children." | 5.24 | Selective induction of IL-1β after a brief isoflurane anesthetic in children undergoing MRI examination. ( Bissonnette, B; Christofi, FL; Quinn, KM; Tobias, JD; Whitaker, EE; Wiemann, BZ; Xia, JC, 2017) |
| "The results indicated that low dosage of fentanyl supplemented with DEX almost had the same anesthesia effects and inflammation extent compared with high dose of fentanyl, which suggested that infusion DEX might decrease fentanyl consumption in pediatric cardiac surgery." | 5.24 | Clinical efficacy of dexmedetomidine in the diminution of fentanyl dosage in pediatric cardiac surgery. ( Li, Y; Sun, Y; Wang, X; Xia, Y; Ye, H; Yuan, X, 2017) |
| "Databases were searched for randomized controlled trials examining perioperative inflammation after general anesthesia using propofol compared to sevoflurane." | 5.22 | Inflammatory Biomarker Levels After Propofol or Sevoflurane Anesthesia: A Meta-analysis. ( Atkins, KJ; Evered, LA; Lipszyc, A; O'Bryan, LJ; Scott, DA; Silbert, BS, 2022) |
| " Our hypothesis was that sevoflurane-based anaesthesia is associated with a reduced release of biomarkers of inflammation compared with TIVA with propofol/remifentanil." | 5.20 | Biomarkers of inflammation in major vascular surgery: a prospective randomised trial. ( Aune, E; Kirkebøen, KA; Lindholm, EE; Otterstad, JE; Seljeflot, I, 2015) |
| " The aim of this study was to establish and compare differences in inflammatory response among colorectal cancer surgery patients receiving either total intravenous anesthesia (TIVA) with propofol and remifentanil or inhalational anesthesia (INHAL) with sevoflurane and fentanyl." | 5.15 | Inflammatory response in patients undergoing colorectal cancer surgery: the effect of two different anesthetic techniques. ( Bengtson, JP; Bengtsson, A; Kvarnström, A; Sarbinowski, R; Tylman, M, 2011) |
| "Downregulation of SNHG3 attenuates sevoflurane-induced neuronal inflammation and pyroptosis by mediating the NEK7/NLRP3 axis, suggesting that SNHG3 could be a potential target gene for neuronal injury." | 4.31 | LncRNA SNHG3 Promotes Sevoflurane-Induced Neuronal Injury by Activating NLRP3 via NEK7. ( Chen, Y; Hu, N; Lei, X; Li, Q; Liang, MQ; Wang, FF, 2023) |
| "The expression of HOXA11-AS was observed in sevoflurane-treated rats or cells and promoted neuronal apoptosis and inflammation." | 4.31 | Effects of lncRNA HOXA11-AS on Sevoflurane-Induced Neuronal Apoptosis and Inflammatory Responses by Regulating miR-98-5p/EphA4. ( Chen, H; Du, Y; Ma, W; Ma, X; Peng, J; Tao, Q; Wang, Z; Wu, Z; Zhao, L, 2023) |
| "Postoperative cognitive dysfunction (POCD) is regularly observed in patients postsurgery due to the usage of anesthetics, including Sevoflurane." | 4.31 | Effects of miR-190a-3p on Sevoflurane-induced postoperative cognitive dysfunction (POCD). ( Guo, LL; Song, S; Wang, HY; Wang, Y; Zhang, J, 2023) |
| "This study assessed, for the first time, the expression of the genes hOGG1, TP53, and IL-6 in leukocytes by real-time quantitative polymerase chain reaction in surgical patients before (baseline), during (2 h of anesthesia) and 1 day after sevoflurane anesthesia." | 4.31 | Modulation of gene expression and inflammation but not DNA damage after sevoflurane anesthesia. ( Braz, JRC; Braz, LG; Braz, MG; Silva, MAP, 2023) |
| "Sevoflurane reduced inflammation, recovered cell division so as to suppress cell apoptosis and maintain cell survival, and activated autophagic flux in LPS-induced ALI models in vivo and in vitro." | 4.12 | Activation of the AMPK-ULK1 pathway mediated protective autophagy by sevoflurane anesthesia restrains LPS-induced acute lung injury (ALI). ( Fu, Z; Wu, X; Zhang, Y; Zheng, F, 2022) |
| "The anesthetic sevoflurane (SEV) has been shown to protect against organ's injury during sepsis." | 4.12 | Sevoflurane ameliorates LPS-induced inflammatory injury of HK-2 cells through Sirtuin1/NF-κB pathway. ( Miaomiao, Y; Peipei, W; Ping, W; Shuo, W, 2022) |
| "Sevoflurane or LPS treatment increased activated caspase-3 and caspase-9 expression in the hippocampal subiculum and CA1, which was greater when sevoflurane was administered in the setting of LPS-induced inflammation." | 4.12 | Systemic inflammation exacerbates developmental neurotoxicity induced by sevoflurane in neonatal rats. ( Cabrera, OH; Jevtovic-Todorovic, V; Liechty, C; Maksimovic, S; Quillinan, N; Useinovic, N, 2022) |
| "We aimed to explore the effects of hypercholesterolemia on sevoflurane-induced cognitive impairment in aged rats and the underlying mechanism(s)." | 4.12 | Hypercholesterolemia aggravates sevoflurane-induced cognitive impairment in aged rats by inducing neurological inflammation and apoptosis. ( Liu, L; Long, B; Wang, C; Wu, X; Zhang, X, 2022) |
| "In this study, the effects of exposure to isoflurane, sevoflurane and desflurane on the oxidative response and inflammation at different times was analyzed in the lungs of adult C57BL/6 mice." | 4.12 | The deleterious impact of exposure to different inhaled anesthetics is time dependent. ( Bezerra, FS; Cangussú, SD; Castro, TF; de Souza, ABF; Machado-Junior, PA; Perucci, LO; Talvani, A, 2022) |
| " The exposed group was constituted by anesthesia providers who were mainly exposed to the anesthetics sevoflurane and isoflurane (10 ppm) and to a lesser degree to nitrous oxide (150 ppm), and the control group was constituted by physicians who had no exposure to WAGs." | 4.02 | Oxidative stress, DNA damage, inflammation and gene expression in occupationally exposed university hospital anesthesia providers. ( Arruda, NM; Aun, AG; Braz, JRC; Braz, LG; Braz, MG; Chen, CY; Corrêa, CR; de Carvalho, LR; De Vivo, I; Figueiredo, DBS; Lara, JR; Nogueira, FR; Silva, MAP; Souza, KM, 2021) |
| "Sevoflurane induces inflammation of microglia in hippocampus of neonatal rats by inhibiting Wnt/β-Catenin/CaMKIV pathway." | 4.02 | Sevoflurane induces inflammation of microglia in hippocampus of neonatal rats by inhibiting Wnt/β-Catenin/CaMKIV pathway. ( Li, C; Ma, J; Shao, J; Wang, F, 2021) |
| " To elucidate the POCD molecular mechanism, sevoflurane was employed in the present study to generate neuroinflammation mice model." | 4.02 | Sevoflurane induces inflammation in primary hippocampal neurons by regulating Hoxa5/Gm5106/miR-27b-3p positive feedback loop. ( Ma, L; Zhu, Z, 2021) |
| "Sevoflurane administration in acute TBI did not prevent the development of oxidative stress and inflammation." | 3.96 | Evaluation of Neuroprotective Effect of Sevoflurane in Acute Traumatic Brain Injury: An Experimental Study in Rats. ( Dogan, G; Karaca, O, 2020) |
