Page last updated: 2024-11-04

sevoflurane and Hyperventilation

sevoflurane has been researched along with Hyperventilation in 20 studies

Sevoflurane: A non-explosive inhalation anesthetic used in the induction and maintenance of general anesthesia. It does not cause respiratory irritation and may also prevent PLATELET AGGREGATION.
sevoflurane : An ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups.

Hyperventilation: A pulmonary ventilation rate faster than is metabolically necessary for the exchange of gases. It is the result of an increased frequency of breathing, an increased tidal volume, or a combination of both. It causes an excess intake of oxygen and the blowing off of carbon dioxide.

Research Excerpts

ExcerptRelevanceReference
"The first aim of this study was to compare the changes in rSO2 between propofol and sevoflurane anaesthesia during hyperventilation."9.22Effects of hyperventilation on cerebral oxygen saturation estimated using near-infrared spectroscopy: A randomised comparison between propofol and sevoflurane anaesthesia. ( Asano, N; Ikemoto, K; Ishiyama, T; Kotoda, M; Matsukawa, T; Matsuoka, T; Shintani, N, 2016)
"During the first 10 min after sevoflurane administration, A (sev) in the hyperventilation group was the highest and differed significantly from those in the normal ventilation group, followed by those in the hypoventilation group."9.17Hyperventilation accelerates rise in arterial blood concentrations of sevoflurane in gynecologic patients. ( Chen, RM; Chen, TL; Ho, ST; Hsu, CH; Ku, CH; Lin, TC; Lu, CC; Yu, MH, 2013)
"The purpose of this study was to compare the degree of increase in middle cerebral artery (MCA) blood flow velocity after tourniquet deflation when modulating hyperventilation during orthopedic surgery under sevoflurane, isoflurane, or propofol anesthesia."9.14Differential effects of hyperventilation on cerebral blood flow velocity after tourniquet deflation during sevoflurane, isoflurane, or propofol anesthesia. ( Hinohara, H; Ide, M; Kadoi, Y; Kuroda, M; Mizutani, A; Saito, S, 2010)
"We investigated the effects of sevoflurane and hyperventilation on intraoperative electrocorticogram (ECoG) spike activity in 13 patients with intractable epilepsy."9.11The effects of sevoflurane and hyperventilation on electrocorticogram spike activity in patients with refractory epilepsy. ( Furuya, H; Hoshida, T; Kawaguchi, M; Kurita, N; Nakase, H; Sakaki, T, 2005)
"Hyperventilation during sevoflurane-N2O-O2 mask induction in adults is associated with a hyperdynamic circulatory response and epileptiform electroencephalogram (EEG)."9.09Epileptiform EEG during sevoflurane mask induction: effect of delaying the onset of hyperventilation. ( Jantti, V; Korttila, K; Lindgren, L; Särkelä, M; Vakkuri, A; Yli-Hankala, A, 2000)
"In this experimental in vivo model of isocapnic hyperventilation, the washout time of sevoflurane anaesthesia was one-third compared to normal ventilation."7.83Isocapnic hyperventilation shortens washout time for sevoflurane - an experimental in vivo study. ( Hallén, K; Lindgren, S; Ricksten, SE; Stenqvist, O, 2016)
" We evaluated the effects of hyperventilation on regional cerebral blood flow (rCBF) in healthy volunteers during sevoflurane anaesthesia measured with positron emission tomography (PET)."7.76Regional cerebral blood flow responses to hyperventilation during sevoflurane anaesthesia studied with PET. ( Cold, GE; Juul, N; Schlünzen, L; Vafaee, MS, 2010)
"Hypercapnia with hyperventilation shortens the time between turning off the vaporizer (1 MAC) and when patients open their eyes after isoflurane anesthesia by 62%."7.74Rapid recovery from sevoflurane and desflurane with hypercapnia and hyperventilation. ( Gopalakrishnan, NA; Orr, JA; Sakata, DJ; Westenskow, DR; White, JL, 2007)
"Energy metabolism of the cat brain was studied using phosphorous-31 nuclear magnetic resonance (31P-NMR) during sevoflurane/halothane anesthesia with normo- and hyperventilation."7.68[The effects of sevoflurane/halothane anesthesia during normo- and hyperventilation on the energy metabolism of the cat brain]. ( Fujibayashi, T; Goto, Y; Harada, J; Sugiura, Y; Yanagimoto, M, 1992)
"During the first 10 min after sevoflurane administration, A (sev) in the hyperventilation group was the highest and differed significantly from those in the normal ventilation group, followed by those in the hypoventilation group."5.17Hyperventilation accelerates rise in arterial blood concentrations of sevoflurane in gynecologic patients. ( Chen, RM; Chen, TL; Ho, ST; Hsu, CH; Ku, CH; Lin, TC; Lu, CC; Yu, MH, 2013)
