Page last updated: 2024-11-04

sevoflurane and Hypercapnia

sevoflurane has been researched along with Hypercapnia in 28 studies

Sevoflurane: A non-explosive inhalation anesthetic used in the induction and maintenance of general anesthesia. It does not cause respiratory irritation and may also prevent PLATELET AGGREGATION.
sevoflurane : An ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups.

Hypercapnia: A clinical manifestation of abnormal increase in the amount of carbon dioxide in arterial blood.

Research Excerpts

ExcerptRelevanceReference
" We compared the effects of remimazolam and sevoflurane on cerebral oxygenation, intracranial pressure, and intraoperative hemodynamic parameters during mild hypercapnia in patients undergoing laparoscopy in the Trendelenburg position."9.69Impact of Remimazolam versus Sevoflurane Anesthesia on Cerebral Oxygenation and Intracranial Pressure during Gynecological Laparoscopy with Mild Hypercapnia. ( Jo, YY; Jung, WS; Kim, DS; Kwak, HJ; Lee, D; Park, CG, 2023)
"1 minimum alveolar concentration (MAC) of sevoflurane on ventilation, the acute ventilatory response to a step change in end-tidal carbon dioxide and the ventilatory response to sustained hypercapnia in 10 healthy adult volunteers."9.09Effects of subanaesthetic sevoflurane on ventilation. 1: Response to acute and sustained hypercapnia in humans. ( Dorrington, KL; Manning-Fox, J; Pandit, JJ; Robbins, PA, 1999)
" In this study, we quantified the influence of sevoflurane anesthesia on CO 2 reactivity and the CA-CO 2 relationship."8.31The Influence of Carbon Dioxide on Cerebral Autoregulation During Sevoflurane-based Anesthesia in Patients With Type 2 Diabetes. ( Hermanides, J; Hollmann, MW; Immink, RV; Preckel, B; Sperna Weiland, NH; van den Dool, REC; van der Ster, BJP; van Lieshout, JJ, 2023)
"To evaluate the effects of induced hypercapnia on the electroretinogram (ERG) in beagle dogs anaesthetized with isoflurane and sevoflurane."7.76Effects of hypercapnia on the electroretinogram in sevoflurane and isoflurane anaesthetized dogs. ( Alvarez Vazquez, JC; Gonzalez Cantalapiedra, A; Rosolen, SG; Varela Lopez, O, 2010)
"We report the case of a severe acute asthma, which required, after optimal medical therapy, helium and sevoflurane CO-administration after tracheal intubation."7.75[Helium-sevoflurane association: a rescue treatment in case of acute severe asthma]. ( Favier, JC; Landy, C; Nadaud, J; Pernod, G; Steiner, T, 2009)
"Hypercapnia with hyperventilation shortens the time between turning off the vaporizer (1 MAC) and when patients open their eyes after isoflurane anesthesia by 62%."7.74Rapid recovery from sevoflurane and desflurane with hypercapnia and hyperventilation. ( Gopalakrishnan, NA; Orr, JA; Sakata, DJ; Westenskow, DR; White, JL, 2007)
"In a randomized controlled crossover study, general anesthesia with propofol or sevoflurane was titrated using an up-down method to identify the threshold for suppression of the motor response to electrical stimulation of the forearm."5.19Anesthesia and increased hypercarbic drive impair the coordination between breathing and swallowing. ( D'Angelo, OM; Diaz-Gil, D; Eikermann, M; Gianatasio, C; Meyer, MJ; Mueller, N; Nunn, D; Pierce, E; Rosow, C; Simons, JC, 2014)