| "To investigate the expression of miR-203 by sevoflurane treatment and its effect on neuroinflammation induced by cerebral ischemia-reperfusion." | 3.96 | Sevoflurane Post-treatment Upregulated miR-203 Expression to Attenuate Cerebral Ischemia-Reperfusion-Induced Neuroinflammation by Targeting MyD88. ( Chen, H; Gu, C; Zhong, H, 2020) |
| " Sevoflurane, a clinical anesthetic, could stimulate neuro-inflammation and lead to POCD." | 3.96 | Silencing SP1 Alleviated Sevoflurane-Induced POCD Development via Cholinergic Anti-inflammatory Pathway. ( Li, C; Li, N; Lv, G; Wang, K; Wang, W, 2020) |
| "Our findings imply that apoptosis, inflammation, and oxidative stress in the hippocampal region of neonatal mouse brain were significantly reduced by pre-treatment with PCA before sevoflurane exposure." | 3.96 | Protective role of protocatechuic acid in sevoflurane-induced neuron apoptosis, inflammation and oxidative stress in mice. ( Gao, Y; Han, T; Ma, L; Wang, M; Wang, Y; Zhang, D, 2020) |
| "These data indicated that miR-410-3p exhibited its neuroprotective effect on sevoflurane anesthesia-induced CD by targeting CXCR5 via PI3K/Akt signaling pathway." | 3.91 | Neuroprotective effect of miR-410-3p against sevoflurane anesthesia-induced cognitive dysfunction in rats through PI3K/Akt signaling pathway via targeting C-X-C motif chemokine receptor 5. ( Feng, C; Su, R; Sun, P; Xiao, W; Zhang, D; Zhong, L, 2019) |
| "These results suggested that activation of SIRT3 by honokiol may attenuate surgery/anesthesia-induced cognitive impairment in mice through regulation of oxidative stress and neuroinflammatory in hippocampus." | 3.91 | SIRT3 activator honokiol ameliorates surgery/anesthesia-induced cognitive decline in mice through anti-oxidative stress and anti-inflammatory in hippocampus. ( Chen, L; Lei, SQ; Lu, YY; Peng, M; Xia, ZY; Ye, JS, 2019) |
| "These data suggest that the PI3K/Akt/mTOR pathway contributes to sevoflurane-induced neuroinflammation and that activation of PI3K/Akt/mTOR signaling by DEX could help reduce the neuroinflammatory effects of sevoflurane." | 3.91 | Dexmedetomidine suppresses sevoflurane anesthesia-induced neuroinflammation through activation of the PI3K/Akt/mTOR pathway. ( Wang, M; Wang, N, 2019) |
| "Sevoflurane was found to show protective roles in mice with asthma, however, the mechanism of which needs further exploring." | 3.91 | Sevoflurane modulates AQPs (1,5) expression and endoplasmic reticulum stress in mice lung with allergic airway inflammation. ( Lv, CM; Shen, QY; Wu, HM; Wu, L; Xu, GH; Yang, ZL, 2019) |
| " Sevoflurane (SEV), a widely used inhalational anesthetic, can exaggerate neuroinflammation and cause cognitive dysfunction under chronic intermittent hypoxia (CIH) conditions by downregulating hippocampal peroxisome proliferator‑activated receptor‑γ (PPAR‑γ)." | 3.91 | Pioglitazone prevents sevoflurane‑induced neuroinflammation and cognitive decline in a rat model of chronic intermittent hypoxia by upregulating hippocampal PPAR‑γ. ( Dong, P; Fei, J; Li, D; Li, L; Li, N; Lin, Q; Lu, L; Yang, B; Zhang, X, 2019) |
| "Our colleagues have demonstrated an impressive therapeutic role of sevoflurane in a murine allergic airway inflammation model, but the mechanisms underlying this effect remain undefined." | 3.88 | Sevoflurane Inhibits the Th2 Response and NLRP3 Expression in Murine Allergic Airway Inflammation. ( Cheng, C; Liu, R; Shen, Q; Wang, L; Wu, H; Zha, B; Zou, H, 2018) |
| "Anti-IL-17A may alleviate neuroinflammation and oxidative stress via inhibiting NF-κB pathway, thereby attenuating post-operative cognitive dysfunction (POCD) in aged rats anaesthetized with sevoflurane." | 3.88 | IL-17A promotes the neuroinflammation and cognitive function in sevoflurane anesthetized aged rats via activation of NF-κB signaling pathway. ( Yang, ZY; Yuan, CX, 2018) |
| "We have shown that systemic attenuation of inflammation by the volatile anaesthetic sevoflurane did not translate into attenuated neuro-inflammation in this LPS-induced inflammation model." | 3.85 | Sevoflurane attenuates systemic inflammation compared with propofol, but does not modulate neuro-inflammation: A laboratory rat study. ( Baumann, L; Beck-Schimmer, B; Booy, C; Eugster, P; Hasler, M; Restin, T; Schläpfer, M, 2017) |
| "Compared with isoflurane, sevoflurane did not affect lung inflammation in ARDSexp, but it did reduce lung inflammation in ARDSp." | 3.85 | Sevoflurane, Compared With Isoflurane, Minimizes Lung Damage in Pulmonary but Not in Extrapulmonary Acute Respiratory Distress Syndrome in Rats. ( Araújo, MN; Cavalcanti, VCM; Cruz, FF; Felix, NS; Fernandes, FC; Heil, LBB; Morales, MM; Pelosi, P; Rocco, PRM; Samary, CS; Santos, CL; Silva, JD; Silva, PL; Villela, NR, 2017) |
| "Deep anesthesia with sevoflurane even for a short-term period augments the release of inflammatory cytokines evoked by inflammatory insults like surgical stress, impairs the acid-base balance, and subsequently deteriorates the outcomes." | 3.83 | Deep anesthesia worsens outcome of rats with inflammatory responses. ( Igarashi, T; Inoue, K; Katori, N; Kosugi, S; Minamishima, S; Morisaki, H; Seki, H; Suzuki, T, 2016) |
| "Toll like receptor 2 involved in the anti-inflammatory effect of sevoflurane on asthmatic airway inflammation in mice." | 3.83 | [Effect of Toll-like receptor 2 on the inhibition role of sevoflurane on airway inflammation in asthmatic mice]. ( Fang, L; He, F; Liu, RY; Shen, QY; Wu, HM; Wu, L, 2016) |
| "Increases in plasma kynurenic acid (KYNA) concentration relate to the severity of inflammation." | 3.81 | Plasma kynurenic acid concentration in patients undergoing cardiac surgery: effect of anaesthesia. ( Dabrowski, W; Kotlinska-Hasiec, E; Nowicka-Stazka, P; Parada-Turska, J; Stazka, J; Stazka, K; Zadora, P, 2015) |
| " The aim of this study was to evaluate the effect of propofol on the apoptosis, Aβ accumulation, and inflammation induced by sevoflurane in human neuroglioma cells." | 3.81 | Anesthetic Propofol Attenuates Apoptosis, Aβ Accumulation, and Inflammation Induced by Sevoflurane Through NF-κB Pathway in Human Neuroglioma Cells. ( Guo, S; Guo, Y; Jian, L; Tian, Y, 2015) |
| "Repeated inhalation of sevoflurane (SVF) can benefit asthmatic patients by bronchodilation." | 3.81 | Repeated inhalation of sevoflurane inhibits airway inflammation in an OVA-induced mouse model of allergic airway inflammation. ( Ding, PS; Fang, L; He, F; Liu, RY; Shen, QY; Wu, HM, 2015) |
