sevoflurane has been researched along with Electrocardiogram QT Prolonged in 31 studies
Sevoflurane: A non-explosive inhalation anesthetic used in the induction and maintenance of general anesthesia. It does not cause respiratory irritation and may also prevent PLATELET AGGREGATION.
sevoflurane : An ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We describe a case of torsade de pointes (TdP) caused by sevoflurane in a patient with c-LQTS genotype 2 (LQT2)." | 7.83 | Sevoflurane-associated torsade de pointes in a patient with congenital long QT syndrome genotype 2. ( Hara, K; Kumakura, M; Sata, T, 2016) |
| "We present the occurrence of 'torsade de pointes' induced by the combination of peroperative fluconazole administration and sevoflurane anesthesia in a patient with 'long QT syndrome' (LQTS) scheduled for resection of a sacral abscess." | 7.77 | Torsade de pointes during sevoflurane anesthesia and fluconazole infusion in a patient with long QT syndrome. A case report. ( Bracke, FA; Tacken, MC; Van Zundert, AA, 2011) |
| "We report a case of torsade de pointes secondary to acute QT interval prolongation in a patient with poorly controlled diabetes mellitus towards the end of a laparoscopic nephrectomy under sevoflurane anaesthesia." | 7.76 | Torsade de pointes in a patient with acute prolonged QT syndrome and poorly controlled diabetes during sevoflurane anaesthesia. ( Biradar, V; Euler, P; Moodie, S; Osborn, KD; Sethi, R; Thiruvenkatarajan, V; Van Wijk, RM, 2010) |
| " DPI 201-106 is an experimental drug that produces QT prolongation by reducing Na(+) channel inactivation, thereby mimicking congenital long QT syndrome type 3 (LQT3)." | 7.74 | Functional interaction between DPI 201-106, a drug that mimics congenital long QT syndrome, and sevoflurane on the guinea-pig cardiac action potential. ( Chen, XL; Kang, J; Rampe, D; Reynolds, WP, 2007) |
| "We present a case of congenital long QT syndrome which developed torsade de pointes during sevoflurane anesthesia for implantation of an internal cardioverter-defibrillator." | 7.73 | Torsade de pointes during sevoflurane anesthesia in a child with congenital long QT syndrome. ( Davy, JM; Frapier, JM; Massad, I; Raczka, F; Saussine, M, 2006) |
| "Palonosetron is a recently introduced 5-HT3 receptor antagonist for postoperative nausea and vomiting." | 5.19 | Effect of palonosetron on the QTc interval in patients undergoing sevoflurane anaesthesia. ( Choi, EK; Hong, DM; Jeon, Y; Jung, YS; Kim, HJ; Lee, HC; Lee, J; Min, JJ; Oh, S, 2014) |
| "This simulation study was designed to predict the torsadogenicity of sevoflurane and propofol in healthy control, as well as type 1 and type 2 long QT syndrome (LQT1 and LQT2, respectively), using the O'Hara-Rudy dynamic model." | 4.31 | Prediction of anesthetic torsadogenicity using a human ventricular cell model. ( Fukushima, Y; Kojima, A; Matsuura, H, 2023) |
| " We describe a case of torsade de pointes (TdP) caused by sevoflurane in a patient with c-LQTS genotype 2 (LQT2)." | 3.83 | Sevoflurane-associated torsade de pointes in a patient with congenital long QT syndrome genotype 2. ( Hara, K; Kumakura, M; Sata, T, 2016) |
| "We present the occurrence of 'torsade de pointes' induced by the combination of peroperative fluconazole administration and sevoflurane anesthesia in a patient with 'long QT syndrome' (LQTS) scheduled for resection of a sacral abscess." | 3.77 | Torsade de pointes during sevoflurane anesthesia and fluconazole infusion in a patient with long QT syndrome. A case report. ( Bracke, FA; Tacken, MC; Van Zundert, AA, 2011) |
