Page last updated: 2024-11-04

sevoflurane and Cough

sevoflurane has been researched along with Cough in 44 studies

Sevoflurane: A non-explosive inhalation anesthetic used in the induction and maintenance of general anesthesia. It does not cause respiratory irritation and may also prevent PLATELET AGGREGATION.
sevoflurane : An ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups.

Cough: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.

Research Excerpts

ExcerptRelevanceReference
"Sevoflurane attenuated cough reflex under propofol-based TIVA and did not increase the incidence of PONV and extubation time in nonintubated VATS."9.27Sevoflurane is an effective adjuvant to propofol-based total intravenous anesthesia for attenuating cough reflex in nonintubated video-assisted thoracoscopic surgery. ( Chang, H; Huang, TW; Lai, HC; Lin, WL; Tseng, WC; Wu, ZF, 2018)
"To determine the effects of low-dose ketamine and propofol on cough during emergence and the recovery period when administered at emergence in children undergoing fiberoptic bronchoscopy for bronchoalveolar lavage (FOBL) with sevoflurane-remifentanil anesthesia."9.22Effects of low-dose propofol vs ketamine on emergence cough in children undergoing flexible bronchoscopy with sevoflurane-remifentanil anesthesia: a randomized, double-blind, placebo-controlled trial. ( Acıkel, A; Çevıkkalp, E; Ozturk, T; Topçu, I; Yılmaz, O; Yuksel, H, 2016)
"5 μg·kg(-1)) of dexmedetomidine during emergence from sevoflurane-remifentanil anesthesia was effective in attenuating coughing and hemodynamic changes and did not exacerbate respiratory depression after thyroid surgery."9.20Efficacy of a single dose of dexmedetomidine for cough suppression during anesthetic emergence: a randomized controlled trial. ( Choi, SH; Kang, YR; Kim, Y; Lee, JS; Shim, YH, 2015)
"The half maximal effective concentration (EC50) values of remifentanil for preventing coughing in the groups were estimated using isotonic regression and compared among the groups."9.19Does the type of anesthetic agent affect remifentanil effect-site concentration for preventing endotracheal tube-induced cough during anesthetic emergence? Comparison of propofol, sevoflurane, and desflurane. ( Choi, SH; Choi, YS; Lee, B; Lee, JH; Lee, JR; Yang, SJ, 2014)
"To compare the effect-site concentrations of remifentanil target-controlled infusion (TCI) that produced 50% and 95% of the maximal effect (EC50 and EC95, respectively) for preventing cough during emergence from desflurane or sevoflurane anaesthesia, in patients undergoing elective thyroidectomy."9.16Comparison of the optimal effect-site concentrations of remifentanil for preventing cough during emergence from desflurane or sevoflurane anaesthesia. ( Chae, YJ; Cho, HB; Kim, DH; Kim, DW; Kim, JY, 2012)
"Although fentanyl suppresses tracheal tube-induced cough during anesthetic recovery, it has not been proven if its antitussive effect is dose dependent and complication free."9.15Dose-dependent attenuation by fentanyl on cough during emergence from general anesthesia. ( Choi, EM; Jeong, JJ; Lee, JR; Moon, BE; Na, S; Yoo, YC, 2011)
"Use of desflurane for maintenance of anesthesia was associated with a faster emergence and a higher incidence of coughing."9.14Desflurane versus sevoflurane for maintenance of outpatient anesthesia: the effect on early versus late recovery and perioperative coughing. ( Kariger, R; Mandel, S; Naruse, R; Norel, E; Sloninsky, A; Stokes, OJ; Tang, J; Webb, T; Wender, RH; White, PF; Yumul, R; Zaentz, A, 2009)