"We investigated the effects of sevoflurane and hyperventilation on intraoperative electrocorticogram (ECoG) spike activity in 13 patients with intractable epilepsy."5.11The effects of sevoflurane and hyperventilation on electrocorticogram spike activity in patients with refractory epilepsy. ( Furuya, H; Hoshida, T; Kawaguchi, M; Kurita, N; Nakase, H; Sakaki, T, 2005)
"The study indicates that before as well as during hyperventilation, subdural ICP and AVDo2 are lower and CPP higher in propofol-anesthetized patients compared with patients anesthetized with isoflurane or sevoflurane."5.10Intracranial pressure and cerebral hemodynamic in patients with cerebral tumors: a randomized prospective study of patients subjected to craniotomy in propofol-fentanyl, isoflurane-fentanyl, or sevoflurane-fentanyl anesthesia. ( Cold, GE; Hauerberg, J; Holst, P; Landsfeldt, U; Mau, S; Olsen, KS; Petersen, CB; Petersen, KD, 2003)
"Hyperventilation during sevoflurane-N2O-O2 mask induction in adults is associated with a hyperdynamic circulatory response and epileptiform electroencephalogram (EEG)."5.09Epileptiform EEG during sevoflurane mask induction: effect of delaying the onset of hyperventilation. ( Jantti, V; Korttila, K; Lindgren, L; Särkelä, M; Vakkuri, A; Yli-Hankala, A, 2000)
"The main mechanism responsible for the hyperventilation-induced decrease in SctO2 is hypocapnia during both propofol-remifentanil and sevoflurane anesthesia."3.79Impact of stepwise hyperventilation on cerebral tissue oxygen saturation in anesthetized patients: a mechanistic study. ( Alexander, BS; Cerussi, AE; Gelb, AW; Lee, C; Mantulin, WW; Meng, L; Tromberg, BJ; Yu, Z, 2013)
" We evaluated the effects of hyperventilation on regional cerebral blood flow (rCBF) in healthy volunteers during sevoflurane anaesthesia measured with positron emission tomography (PET)."3.76Regional cerebral blood flow responses to hyperventilation during sevoflurane anaesthesia studied with PET. ( Cold, GE; Juul, N; Schlünzen, L; Vafaee, MS, 2010)
"Hypercapnia with hyperventilation shortens the time between turning off the vaporizer (1 MAC) and when patients open their eyes after isoflurane anesthesia by 62%."3.74Rapid recovery from sevoflurane and desflurane with hypercapnia and hyperventilation. ( Gopalakrishnan, NA; Orr, JA; Sakata, DJ; Westenskow, DR; White, JL, 2007)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (5.00)18.2507
2000's9 (45.00)29.6817
2010's10 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lindgren, S2
Hallén, K2
Ricksten, SE2
Stenqvist, O2
De Baerdemaeker, A1
De Wolf, AM1
Poelaert, J1
Ross Kennedy, R1
Hendrickx, JFA1
Katznelson, R1
Djaiani, G1
Naughton, F1
Wasowicz, M1
Ragoonanan, T1
Duffin, J1
Fedorko, L1
Murphy, J1
Fisher, JA1
Sitkin, SI1
Gasparian, AL1
Ivanova, TI1
Nesterova, EI1
Drozdova, NI1
Ishiyama, T1
Kotoda, M1
Asano, N1
Ikemoto, K1
Shintani, N1
Matsuoka, T1
Matsukawa, T1
Hayashi, K1
Fujikawa, M1
Sawa, T1
Schlünzen, L1
Vafaee, MS1
Juul, N1
Cold, GE2
Hinohara, H1
Kadoi, Y1
Ide, M1
Kuroda, M1
Saito, S1
Mizutani, A1
Lu, CC1
Lin, TC1
Hsu, CH1
Yu, MH1
Ku, CH1
Chen, TL1
Chen, RM1
Ho, ST1
Alexander, BS1
Gelb, AW1
Mantulin, WW1
Cerussi, AE1
Tromberg, BJ1
Yu, Z1
Lee, C1
Meng, L1
Petersen, KD1
Landsfeldt, U1
Petersen, CB1
Mau, S1
Hauerberg, J1
Holst, P1
Olsen, KS1
Hsieh, SW1
Lan, KM1
Luk, HN1
Jawan, B1
Werner, C1
Lu, H1
Engelhard, K1
Unbehaun, N1
Kochs, E1
Kurita, N1
Kawaguchi, M1
Hoshida, T1
Nakase, H1
Sakaki, T1
Furuya, H1
Gopalakrishnan, NA2
Sakata, DJ2
Orr, JA2
McJames, S1
Westenskow, DR2
White, JL1
Vakkuri, A2
Jantti, V2
Särkelä, M2
Lindgren, L2
Korttila, K2
Yli-Hankala, A2
Mennander, S1
Saarnivaara, L1
Fujibayashi, T1
Sugiura, Y1
Yanagimoto, M1
Harada, J1
Goto, Y1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Isocapnic Hyperventilation for Enhancing Recovery After Inhalation Anaesthesia - an Alternative Method[NCT03074110]31 participants (Actual)Interventional2016-11-11Completed
Influence of Vasopressors on Brain Oxygenation and Microcirculation in Anesthetized Patients With Cerebral Tumors[NCT02713087]Phase 448 participants (Actual)Interventional2015-09-30Completed
Emergence Delirium in Children: a Randomized Clinical Trial of Different Doses of Sevoflurane During Induction of Anesthesia[NCT02707016]80 participants (Anticipated)Interventional2015-12-31Recruiting
Influence of Volatile Induction of General Anaesthesia With Sevoflurane Using Two Different Techniques and Intravenous Induction Using Propofol on the Epileptiform Electroencephalograph Patterns:[NCT03209323]60 participants (Actual)Interventional2007-01-01Completed
Propofol for Pediatric Tracheal Intubation With Deep Anesthesia During Sevoflurane Induction: Dosing According to Elapsed Time for Two Age Groups,IRB-HSR# 13666[NCT01150838]Phase 4106 participants (Actual)Interventional2008-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Estimated Propofol Doses Producing 50% Excellent Intubation Conditions