"In elderly patients, hypercapnia has less effect on cerebral circulation during propofol anesthesia than with sevoflurane."5.14The comparative effects of equipotent Bispectral Index dosages of propofol and sevoflurane on cerebrovascular carbon dioxide reactivity in elderly patients. ( Kadoi, Y; Kawauchi, C; Saito, S; Takahashi, K, 2009)
" The aim of the current study was to determine the effects of clonidine premedication on the ventilatory response to hypercapnia during sevoflurane anesthesia using the carbon dioxide (CO(2)) steady state method."5.11Oral clonidine does not change ventilatory response to carbon dioxide in sevoflurane-anesthetized children. ( Mikawa, K; Nishina, K; Obara, H; Uesugi, T, 2004)
"1 minimum alveolar concentration (MAC) of sevoflurane on ventilation, the acute ventilatory response to a step change in end-tidal carbon dioxide and the ventilatory response to sustained hypercapnia in 10 healthy adult volunteers."5.09Effects of subanaesthetic sevoflurane on ventilation. 1: Response to acute and sustained hypercapnia in humans. ( Dorrington, KL; Manning-Fox, J; Pandit, JJ; Robbins, PA, 1999)
" In this study, we quantified the influence of sevoflurane anesthesia on CO 2 reactivity and the CA-CO 2 relationship."4.31The Influence of Carbon Dioxide on Cerebral Autoregulation During Sevoflurane-based Anesthesia in Patients With Type 2 Diabetes. ( Hermanides, J; Hollmann, MW; Immink, RV; Preckel, B; Sperna Weiland, NH; van den Dool, REC; van der Ster, BJP; van Lieshout, JJ, 2023)
"Compared to isoflurane, sevoflurane caused greater hypoventilation and was associated with longer times until standing recovery."3.78Effects of hypercapnic hyperpnea on recovery from isoflurane or sevoflurane anesthesia in horses. ( Brosnan, RJ; Escobar, A; Steffey, EP, 2012)
"To evaluate the effects of induced hypercapnia on the electroretinogram (ERG) in beagle dogs anaesthetized with isoflurane and sevoflurane."3.76Effects of hypercapnia on the electroretinogram in sevoflurane and isoflurane anaesthetized dogs. ( Alvarez Vazquez, JC; Gonzalez Cantalapiedra, A; Rosolen, SG; Varela Lopez, O, 2010)
"We report the case of a severe acute asthma, which required, after optimal medical therapy, helium and sevoflurane CO-administration after tracheal intubation."3.75[Helium-sevoflurane association: a rescue treatment in case of acute severe asthma]. ( Favier, JC; Landy, C; Nadaud, J; Pernod, G; Steiner, T, 2009)
"Hypercapnia with hyperventilation shortens the time between turning off the vaporizer (1 MAC) and when patients open their eyes after isoflurane anesthesia by 62%."3.74Rapid recovery from sevoflurane and desflurane with hypercapnia and hyperventilation. ( Gopalakrishnan, NA; Orr, JA; Sakata, DJ; Westenskow, DR; White, JL, 2007)
"Therefore, a genetic predisposition to a blunted carbon dioxide response represents a susceptibility factor that interacts with hypercapnoeic hypoventilation during maintenance of anaesthesia and in the emergence from anaesthesia, regardless of the agent used."1.32Influence of volatile anaesthetics on hypercapnoeic ventilatory responses in mice with blunted respiratory drive. ( Brown, RH; Groeben, H; Meier, S; Mitzner, W; Tankersley, CG, 2004)

