sevoflurane has been researched along with Delayed Effects, Prenatal Exposure in 23 studies
Sevoflurane: A non-explosive inhalation anesthetic used in the induction and maintenance of general anesthesia. It does not cause respiratory irritation and may also prevent PLATELET AGGREGATION.
sevoflurane : An ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These results suggest that the exposure during late pregnancy to a clinically relevant concentration of sevoflurane does not affect neuronal development and learning/memory ability of offspring mice." | 7.83 | Effects of sevoflurane exposure during late pregnancy on brain development of offspring mice. ( Maekawa, N; Mizobuchi, S; Morishita, J; Suehara, T; Ueki, M; Ueno, M, 2016) |
| " Recently, we have found that sevoflurane anesthesia during pregnancy in mice-induced cognitive impairment in the offspring by causing iron deficiency and inhibiting myelinogenesis." | 5.12 | Prenatal sevoflurane exposure: Effects of iron metabolic dysfunction on offspring cognition and potential mechanism. ( Chang, Y; Shi, Z; Thirupathi, A; Zhou, C; Zuo, Y, 2021) |
| " This study was conducted to investigate the mechanism of potential neurotoxicity on their offspring generation after sevoflurane anesthesia in adult animals during pregnancy based on metabolomics." | 3.85 | Potential neurotoxicity of prenatal exposure to sevoflurane on offspring: Metabolomics investigation on neurodevelopment and underlying mechanism. ( Jiang, J; Jin, Y; Li, S; Li, Y; Wang, Y; Xiao, X; Yan, S; Yang, Z, 2017) |
| "These results suggest that the exposure during late pregnancy to a clinically relevant concentration of sevoflurane does not affect neuronal development and learning/memory ability of offspring mice." | 3.83 | Effects of sevoflurane exposure during late pregnancy on brain development of offspring mice. ( Maekawa, N; Mizobuchi, S; Morishita, J; Suehara, T; Ueki, M; Ueno, M, 2016) |
| "Sevoflurane is a widely used volatile anesthetic in clinical practice." | 1.51 | Suberoylanilide hydroxamic acid (SAHA) alleviates the learning and memory impairment in rat offspring caused by maternal sevoflurane exposure during late gestation. ( Feng, N; Hu, Y; Li, M; Liu, Y; Liu, Z; Luo, F; Wu, L; Xu, L; Yu, Q; Zhao, W, 2019) |
| "Sevoflurane is a new inhalation anesthetic agent commonly used in the clinic." | 1.38 | Chronic exposure of gestation rat to sevoflurane impairs offspring brain development. ( Cheng, Y; Liu, G; Tian, X; Tu, X; Wang, J; Wang, Y, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 14 (60.87) | 24.3611 |
| 2020's | 9 (39.13) | 2.80 |
| Authors | Studies |
|---|---|
| Gao, Y | 2 |
| Zhao, T | 1 |
| Chen, Y | 1 |
| Sun, Z | 1 |
| Lu, J | 1 |
| Shi, Z | 3 |
| Song, X | 1 |
| Liu, H | 2 |
| Meng, X | 1 |
| Li, Y | 3 |
| Chen, S | 1 |
| Ji, Y | 1 |
| Song, S | 3 |
| Ji, F | 3 |
| Jin, X | 2 |
| Zhou, B | 1 |
| Chen, L | 1 |
| Liao, P | 1 |
| Huang, L | 1 |
| Chen, Z | 1 |
| Liao, D | 1 |
| Yang, L | 1 |
| Wang, J | 2 |
| Yu, G | 1 |
| Wang, L | 1 |
| Zhang, J | 1 |
| Zuo, Y | 3 |
| Liu, J | 1 |
| Jiang, R | 1 |
| Chai, D | 2 |
| Cheng, Y | 3 |
| Sun, Y | 1 |
| Yan, J | 1 |
| Hu, R | 1 |
| Zhang, L | 1 |
| Jiang, H | 2 |
| Li, B | 1 |
| Xie, J | 1 |
| Ma, Z | 1 |
| Thirupathi, A | 2 |
| Yu, P | 1 |
