sevoflurane has been researched along with Encephalopathy, Toxic in 47 studies
Sevoflurane: A non-explosive inhalation anesthetic used in the induction and maintenance of general anesthesia. It does not cause respiratory irritation and may also prevent PLATELET AGGREGATION.
sevoflurane : An ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sevoflurane or LPS treatment increased activated caspase-3 and caspase-9 expression in the hippocampal subiculum and CA1, which was greater when sevoflurane was administered in the setting of LPS-induced inflammation." | 8.12 | Systemic inflammation exacerbates developmental neurotoxicity induced by sevoflurane in neonatal rats. ( Cabrera, OH; Jevtovic-Todorovic, V; Liechty, C; Maksimovic, S; Quillinan, N; Useinovic, N, 2022) |
| "Our findings suggested that sevoflurane can induce neuroapoptosis and cognitive dysfunction in adolescent rats that received repeated sevoflurane (2% for 1 h) during the postnatal period." | 7.85 | Repeated 2% sevoflurane administration in 7‑ and 60-day-old rats : Neurotoxicity and neurocognitive dysfunction. ( Chen, J; Huang, H; Jin, WJ; Liu, CM; Sun, J; Wu, YQ, 2017) |
| "Sevoflurane (Sev) is a commonly used surgical anaesthetic; it has neurotoxic effects on the brain." | 5.72 | Echinatin mitigates sevoflurane-induced hippocampal neurotoxicity and cognitive deficits through mitigation of iron overload and oxidative stress. ( Li, F; Tang, Q; Wang, J; Xu, Z; You, Y; Zeng, H; Zhao, T, 2022) |
| "Sevoflurane (Sev) might cause neurotoxicity in elderly rats." | 5.72 | Lin28A Reduced Sevoflurane-Induced Nerve Injury and Cognitive Dysfunction by Inhibiting Tau Acetylation and Phosphorylation via Activating SIRT1 in Elderly Rats. ( Wang, J; Wang, Q; Zhang, M; Zhu, Y, 2022) |
| "Coenzyme Q10 (CoQ10) has been reported to reduce sevoflurane anesthesia‑induced cognitive deficiency in 6‑day‑old mice." | 5.56 | Coenzyme Q10 alleviates sevoflurane‑induced neuroinflammation by regulating the levels of apolipoprotein E and phosphorylated tau protein in mouse hippocampal neurons. ( Lian, N; Wang, Y; Xie, K; Yang, M; Yu, Y, 2020) |
| "Sevoflurane or LPS treatment increased activated caspase-3 and caspase-9 expression in the hippocampal subiculum and CA1, which was greater when sevoflurane was administered in the setting of LPS-induced inflammation." | 4.12 | Systemic inflammation exacerbates developmental neurotoxicity induced by sevoflurane in neonatal rats. ( Cabrera, OH; Jevtovic-Todorovic, V; Liechty, C; Maksimovic, S; Quillinan, N; Useinovic, N, 2022) |
| "Mid-pregnancy exposure to sevoflurane led to excessive PARP-1 activation, poly (ADP-ribose) (PAR) polymer accumulation, apoptosis-inducing factor (AIF) nuclear translocation, and Nogo-A accumulation." | 4.12 | Sevoflurane exposure during the second trimester induces neurotoxicity in offspring rats by hyperactivation of PARP-1. ( Jiang, Q; Wang, C; Zhao, P, 2022) |