"The patients who inhaled desflurane through a laryngeal mask had a higher incidence of cough than those who inhaled sevoflurane."9.14[Incidence of cough after desflurane and sevoflurane administration through a laryngeal mask: a controlled clinical trial]. ( Delgado, MA; Giraldo, C; Lema, FE; Tafur, LA, 2010)
"This randomised, double-blinded, controlled trial was designed to identify the optimal dose of remifentanil for cough suppression without adverse effects during emergence from sevoflurane-remifentanil anaesthesia for thyroidectomy."9.14Optimal effect-site concentration of remifentanil for preventing cough during emergence from sevoflurane-remifentanil anaesthesia. ( Jun, NH; Koh, JC; Lee, JW; Park, WS; Shim, YH; Song, JW, 2010)
"The incidence of coughing after cervical spine surgery when tracheal extubation is performed according to clinical criteria is lower after propofol anaesthesia compared with sevoflurane anaesthesia."9.13Effect of propofol and sevoflurane on coughing in smokers and non-smokers awakening from general anaesthesia at the end of a cervical spine surgery. ( Bonhomme, V; Hans, P; Marechal, H, 2008)
"Target-controlled infusion of remifentanil is known to reduce cough effectively during emergence from general anesthesia."8.02Effects of smoking on the optimal effect-site concentration of remifentanil required for preventing cough during anesthetic emergence in male patients undergoing laparoscopic or robotic cholecystectomy. ( Choi, JB; Kim, HY; Kim, JE; Kwon, SH; Lee, EA; Lee, SY, 2021)
"To investigate the influence of sex on the cough-preventing effect of target-controlled infusion(TCI)of remifentanil during anesthetic emergence."7.81Influence of Sex on Remifentanil's Cough-prevention Effect during Anesthetic Emergence. ( Cui, XL; Huang, YG; Ma, MJ; Wang, L; Yu, XR, 2015)
" The effective effect-site concentration for 50% of patients (EC(50) ) and and that for 95% of patients (EC(95) ) of remifentanil for preventing cough were determined by Dixon's up-and-down method and by isotonic regression method with a bootstrapping approach."7.78Smooth emergence in men undergoing nasal surgery: the effect site concentration of remifentanil for preventing cough after sevoflurane-balanced anaesthesia. ( Choi, EM; Choi, SH; Lee, JR; Park, WK; Soh, S, 2012)
"Opioids are used as a treatment for coughing."6.82Optimal effect-site concentration of remifentanil for preventing cough during removal of the double-lumen endotracheal tube from sevoflurane-remifentanil anesthesia: A prospective clinical trial. ( Kim, DH; Kim, JY; Lee, JD; Lee, SY; Park, H; Park, SY; Rho, GU; Yoo, JY, 2016)
"Sevoflurane attenuated cough reflex under propofol-based TIVA and did not increase the incidence of PONV and extubation time in nonintubated VATS."5.27Sevoflurane is an effective adjuvant to propofol-based total intravenous anesthesia for attenuating cough reflex in nonintubated video-assisted thoracoscopic surgery. ( Chang, H; Huang, TW; Lai, HC; Lin, WL; Tseng, WC; Wu, ZF, 2018)
"To compare the effectiveness of the jaw thrust and the trapezius squeezing test(TST) for laryngeal mask airway (LMA) insertion in infants and children under sevoflurane anesthesia."5.22[Comparison of jaw thrust and trapezius squeezing test as indicators for laryngeal mask airway insertion in infants and young children]. ( Liu, JZ; Zhang, YJ; Zhao, J, 2016)
"To determine the effects of low-dose ketamine and propofol on cough during emergence and the recovery period when administered at emergence in children undergoing fiberoptic bronchoscopy for bronchoalveolar lavage (FOBL) with sevoflurane-remifentanil anesthesia."5.22Effects of low-dose propofol vs ketamine on emergence cough in children undergoing flexible bronchoscopy with sevoflurane-remifentanil anesthesia: a randomized, double-blind, placebo-controlled trial. ( Acıkel, A; Çevıkkalp, E; Ozturk, T; Topçu, I; Yılmaz, O; Yuksel, H, 2016)