| "Sevoflurane, one of the most commonly used anesthetics in clinic, induced neuroinflammation and caused cognitive impairment." | 3.80 | 2-Deoxy-d-glucose attenuates sevoflurane-induced neuroinflammation through nuclear factor-kappa B pathway in vitro. ( Li, B; Liu, S; Sun, M; Wang, Q; Yang, L; Zhang, L; Zhao, Y, 2014) |
| "The goal of this study was to confirm whether or not sevoflurane is more effective than propofol in ameliorating the inflammatory response in an animal model of acute respiratory distress syndrome." | 3.79 | Sevoflurane, but not propofol, reduces the lung inflammatory response and improves oxygenation in an acute respiratory distress syndrome model: a randomised laboratory study. ( Aguilar, G; Belda, FJ; Ferrando, C; Moreno, J; Piqueras, L; Soro, M, 2013) |
| "Sevoflurane is an anesthetic agent which also participates in protective mechanisms in sepsis, likely due to anti-inflammatory properties." | 3.79 | Effects of sevoflurane postconditioning on cell death, inflammation and TLR expression in human endothelial cells exposed to LPS. ( Álvarez, J; Baluja, A; Brea, D; Rodríguez, A; Rodríguez, J; Rodríguez-González, R; Taboada, M; Veiras Del Río, S, 2013) |
| "Mice (N = 12 per treatment group) were exposed to anesthetic concentrations of desflurane, isoflurane, and sevoflurane either during induction of sepsis or when the mice showed pronounced symptoms of inflammation." | 3.79 | Volatile anesthetics improve survival after cecal ligation and puncture. ( Beck-Schimmer, B; Castellon, M; Hasler, M; Herrmann, IK; Hu, G; Minshall, RD; Schwartz, DE; Urner, M, 2013) |
| " We hypothesized that the volatile anesthetic sevoflurane (SEVO) attenuates lung inflammation through activation of lung epithelial GABA(A) receptors." | 3.78 | Effects of anesthetic regimes on inflammatory responses in a rat model of acute lung injury. ( Fortis, S; Haitsma, JJ; Lu, WY; Mazer, CD; Parotto, M; Slutsky, AS; Spieth, PM; Zhang, H; Zhong, N, 2012) |
| "Compared with sevoflurane, propofol administration during suprarenal aortic clamping and unclamping led to modulation of markers of inflammation and decreased NFkappaB expression." | 3.74 | The comparative abilities of propofol and sevoflurane to modulate inflammation and oxidative stress in the kidney after aortic cross-clamping. ( Cascajo, C; García-Criado, FJ; González-Sarmiento, R; Lozano, FS; Muriel, C; Nicolás, JL; Rodríguez-López, JM; Sánchez-Conde, P, 2008) |
| "We observed that preoperative hind limb muscle atrophy, indicated by TS, was associated with an increased occurrence of PND through the reduction in BDNF and neurogenesis after abdominal surgery in young adult rats." | 1.72 | Low Skeletal Muscle Mass Is Associated With Perioperative Neurocognitive Disorder Due To Decreased Neurogenesis in Rats. ( Goyagi, T; Nakagawasai, O; Nemoto, A; Nemoto, W; Niiyama, Y; Tan-No, K, 2022) |
| "Coenzyme Q10 (CoQ10) has been reported to reduce sevoflurane anesthesia‑induced cognitive deficiency in 6‑day‑old mice." | 1.56 | Coenzyme Q10 alleviates sevoflurane‑induced neuroinflammation by regulating the levels of apolipoprotein E and phosphorylated tau protein in mouse hippocampal neurons. ( Lian, N; Wang, Y; Xie, K; Yang, M; Yu, Y, 2020) |
| "Although preoperative sleep deprivation is known to be an independent risk factor for postoperative cognitive dysfunction (POCD) after inhalation anesthesia, the circadian mechanisms involved are currently unclear." | 1.51 | REM sleep deprivation-induced circadian clock gene abnormalities participate in hippocampal-dependent memory impairment by enhancing inflammation in rats undergoing sevoflurane inhalation. ( Hou, J; Shen, Q; Wan, X; Wu, Y; Xia, Z; Zhao, B, 2019) |
| "Sevoflurane has been used to treat life-threatening asthma and our previous study shows that sevoflurane inhibits acute lung inflammation in ovalbumin (OVA)-induced allergic mice." | 1.51 | Sevoflurane Prevents Airway Remodeling via Downregulation of VEGF and TGF-β1 in Mice with OVA-Induced Chronic Airway Inflammation. ( Shen, QY; Wei, CS; Wu, HM; Wu, L; Zhou, YN, 2019) |
| "Sevoflurane is a widely used volatile anesthetic in the clinical setting." | 1.48 | Sevoflurane exaggerates cognitive decline in a rat model of chronic intermittent hypoxia by aggravating microglia-mediated neuroinflammation via downregulation of PPAR-γ in the hippocampus. ( Dong, P; Li, D; Li, L; Li, N; Lu, L; Yang, B; Zhang, L; Zhang, X; Zhao, J, 2018) |
| "Tetrandrine is a bisbenzylisoquinoline alkaloid extracted from Stephania tetrandra, a traditional Chinese herbal medicine, which has been observed to exert anti‑inflammatory effects." | 1.43 | Tetrandrine ameliorates sevoflurane‑induced cognitive impairment via the suppression of inflammation and apoptosis in aged rats. ( Li, X; Ma, H; Pang, L; Yao, L; Yao, Q, 2016) |
| " Sevoflurane combined with ATP could increase the level of activated caspase-1, pyroptosis, and reactive oxygen species (ROS)." | 1.39 | Sevoflurane combined with ATP activates caspase-1 and triggers caspase-1-dependent pyroptosis in murine J774 macrophages. ( Chen, S; Fang, X; Jin, Y; Li, H; Wu, S; Xie, G, 2013) |
| "Sevoflurane is a specific activator of the apoptosis signal-regulating kinase-1-, MKK3/MKK6-p38 MAP kinase cascade in Jurkat T-cells." | 1.35 | Sevoflurane-mediated activation of p38-mitogen-activated stresskinase is independent of apoptosis in Jurkat T-cells. ( Auwaerter, V; Frick, M; Geiger, KK; Goebel, U; Humar, M; Loop, T; Pahl, HL; Pannen, BH; Roesslein, M; Schwer, C, 2008) |
| "Sevoflurane treatment resulted in phosphorylation of prosurvival kinases, ERK and Akt, and increased de novo HSP-70 protein synthesis without affecting the synthesis of HSP-27 or HSP-32." | 1.33 | Anti-inflammatory and antinecrotic effects of the volatile anesthetic sevoflurane in kidney proximal tubule cells. ( Emala, CW; Jan, M; Kim, M; Lee, HT, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (7.29) | 29.6817 |
| 2010's | 53 (55.21) | 24.3611 |
| 2020's | 36 (37.50) | 2.80 |
| Authors | Studies |
|---|---|
| Zhu, Z | 3 |
| Ma, L | 3 |
| O'Bryan, LJ | 1 |
| Atkins, KJ | 1 |
| Lipszyc, A | 1 |
| Scott, DA | 1 |
| Silbert, BS | 1 |
| Evered, LA | 1 |
| Gao, Y | 2 |
| Dai, P | 1 |
| Shi, L | 1 |
| Chen, W | 1 |
| Bao, W | 1 |
| He, L | 1 |
| Tan, Y | 1 |
| Neudecker, V | 1 |
| Perez-Zoghbi, JF | 1 |
| Brambrink, AM | 1 |
| Song, J | 1 |
| He, K | 1 |
| Yang, L | 2 |
| Shen, J | 1 |
| Nemoto, T | 1 |
| Irukayama-Tomobe, Y | 1 |
| Hirose, Y | 1 |
| Tanaka, H | 1 |