| Gao, G | 1 |
| Zhou, J | 1 |
| Zhou, C | 2 |
| Xu, H | 1 |
| Chang, Y | 2 |
| Wu, Z | 1 |
| Zhang, Y | 4 |
| Yang, X | 1 |
| Zhao, P | 2 |
| Chen, B | 1 |
| Liu, Y | 2 |
| Cai, Y | 1 |
| Tang, D | 1 |
| Xu, S | 1 |
| Gao, P | 1 |
| Yu, W | 1 |
| Jiao, Y | 1 |
| Li, W | 1 |
| Chen, Q | 2 |
| Chu, W | 2 |
| Sheng, R | 1 |
| Yang, J | 1 |
| Jiang, M | 1 |
| Tang, T | 1 |
| Liang, X | 1 |
| Li, J | 1 |
| Qiu, Y | 1 |
| Liu, S | 1 |
| Bian, S | 1 |
| Xie, Y | 1 |
| Fang, F | 2 |
| Cang, J | 2 |
| Liu, M | 1 |
| Sun, J | 1 |
| Wang, Y | 5 |
| Xing, Q | 1 |
| Han, XG | 1 |
| Dong, X | 1 |
| Lu, Y | 1 |
| Zhou, M | 1 |
| Lee, S | 1 |
| Chung, W | 1 |
| Park, H | 2 |
| Yoon, S | 1 |
| Park, S | 1 |
| Park, J | 1 |
| Heo, JY | 1 |
| Ju, X | 1 |
| Yoon, SH | 1 |
| Kim, YH | 1 |
| Ko, Y | 1 |
| Jiang, J | 1 |
| Li, S | 1 |
| Xiao, X | 1 |
| Jin, Y | 1 |
| Yang, Z | 1 |
| Yan, S | 1 |
| Yin, S | 1 |
| Xue, H | 1 |
| Yang, Y | 1 |
| Zhang, N | 1 |
| Yu, Q | 1 |
| Feng, N | 1 |
| Hu, Y | 1 |
| Luo, F | 1 |
| Zhao, W | 2 |
| Liu, Z | 1 |
| Li, M | 1 |
| Xu, L | 1 |
| Wu, L | 1 |
| Yang, F | 1 |
| Shan, Y | 1 |
| Dong, Y | 2 |
| Van der Veeken, L | 1 |
| Van der Merwe, J | 1 |
| Devroe, S | 1 |
| Inversetti, A | 1 |
| Galgano, A | 1 |
| Bleeser, T | 1 |
| Meeusen, R | 1 |
| Rex, S | 1 |
| Deprest, J | 1 |
| Suehara, T | 1 |
| Morishita, J | 1 |
| Ueki, M | 1 |
| Ueno, M | 1 |
| Maekawa, N | 1 |
| Mizobuchi, S | 1 |
| Song, R | 1 |
| Ling, X | 1 |
| Peng, M | 1 |
| Xue, Z | 1 |
| Liu, G | 1 |
| Tian, X | 1 |
| Tu, X | 1 |
| Zheng, H | 1 |
| Xu, Z | 1 |
| Crosby, G | 1 |
| Culley, DJ | 1 |
| Xie, Z | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Brain Health & the Microbiome: A Proof-of-Concept Study in Patients With Mild Cognitive Impairment[NCT06039267] | 90 participants (Anticipated) | Observational | 2023-08-25 | Recruiting | |||
| Effect of Sevoflurane on the Success of External Cephalic Version for Breech Presentation[NCT04346823] | Phase 4 | 40 participants (Anticipated) | Interventional | 2020-05-25 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for sevoflurane and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Prenatal sevoflurane exposure: Effects of iron metabolic dysfunction on offspring cognition and potential mechanism.
Topics: Adult; Anesthesia, General; Anesthetics, Inhalation; Animals; Cognition Disorders; Female; Humans; I | 2021 |
Fundamentals of fetal toxicity relevant to sevoflurane exposures during pregnancy.
Topics: Anesthetics, Inhalation; Female; Fetus; Humans; Pregnancy; Pregnancy Complications; Prenatal Exposur | 2019 |
21 other studies available for sevoflurane and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Prenatal sevoflurane exposure causes abnormal development of the entorhinal cortex in rat offspring.
Topics: Animals; Disease Models, Animal; Entorhinal Cortex; Female; GABA-A Receptor Agonists; Interneurons; | 2021 |
Neonatal exposure to sevoflurane impairs preference for social novelty in C57BL/6 female mice at early-adulthood.
Topics: Animals; Animals, Newborn; Behavior, Animal; Cerebral Cortex; Female; Hippocampus; Male; Mice; Mice, | 2022 |
Astroglial dysfunctions drive aberrant synaptogenesis and social behavioral deficits in mice with neonatal exposure to lengthy general anesthesia.