| "Evidence has shown that suppression of the activation of NLRP3 inflammasome could ameliorate surgery/sevoflurane (SEV)-induced post-operative cognitive dysfunction (POCD)." | 4.12 | Knockdown of UAF1 alleviates sevoflurane-induced cognitive impairment and neurotoxicity in rats by inhibiting pro-inflammatory signaling and oxidative stress. ( Wang, J; Wang, Q; Zhang, M; Zhu, Y, 2022) |
| " Neuroblastoma cells were exposed to sevoflurane and then cultured in 1% oxygen." | 3.96 | Conflicting Actions of Inhalational Anesthetics, Neurotoxicity and Neuroprotection, Mediated by the Unfolded Protein Response. ( Aoe, T; Jin, H; Kokubun, H; Komita, M, 2020) |
| "Our results demonstrated that GA, induced by intravenous ketamine or inhalational sevoflurane, disturbed iron homeostasis and caused iron overload in both in vitro hippocampal neuron culture and in vivo hippocampus." | 3.96 | Iron overload contributes to general anaesthesia-induced neurotoxicity and cognitive deficits. ( Cao, Y; Li, H; Li, K; Wu, J; Yang, JJ; Yang, S; Zhao, H, 2020) |
| "Our findings suggested that sevoflurane can induce neuroapoptosis and cognitive dysfunction in adolescent rats that received repeated sevoflurane (2% for 1 h) during the postnatal period." | 3.85 | Repeated 2% sevoflurane administration in 7‑ and 60-day-old rats : Neurotoxicity and neurocognitive dysfunction. ( Chen, J; Huang, H; Jin, WJ; Liu, CM; Sun, J; Wu, YQ, 2017) |
| " This review addressed the tolerability of sevoflurane in specific populations, particularly pediatrics, and is divided into 3 parts: (1) the history of sevoflurane use in anesthetic practice and the pharmacokinetic properties that make it advantageous in pediatric populations; (2) proposed mechanisms of anesthesia-induced neurotoxicity; and (3) considerations due to potential adverse effects of sevoflurane in both short and long procedures." | 2.72 | Anesthesia and the Developing Brain: A Review of Sevoflurane-induced Neurotoxicity in Pediatric Populations. ( Apai, C; Pandya Shah, S; Shah, R; Tran, K, 2021) |
| "Sevoflurane (Sev) is a widely used inhalational anesthetic for general anesthesia in children." | 1.72 | Sevoflurane-Induced Neurotoxicity in the Developing Hippocampus via HIPK2/AKT/mTOR Signaling. ( Fan, Z; He, D; Kang, J; Liang, L; Liu, B; Ma, T; Zeng, T; Zhang, H; Zhao, Y, 2022) |
| "Sevoflurane is a general anesthetic agent which is commonly used in clinical practice." | 1.72 | Sevoflurane Induces Neurotoxicity in the Animal Model with Alzheimer's Disease Neuropathology via Modulating Glutamate Transporter and Neuronal Apoptosis. ( Chang, RCC; Chu, JMT; Huang, C; Kwong, VSW; Liu, Y; Wong, GTC, 2022) |
| "Sevoflurane is a common anesthetic and is widely used in pediatric clinical surgery to induce and maintain anesthesia through inhalation." | 1.72 | miRNA-384-3p alleviates sevoflurane-induced nerve injury by inhibiting Aak1 kinase in neonatal rats. ( Chen, Y; Gao, X; Pei, H, 2022) |
| "Sevoflurane (Sev) is a commonly used surgical anaesthetic; it has neurotoxic effects on the brain." | 1.72 | Echinatin mitigates sevoflurane-induced hippocampal neurotoxicity and cognitive deficits through mitigation of iron overload and oxidative stress. ( Li, F; Tang, Q; Wang, J; Xu, Z; You, Y; Zeng, H; Zhao, T, 2022) |