| Takahashi, G | 1 |
| Takahashi, S | 1 |
| Yanagisawa, M | 1 |
| Kanbayashi, T | 1 |
| Liu, L | 1 |
| Zhang, X | 3 |
| Wang, C | 2 |
| Wu, X | 6 |
| Long, B | 1 |
| Dai, Y | 1 |
| Yan, M | 1 |
| Wan, J | 1 |
| Xiao, T | 1 |
| Zheng, F | 2 |
| Zhang, J | 4 |
| Fu, Z | 2 |
| Zhang, Y | 2 |
| Useinovic, N | 1 |
| Maksimovic, S | 1 |
| Liechty, C | 1 |
| Cabrera, OH | 1 |
| Quillinan, N | 1 |
| Jevtovic-Todorovic, V | 1 |
| Peipei, W | 1 |
| Ping, W | 1 |
| Miaomiao, Y | 1 |
| Shuo, W | 1 |
| Machado-Junior, PA | 1 |
| de Souza, ABF | 1 |
| Castro, TF | 1 |
| Perucci, LO | 1 |
| Talvani, A | 1 |
| Cangussú, SD | 1 |
| Bezerra, FS | 1 |
| Deng, L | 1 |
| Jiang, L | 2 |
| Wei, N | 1 |
| Bleeser, T | 1 |
| Basurto, D | 1 |
| Russo, F | 1 |
| Vergote, S | 1 |
| Valenzuela, I | 1 |
| Van den Broucke, S | 1 |
| Kunpalin, Y | 1 |
| Joyeux, L | 1 |
| Van der Veeken, L | 1 |
| Vally, JC | 1 |
| Emam, D | 1 |
| van der Merwe, J | 1 |
| Van de Velde, M | 1 |
| Devroe, S | 1 |
| Deprest, J | 1 |
| Rex, S | 1 |
| Silva, MAP | 2 |
| Braz, LG | 4 |
| Braz, JRC | 2 |
| Braz, MG | 4 |
| Guo, LL | 1 |
| Wang, Y | 3 |
| Wang, HY | 1 |
| Song, S | 1 |
| Zhao, L | 2 |
| Wang, Z | 1 |
| Chen, H | 2 |
| Du, Y | 1 |
| Ma, W | 1 |
| Tao, Q | 1 |
| Ma, X | 1 |
| Wu, Z | 1 |
| Peng, J | 1 |
| Liang, MQ | 1 |
| Wang, FF | 1 |
| Li, Q | 1 |
| Lei, X | 1 |
| Chen, Y | 2 |
| Hu, N | 1 |
| Tang, C | 1 |
| Zheng, X | 1 |
| Zhong, Y | 1 |
| Chen, D | 1 |
| Zhu, Y | 3 |
| Wang, S | 1 |
| Xiong, L | 1 |
| Luo, Y | 1 |
| Liu, J | 1 |
| Hong, Y | 1 |
| Peng, S | 1 |
| Meng, S | 1 |
| Bie, X | 1 |
| Ao, J | 1 |
| Zhu, D | 1 |
| Zhang, C | 1 |
| Cao, G | 1 |
| Dong, X | 1 |
| Li, D | 3 |
| Yin, J | 1 |
| Zhao, X | 3 |
| Wang, L | 2 |
| Xie, X | 1 |
| Geng, H | 1 |
| Zhan, X | 1 |
| Teng, J | 1 |
| Lv, CM | 1 |
| Wu, HM | 4 |
| Wu, L | 3 |
| Xu, GH | 1 |
| Yang, ZL | 1 |
| Shen, QY | 4 |
| Zhong, H | 1 |
| Gu, C | 1 |
| Dogan, G | 1 |
| Karaca, O | 1 |
| Yang, M | 1 |
| Lian, N | 1 |
| Yu, Y | 2 |
| Xie, K | 1 |
| Lv, G | 1 |
| Li, C | 2 |
| Wang, W | 1 |
| Li, N | 3 |
| Wang, K | 1 |
| Han, T | 1 |
| Wang, M | 2 |
| Zhang, D | 2 |
| Chen, X | 1 |
| Li, M | 1 |
| Zheng, R | 1 |
| Huang, Q | 1 |
| Li, Y | 2 |
| Chen, Z | 1 |
| Lin, J | 1 |
| Li, W | 1 |
| Hu, Z | 1 |
| Xu, Y | 1 |
| Zhao, S | 1 |
| Fan, Z | 1 |
| Hu, J | 1 |
| Lin, C | 1 |
| Shen, T | 1 |
| Li, Z | 1 |
| Li, K | 1 |
| Liu, Z | 1 |
| Zhang, B | 1 |
| Souza, KM | 1 |
| De Vivo, I | 1 |
| Chen, CY | 1 |
| Nogueira, FR | 1 |
| Aun, AG | 1 |
| Arruda, NM | 1 |
| Lara, JR | 1 |
| Figueiredo, DBS | 1 |
| Corrêa, CR | 1 |
| de Carvalho, LR | 1 |
| Yuki, K | 1 |
| Mitsui, Y | 1 |
| Shibamura-Fujiogi, M | 1 |
| Hou, L | 1 |
| Odegard, KC | 1 |
| Soriano, SG | 1 |
| Priebe, GP | 1 |
| Koutsogiannaki, S | 1 |
| Wang, F | 1 |
| Shao, J | 1 |
| Ma, J | 1 |
| Wang, H | 1 |
| Sun, X | 1 |
| Nemoto, A | 1 |
| Goyagi, T | 1 |
| Nemoto, W | 1 |
| Nakagawasai, O | 1 |
| Tan-No, K | 1 |
| Niiyama, Y | 1 |
| Beck-Schimmer, B | 5 |
| Baumann, L | 1 |
| Restin, T | 1 |
| Eugster, P | 1 |
| Hasler, M | 4 |
| Booy, C | 3 |
| Schläpfer, M | 3 |
| Satomoto, M | 1 |
| Sun, Z | 1 |
| Adachi, YU | 1 |
| Kinoshita, H | 1 |
| Makita, K | 1 |
| Wagner, J | 1 |
| Strosing, KM | 1 |
| Spassov, SG | 1 |
| Lin, Z | 1 |
| Engelstaedter, H | 1 |
| Tacke, S | 1 |
| Hoetzel, A | 1 |
| Faller, S | 1 |
| Dong, P | 2 |
| Zhao, J | 1 |
| Lu, L | 2 |
| Li, L | 2 |
| Yang, B | 2 |
| Zhang, L | 2 |
| Sánchez-Pedrosa, G | 1 |
| Vara Ameigeiras, E | 1 |
| Casanova Barea, J | 1 |
| Rancan, L | 2 |
| Simón Adiego, CM | 1 |
| Garutti Martínez, I | 1 |
| Fan, CH | 1 |
| Peng, B | 1 |
| Zhang, FC | 1 |
| Ye, JS | 1 |
| Chen, L | 1 |
| Lu, YY | 1 |
| Lei, SQ | 1 |
| Peng, M | 1 |
| Xia, ZY | 1 |
| Yang, ZY | 1 |
| Yuan, CX | 1 |
| Zha, B | 1 |
| Shen, Q | 2 |
| Zou, H | 1 |
| Cheng, C | 1 |
| Wu, H | 1 |
| Liu, R | 1 |
| Wei, CS | 1 |
| Zhou, YN | 1 |
| Hou, J | 1 |
| Wan, X | 1 |
| Zhao, B | 1 |
| Wu, Y | 1 |
| Xia, Z | 1 |
| Lin, Q | 1 |
| Fei, J | 1 |
| Zhao, Y | 2 |
| Ai, Y | 1 |
| Su, R | 1 |
| Sun, P | 1 |
| Xiao, W | 1 |
| Feng, C | 1 |
| Zhong, L | 1 |
| Wang, N | 1 |
| Zhou, H | 1 |
| Zhou, D | 1 |
| Lu, J | 1 |
| Wu, C | 1 |
| Ferrando, C | 1 |
| Aguilar, G | 1 |
| Piqueras, L | 1 |
| Soro, M | 1 |
| Moreno, J | 1 |
| Belda, FJ | 1 |
| Rodríguez-González, R | 1 |
| Baluja, A | 1 |
| Veiras Del Río, S | 1 |
| Rodríguez, A | 1 |
| Rodríguez, J | 1 |
| Taboada, M | 1 |
| Brea, D | 1 |
| Álvarez, J | 1 |
| Herrmann, IK | 3 |
| Castellon, M | 1 |
| Schwartz, DE | 1 |
| Urner, M | 3 |
| Hu, G | 1 |
| Minshall, RD | 2 |
| Wang, Q | 1 |
| Sun, M | 1 |
| Liu, S | 1 |
| Li, B | 1 |
| Müller-Edenborn, B | 2 |
| Frick, R | 1 |
| Piegeler, T | 1 |
| Roth-Z'graggen, B | 2 |
| Schlicker, A | 2 |
| Kotlinska-Hasiec, E | 1 |
| Nowicka-Stazka, P | 1 |
| Parada-Turska, J | 1 |
| Stazka, K | 1 |
| Stazka, J | 1 |
| Zadora, P | 1 |
| Dabrowski, W | 1 |
| Huerta, L | 1 |
| Cusati, G | 1 |
| Erquicia, I | 1 |
| Isea, J | 1 |
| Paredes, SD | 1 |
| García, C | 1 |
| Garutti, I | 1 |
| Simón, C | 1 |
| Vara, E | 1 |
| Fang, L | 2 |
| He, F | 2 |
| Ding, PS | 1 |
| Liu, RY | 2 |
| Potočnik, I | 1 |
| Novak Janković, V | 1 |
| Šostarič, M | 1 |
| Jerin, A | 1 |
| Štupnik, T | 1 |
| Skitek, M | 1 |
| Markovič-Božič, J | 1 |
| Klokočovnik, T | 1 |
| Tian, Y | 2 |
| Guo, S | 2 |
| Lindholm, EE | 1 |
| Aune, E | 1 |
| Seljeflot, I | 1 |
| Otterstad, JE | 1 |
| Kirkebøen, KA | 1 |
| Guo, Y | 1 |
| Jian, L | 1 |
| Schimmer, RR | 1 |
| Roth Z'graggen, B | 1 |
| Rehrauer, H | 1 |
| Aigner, F | 1 |
| Stark, WJ | 2 |
| Lee, YM | 1 |
| Song, BC | 1 |
| Yeum, KJ | 1 |
| Sun, Y | 1 |
| Ye, H | 1 |
| Xia, Y | 1 |
| Yuan, X | 1 |
| Wang, X | 1 |
| Chaoul, MM | 1 |
| Braz, JR | 2 |
| Lucio, LM | 1 |
| Golim, MA | 2 |
| Breuer, T | 1 |
| Emontzpohl, C | 1 |
| Coburn, M | 1 |
| Benstoem, C | 1 |
| Rossaint, R | 1 |
| Marx, G | 1 |
| Schälte, G | 1 |
| Bernhagen, J | 1 |
| Bruells, CS | 1 |
| Goetzenich, A | 1 |
| Stoppe, C | 1 |
| Qiao, Y | 1 |
| Feng, H | 1 |
| Zhao, T | 1 |
| Yan, H | 1 |
| Zhang, H | 2 |
| Nakanuno, R | 1 |
| Yasuda, T | 1 |
| Hamada, H | 1 |
| Yoshikawa, H | 1 |
| Nakamura, R | 1 |
| Saeki, N | 1 |
| Kawamoto, M | 1 |
| Inoue, K | 1 |
| Suzuki, T | 1 |
| Igarashi, T | 1 |
| Minamishima, S | 1 |
| Seki, H | 1 |
| Kosugi, S | 1 |
| Katori, N | 1 |
| Morisaki, H | 1 |
| Ma, H | 1 |
| Yao, L | 1 |
| Pang, L | 1 |
| Li, X | 1 |
| Yao, Q | 1 |
| Whitaker, EE | 1 |
| Christofi, FL | 1 |
| Quinn, KM | 1 |
| Wiemann, BZ | 1 |
| Xia, JC | 1 |
| Tobias, JD | 1 |