"5 μg·kg(-1)) of dexmedetomidine during emergence from sevoflurane-remifentanil anesthesia was effective in attenuating coughing and hemodynamic changes and did not exacerbate respiratory depression after thyroid surgery."5.20Efficacy of a single dose of dexmedetomidine for cough suppression during anesthetic emergence: a randomized controlled trial. ( Choi, SH; Kang, YR; Kim, Y; Lee, JS; Shim, YH, 2015)
"The half maximal effective concentration (EC50) values of remifentanil for preventing coughing in the groups were estimated using isotonic regression and compared among the groups."5.19Does the type of anesthetic agent affect remifentanil effect-site concentration for preventing endotracheal tube-induced cough during anesthetic emergence? Comparison of propofol, sevoflurane, and desflurane. ( Choi, SH; Choi, YS; Lee, B; Lee, JH; Lee, JR; Yang, SJ, 2014)
" Intraocular pressure was measured after inhalation of sevoflurane (IOP(Baseline)) and 10 min after intravenous administration of dexmedetomidine 0."5.16The application of dexmedetomidine in children undergoing vitreoretinal surgery. ( Haiyan, Z; Jianjun, S; Lili, X, 2012)
"To compare the effect-site concentrations of remifentanil target-controlled infusion (TCI) that produced 50% and 95% of the maximal effect (EC50 and EC95, respectively) for preventing cough during emergence from desflurane or sevoflurane anaesthesia, in patients undergoing elective thyroidectomy."5.16Comparison of the optimal effect-site concentrations of remifentanil for preventing cough during emergence from desflurane or sevoflurane anaesthesia. ( Chae, YJ; Cho, HB; Kim, DH; Kim, DW; Kim, JY, 2012)
"Although fentanyl suppresses tracheal tube-induced cough during anesthetic recovery, it has not been proven if its antitussive effect is dose dependent and complication free."5.15Dose-dependent attenuation by fentanyl on cough during emergence from general anesthesia. ( Choi, EM; Jeong, JJ; Lee, JR; Moon, BE; Na, S; Yoo, YC, 2011)
"Use of desflurane for maintenance of anesthesia was associated with a faster emergence and a higher incidence of coughing."5.14Desflurane versus sevoflurane for maintenance of outpatient anesthesia: the effect on early versus late recovery and perioperative coughing. ( Kariger, R; Mandel, S; Naruse, R; Norel, E; Sloninsky, A; Stokes, OJ; Tang, J; Webb, T; Wender, RH; White, PF; Yumul, R; Zaentz, A, 2009)
"The patients who inhaled desflurane through a laryngeal mask had a higher incidence of cough than those who inhaled sevoflurane."5.14[Incidence of cough after desflurane and sevoflurane administration through a laryngeal mask: a controlled clinical trial]. ( Delgado, MA; Giraldo, C; Lema, FE; Tafur, LA, 2010)
" sevoflurane and remifentanil on cough and agitation during emergence and recovery after fiberoptic bronchoscopy."5.14The effect of remifentanil on the emergence characteristics of children undergoing FBO for bronchoalveolar lavage with sevoflurane anaesthesia. ( Erbuyun, K; Keles, GT; Ozer, M; Ozturk, T; Tok, D; Yuksel, H, 2009)
"This randomised, double-blinded, controlled trial was designed to identify the optimal dose of remifentanil for cough suppression without adverse effects during emergence from sevoflurane-remifentanil anaesthesia for thyroidectomy."5.14Optimal effect-site concentration of remifentanil for preventing cough during emergence from sevoflurane-remifentanil anaesthesia. ( Jun, NH; Koh, JC; Lee, JW; Park, WS; Shim, YH; Song, JW, 2010)