"Logistic regression utilized to measure the amount of propofol to obtain 50% excellent intubation conditions for each age/time group.~The quality of tracheal intubation will be graded according to the Steyn modification of the Helbo-Hansen scoring system for tracheal intubation, which includes evaluation of ease of laryngoscopy, position of the vocal cords, coughing, jaw relaxation and movement of limbs, each evaluated on a 1-4 scale, with 1 being the best possible condition and 4 the worst. The intubation conditions will be classified as either excellent or not-excellent. Excellent will be defined as a total score of 5, a score of 1 for each category, and not-excellent will be a total score of 6-20, meaning a score of >1 in any category. While the outcome measure of each intubation is excellent or not excellent, the overall outcome being generated is the amount of propofol in mg/kg required for 50% excellent intubation score." (NCT01150838)
Timeframe: Amount of time it takes to intubate each patient; approximate time is 15-45 seconds

Interventionmg/kg (Mean)
Age 1-6 Years, Time 2-4 Minutes of Sevoflurane Until Propofol Administration1.48
Age 1-6 Years, Time 4-6 Minutes of Sevoflurane Until Propofol Administration0.00
Age 1-6 Years, Time 6-8 Minutes of Sevoflurane Until Propofol Administration0.07
Age 6-11 Years, Time 2-4 Minutes of Sevoflurane Until Propofol Administration2.35
Age 6-11 Years, Time 4-6 Minutes of Sevoflurane Until Propofol Administration2.33

Trials

9 trials available for sevoflurane and Hyperventilation

ArticleYear
Post-operative hypercapnia-induced hyperpnoea accelerates recovery from sevoflurane anaesthesia: a prospective randomised controlled trial.
    Acta anaesthesiologica Scandinavica, 2013, Volume: 57, Issue:5

    Topics: Analysis of Variance; Anesthesia Recovery Period; Anesthetics, Inhalation; Female; Humans; Hypercapn

2013
[Long-term dental interventions in mentally retarded children under general anesthesia with sevoflurane].
    Stomatologiia, 2015, Volume: 94, Issue:1

    Topics: Anesthesia, Dental; Anesthesia, General; Anesthetics, Inhalation; Carbon Dioxide; Child; Dental Care

2015
Effects of hyperventilation on cerebral oxygen saturation estimated using near-infrared spectroscopy: A randomised comparison between propofol and sevoflurane anaesthesia.
    European journal of anaesthesiology, 2016, Volume: 33, Issue:12