| Bissonnette, B | 1 |
| Araújo, MN | 1 |
| Santos, CL | 1 |
| Samary, CS | 1 |
| Heil, LBB | 1 |
| Cavalcanti, VCM | 1 |
| Cruz, FF | 1 |
| Felix, NS | 1 |
| Silva, JD | 1 |
| Morales, MM | 1 |
| Pelosi, P | 1 |
| Fernandes, FC | 1 |
| Villela, NR | 1 |
| Silva, PL | 1 |
| Rocco, PRM | 1 |
| Sanders, RD | 1 |
| Maze, M | 1 |
| Tylman, M | 1 |
| Sarbinowski, R | 1 |
| Bengtson, JP | 1 |
| Kvarnström, A | 1 |
| Bengtsson, A | 1 |
| Limbach, LK | 1 |
| Reyes, L | 1 |
| Schilling, T | 1 |
| Kozian, A | 1 |
| Senturk, M | 1 |
| Huth, C | 1 |
| Reinhold, A | 1 |
| Hedenstierna, G | 1 |
| Hachenberg, T | 1 |
| Hasegawa, A | 1 |
| Iwasaka, H | 1 |
| Hagiwara, S | 1 |
| Hasegawa, R | 1 |
| Kudo, K | 1 |
| Kusaka, J | 1 |
| Asai, N | 1 |
| Noguchi, T | 1 |
| Fortis, S | 1 |
| Spieth, PM | 1 |
| Lu, WY | 1 |
| Parotto, M | 1 |
| Haitsma, JJ | 1 |
| Slutsky, AS | 1 |
| Zhong, N | 1 |
| Mazer, CD | 1 |
| Orosz, JE | 1 |
| Barreira, MA | 1 |
| Fecchio, D | 1 |
| Jin, Y | 1 |
| Li, H | 1 |
| Xie, G | 1 |
| Chen, S | 1 |
| Wu, S | 1 |
| Fang, X | 1 |
| Qiao, S | 1 |
| Xie, H | 1 |
| Liu, H | 1 |
| Liu, C | 1 |
| Watanabe, K | 1 |
| Iwahara, C | 1 |
| Nakayama, H | 1 |
| Iwabuchi, K | 1 |
| Matsukawa, T | 1 |
| Yokoyama, K | 1 |
| Yamaguchi, K | 1 |
| Kamiyama, Y | 1 |
| Inada, E | 1 |
| Ye, X | 1 |
| Lian, Q | 1 |
| Eckenhoff, MF | 1 |
| Eckenhoff, RG | 1 |
| Pan, JZ | 1 |
| Longás Valién, J | 1 |
| Guerrero Pardos, LM | 1 |
| Gonzalo González, A | 1 |
| Infantes Morales, M | 1 |
| Rodríguez Zazo, A | 1 |
| Abengochea Beisty, JM | 1 |
| Lee, HT | 1 |
| Kim, M | 1 |
| Jan, M | 1 |
| Emala, CW | 1 |
| Winterhalter, M | 1 |
| Brandl, K | 1 |
| Rahe-Meyer, N | 1 |
| Osthaus, A | 1 |
| Hecker, H | 1 |
| Hagl, C | 1 |
| Adams, HA | 1 |
| Piepenbrock, S | 1 |
| Sánchez-Conde, P | 1 |
| Rodríguez-López, JM | 1 |
| Nicolás, JL | 1 |
| Lozano, FS | 1 |
| García-Criado, FJ | 1 |
| Cascajo, C | 1 |
| González-Sarmiento, R | 1 |
| Muriel, C | 1 |
| Roesslein, M | 1 |
| Frick, M | 1 |
| Auwaerter, V | 1 |
| Humar, M | 1 |
| Goebel, U | 1 |
| Schwer, C | 1 |
| Geiger, KK | 1 |
| Pahl, HL | 1 |
| Pannen, BH | 1 |
| Loop, T | 1 |
| Cavalca, V | 1 |
| Colli, S | 1 |
| Veglia, F | 1 |
| Eligini, S | 1 |
| Zingaro, L | 1 |
| Squellerio, I | 1 |
| Rondello, N | 1 |
| Cighetti, G | 1 |
| Tremoli, E | 1 |
| Sisillo, E | 1 |
| Goto, Y | 1 |
| Ho, SL | 1 |
| McAdoo, J | 1 |
| Fanning, NF | 1 |
| Wang, J | 1 |
| Redmond, HP | 1 |
| Shorten, GD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of a Perioperative Opioid Free Anaesthesia-Analgesia (OFA-A) Strategy on Surgical Stress Response and Immunomodulation in Elective VATS Lobectomy for NSCLC Lung Cancer: A Prospective Randomized Study[NCT05172739] | Phase 4 | 70 participants (Anticipated) | Interventional | 2021-10-01 | Recruiting | ||
| AnaConDa-therapy in COVID-19 Patients[NCT05586126] | 42 participants (Actual) | Observational | 2020-10-01 | Terminated (stopped due to Concerns about possible association between drug and increased ICU mortality) | |||
| Volatile Anesthetic Pharmacokinetics During Extracorporeal Membrane[NCT05680545] | 10 participants (Anticipated) | Interventional | 2024-07-01 | Not yet recruiting | |||
| A Randomized Pilot Clinical Trial of the Effects in Oxygenation and Hypoxic Pulmonary Vasoconstriction of Sevoflurane in Patient's Whit ARDS Secondary to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2)[NCT04998253] | Early Phase 1 | 24 participants (Actual) | Interventional | 2020-10-01 | Completed | ||
| Phase 1 Study of Antiinflammatory Effect of Sevoflurane in Open Lung Surgery With One-Lung Ventilation[NCT02188407] | Phase 1 | 40 participants (Actual) | Interventional | 2008-07-31 | Completed | ||
| The Safety and Feasibility of Delivering Xenon to Patients Before and After Coronary Artery Bypass Graft Implantation: a Pilot Study[NCT01285271] | Phase 3 | 30 participants (Actual) | Interventional | 2011-05-31 | Completed | ||
| Comparison of the Effects of Total Intravenous Anesthesia and Inhalation Anesthesia on Lymphocytes in Patients Undergoing Colorectal Cancer Resection and the Mechanism Involved: a Single-center, Randomized, Prospective Study[NCT03193710] | 260 participants (Anticipated) | Observational | 2017-09-01 | Recruiting | |||
| Neuroplasticity Induced by General Anaesthesia[NCT04125121] | 20 participants (Actual) | Interventional | 2019-09-26 | Completed | |||
| Effect of Remifentanil on Postoperative Cognitive Function in Patients Undergoing Major Abdominal Surgery[NCT01627873] | Phase 4 | 622 participants (Actual) | Interventional | 2009-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for sevoflurane and Innate Inflammatory Response
| Article | Year |
|---|---|
Inflammatory Biomarker Levels After Propofol or Sevoflurane Anesthesia: A Meta-analysis.
Topics: Anesthesia, General; Anesthetics; Anesthetics, Inhalation; Anesthetics, Intravenous; Biomarkers; C-R | 2022 |
Impact of Volatile Anesthetics on Oxidative Stress and Inflammation.
Topics: Anesthetics; Antioxidants; DNA Damage; Humans; Inflammation; Isoflurane; Methyl Ethers; Oxidative St | 2015 |
14 trials available for sevoflurane and Innate Inflammatory Response
| Article | Year |
|---|---|
Effect of sevoflurane preconditioning on sleep reintegration after alteration by lipopolysaccharide.
Topics: Animals; Choline O-Acetyltransferase; Electroencephalography; Inflammation; Lipopolysaccharides; Mic | 2022 |
Effects of Pre-Cardiopulmonary Bypass Administration of Dexmedetomidine on Cardiac Injuries and the Inflammatory Response in Valve Replacement Surgery With a Sevoflurane Postconditioning Protocol: A Pilot Study.
Topics: Aged; Anti-Inflammatory Agents; Biomarkers; Cardiopulmonary Bypass; China; Cytokines; Dexmedetomidin | 2019 |
Antiinflammatory effect of sevoflurane in open lung surgery with one-lung ventilation.
Topics: Adult; Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Cytokines; Female; Humans; Inflammat | 2014 |
Biomarkers of inflammation in major vascular surgery: a prospective randomised trial.
Topics: Aged; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intravenous; Biomarkers; C-Reac | 2015 |
Clinical efficacy of dexmedetomidine in the diminution of fentanyl dosage in pediatric cardiac surgery.
Topics: Adjuvants, Anesthesia; Airway Extubation; Cardiac Surgical Procedures; Child; Child, Preschool; Dexm | 2017 |
Xenon triggers pro-inflammatory effects and suppresses the anti-inflammatory response compared to sevoflurane in patients undergoing cardiac surgery.