Topics: Anesthesia, General; Anesthetics, Inhalation; Animals; Animals, Newborn; Astrocytes; Behavior, Anima | 2019 |
Multiple sevoflurane exposures during pregnancy inhibit neuronal migration by upregulating prostaglandin D2 synthase.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Cell Movement; Cerebral Cortex; Female; Intramol | 2019 |
Sevoflurane anesthesia during pregnancy in mice induces cognitive impairment in the offspring by causing iron deficiency and inhibiting myelinogenesis.
Topics: Administration, Inhalation; Anemia, Iron-Deficiency; Anesthetics, Inhalation; Animals; Cognitive Dys | 2020 |
Maternal Treadmill Exercise Reduces the Neurotoxicity of Prenatal Sevoflurane Exposure in Rats via Activation of p300 Histone Acetyltransferase.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; E1A-Associated p300 Protein; Exercise Test; Fema | 2020 |
Hippocampus is more vulnerable to neural damages induced by repeated sevoflurane exposure in the second trimester than other brain areas.
Topics: Animals; Female; Hippocampus; Maternal Exposure; Maze Learning; Memory; Mice; Pregnancy; Prenatal Ex | 2020 |
Maternal anesthesia with sevoflurane during the mid-gestation induces social interaction deficits in offspring C57BL/6 mice.
Topics: Aging; Anesthetics, Inhalation; Animals; Brain; Female; Male; Mice; Mice, Inbred C57BL; Mothers; Pre | 2021 |
Maternal sevoflurane exposure induces temporary defects in interkinetic nuclear migration of radial glial progenitors in the fetal cerebral cortex through the Notch signalling pathway.
Topics: Anesthetics, Inhalation; Animals; Cell Line; Cell Movement; Cerebral Cortex; Female; Fetus; Humans; | 2021 |
Gut microbiota mediates cognitive impairment in young mice after multiple neonatal exposures to sevoflurane.
Topics: Anesthesia; Animals; Anti-Bacterial Agents; Behavior, Animal; Cognitive Dysfunction; Feces; Female; | 2021 |
Sevoflurane anesthesia in pregnant rats negatively affects nerve function in offspring potentially via inhibition of the Wnt/β-catenin pathway.
Topics: Anesthesia; Animals; beta Catenin; Female; Learning; Memory; Methyl Ethers; Nervous System; Pregnanc | 2017 |
Single and multiple sevoflurane exposures during pregnancy and offspring behavior in mice.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Anxiety; Behavior, Animal; Excitatory Postsynapt | 2017 |
Potential neurotoxicity of prenatal exposure to sevoflurane on offspring: Metabolomics investigation on neurodevelopment and underlying mechanism.
Topics: Amino Acids; Anesthetics, Inhalation; Animals; Biomarkers; Blood Gas Analysis; Female; Male; Methyl | 2017 |
Mid-gestational sevoflurane exposure inhibits fetal neural stem cell proliferation and impairs postnatal learning and memory function in a dose-dependent manner.
Topics: Anesthetics, Inhalation; Animals; Cell Division; Cyclin D1; Dose-Response Relationship, Drug; Female | 2018 |
Suberoylanilide hydroxamic acid (SAHA) alleviates the learning and memory impairment in rat offspring caused by maternal sevoflurane exposure during late gestation.
Topics: Anesthetics, Inhalation; Animals; Cyclic AMP Response Element-Binding Protein; Female; Hippocampus; | 2019 |
Neuroglobin protects offspring rats from neuronal damage induced by sevoflurane exposure to pregnant rats by inhibiting endogenous apoptosis.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Brain; Brain Chemistry; Cytochromes c; Female; Hemin; H | 2019 |
Maternal surgery during pregnancy has a transient adverse effect on the developing fetal rabbit brain.
Topics: Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Blood Gas Analysis; | 2019 |
Effects of sevoflurane exposure during late pregnancy on brain development of offspring mice.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Caspase 3; Fe | 2016 |
Multiple sevoflurane anesthesia in pregnant mice inhibits neurogenesis of fetal hippocampus via repressing transcription factor Pax6.
Topics: Anesthesia; Animals; Cells, Cultured; Cyclin D1; Female; Fetus; Hippocampus; Learning; Maternal Expo | 2017 |
Chronic exposure of gestation rat to sevoflurane impairs offspring brain development.
Topics: Age Factors; Anesthetics, Inhalation; Animals; Apoptosis; Blood Gas Analysis; Brain; Female; GAP-43 | 2012 |
Sevoflurane anesthesia in pregnant mice induces neurotoxicity in fetal and offspring mice.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Brain; Female; Maze Learning; Methyl Ethers; Mic | 2013 |