| "Sevoflurane (Sev) might cause neurotoxicity in elderly rats." | 1.72 | Lin28A Reduced Sevoflurane-Induced Nerve Injury and Cognitive Dysfunction by Inhibiting Tau Acetylation and Phosphorylation via Activating SIRT1 in Elderly Rats. ( Wang, J; Wang, Q; Zhang, M; Zhu, Y, 2022) |
| "Sevoflurane is a widely used volatile anesthetic, that can cause long-term neurotoxicity and learning and memory impairment." | 1.62 | LncRNA Neat1/miR-298-5p/Srpk1 Contributes to Sevoflurane-Induced Neurotoxicity. ( Chen, L; Wei, X; Xu, S, 2021) |
| "Sevoflurane at 2." | 1.62 | Effect of dexmedetomidine on sevoflurane-induced neurodegeneration in neonatal rats. ( Danzer, SC; Ewing, L; Hofacer, RD; Joseph, B; Lee, JR; Lee, SY; Loepke, AW; Upton, B; Zhang, B, 2021) |
| "Coenzyme Q10 (CoQ10) has been reported to reduce sevoflurane anesthesia‑induced cognitive deficiency in 6‑day‑old mice." | 1.56 | Coenzyme Q10 alleviates sevoflurane‑induced neuroinflammation by regulating the levels of apolipoprotein E and phosphorylated tau protein in mouse hippocampal neurons. ( Lian, N; Wang, Y; Xie, K; Yang, M; Yu, Y, 2020) |
| " Alternative or mitigating strategies to counteract such adverse effects are desirable." | 1.56 | Neurotoxicity of sub-anesthetic doses of sevoflurane and dexmedetomidine co-administration in neonatal rats. ( Brambrink, AM; Grafe, MR; Neudecker, V; Perez-Zoghbi, JF; Zhu, W, 2020) |
| " In this study, we investigated the toxic effects of SEVO on human induced pluripotent stem cell (iPS)-derived neurons." | 1.56 | TrkC Overexpression Protects Sevoflurane-Induced Neurotoxicity in Human Induced Pluripotent Stem Cell-Derived Neurons. ( Chen, Z; Luo, X; Yang, Z; Zhang, J, 2020) |
| "Sevoflurane is a common anesthetic agent used in surgical settings and previous studies have indicated that it exerts a neurotoxic effect." | 1.48 | Sevoflurane‑induced neurotoxicity is driven by OXR1 post‑transcriptional downregulation involving hsa‑miR‑302e. ( Lei, X; Peng, J; Shen, Q; Xia, Y; Yang, L, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (2.13) | 29.6817 |
| 2010's | 16 (34.04) | 24.3611 |
| 2020's | 30 (63.83) | 2.80 |
| Authors | Studies |
|---|---|
| Wei, X | 1 |
| Xu, S | 2 |
| Chen, L | 3 |
| Gao, R | 1 |
| Neudecker, V | 2 |
| Perez-Zoghbi, JF | 3 |
| Brambrink, AM | 3 |
| Zhang, Y | 1 |
| Gao, Y | 1 |
| Yang, F | 1 |
| Wu, X | 1 |
| Tang, Z | 1 |
| Liu, H | 1 |
| Liang, L | 1 |
| Fan, Z | 1 |
| He, D | 1 |
| Zhao, Y | 3 |
| Zeng, T | 1 |
| Liu, B | 2 |
| Ma, T | 1 |
| Kang, J | 1 |
| Zhang, H | 3 |
| Zuo, C | 1 |
| Ma, J | 1 |
| Pan, Y | 1 |
| Zheng, D | 1 |
| Chen, C | 1 |
| Ruan, N | 1 |
| Su, Y | 1 |
| Nan, H | 1 |
| Lian, Q | 1 |
| Lin, H | 1 |
| Huang, C | 1 |
| Chu, JMT | 1 |
| Liu, Y | 1 |
| Kwong, VSW | 1 |
| Chang, RCC | 1 |
| Wong, GTC | 1 |
| Useinovic, N | 1 |
| Maksimovic, S | 1 |
| Liechty, C | 1 |
| Cabrera, OH | 1 |
| Quillinan, N | 1 |
| Jevtovic-Todorovic, V | 2 |
| Chen, Y | 3 |
| Gao, X | 1 |
| Pei, H | 1 |
| Chen, J | 2 |
| Feng, S | 1 |
| Li, L | 2 |
| Qiu, S | 1 |