| "We report a case of torsade de pointes secondary to acute QT interval prolongation in a patient with poorly controlled diabetes mellitus towards the end of a laparoscopic nephrectomy under sevoflurane anaesthesia." | 3.76 | Torsade de pointes in a patient with acute prolonged QT syndrome and poorly controlled diabetes during sevoflurane anaesthesia. ( Biradar, V; Euler, P; Moodie, S; Osborn, KD; Sethi, R; Thiruvenkatarajan, V; Van Wijk, RM, 2010) |
| " DPI 201-106 is an experimental drug that produces QT prolongation by reducing Na(+) channel inactivation, thereby mimicking congenital long QT syndrome type 3 (LQT3)." | 3.74 | Functional interaction between DPI 201-106, a drug that mimics congenital long QT syndrome, and sevoflurane on the guinea-pig cardiac action potential. ( Chen, XL; Kang, J; Rampe, D; Reynolds, WP, 2007) |
| "We present a case of congenital long QT syndrome which developed torsade de pointes during sevoflurane anesthesia for implantation of an internal cardioverter-defibrillator." | 3.73 | Torsade de pointes during sevoflurane anesthesia in a child with congenital long QT syndrome. ( Davy, JM; Frapier, JM; Massad, I; Raczka, F; Saussine, M, 2006) |
| "Patients with congenital sensorineural hearing loss (SNHL) often have a prolonged QTI." | 2.74 | Effects of sevoflurane on QT parameters in children with congenital sensorineural hearing loss. ( Kim, CS; Kim, HS; Kim, JT; Kim, K; Kim, SD; Yum, MK, 2009) |
| "005), with no dose-response relationship, but had no effect on preoperative Tp-e." | 2.73 | A comparison of the effect on dispersion of repolarization of age-adjusted MAC values of sevoflurane in children. ( Booker, PD; Lim, J; Sanatani, S; Whyte, SD, 2007) |
| "A 30-month-old boy had sudden cardiac arrest during anesthesia induction before plastic surgery for bilateral cutaneous syndactyly." | 1.39 | Sudden cardiac arrest during anesthesia in a 30-month-old boy with syndactyly: a case of genetically proven Timothy syndrome. ( An, HS; Bae, EJ; Choi, EY; Choi, JY; Kim, GB; Kwon, BS; Noh, CI; Park, SS, 2013) |
| "Acquired long QT syndrome is a rare condition whose diagnosis is of vital importance given the risk of torsade de pointes and sudden death." | 1.36 | [Perioperative acquired long QT syndrome: a case report]. ( Arizaga, A; Goitia, L; Pérez, P; Sebastián, P; Taibo, JM, 2010) |
| " We performed a pharmacodynamic analysis of the relationship between end-tidal sevoflurane concentration (CET) and the QTc." | 1.36 | Modeling the effect of sevoflurane on corrected QT prolongation: a pharmacodynamic analysis. ( Han, DW; Jang, SB; Kern, SE; Park, K, 2010) |
| "Sevoflurane produced an increase in action potential duration at concentrations of 0." | 1.33 | Mechanisms underlying the QT interval-prolonging effects of sevoflurane and its interactions with other QT-prolonging drugs. ( Chen, XL; Ji, J; Kang, J; Rampe, DE; Reynolds, WP; Wang, H, 2006) |
| "Sevoflurane was applied by bubbling into the bathing solution." | 1.32 | [Mechanism of QT interval prolongation induced by sevoflurane in guinea-pig ventricular myocyte]. ( Hatakeyama, N; Momose, Y; Shibuya, N; Yamada, M; Yamazaki, M, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (3.23) | 18.2507 |