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (21.43)18.2507
2000's10 (35.71)29.6817
2010's10 (35.71)24.3611
2020's2 (7.14)2.80

Authors

AuthorsStudies
Park, CG1
Lee, D1
Jung, WS1
Kim, DS1
Jo, YY1
Kwak, HJ1
van den Dool, REC1
Immink, RV1
van der Ster, BJP1
Hermanides, J1
Hollmann, MW1
Preckel, B1
van Lieshout, JJ1
Sperna Weiland, NH1
Sakata, K1
Kito, K1
Fukuoka, N1
Nagase, K1
Tanabe, K1
Iida, H1
Lee, S1
Katznelson, R1
Djaiani, G1
Naughton, F1
Wasowicz, M1
Ragoonanan, T1
Duffin, J1
Fedorko, L1
Murphy, J1
Fisher, JA1
Suzuki, T1
Ikeda, H1
Iwamoto, T1
Sano, H1
Hashimoto, M1
Oe, K1
Inoue, H1
Serada, K1
D'Angelo, OM1
Diaz-Gil, D1
Nunn, D1
Simons, JC1
Gianatasio, C1
Mueller, N1
Meyer, MJ1
Pierce, E1
Rosow, C1
Eikermann, M1
Cornelius, B1
Sakai, T1
Nadaud, J1
Landy, C1
Steiner, T1
Pernod, G1
Favier, JC1
Kadoi, Y1
Kawauchi, C1
Saito, S1
Takahashi, K1
Voigtsberger, S1
Lachmann, RA1
Leutert, AC1
Schläpfer, M1
Booy, C1
Reyes, L1
Urner, M1
Schild, J1
Schimmer, RC1
Beck-Schimmer, B1
Varela Lopez, O1
Alvarez Vazquez, JC1
Gonzalez Cantalapiedra, A1
Rosolen, SG1
Haberstroh, J1
Eberspächer, E1
Becker, K1
Henke, J1
Sager, M1
Arras, M1
Brosnan, RJ1
Steffey, EP1
Escobar, A1
Sen, P1
Izdes, S1
But, A1
Groeben, H1
Meier, S1
Tankersley, CG1
Mitzner, W1
Brown, RH1
Nishina, K1
Mikawa, K1
Uesugi, T1
Obara, H1
Gopalakrishnan, NA2
Sakata, DJ2
Orr, JA2
McJames, S1
Westenskow, DR2
White, JL1
Masuda, A1
Haji, A1
Kiriyama, M1
Ito, Y1
Takeda, R1
Koenig, HM1
van den Elsen, M1
Sarton, E1
Teppema, L1
Berkenbosch, A1
Dahan, A1
Pandit, JJ2
Manning-Fox, J2
Dorrington, KL2
Robbins, PA2
Maekawa, T1
Cho, S1
Fukusaki, M1
Shibata, O1
Sumikawa, K1
Kil, HK1
McCulloch, TJ1
Visco, E1
Lam, AM1
Wilson, DV1
Evans, AT1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized Pilot Clinical Trial of the Effects in Oxygenation and Hypoxic Pulmonary Vasoconstriction of Sevoflurane in Patient's Whit ARDS Secondary to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2)[NCT04998253]Early Phase 124 participants (Actual)Interventional2020-10-01Completed
A Comparison of Cerebral Oximetry After Propofol-Based Total Intravenous Anesthesia and Sevoflurane Inhalation Anesthesia in Morbidly Obese Patients Undergoing LSG: a Prospective, Single-Blinded, Randomized, Parallel-Group Study.[NCT03946657]Phase 460 participants (Actual)Interventional2019-01-20Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

9 trials available for sevoflurane and Hypercapnia

ArticleYear
Impact of Remimazolam versus Sevoflurane Anesthesia on Cerebral Oxygenation and Intracranial Pressure during Gynecological Laparoscopy with Mild Hypercapnia.
    Medical science monitor : international medical journal of experimental and clinical research, 2023, Sep-17, Volume: 29

    Topics: Adult; Aged; Anesthesia; Humans; Hypercapnia; Intracranial Pressure; Laparoscopy; Lung; Middle Aged;

2023
Post-operative hypercapnia-induced hyperpnoea accelerates recovery from sevoflurane anaesthesia: a prospective randomised controlled trial.
    Acta anaesthesiologica Scandinavica, 2013, Volume: 57, Issue:5

    Topics: Analysis of Variance; Anesthesia Recovery Period; Anesthetics, Inhalation; Female; Humans; Hypercapn

2013
Anesthesia and increased hypercarbic drive impair the coordination between breathing and swallowing.
    Anesthesiology, 2014, Volume: 121, Issue:6

    Topics: Adolescent; Adult; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Cross-Over Studies