| Jin, Y | 1 |
| Sun, Y | 1 |
| Wang, C | 1 |
| Jiang, Q | 1 |
| Zhao, P | 1 |
| Zhu, Y | 3 |
| Zhang, M | 2 |
| Wang, J | 3 |
| Wang, Q | 2 |
| Xu, Z | 1 |
| You, Y | 1 |
| Tang, Q | 1 |
| Zeng, H | 1 |
| Zhao, T | 1 |
| Li, F | 1 |
| Wen-Yuan, W | 1 |
| Wan-Qing, Y | 1 |
| Qi-Yun, H | 1 |
| Yu-Si, L | 1 |
| Shao-Jie, Q | 1 |
| Jin-Tao, L | 1 |
| Hui, M | 1 |
| Fang, C | 1 |
| Hui-Ling, Y | 1 |
| Xie, Y | 1 |
| Ni, H | 1 |
| Zhou, R | 1 |
| Li, X | 1 |
| Kokubun, H | 1 |
| Jin, H | 1 |
| Komita, M | 1 |
| Aoe, T | 1 |
| Tang, X | 1 |
| Zhou, Z | 2 |
| Yan, J | 2 |
| Zhou, B | 1 |
| Chi, X | 1 |
| Luo, A | 1 |
| Li, S | 1 |
| Wu, J | 1 |
| Yang, JJ | 1 |
| Cao, Y | 1 |
| Li, H | 1 |
| Zhao, H | 1 |
| Yang, S | 1 |
| Li, K | 1 |
| Yang, M | 1 |
| Lian, N | 1 |
| Yu, Y | 2 |
| Wang, Y | 1 |
| Xie, K | 1 |
| Zhu, W | 2 |
| Grafe, MR | 2 |
| Suo, L | 1 |
| Wang, M | 1 |
| Neag, MA | 1 |
| Mitre, AO | 1 |
| Catinean, A | 1 |
| Mitre, CI | 1 |
| Zhang, J | 4 |
| Chen, Z | 1 |
| Luo, X | 1 |
| Yang, Z | 1 |
| Tang, XL | 1 |
| Wang, X | 1 |
| Fang, G | 1 |
| Zhao, YL | 1 |
| Sun, R | 1 |
| Luo, AL | 1 |
| Li, SY | 1 |
| Jiang, C | 1 |
| Arzua, T | 1 |
| Yan, Y | 1 |
| Bai, X | 1 |
| Apai, C | 1 |
| Shah, R | 1 |
| Tran, K | 1 |
| Pandya Shah, S | 1 |
| Lee, JR | 1 |
| Joseph, B | 1 |
| Hofacer, RD | 1 |
| Upton, B | 1 |
| Lee, SY | 1 |
| Ewing, L | 1 |
| Zhang, B | 1 |
| Danzer, SC | 1 |
| Loepke, AW | 1 |
| Xu, R | 1 |
| Jia, J | 1 |
| Li, WX | 1 |
| Lu, Y | 1 |
| Huang, H | 1 |
| Liu, CM | 1 |
| Sun, J | 1 |
| Jin, WJ | 1 |
| Wu, YQ | 1 |
| Sanders, RD | 1 |
| Andropoulos, D | 1 |
| Ma, D | 1 |
| Maze, M | 1 |
| Bo, LJ | 1 |
| Yu, PX | 1 |
| Zhang, FZ | 1 |
| Dong, ZM | 1 |
| Yang, L | 1 |
| Shen, Q | 1 |
| Xia, Y | 1 |
| Lei, X | 1 |
| Peng, J | 1 |
| Ou, G | 1 |
| Hu, X | 2 |
| Huang, G | 1 |
| Wang, WY | 2 |
| Jia, LJ | 2 |
| Luo, Y | 1 |
| Zhang, HH | 2 |
| Cai, F | 2 |
| Mao, H | 2 |
| Xu, WC | 2 |
| Fang, JB | 1 |
| Peng, ZY | 1 |
| Ma, ZW | 1 |
| Chen, YH | 1 |
| Wei, Z | 1 |
| Yu, BW | 1 |
| Hu, SF | 2 |
| Chen, K | 1 |
| Shen, X | 1 |
| Wu, XM | 1 |
| Song, Q | 1 |
| Ma, YL | 1 |
| Song, JQ | 1 |
| Chen, Q | 1 |
| Xia, GS | 1 |
| Ma, JY | 1 |
| Feng, F | 1 |
| Fei, XJ | 1 |
| Wang, QM | 1 |
| Wang, W | 1 |
| Lu, R | 1 |
| Feng, DY | 1 |
| Edwards, DA | 1 |
| Shah, HP | 1 |
| Cao, W | 1 |
| Gravenstein, N | 1 |
| Seubert, CN | 1 |
| Martynyuk, AE | 1 |
| Yonamine, R | 1 |
| Satoh, Y | 1 |
| Kodama, M | 1 |
| Araki, Y | 1 |
| Kazama, T | 1 |
| Gentry, KR | 1 |
| Steele, LM | 1 |
| Sedensky, MM | 1 |
| Morgan, PG | 1 |
| Krane, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Dexmedetomidine on Cognitive Outcome and Brain Injury Markers After General Anesthesia for Cardiac Surgery on Cardiopulmonary Bypass[NCT03585452] | 23 participants (Actual) | Interventional | 2018-08-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for sevoflurane and Encephalopathy, Toxic
| Article | Year |
|---|---|
An Overview on the Mechanisms of Neuroprotection and Neurotoxicity of Isoflurane and Sevoflurane in Experimental Studies.