| 2000's | 14 (45.16) | 29.6817 |
| 2010's | 13 (41.94) | 24.3611 |
| 2020's | 3 (9.68) | 2.80 |
| Authors | Studies |
|---|---|
| Kojima, A | 2 |
| Fukushima, Y | 2 |
| Matsuura, H | 2 |
| Nagasawa, Y | 1 |
| Sakai, K | 1 |
| Kurimoto, R | 1 |
| Kawakami, S | 1 |
| Aimoto, M | 1 |
| Takahara, A | 1 |
| Itoh, H | 1 |
| Imoto, K | 1 |
| An, HS | 1 |
| Choi, EY | 1 |
| Kwon, BS | 1 |
| Kim, GB | 1 |
| Bae, EJ | 1 |
| Noh, CI | 1 |
| Choi, JY | 1 |
| Park, SS | 1 |
| Kim, HJ | 1 |
| Lee, HC | 1 |
| Jung, YS | 1 |
| Lee, J | 1 |
| Min, JJ | 1 |
| Hong, DM | 1 |
| Choi, EK | 1 |
| Oh, S | 1 |
| Jeon, Y | 1 |
| Lee, JH | 1 |
| Park, YH | 1 |
| Kim, JT | 3 |
| Kim, CS | 2 |
| Kim, HS | 2 |
| Saini, A | 1 |
| Shah, H | 1 |
| Saba, S | 1 |
| Choromanski, DW | 1 |
| Amin, S | 1 |
| Zestos, MM | 1 |
| Kumakura, M | 1 |
| Hara, K | 1 |
| Sata, T | 1 |
| Çimen, NK | 1 |
| Kösem, B | 1 |
| Çimen, T | 1 |
| Kartal, S | 1 |
| Muslu, B | 1 |
| Karabayırlı, S | 1 |
| Gözdemir, M | 1 |
| Kılınç, H | 1 |
| Roepke, TK | 1 |
| Kontogeorgis, A | 1 |
| Ovanez, C | 1 |
| Xu, X | 1 |
| Young, JB | 1 |
| Purtell, K | 1 |
| Goldstein, PA | 1 |
| Christini, DJ | 1 |
| Peters, NS | 1 |
| Akar, FG | 1 |
| Gutstein, DE | 1 |
| Lerner, DJ | 1 |
| Abbott, GW | 1 |
| Zhang, X | 1 |
| Firth, PG | 1 |
| Kim, SD | 1 |
| Kim, K | 1 |
| Yum, MK | 1 |
| Goitia, L | 1 |
| Pérez, P | 1 |
| Sebastián, P | 1 |
| Taibo, JM | 1 |
| Arizaga, A | 1 |
| Thiruvenkatarajan, V | 1 |
| Osborn, KD | 1 |
| Van Wijk, RM | 1 |
| Euler, P | 1 |
| Sethi, R | 1 |
| Moodie, S | 1 |
| Biradar, V | 1 |
| Scuderi, PE | 1 |
| Han, DW | 2 |
| Park, K | 1 |
| Jang, SB | 1 |
| Kern, SE | 1 |
| Tacken, MC | 1 |
| Bracke, FA | 1 |
| Van Zundert, AA | 1 |
| Spevak, C | 1 |
| Hamsher, C | 1 |
| Brown, CQ | 1 |
| Wedam, EF | 1 |
| Haigney, MC | 1 |
| Yamada, M | 2 |
| Hatakeyama, N | 2 |
| Shibuya, N | 1 |
| Momose, Y | 2 |
| Yamazaki, M | 2 |
| Whyte, SD | 3 |
| Booker, PD | 3 |
| Buckley, DG | 1 |
| Malykhina, AP | 1 |
| Akbarali, HI | 1 |
| Saussine, M | 1 |
| Massad, I | 1 |
| Raczka, F | 1 |
| Davy, JM | 1 |
| Frapier, JM | 1 |
| Muntyan, I | 1 |
| Bashkirov, IL | 1 |
| Bloom, M | 1 |
| Hartmannsgruber, MW | 1 |
| Kang, J | 2 |
| Reynolds, WP | 2 |
| Chen, XL | 2 |
| Ji, J | 1 |
| Wang, H | 1 |
| Rampe, DE | 1 |
| Sanatani, S | 2 |
| Lim, J | 1 |
| Rampe, D | 1 |
| Kweon, TD | 1 |
| Nam, SB | 1 |
| Chang, CH | 1 |
| Kim, MS | 1 |
| Lee, JS | 1 |
| Shin, CS | 1 |
| June, DB | 1 |
| Gallagher, JD | 1 |
| Weindling, SN | 1 |
| Anderson, G | 1 |
| Fillinger, MP | 1 |
| Kleinsasser, A | 1 |
| Loeckinger, A | 1 |
| Lindner, KH | 1 |
| Keller, C | 1 |
| Boehler, M | 1 |
| Puehringer, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Palonosetron on the QTc Interval During Perioperative Period[NCT01650961] | 100 participants (Actual) | Interventional | 2012-07-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for sevoflurane and Electrocardiogram QT Prolonged
| Article | Year |
|---|---|
The clinical significance of QT interval prolongation in anesthesia and pain management: what you should and should not worry about.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Anesthetics, Inhalation; Droperidol; Humans; Long QT Synd | 2012 |
7 trials available for sevoflurane and Electrocardiogram QT Prolonged
| Article | Year |
|---|---|
Effect of palonosetron on the QTc interval in patients undergoing sevoflurane anaesthesia.