2014
The comparative effects of equipotent Bispectral Index dosages of propofol and sevoflurane on cerebrovascular carbon dioxide reactivity in elderly patients.
    Journal of clinical anesthesia, 2009, Volume: 21, Issue:3

    Topics: Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Carbon Dioxide; Cerebrovascular Circulation

2009
Oral clonidine does not change ventilatory response to carbon dioxide in sevoflurane-anesthetized children.
    Paediatric anaesthesia, 2004, Volume: 14, Issue:12

    Topics: Administration, Oral; Adolescent; Analgesics; Analysis of Variance; Anesthetics, Inhalation; Carbon

2004
Influence of 0.1 minimum alveolar concentration of sevoflurane, desflurane and isoflurane on dynamic ventilatory response to hypercapnia in humans.
    British journal of anaesthesia, 1998, Volume: 80, Issue:2

    Topics: Adult; Anesthetics, Inhalation; Conscious Sedation; Desflurane; Drug Administration Schedule; Female

1998
Effects of clonidine on human middle cerebral artery flow velocity and cerebrovascular CO2 response during sevoflurane anesthesia.
    Journal of neurosurgical anesthesiology, 1999, Volume: 11, Issue:3

    Topics: Adrenergic alpha-Agonists; Analysis of Variance; Anesthesia, Inhalation; Anesthetics, Inhalation; Bl

1999
Effects of subanaesthetic sevoflurane on ventilation. 1: Response to acute and sustained hypercapnia in humans.
    British journal of anaesthesia, 1999, Volume: 83, Issue:2

    Topics: Acute Disease; Adult; Analysis of Variance; Anesthetics, Inhalation; Depression, Chemical; Female; H

1999
Graded hypercapnia and cerebral autoregulation during sevoflurane or propofol anesthesia.
    Anesthesiology, 2000, Volume: 93, Issue:5

    Topics: Adult; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Carbon Dioxide; Cereb

2000

Other Studies

19 other studies available for sevoflurane and Hypercapnia

ArticleYear
The Influence of Carbon Dioxide on Cerebral Autoregulation During Sevoflurane-based Anesthesia in Patients With Type 2 Diabetes.
    Journal of neurosurgical anesthesiology, 2023, Jan-01, Volume: 35, Issue:1

    Topics: Anesthesia; Anesthetics, Inhalation; Carbon Dioxide; Diabetes Mellitus, Type 2; Homeostasis; Humans;

2023
Cerebrovascular reactivity to hypercapnia during sevoflurane or desflurane anesthesia in rats.
    Korean journal of anesthesiology, 2019, Volume: 72, Issue:3

    Topics: Anesthetics, Inhalation; Animals; Arterioles; Blood Gas Analysis; Cerebral Veins; Cerebrovascular Ci

2019
Can desflurane be an alternative to sevoflurane in neuroanesthesia?
    Korean journal of anesthesiology, 2019, Volume: 72, Issue:3

    Topics: Anesthesia; Animals; Desflurane; Hypercapnia; Isoflurane; Rats; Sevoflurane

2019
Elective use of an uncuffed small-bore cricothyrotomy tube with balloon occlusion of the subglottic airway.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2014, Volume: 61, Issue:1

    Topics: Aged; Balloon Occlusion; Blood Gas Analysis; Cricoid Cartilage; Endoscopy; Equipment Design; Glottis

2014
Inadvertent Endobronchial Intubation in a Patient With a Short Neck Length.
    Anesthesia progress, 2015,Summer, Volume: 62, Issue:2

    Topics: Anesthetics, Intravenous; Bronchi; Cholecystectomy, Laparoscopic; Fentanyl; Humans; Hypercapnia; Int

2015
[Helium-sevoflurane association: a rescue treatment in case of acute severe asthma].
    Annales francaises d'anesthesie et de reanimation, 2009, Volume: 28, Issue:1

    Topics: Acidosis, Respiratory; Acute Disease; Anesthetics, Inhalation; Asthma; Bronchial Spasm; Drug Combina