Topics: Anesthetics, Inhalation; Cell Migration Assays, Leukocyte; Chemokine CXCL12; Coronary Artery Bypass; | 2015 |
Postoperative cognitive dysfunction after inhalational anesthesia in elderly patients undergoing major surgery: the influence of anesthetic technique, cerebral injury and systemic inflammation.
Topics: Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Cognition Disorders; Double-Blind Method; E | 2015 |
Selective induction of IL-1β after a brief isoflurane anesthetic in children undergoing MRI examination.
Topics: Anesthesia, General; Anesthetics, Inhalation; Child; Child, Preschool; Cytokines; Female; Humans; In | 2017 |
Inflammatory response in patients undergoing colorectal cancer surgery: the effect of two different anesthetic techniques.
Topics: Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intrave | 2011 |
Effects of volatile and intravenous anesthesia on the alveolar and systemic inflammatory response in thoracic surgical patients.
Topics: Adult; Aged; Airway Management; Anesthesia, General; Anesthesia, Inhalation; Anesthesia, Intravenous | 2011 |
Effects of volatile and intravenous anesthesia on the alveolar and systemic inflammatory response in thoracic surgical patients.
Topics: Adult; Aged; Airway Management; Anesthesia, General; Anesthesia, Inhalation; Anesthesia, Intravenous | 2011 |
Effects of volatile and intravenous anesthesia on the alveolar and systemic inflammatory response in thoracic surgical patients.
Topics: Adult; Aged; Airway Management; Anesthesia, General; Anesthesia, Inhalation; Anesthesia, Intravenous | 2011 |
Effects of volatile and intravenous anesthesia on the alveolar and systemic inflammatory response in thoracic surgical patients.
Topics: Adult; Aged; Airway Management; Anesthesia, General; Anesthesia, Inhalation; Anesthesia, Intravenous | 2011 |
[Comparison of 4 techniques for general anesthesia for carotid endarterectomy: inflammatory response, cardiocirculatory complications, and postoperative analgesia].
Topics: Aged; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Cardiovascular Disease | 2004 |
Endocrine stress response and inflammatory activation during CABG surgery. A randomized trial comparing remifentanil infusion to intermittent fentanyl.
Topics: Adrenocorticotropic Hormone; Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Coronary Arter | 2008 |
Anesthetic propofol enhances plasma gamma-tocopherol levels in patients undergoing cardiac surgery.
Topics: Aged; Aged, 80 and over; alpha-Tocopherol; Anesthetics, Inhalation; Anesthetics, Intravenous; Biomar | 2008 |
General versus regional anaesthesia for cataract surgery: effects on neutrophil apoptosis and the postoperative pro-inflammatory state.
Topics: Aged; Analysis of Variance; Anesthesia, Inhalation; Anesthesia, Local; Anesthetics, Inhalation; Anes | 2000 |
80 other studies available for sevoflurane and Innate Inflammatory Response
| Article | Year |
|---|---|
Sevoflurane induces inflammation in primary hippocampal neurons by regulating Hoxa5/Gm5106/miR-27b-3p positive feedback loop.
Topics: Animals; Base Sequence; Cell Line, Tumor; Cells, Cultured; Feedback, Physiological; Gene Expression | 2021 |
Effects of ultrasound-guided brachial plexus block combined with laryngeal mask sevoflurane general anesthesia on inflammation and stress response in children undergoing upper limb fracture surgery.
Topics: Anesthesia, General; Brachial Plexus Block; Child; Humans; Inflammation; Laryngeal Masks; Sevofluran | 2022 |
Does inflammation mediate behavioural alterations in anaesthesia-induced developmental neurotoxicity?
Topics: Anesthesia; Animals; Humans; Inflammation; Neurotoxicity Syndromes; Rats; Sevoflurane | 2022 |
Sevoflurane protects mice from cerebral ischaemic injury by regulating microRNA-203-3p/HDAC4/Bcl-2 axis.
Topics: Animals; Apoptosis; Histone Deacetylases; Infarction, Middle Cerebral Artery; Inflammation; Mice; Mi | 2022 |
Hypercholesterolemia aggravates sevoflurane-induced cognitive impairment in aged rats by inducing neurological inflammation and apoptosis.
Topics: Animals; Apoptosis; Cognitive Dysfunction; Hypercholesterolemia; Inflammation; Rats; Rats, Sprague-D | 2022 |
Maf1 mitigates sevoflurane-induced microglial inflammatory damage and attenuates microglia-mediated neurotoxicity in HT-22 cells by activating the AMPK/Nrf2 signaling.
Topics: AMP-Activated Protein Kinases; Animals; Cell Line; Inflammation; Lipopolysaccharides; Mice; Microgli | 2022 |
Sevoflurane suppresses NLRP3 inflammasome-mediated pyroptotic cell death to attenuate lipopolysaccharide-induced acute lung injury through inducing GSK-3β phosphorylation and activation.
Topics: Acute Lung Injury; Animals; Glycogen Synthase Kinase 3 beta; Inflammasomes; Inflammation; Lipopolysa | 2022 |
Activation of the AMPK-ULK1 pathway mediated protective autophagy by sevoflurane anesthesia restrains LPS-induced acute lung injury (ALI).
Topics: Acute Lung Injury; AMP-Activated Protein Kinases; Anesthesia; Animals; Autophagy; Autophagy-Related | 2022 |
Systemic inflammation exacerbates developmental neurotoxicity induced by sevoflurane in neonatal rats.
Topics: Animals; Animals, Newborn; Caspase 1; Caspase 3; Caspase 9; Cytokines; Inflammation; Interleukin-18; | 2022 |
Sevoflurane ameliorates LPS-induced inflammatory injury of HK-2 cells through Sirtuin1/NF-κB pathway.
Topics: Acute Kidney Injury; Epithelial Cells; Humans; Inflammation; Lipopolysaccharides; NF-kappa B; Sepsis | 2022 |
The deleterious impact of exposure to different inhaled anesthetics is time dependent.
Topics: Anesthetics, Inhalation; Animals; Catalase; Desflurane; Inflammation; Isoflurane; Methyl Ethers; Mic | 2022 |
Anesthetic sevoflurane simultaneously regulates autophagic flux and pyroptotic cell death-associated cellular inflammation in the hypoxic/re-oxygenated cardiomyocytes: Identification of sevoflurane as putative drug for the treatment of myocardial ischemia
Topics: AMP-Activated Protein Kinases; Anesthetics; Animals; Autophagy; Hypoxia; Inflammation; Mice; Myocard | 2022 |
Effects of cumulative duration of repeated anaesthesia exposure on foetal brain development in the ovine model.
Topics: Anesthesia; Animals; Brain; Female; Fetus; Inflammation; Pregnancy; Sevoflurane; Sheep | 2023 |
Modulation of gene expression and inflammation but not DNA damage after sevoflurane anesthesia.
Topics: Anesthesia; Anesthetics, Inhalation; Gene Expression; Humans; Inflammation; Interleukin-6; Sevoflura | 2023 |
Effects of miR-190a-3p on Sevoflurane-induced postoperative cognitive dysfunction (POCD).
Topics: Animals; Cognitive Dysfunction; Inflammation; MicroRNAs; NF-E2-Related Factor 2; Postoperative Cogni | 2023 |
Effects of lncRNA HOXA11-AS on Sevoflurane-Induced Neuronal Apoptosis and Inflammatory Responses by Regulating miR-98-5p/EphA4.
Topics: Animals; Apoptosis; Inflammation; Interleukin-6; MicroRNAs; Rats; Receptor, EphA4; RNA, Long Noncodi | 2023 |
LncRNA SNHG3 Promotes Sevoflurane-Induced Neuronal Injury by Activating NLRP3 via NEK7.
Topics: Heterogeneous-Nuclear Ribonucleoproteins; Humans; Inflammation; MicroRNAs; Neurons; NIMA-Related Kin | 2023 |
The role of TREM1 in regulating microglial polarization in sevoflurane-induced perioperative neurocognitive disorders.
Topics: Animals; Inflammation; Mice; Microglia; Neurocognitive Disorders; Sevoflurane; Triggering Receptor E | 2023 |
Sevoflurane-induced hypotension causes cognitive dysfunction and hippocampal inflammation in mice.
Topics: Animals; Cognitive Dysfunction; Hippocampus; Hypotension, Controlled; Inflammation; Mice; Sevofluran | 2023 |
Sevoflurane attenuates myocardial ischemia/reperfusion injury by up-regulating microRNA-99a and down-regulating BRD4.
Topics: Animals; Apoptosis; Inflammation; Mice; MicroRNAs; Myocardial Reperfusion Injury; Myocytes, Cardiac; | 2023 |
Higher Circulating Trimethylamine N-oxide Sensitizes Sevoflurane-Induced Cognitive Dysfunction in Aged Rats Probably by Downregulating Hippocampal Methionine Sulfoxide Reductase A.