Topics: Animals; Humans; Isoflurane; Neuroprotection; Neuroprotective Agents; Neurotoxicity Syndromes; Sevof | 2020 |
Anesthesia and the Developing Brain: A Review of Sevoflurane-induced Neurotoxicity in Pediatric Populations.
Topics: Aged; Anesthesia, General; Anesthetics, Inhalation; Animals; Brain; Child; Humans; Methyl Ethers; Ne | 2021 |
45 other studies available for sevoflurane and Encephalopathy, Toxic
| Article | Year |
|---|---|
LncRNA Neat1/miR-298-5p/Srpk1 Contributes to Sevoflurane-Induced Neurotoxicity.
Topics: Anesthetics, Inhalation; Animals; Gene Expression Regulation; Hippocampus; Mice; MicroRNAs; Neurons; | 2021 |
Dexmedetomidine regulates sevoflurane-induced neurotoxicity through the miR-330-3p/ULK1 axis.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Autophagy-Related Protein-1 Homolog; Dexmedetomidine; M | 2021 |
Does inflammation mediate behavioural alterations in anaesthesia-induced developmental neurotoxicity?
Topics: Anesthesia; Animals; Humans; Inflammation; Neurotoxicity Syndromes; Rats; Sevoflurane | 2022 |
Neuroglobin alleviates the neurotoxicity of sevoflurane to fetal rats by inhibiting neuroinflammation and affecting microglial polarization.
Topics: Animals; Female; Microglia; Neuroglobin; Neuroinflammatory Diseases; Neurotoxicity Syndromes; Pregna | 2022 |
Sevoflurane-Induced Neurotoxicity in the Developing Hippocampus via HIPK2/AKT/mTOR Signaling.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Hippocampus; Mice; Neurotoxicity Syndromes; Protein Ser | 2022 |
Isoflurane and Sevoflurane Induce Cognitive Impairment in Neonatal Rats by Inhibiting Neural Stem Cell Development Through Microglial Activation, Neuroinflammation, and Suppression of VEGFR2 Signaling Pathway.
Topics: Anesthetics; Anesthetics, Inhalation; Animals; Animals, Newborn; Cognitive Dysfunction; Hippocampus; | 2022 |
Sevoflurane Induces Neurotoxicity in the Animal Model with Alzheimer's Disease Neuropathology via Modulating Glutamate Transporter and Neuronal Apoptosis.
Topics: Alzheimer Disease; Amino Acid Transport System X-AG; Anesthetics, Inhalation; Animals; Apoptosis; Di | 2022 |
Systemic inflammation exacerbates developmental neurotoxicity induced by sevoflurane in neonatal rats.
Topics: Animals; Animals, Newborn; Caspase 1; Caspase 3; Caspase 9; Cytokines; Inflammation; Interleukin-18; | 2022 |
miRNA-384-3p alleviates sevoflurane-induced nerve injury by inhibiting Aak1 kinase in neonatal rats.
Topics: Animals; Animals, Newborn; Apoptosis; Hippocampus; Humans; Maze Learning; MicroRNAs; Neurotoxicity S | 2022 |
Protective role of trametenolic acid B against sevoflurane-induced cognitive impairments by its different regulatory modalities of mir-329-3p in neurons and microglia.
Topics: Animals; Cognitive Dysfunction; Microglia; MicroRNAs; Neurons; Neurotoxicity Syndromes; NF-kappa B; | 2022 |
Sevoflurane exposure during the second trimester induces neurotoxicity in offspring rats by hyperactivation of PARP-1.
Topics: Anesthetics, Inhalation; Animals; Female; Focal Adhesion Kinase 2; Neurotoxicity Syndromes; Nogo Pro | 2022 |
Knockdown of UAF1 alleviates sevoflurane-induced cognitive impairment and neurotoxicity in rats by inhibiting pro-inflammatory signaling and oxidative stress.
Topics: Animals; Cognitive Dysfunction; Inflammasomes; Neurotoxicity Syndromes; NLR Family, Pyrin Domain-Con | 2022 |
Echinatin mitigates sevoflurane-induced hippocampal neurotoxicity and cognitive deficits through mitigation of iron overload and oxidative stress.