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthetics, Inhalation; Antiemetics; Blood Pressure; Double-Bl | 2014 |
Effects of remifentanil, nitroglycerin, and sevoflurane on the corrected QT and Tp-e intervals during controlled hypotensive anesthesia.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Anesthesia; Anesthetics, Inhalation; Arrhythmias, Cardi | 2016 |
Effects of sevoflurane on QT parameters in children with congenital sensorineural hearing loss.
Topics: Adolescent; Algorithms; Anesthetics, Inhalation; Child; Child, Preschool; Electrocardiography; Heari | 2009 |
The effects of propofol and sevoflurane on the QT interval and transmural dispersion of repolarization in children.
Topics: Adolescent; Anesthesia, General; Anesthetics, Intravenous; Child; Child, Preschool; Electrocardiogra | 2005 |
A comparison of the effect on dispersion of repolarization of age-adjusted MAC values of sevoflurane in children.
Topics: Age Factors; Child; Child, Preschool; Electroencephalography; Female; Humans; Long QT Syndrome; Male | 2007 |
The effect of bolus administration of remifentanil on QTc interval during induction of sevoflurane anaesthesia.
Topics: Adult; Analgesics, Opioid; Anesthetics, Inhalation; Blood Pressure; Dose-Response Relationship, Drug | 2008 |
Reversing sevoflurane-associated Q-Tc prolongation by changing to propofol.
Topics: Adult; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Electrocardiography; | 2001 |
23 other studies available for sevoflurane and Electrocardiogram QT Prolonged
| Article | Year |
|---|---|
Prediction of anesthetic torsadogenicity using a human ventricular cell model.
Topics: Action Potentials; Anesthetics; Humans; Long QT Syndrome; Propofol; Sevoflurane | 2023 |
Sensitivity of inhalation anesthetics isoflurane and sevoflurane for the drug-induced QT-interval prolongation in guinea pigs.
Topics: Action Potentials; Anesthetics, Inhalation; Animals; Electrocardiography; Fluoroquinolones; Guinea P | 2020 |
A computational analysis of the effect of sevoflurane in a human ventricular cell model of long QT syndrome: Importance of repolarization reserve in the QT-prolonging effect of sevoflurane.
Topics: Action Potentials; Case-Control Studies; Computer Simulation; Delayed Rectifier Potassium Channels; | 2020 |
Sudden cardiac arrest during anesthesia in a 30-month-old boy with syndactyly: a case of genetically proven Timothy syndrome.
Topics: Anesthesia; Autistic Disorder; Calcium Channels, L-Type; Death, Sudden, Cardiac; Electroencephalogra | 2013 |
The effect of sevoflurane and ondansetron on QT interval and transmural dispersion of repolarization in children.
Topics: Adolescent; Anesthetics, Inhalation; Antiemetics; Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Co | 2014 |
QT prolongation and T-wave alternans during catheter ablation of atrial fibrillation: a case report.
Topics: Anesthetics, Inhalation; Atrial Fibrillation; Catheter Ablation; Electrocardiography; Female; Humans | 2014 |
SEVOFLURANE AS A CAUSE OF TORSADE DE POINTES IN PATIENT WITH THE LONG QT SYNDROME: Case Report.