Topics: Animals; Cognitive Dysfunction; Down-Regulation; Fear; Hippocampus; Inflammation; Interleukin-1beta; | 2019 |
Sevoflurane-induced inflammation development: involvement of cholinergic anti-inflammatory pathway.
Topics: Acetylcholinesterase; alpha7 Nicotinic Acetylcholine Receptor; Anesthetics, Inhalation; Animals; Ben | 2019 |
Sevoflurane modulates AQPs (1,5) expression and endoplasmic reticulum stress in mice lung with allergic airway inflammation.
Topics: Animals; Aquaporins; Asthma; Cytokines; Endoplasmic Reticulum Stress; Female; Hypersensitivity; Infl | 2019 |
Sevoflurane Post-treatment Upregulated miR-203 Expression to Attenuate Cerebral Ischemia-Reperfusion-Induced Neuroinflammation by Targeting MyD88.
Topics: Animals; Brain Ischemia; Drug Delivery Systems; Gene Expression; Inflammation; Male; MicroRNAs; Myel | 2020 |
Evaluation of Neuroprotective Effect of Sevoflurane in Acute Traumatic Brain Injury: An Experimental Study in Rats.
Topics: Animals; Brain Injuries, Traumatic; Inflammation; Male; Neuroprotective Agents; Oxidative Stress; Ra | 2020 |
Coenzyme Q10 alleviates sevoflurane‑induced neuroinflammation by regulating the levels of apolipoprotein E and phosphorylated tau protein in mouse hippocampal neurons.
Topics: Anesthetics, Inhalation; Animals; Apolipoproteins E; Cells, Cultured; Hippocampus; Inflammation; Mic | 2020 |
Silencing SP1 Alleviated Sevoflurane-Induced POCD Development via Cholinergic Anti-inflammatory Pathway.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Anesthetics, Inhalation; Animals; Apoptosis; Gene Knockdown | 2020 |
Protective role of protocatechuic acid in sevoflurane-induced neuron apoptosis, inflammation and oxidative stress in mice.
Topics: Animals; Animals, Newborn; Apoptosis; Cognition; Hippocampus; Hydroxybenzoates; Inflammation; Maze L | 2020 |
Effects of sevoflurane inhalation anesthesia on IL-6, TNF-α and MMP-9 expression and hemodynamics in elderly patients undergoing lobectomy for lung cancer.
Topics: Aged; Anesthesia, Inhalation; Blood Pressure; Female; Heart Rate; Hemodynamics; Humans; Inflammation | 2020 |
Overexpression of NLRC3 enhanced inhibition effect of sevoflurane on inflammation in an ischaemia reperfusion cell model.
Topics: Animals; Inflammasomes; Inflammation; Intercellular Signaling Peptides and Proteins; NF-kappa B; PC1 | 2020 |
The differential effects of isoflurane and sevoflurane on neonatal mice.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Female; Infl | 2020 |
Oxidative stress, DNA damage, inflammation and gene expression in occupationally exposed university hospital anesthesia providers.
Topics: Adult; Aged; Air Pollutants, Occupational; Anesthesia; Anesthetics, Inhalation; Antioxidants; DNA Da | 2021 |
Anesthetics isoflurane and sevoflurane attenuate flagellin-mediated inflammation in the lung.
Topics: Anesthetics, Inhalation; Animals; Cell Line, Tumor; Cystic Fibrosis; Epithelial Cells; Female; Flage | 2021 |
Sevoflurane induces inflammation of microglia in hippocampus of neonatal rats by inhibiting Wnt/β-Catenin/CaMKIV pathway.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; beta Catenin; Calcium-Calmodulin-Dependent Prote | 2021 |
Sevoflurane Postconditioning Reduces Hypoxia/Reoxygenation Injury in Cardiomyocytes via Upregulation of Heat Shock Protein 70.
Topics: Animals; Apoptosis; Cell Cycle; Cell Line; Cell Survival; Gene Expression; HSP70 Heat-Shock Proteins | 2021 |
Low Skeletal Muscle Mass Is Associated With Perioperative Neurocognitive Disorder Due To Decreased Neurogenesis in Rats.
Topics: Animals; Atrophy; Behavior, Animal; Blood Pressure; Cognition; Cognitive Dysfunction; Fear; Hippocam | 2022 |
Sevoflurane attenuates systemic inflammation compared with propofol, but does not modulate neuro-inflammation: A laboratory rat study.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Inflammation; Inflammation Mediators; Li | 2017 |
Sevoflurane preconditioning ameliorates lipopolysaccharide-induced cognitive impairment in mice.
Topics: Amyloid beta-Peptides; Animals; Cognitive Dysfunction; Delirium; Disease Models, Animal; Inflammatio | 2018 |
Sevoflurane posttreatment prevents oxidative and inflammatory injury in ventilator-induced lung injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Chemokine CCL4; Disease Models, Anim | 2018 |
Sevoflurane exaggerates cognitive decline in a rat model of chronic intermittent hypoxia by aggravating microglia-mediated neuroinflammation via downregulation of PPAR-γ in the hippocampus.
Topics: Anesthetics, Inhalation; Animals; Chronic Disease; Cognitive Dysfunction; Disease Models, Animal; Do | 2018 |
Role of surgical manipulation in lung inflammatory response in a model of lung resection surgery.
Topics: Anesthetics, Inhalation; Animals; Biomarkers; Cytokines; Disease Models, Animal; Inflammation; Lung; | 2018 |
The postoperative effect of sevoflurane inhalational anesthesia on cognitive function and inflammatory response of pediatric patients.
Topics: Adolescent; Anesthesia, Inhalation; Child; Child, Preschool; Cognitive Dysfunction; Female; Humans; | 2018 |
SIRT3 activator honokiol ameliorates surgery/anesthesia-induced cognitive decline in mice through anti-oxidative stress and anti-inflammatory in hippocampus.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Anti-Inflammatory Agents; Biphenyl Compounds; Cognitiv | 2019 |
IL-17A promotes the neuroinflammation and cognitive function in sevoflurane anesthetized aged rats via activation of NF-κB signaling pathway.
Topics: Age Factors; Anesthetics, Inhalation; Animals; Cognition; Cognitive Dysfunction; Enzyme-Linked Immun | 2018 |
Sevoflurane Inhibits the Th2 Response and NLRP3 Expression in Murine Allergic Airway Inflammation.
Topics: Animals; Anti-Allergic Agents; Asthma; Cytokines; Disease Models, Animal; Female; Humans; Hypersensi | 2018 |
Sevoflurane Prevents Airway Remodeling via Downregulation of VEGF and TGF-β1 in Mice with OVA-Induced Chronic Airway Inflammation.
Topics: Airway Remodeling; Anesthetics, Inhalation; Animals; Asthma; Down-Regulation; Female; Inflammation; | 2019 |
REM sleep deprivation-induced circadian clock gene abnormalities participate in hippocampal-dependent memory impairment by enhancing inflammation in rats undergoing sevoflurane inhalation.
Topics: Animals; Circadian Clocks; Cognition Disorders; Gene Expression; Gene Expression Regulation; Hippoca | 2019 |
Pioglitazone prevents sevoflurane‑induced neuroinflammation and cognitive decline in a rat model of chronic intermittent hypoxia by upregulating hippocampal PPAR‑γ.
Topics: Animals; Chronic Disease; Cognitive Dysfunction; Disease Models, Animal; Hippocampus; Hypoglycemic A | 2019 |
Overexpression of lncRNA Gm15621 alleviates apoptosis and inflammation response resulting from sevoflurane treatment through inhibiting miR-133a/Sox4.
Topics: Animals; Apoptosis; Cells, Cultured; Cognitive Dysfunction; Gene Expression Regulation; Hippocampus; | 2020 |
Neuroprotective effect of miR-410-3p against sevoflurane anesthesia-induced cognitive dysfunction in rats through PI3K/Akt signaling pathway via targeting C-X-C motif chemokine receptor 5.
Topics: Anesthesia; Animals; Apoptosis; Cognitive Dysfunction; Disease Models, Animal; Down-Regulation; Hipp | 2019 |
Dexmedetomidine suppresses sevoflurane anesthesia-induced neuroinflammation through activation of the PI3K/Akt/mTOR pathway.