Topics: Animals; Antioxidants; Apoptosis; Chalcones; Cognition; Hippocampus; Iron Overload; Male; Neurotoxic | 2022 |
mTORC1-Dependent and GSDMD-Mediated Pyroptosis in Developmental Sevoflurane Neurotoxicity.
Topics: Gasdermins; Humans; Intracellular Signaling Peptides and Proteins; Mechanistic Target of Rapamycin C | 2023 |
Effects of overexpression of Hsp70 in neural stem cells on neurotoxicity and cognitive dysfunction in neonatal mice under sevoflurane exposure.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Cognitive Dysfunction; Hippocampus; HSP70 Heat-S | 2022 |
Lin28A Reduced Sevoflurane-Induced Nerve Injury and Cognitive Dysfunction by Inhibiting Tau Acetylation and Phosphorylation via Activating SIRT1 in Elderly Rats.
Topics: Acetylation; Animals; Apoptosis; Cognitive Dysfunction; Hippocampus; Neurotoxicity Syndromes; Phosph | 2022 |
Theaflavins alleviate sevoflurane-induced neurocytotoxicity via Nrf2 signaling pathway.
Topics: Animals; Apoptosis; Biflavonoids; Caspase 3; Caspase 9; Catechin; Cell Survival; Dose-Response Relat | 2020 |
Conflicting Actions of Inhalational Anesthetics, Neurotoxicity and Neuroprotection, Mediated by the Unfolded Protein Response.
Topics: Anesthetics, Inhalation; Animals; Brain; Endoplasmic Reticulum Stress; Female; Male; Mice; Mice, Inb | 2020 |
Resveratrol Mitigates Sevoflurane-Induced Neurotoxicity by the SIRT1-Dependent Regulation of BDNF Expression in Developing Mice.
Topics: Animals; Antioxidants; Brain-Derived Neurotrophic Factor; Humans; Male; Mice; Neurotoxicity Syndrome | 2020 |
Iron overload contributes to general anaesthesia-induced neurotoxicity and cognitive deficits.
Topics: Anesthesia, General; Anesthetics, General; Animals; Hippocampus; Iron; Iron Overload; Ketamine; Male | 2020 |
Coenzyme Q10 alleviates sevoflurane‑induced neuroinflammation by regulating the levels of apolipoprotein E and phosphorylated tau protein in mouse hippocampal neurons.
Topics: Anesthetics, Inhalation; Animals; Apolipoproteins E; Cells, Cultured; Hippocampus; Inflammation; Mic | 2020 |
Neurotoxicity of sub-anesthetic doses of sevoflurane and dexmedetomidine co-administration in neonatal rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Anesthetics, Inhalation; Animals; Animals, Newborn; Apoptosis; | 2020 |
Dexmedetomidine alleviates sevoflurane-induced neurotoxicity via mitophagy signaling.
Topics: Animals; Dexmedetomidine; Mitophagy; Neurotoxicity Syndromes; Rats; Rats, Sprague-Dawley; Sevofluran | 2020 |
TrkC Overexpression Protects Sevoflurane-Induced Neurotoxicity in Human Induced Pluripotent Stem Cell-Derived Neurons.
Topics: Anesthetics, Inhalation; Humans; Induced Pluripotent Stem Cells; Neurons; Neurotoxicity Syndromes; R | 2020 |
Resveratrol ameliorates sevoflurane-induced cognitive impairment by activating the SIRT1/NF-κB pathway in neonatal mice.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Anti-Inflammatory Agents; Cognitive Dysfunction; | 2021 |
Expression Signature of lncRNAs and mRNAs in Sevoflurane-Induced Mouse Brain Injury: Implication of Involvement of Wide Molecular Networks and Pathways.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Child Development; Computational Biology; Disease Model | 2021 |
Effect of dexmedetomidine on sevoflurane-induced neurodegeneration in neonatal rats.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Apoptosis; Brain; Cell Death; Dexmedetomidine; D | 2021 |
RIPK1/RIPK3-Mediated Necroptosis is Involved in Sevoflurane-Induced Neonatal Neurotoxicity in the Rat Hippocampus.