Topics: Adolescent; Electrocardiography; Female; Humans; Long QT Syndrome; Methyl Ethers; Sevoflurane; Torsa | 2016 |
Sevoflurane-associated torsade de pointes in a patient with congenital long QT syndrome genotype 2.
Topics: Abortion, Therapeutic; Adult; Anesthetics, Inhalation; Electrocardiography; Female; Genotype; Humans | 2016 |
Targeted deletion of kcne2 impairs ventricular repolarization via disruption of I(K,slow1) and I(to,f).
Topics: Anesthetics, Inhalation; Animals; Heart Conduction System; Heart Ventricles; Humans; Immunoprecipita | 2008 |
Third degree atrio-ventricular block in a 4-year-old child during sevoflurane anesthesia.
Topics: Anesthesia, General; Anesthetics, Inhalation; Atrioventricular Block; Child, Preschool; Electrocardi | 2008 |
[Perioperative acquired long QT syndrome: a case report].
Topics: Adjuvants, Anesthesia; Adrenergic beta-Antagonists; Amoxicillin-Potassium Clavulanate Combination; A | 2010 |
Torsade de pointes in a patient with acute prolonged QT syndrome and poorly controlled diabetes during sevoflurane anaesthesia.
Topics: Acute Disease; Aged; Anesthetics, Inhalation; Diabetes Mellitus, Type 2; Electrocardiography; Female | 2010 |
Sevoflurane and QTc Prolongation: An Interesting Observation, or a Clinically Significant Finding?
Topics: Anesthetics, Inhalation; Dose-Response Relationship, Drug; Humans; Long QT Syndrome; Methyl Ethers; | 2010 |
Modeling the effect of sevoflurane on corrected QT prolongation: a pharmacodynamic analysis.
Topics: Adult; Anesthetics, Inhalation; Data Interpretation, Statistical; Dose-Response Relationship, Drug; | 2010 |
Torsade de pointes during sevoflurane anesthesia and fluconazole infusion in a patient with long QT syndrome. A case report.
Topics: Abscess; Aged; Anesthetics, Inhalation; Antifungal Agents; Electrocardiography; Female; Fluconazole; | 2011 |
[Mechanism of QT interval prolongation induced by sevoflurane in guinea-pig ventricular myocyte].
Topics: Action Potentials; Anesthetics, Inhalation; Animals; Calcium Channels; Electrocardiography; Female; | 2003 |
The effects of sevoflurane and propofol on QT interval and heterologously expressed human ether-a-go-go related gene currents in Xenopus oocytes.
Topics: Animals; Dose-Response Relationship, Drug; Ether-A-Go-Go Potassium Channels; Female; Gene Expression | 2006 |
Torsade de pointes during sevoflurane anesthesia in a child with congenital long QT syndrome.
Topics: Anesthetics, Inhalation; Anticonvulsants; Child; Defibrillators, Implantable; Electrocardiography; H | 2006 |
The use of bispectral index monitoring in the anesthetic management of a patient with Rett syndrome undergoing scoliosis surgery.
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Child; Electroencephalography; Female; Humans; Long | 2006 |
Mechanisms underlying the QT interval-prolonging effects of sevoflurane and its interactions with other QT-prolonging drugs.
Topics: Action Potentials; Adrenergic beta-Antagonists; Anesthetics, Inhalation; Animals; Anti-Arrhythmia Ag | 2006 |
Torsades de pointes with sevoflurane.
Topics: Anesthetics, Inhalation; Electrocardiography; Humans; Long QT Syndrome; Methyl Ethers; Sevoflurane; | 2006 |
Functional interaction between DPI 201-106, a drug that mimics congenital long QT syndrome, and sevoflurane on the guinea-pig cardiac action potential.
Topics: Action Potentials; Anesthetics, Inhalation; Animals; Cardiotonic Agents; Guinea Pigs; Heart; Long QT | 2007 |
Effects of sevoflurane on QT interval in a patient with congenital long QT syndrome.
Topics: Adolescent; Anesthesia, Inhalation; Anesthetics, Inhalation; Electrocardiography; Female; Heart Rate | 1998 |