Topics: Anesthetics, Inhalation; Animals; Cerebral Cortex; Chromones; Cytokines; Dexmedetomidine; Disease Mo | 2019 |
Sevoflurane, but not propofol, reduces the lung inflammatory response and improves oxygenation in an acute respiratory distress syndrome model: a randomised laboratory study.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Cell Membrane Permeability; Disease Models, Animal; He | 2013 |
Sevoflurane, but not propofol, reduces the lung inflammatory response and improves oxygenation in an acute respiratory distress syndrome model: a randomised laboratory study.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Cell Membrane Permeability; Disease Models, Animal; He | 2013 |
Sevoflurane, but not propofol, reduces the lung inflammatory response and improves oxygenation in an acute respiratory distress syndrome model: a randomised laboratory study.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Cell Membrane Permeability; Disease Models, Animal; He | 2013 |
Sevoflurane, but not propofol, reduces the lung inflammatory response and improves oxygenation in an acute respiratory distress syndrome model: a randomised laboratory study.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Cell Membrane Permeability; Disease Models, Animal; He | 2013 |
Sevoflurane, but not propofol, reduces the lung inflammatory response and improves oxygenation in an acute respiratory distress syndrome model: a randomised laboratory study.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Cell Membrane Permeability; Disease Models, Animal; He | 2013 |
Sevoflurane, but not propofol, reduces the lung inflammatory response and improves oxygenation in an acute respiratory distress syndrome model: a randomised laboratory study.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Cell Membrane Permeability; Disease Models, Animal; He | 2013 |
Sevoflurane, but not propofol, reduces the lung inflammatory response and improves oxygenation in an acute respiratory distress syndrome model: a randomised laboratory study.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Cell Membrane Permeability; Disease Models, Animal; He | 2013 |
Sevoflurane, but not propofol, reduces the lung inflammatory response and improves oxygenation in an acute respiratory distress syndrome model: a randomised laboratory study.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Cell Membrane Permeability; Disease Models, Animal; He | 2013 |
Sevoflurane, but not propofol, reduces the lung inflammatory response and improves oxygenation in an acute respiratory distress syndrome model: a randomised laboratory study.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Cell Membrane Permeability; Disease Models, Animal; He | 2013 |
Effects of sevoflurane postconditioning on cell death, inflammation and TLR expression in human endothelial cells exposed to LPS.
Topics: Cell Death; Cell Survival; Culture Media; Escherichia coli; Gene Expression Regulation; Human Umbili | 2013 |
Volatile anesthetics improve survival after cecal ligation and puncture.
Topics: Anesthetics, Inhalation; Animals; Cecum; Desflurane; Disease Models, Animal; Inflammation; Isofluran | 2013 |
2-Deoxy-d-glucose attenuates sevoflurane-induced neuroinflammation through nuclear factor-kappa B pathway in vitro.
Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Deoxyglucose; Inflammation; Interleukin-6; Methy | 2014 |
Volatile anaesthetics reduce neutrophil inflammatory response by interfering with CXC receptor-2 signalling.
Topics: Adult; Anesthetics, Inhalation; Desflurane; Female; Flow Cytometry; Humans; Inflammation; Isoflurane | 2015 |
Plasma kynurenic acid concentration in patients undergoing cardiac surgery: effect of anaesthesia.
Topics: Aged; Anesthesia; Biomarkers; Cardiopulmonary Bypass; Female; Humans; Inflammation; Kynurenic Acid; | 2015 |
Sevoflurane prevents liver inflammatory response induced by lung ischemia-reperfusion.
Topics: Anesthetics, Inhalation; Animals; C-Reactive Protein; Caspase 3; Chemokine CCL2; Ferritins; Hemodyna | 2014 |
Repeated inhalation of sevoflurane inhibits airway inflammation in an OVA-induced mouse model of allergic airway inflammation.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchodilator Agents; Disease Models, Animal; Eosino | 2015 |
Minocycline alleviates sevoflurane-induced cognitive impairment in aged rats.
Topics: Aging; Amyloid beta-Peptides; Animals; Apoptosis; Cognition Disorders; Hippocampus; Inflammation; Le | 2015 |
Anesthetic Propofol Attenuates Apoptosis, Aβ Accumulation, and Inflammation Induced by Sevoflurane Through NF-κB Pathway in Human Neuroglioma Cells.
Topics: Amyloid beta-Peptides; Anesthetics; Apoptosis; Glioma; Humans; Inflammation; Methyl Ethers; Neurogli | 2015 |
Insight into the beneficial immunomodulatory mechanism of the sevoflurane metabolite hexafluoro-2-propanol in a rat model of endotoxaemia.
Topics: Adjuvants, Immunologic; Animals; Cells, Cultured; Cytokines; Disease Models, Animal; Endothelial Cel | 2015 |
Does occupational exposure to anesthetic gases lead to increase of pro-inflammatory cytokines?
Topics: Adult; Anesthetics, Inhalation; Cytokines; Environmental Monitoring; Female; Humans; Inflammation; I | 2015 |
Propofol for Anesthesia and Postoperative Sedation Resulted in Fewer Inflammatory Responses than Sevoflurane Anesthesia and Midazolam Sedation after Thoracoabdominal Esophagectomy.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Esophagectomy; Humans; Inflammation; Methyl Ether | 2015 |
[Effect of Toll-like receptor 2 on the inhibition role of sevoflurane on airway inflammation in asthmatic mice].
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Female; Inflammation; Interle | 2016 |
Deep anesthesia worsens outcome of rats with inflammatory responses.
Topics: Acid-Base Equilibrium; Anesthesia; Anesthetics, Inhalation; Animals; Hypotension; Inflammation; Inte | 2016 |
Tetrandrine ameliorates sevoflurane‑induced cognitive impairment via the suppression of inflammation and apoptosis in aged rats.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Benzylisoquinolines; Caspase 3; Cognitive Dysfunction; | 2016 |
Sevoflurane, Compared With Isoflurane, Minimizes Lung Damage in Pulmonary but Not in Extrapulmonary Acute Respiratory Distress Syndrome in Rats.
Topics: A549 Cells; Anesthetics; Animals; Escherichia coli; Female; Humans; Inflammation; Interleukin-6; Iso | 2017 |
Neuroinflammation and postoperative cognitive dysfunction: can anaesthesia be therapeutic?
Topics: Aged; Anesthesia; Anesthetics, Inhalation; Animals; Cognition Disorders; Coronary Vessels; Humans; I | 2010 |
Fluorinated groups mediate the immunomodulatory effects of volatile anesthetics in acute cell injury.
Topics: Anesthetics; Animals; Aorta; Carbon; Caspase 3; Dose-Response Relationship, Drug; Endothelial Cells; | 2011 |
Remifentanil and glucose suppress inflammation in a rat model of surgical stress.
Topics: Anesthetics, Inhalation; Animals; Blood Glucose; Forkhead Box Protein O3; Forkhead Transcription Fac | 2011 |
Effects of anesthetic regimes on inflammatory responses in a rat model of acute lung injury.
Topics: Acute Lung Injury; Analysis of Variance; Anesthesia; Anesthetics, Dissociative; Anesthetics, General | 2012 |
Cytokine profile in patients undergoing minimally invasive surgery with balanced anesthesia.
Topics: Adult; Anesthetics, Inhalation; Anesthetics, Intravenous; Balanced Anesthesia; Cytokines; Female; Fe | 2012 |
Sevoflurane combined with ATP activates caspase-1 and triggers caspase-1-dependent pyroptosis in murine J774 macrophages.
Topics: Acetylcysteine; Adenosine Triphosphate; Amino Acid Chloromethyl Ketones; Animals; Caspase 1; Caspase | 2013 |
Delayed anesthetic preconditioning protects against myocardial infarction via activation of nuclear factor-κB and upregulation of autophagy.
Topics: Analysis of Variance; Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Apoptosis; Autophagy | 2013 |
Sevoflurane suppresses tumour necrosis factor-α-induced inflammatory responses in small airway epithelial cells after anoxia/reoxygenation.
Topics: Anesthetics, Inhalation; Chemokine CCL2; Cytokines; DNA, Complementary; Enzyme-Linked Immunosorbent | 2013 |
Differential general anesthetic effects on microglial cytokine expression.
Topics: Alzheimer Disease; Anesthetics; Cells, Cultured; Cytokines; Gene Expression Regulation; Humans; Infl | 2013 |
Anti-inflammatory and antinecrotic effects of the volatile anesthetic sevoflurane in kidney proximal tubule cells.
Topics: Anesthetics, Inhalation; Animals; Cell Line; Cell Survival; Enzyme Activation; Epithelial Cells; Ext | 2006 |
The comparative abilities of propofol and sevoflurane to modulate inflammation and oxidative stress in the kidney after aortic cross-clamping.
Topics: Animals; Aorta, Abdominal; Constriction; Inflammation; Kidney; Male; Methyl Ethers; Oxidative Stress | 2008 |
Sevoflurane-mediated activation of p38-mitogen-activated stresskinase is independent of apoptosis in Jurkat T-cells.
Topics: Anesthetics, Inhalation; Apoptosis; Caspases; Desflurane; Enzyme Activation; Humans; Inflammation; I | 2008 |