2009
Sevoflurane ameliorates gas exchange and attenuates lung damage in experimental lipopolysaccharide-induced lung injury.
    Anesthesiology, 2009, Volume: 111, Issue:6

    Topics: Anesthetics, Inhalation; Animals; Blood Pressure; Bronchoalveolar Lavage Fluid; Cell Count; Cells, C

2009
Effects of hypercapnia on the electroretinogram in sevoflurane and isoflurane anaesthetized dogs.
    Documenta ophthalmologica. Advances in ophthalmology, 2010, Volume: 121, Issue:1

    Topics: Anesthesia; Anesthetics, Inhalation; Animals; Dark Adaptation; Dogs; Electroretinography; Female; Hy

2010
Response of the Committee for Anaesthesia, Analgesia and Pain Prophylaxis of the Society for Laboratory Animal Science to 'Temporary inhalation anaesthesia in experimental pigs'.
    Laboratory animals, 2011, Volume: 45, Issue:2

    Topics: Analgesia; Anesthesia, Inhalation; Animals; Dose-Response Relationship, Drug; Heart Arrest; Hypercap

2011
Effects of hypercapnic hyperpnea on recovery from isoflurane or sevoflurane anesthesia in horses.
    Veterinary anaesthesia and analgesia, 2012, Volume: 39, Issue:4

    Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Carbon Dioxide

2012
Effects of sevoflurane and propofol anaesthesia on cerebral oxygenation during normocapnia and mild hypercapnia: a pilot study.
    British journal of anaesthesia, 2013, Volume: 110, Issue:2

    Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Cerebrovascular Circulation; Humans; Hypercapnia;

2013
Influence of volatile anaesthetics on hypercapnoeic ventilatory responses in mice with blunted respiratory drive.
    British journal of anaesthesia, 2004, Volume: 92, Issue:5

    Topics: Anesthetics, Inhalation; Animals; Desflurane; Genetic Predisposition to Disease; Hypercapnia; Isoflu

2004
Hypercapnia shortens emergence time from inhaled anesthesia in pigs.
    Anesthesia and analgesia, 2007, Volume: 104, Issue:4

    Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Carbon Dioxide

2007
Rapid recovery from sevoflurane and desflurane with hypercapnia and hyperventilation.
    Anesthesia and analgesia, 2007, Volume: 105, Issue:1

    Topics: Adult; Anesthesia Recovery Period; Desflurane; Female; Humans; Hypercapnia; Hyperventilation; Isoflu

2007
Effects of sevoflurane on respiratory activities in the phrenic nerve of decerebrate cats.
    Acta anaesthesiologica Scandinavica, 1995, Volume: 39, Issue:6

    Topics: Action Potentials; Anesthetics; Anesthetics, Inhalation; Animals; Cats; Decerebrate State; Depressio

1995
What's up with the new volatile anesthetics, desflurane and sevoflurane, for neurosurgical patients?
    Journal of neurosurgical anesthesiology, 1994, Volume: 6, Issue:4

    Topics: Anesthetics, Inhalation; Animals; Blood Volume; Brain; Brain Injuries; Carbon Dioxide; Cerebrospinal

1994
Chemoreflex effects of low dose sevoflurane in humans.
    Advances in experimental medicine and biology, 1998, Volume: 450

    Topics: Anesthetics, Inhalation; Chemoreceptor Cells; Humans; Hypercapnia; Hypoxia; Methyl Ethers; Respirato

1998
Hypercapnea is an important adjuvant factor of oculocardiac reflex during strabismus surgery.
    Anesthesia and analgesia, 2000, Volume: 91, Issue:4

    Topics: Anesthetics, Inhalation; Child; Halothane; Humans; Hypercapnia; Hypoxia; Methyl Ethers; Oculomotor M

2000
Anesthesia case of the month. Paroxysmal supraventricular tachycardia.
    Journal of the American Veterinary Medical Association, 2002, Feb-01, Volume: 220, Issue:3

    Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Blood Gas Analysis; Dog Diseases; Dogs; Eq

2002