Topics: Animals; Apoptosis; Hippocampus; Necroptosis; Neurotoxicity Syndromes; Protein Kinases; Rats; Rats, | 2022 |
Repeated 2% sevoflurane administration in 7‑ and 60-day-old rats : Neurotoxicity and neurocognitive dysfunction.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Antigens, Nuclear; Apoptosis; Brain; Caspase 3; | 2017 |
Dexmedetomidine-mediated neuroprotection against sevoflurane-induced neurotoxicity extends to several brain regions in neonatal rats.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Apoptosis; Brain; Dexmedetomidine; Disease Model | 2017 |
Theseus, the Labyrinth, and the Minotaur of anaesthetic-induced developmental neurotoxicity.
Topics: Anesthetics; Animals; Dexmedetomidine; Ear, Inner; Neurotoxicity Syndromes; Rats; Sevoflurane | 2017 |
Monkey business: the importance of mounting behavioural evidence for anaesthesia-induced developmental neurotoxicity.
Topics: Anesthesia; Anesthesiology; Animals; Macaca mulatta; Neurotoxicity Syndromes; Sevoflurane | 2018 |
Dexmedetomidine mitigates sevoflurane-induced cell cycle arrest in hippocampus.
Topics: Anesthetics; Animals; Brain-Derived Neurotrophic Factor; Cell Cycle Checkpoints; Dexmedetomidine; Hi | 2018 |
Sevoflurane‑induced neurotoxicity is driven by OXR1 post‑transcriptional downregulation involving hsa‑miR‑302e.
Topics: Apoptosis; Calcium; Flow Cytometry; Gene Expression Regulation; Hippocampus; Humans; L-Lactate Dehyd | 2018 |
Inhibition of protein tyrosine phosphatase 1B protects against sevoflurane-induced neurotoxicity mediated by ER stress in developing brain.
Topics: Animals; Brain; Caspase 3; Dendritic Spines; eIF-2 Kinase; Endoplasmic Reticulum; Endoplasmic Reticu | 2019 |
LncRNA MALAT1 is involved in sevoflurane-induced neurotoxicity in developing rats.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Apoptosis Regulatory Proteins; Brain-Derived Neurotroph | 2019 |
Location- and Subunit-Specific NMDA Receptors Determine the Developmental Sevoflurane Neurotoxicity Through ERK1/2 Signaling.
Topics: Animals; Cell Death; Cell Survival; Excitatory Amino Acid Antagonists; Hippocampus; MAP Kinase Signa | 2016 |
Environmental Enrichment Attenuated Sevoflurane-Induced Neurotoxicity through the PPAR-γ Signaling Pathway.
Topics: Animals; Apoptosis; Cognition Disorders; Down-Regulation; Environment; Male; Memory Disorders; Methy | 2015 |
Beta-arrestin1 and 2 differently modulate metabotropic glutamate receptor 7 signaling in rat developmental sevoflurane-induced neuronal apoptosis.
Topics: Animals; Apoptosis; Arrestins; Benzhydryl Compounds; beta-Arrestin 1; beta-Arrestin 2; beta-Arrestin | 2016 |
Sevoflurane induces neurotoxicity in young mice through FAS/FASL signaling.
Topics: Anesthetics; Animals; Apoptosis; Fas Ligand Protein; fas Receptor; Humans; Maze Learning; Methyl Eth | 2015 |
Sevoflurane Inhibits Glutamate-Aspartate Transporter and Glial Fibrillary Acidic Protein Expression in Hippocampal Astrocytes of Neonatal Rats Through the Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) Pathway.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Down-Regulation; Ex | 2016 |
Bumetanide alleviates epileptogenic and neurotoxic effects of sevoflurane in neonatal rat brain.
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Animals, Newborn; Blotting, Western; Bumet | 2010 |
Coadministration of hydrogen gas as part of the carrier gas mixture suppresses neuronal apoptosis and subsequent behavioral deficits caused by neonatal exposure to sevoflurane in mice.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Blotting, Western; | 2013 |
Early developmental exposure to volatile anesthetics causes behavioral defects in Caenorhabditis elegans.
Topics: Analysis of Variance; Anesthetics, Inhalation; Animals; Apoptosis Regulatory Proteins; Behavior, Ani | 2013 |
Defining the anatomy of Freudian psychiatry.
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Humans; Methyl Ethers; Neurotoxicity Syndromes; Psy | 2000 |