    Topics: Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Female; Humans; Hyperventilation; Male; Met

2016
Differential effects of hyperventilation on cerebral blood flow velocity after tourniquet deflation during sevoflurane, isoflurane, or propofol anesthesia.
    Journal of anesthesia, 2010, Volume: 24, Issue:4

    Topics: Adult; Aged; Anesthesia; Blood Flow Velocity; Carbon Dioxide; Cerebrovascular Circulation; Humans; H

2010
Hyperventilation accelerates rise in arterial blood concentrations of sevoflurane in gynecologic patients.
    Journal of anesthesia, 2013, Volume: 27, Issue:1

    Topics: Adult; Aging; Anesthesia, Inhalation; Anesthetics, Inhalation; Arteries; Carbon Dioxide; Chromatogra

2013
Intracranial pressure and cerebral hemodynamic in patients with cerebral tumors: a randomized prospective study of patients subjected to craniotomy in propofol-fentanyl, isoflurane-fentanyl, or sevoflurane-fentanyl anesthesia.
    Anesthesiology, 2003, Volume: 98, Issue:2

    Topics: Adolescent; Adult; Aged; Anesthesia, General; Anesthesia, Inhalation; Anesthetics, Inhalation; Anest

2003
The effects of sevoflurane and hyperventilation on electrocorticogram spike activity in patients with refractory epilepsy.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:2

    Topics: Adult; Anesthetics, Inhalation; Anticonvulsants; Blood Gas Analysis; Drug Resistance; Electroencepha

2005
Epileptiform EEG during sevoflurane mask induction: effect of delaying the onset of hyperventilation.
    Acta anaesthesiologica Scandinavica, 2000, Volume: 44, Issue:6

    Topics: Adult; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure; Electroencephalography; Epil

2000
Epileptiform EEG during sevoflurane mask induction: effect of delaying the onset of hyperventilation.
    Acta anaesthesiologica Scandinavica, 2000, Volume: 44, Issue:6

    Topics: Adult; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure; Electroencephalography; Epil

2000
Epileptiform EEG during sevoflurane mask induction: effect of delaying the onset of hyperventilation.
    Acta anaesthesiologica Scandinavica, 2000, Volume: 44, Issue:6

    Topics: Adult; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure; Electroencephalography; Epil

2000
Epileptiform EEG during sevoflurane mask induction: effect of delaying the onset of hyperventilation.
    Acta anaesthesiologica Scandinavica, 2000, Volume: 44, Issue:6

    Topics: Adult; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure; Electroencephalography; Epil

2000
Sevoflurane mask induction of anaesthesia is associated with epileptiform EEG in children.
    Acta anaesthesiologica Scandinavica, 2001, Volume: 45, Issue:7

    Topics: Anesthetics, Inhalation; Carbon Dioxide; Child; Electroencephalography; Epilepsy; Female; Heart Rate

2001
Sevoflurane mask induction of anaesthesia is associated with epileptiform EEG in children.
    Acta anaesthesiologica Scandinavica, 2001, Volume: 45, Issue:7

    Topics: Anesthetics, Inhalation; Carbon Dioxide; Child; Electroencephalography; Epilepsy; Female; Heart Rate

2001
Sevoflurane mask induction of anaesthesia is associated with epileptiform EEG in children.
    Acta anaesthesiologica Scandinavica, 2001, Volume: 45, Issue:7

    Topics: Anesthetics, Inhalation; Carbon Dioxide; Child; Electroencephalography; Epilepsy; Female; Heart Rate

2001
Sevoflurane mask induction of anaesthesia is associated with epileptiform EEG in children.
    Acta anaesthesiologica Scandinavica, 2001, Volume: 45, Issue:7

    Topics: Anesthetics, Inhalation; Carbon Dioxide; Child; Electroencephalography; Epilepsy; Female; Heart Rate

2001
Sevoflurane mask induction of anaesthesia is associated with epileptiform EEG in children.
    Acta anaesthesiologica Scandinavica, 2001, Volume: 45, Issue:7

    Topics: Anesthetics, Inhalation; Carbon Dioxide; Child; Electroencephalography; Epilepsy; Female; Heart Rate

2001
Sevoflurane mask induction of anaesthesia is associated with epileptiform EEG in children.
    Acta anaesthesiologica Scandinavica, 2001, Volume: 45, Issue:7

    Topics: Anesthetics, Inhalation; Carbon Dioxide; Child; Electroencephalography; Epilepsy; Female; Heart Rate

2001
Sevoflurane mask induction of anaesthesia is associated with epileptiform EEG in children.
    Acta anaesthesiologica Scandinavica, 2001, Volume: 45, Issue:7

    Topics: Anesthetics, Inhalation; Carbon Dioxide; Child; Electroencephalography; Epilepsy; Female; Heart Rate

2001
Sevoflurane mask induction of anaesthesia is associated with epileptiform EEG in children.
    Acta anaesthesiologica Scandinavica, 2001, Volume: 45, Issue:7

    Topics: Anesthetics, Inhalation; Carbon Dioxide; Child; Electroencephalography; Epilepsy; Female; Heart Rate

2001
Sevoflurane mask induction of anaesthesia is associated with epileptiform EEG in children.
    Acta anaesthesiologica Scandinavica, 2001, Volume: 45, Issue:7

    Topics: Anesthetics, Inhalation; Carbon Dioxide; Child; Electroencephalography; Epilepsy; Female; Heart Rate

2001

Other Studies

11 other studies available for sevoflurane and Hyperventilation

ArticleYear
Comment on De Baerdemaeker et al.
    Acta anaesthesiologica Scandinavica, 2019, Volume: 63, Issue:6

    Topics: Anesthesia; Anesthesiology; Humans; Hyperventilation; Remifentanil; Sevoflurane

2019
Effectiveness of isocapnic hyperventilation: It is not the technique, it is the way you use it.
    Acta anaesthesiologica Scandinavica, 2019, Volume: 63, Issue:6

    Topics: Anesthesia; Forced Expiratory Volume; Humans; Hyperventilation; Remifentanil; Sevoflurane

2019
Isocapnic hyperventilation shortens washout time for sevoflurane - an experimental in vivo study.
    Acta anaesthesiologica Scandinavica, 2016, Volume: 60, Issue:9

    Topics: Anesthetics, Inhalation; Animals; Carbon Dioxide; Female; Hemodynamics; Hyperventilation; Methyl Eth

2016
Hyperventilation-induced hypocapnia changes the pattern of electroencephalographic bicoherence growth during sevoflurane anaesthesia.
    British journal of anaesthesia, 2008, Volume: 101, Issue:5

    Topics: Adolescent; Adult; Aged; Anesthetics, Inhalation; Carbon Dioxide; Electroencephalography; Humans; Hy

2008
Regional cerebral blood flow responses to hyperventilation during sevoflurane anaesthesia studied with PET.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:5

    Topics: Adult; Anesthetics, Inhalation; Carbon Dioxide; Cerebrovascular Circulation; Dose-Response Relations

2010
Impact of stepwise hyperventilation on cerebral tissue oxygen saturation in anesthetized patients: a mechanistic study.
    Acta anaesthesiologica Scandinavica, 2013, Volume: 57, Issue:5

    Topics: Adult; Anesthetics, Inhalation; Anesthetics, Intravenous; Blood Pressure; Carbon Dioxide; Cardiac Ou

2013
Postoperative seizures after sevoflurane anesthesia in a neonate.
    Acta anaesthesiologica Scandinavica, 2004, Volume: 48, Issue:5

    Topics: Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous;

2004
Sevoflurane impairs cerebral blood flow autoregulation in rats: reversal by nonselective nitric oxide synthase inhibition.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:2

    Topics: Anesthetics, Inhalation; Animals; Blood Pressure; Blood Volume; Brain Chemistry; Cerebral Hemorrhage

2005
Hypercapnia shortens emergence time from inhaled anesthesia in pigs.
    Anesthesia and analgesia, 2007, Volume: 104, Issue:4

    Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Carbon Dioxide

2007
Rapid recovery from sevoflurane and desflurane with hypercapnia and hyperventilation.
    Anesthesia and analgesia, 2007, Volume: 105, Issue:1

    Topics: Adult; Anesthesia Recovery Period; Desflurane; Female; Humans; Hypercapnia; Hyperventilation; Isoflu

2007
[The effects of sevoflurane/halothane anesthesia during normo- and hyperventilation on the energy metabolism of the cat brain].
    Masui. The Japanese journal of anesthesiology, 1992, Volume: 41, Issue:1

    Topics: Anesthesia, Inhalation; Anesthetics; Animals; Brain; Cats; Energy Metabolism; Ethers; Halothane; Hyp

1992