"The incidence of coughing after cervical spine surgery when tracheal extubation is performed according to clinical criteria is lower after propofol anaesthesia compared with sevoflurane anaesthesia."5.13Effect of propofol and sevoflurane on coughing in smokers and non-smokers awakening from general anaesthesia at the end of a cervical spine surgery. ( Bonhomme, V; Hans, P; Marechal, H, 2008)
" In the present study, we tested whether the use of a more pungent anesthetic (desflurane) would result in a higher rate of coughing, breath holding, laryngospasm, or desaturation among patients who smoke."5.12Airway responses during desflurane versus sevoflurane administration via a laryngeal mask airway in smokers. ( Balea, MC; Bostrom, A; McKay, RE; McKay, WR, 2006)
"To compare the respiratory depressant effects of propofol and sevoflurane used to facilitate the placement of the cuffed oropharyngeal airway (COPA), and to evaluate the effectiveness of the COPA in supporting positive pressure ventilation during anesthetic-induced apnea."5.09Insertion of the cuffed oropharyngeal airway (COPA) with propofol or sevoflurane in adults. ( Goto, T; Morita, S; Nakata, Y; Niimi, Y; Uchiyama, M; Uezono, S, 1999)
"RCTs investigating the rates of cough overall, cough at emergence, laryngospasm, time to eye opening, time to removal of the LMA, time to respond to command and time to state date of birth in patients with an LMA, during emergence from desflurane, sevoflurane, isoflurane or propofol anaesthesia."4.91Airway reactions and emergence times in general laryngeal mask airway anaesthesia: a meta-analysis. ( Coburn, M; Fritz, HG; Froeba, G; Heine, J; Puehringer, FK; Rossaint, R; Stevanovic, A; Tonner, PH, 2015)
" The confidence interval (CI) was large relative to a clinically significant difference in the incidence of overall cough and laryngospasm in patients receiving desflurane versus sevoflurane (odds ratio [OR; 95% CI] of 1."4.89The effect of sevoflurane versus desflurane on the incidence of upper respiratory morbidity in patients undergoing general anesthesia with a Laryngeal Mask Airway: a meta-analysis of randomized controlled trials. ( de Oliveira, GS; Fitzgerald, PC; Girao, W; McCarthy, RJ, 2013)
"Target-controlled infusion of remifentanil is known to reduce cough effectively during emergence from general anesthesia."4.02Effects of smoking on the optimal effect-site concentration of remifentanil required for preventing cough during anesthetic emergence in male patients undergoing laparoscopic or robotic cholecystectomy. ( Choi, JB; Kim, HY; Kim, JE; Kwon, SH; Lee, EA; Lee, SY, 2021)
"To investigate the influence of sex on the cough-preventing effect of target-controlled infusion(TCI)of remifentanil during anesthetic emergence."3.81Influence of Sex on Remifentanil's Cough-prevention Effect during Anesthetic Emergence. ( Cui, XL; Huang, YG; Ma, MJ; Wang, L; Yu, XR, 2015)
" The effective effect-site concentration for 50% of patients (EC(50) ) and and that for 95% of patients (EC(95) ) of remifentanil for preventing cough were determined by Dixon's up-and-down method and by isotonic regression method with a bootstrapping approach."3.78Smooth emergence in men undergoing nasal surgery: the effect site concentration of remifentanil for preventing cough after sevoflurane-balanced anaesthesia. ( Choi, EM; Choi, SH; Lee, JR; Park, WK; Soh, S, 2012)
"Opioids are used as a treatment for coughing."2.82Optimal effect-site concentration of remifentanil for preventing cough during removal of the double-lumen endotracheal tube from sevoflurane-remifentanil anesthesia: A prospective clinical trial. ( Kim, DH; Kim, JY; Lee, JD; Lee, SY; Park, H; Park, SY; Rho, GU; Yoo, JY, 2016)
"The sevoflurane group had a lower incidence of cough than the propofol group."2.75Remifentail infusion for paediatric bronchoscopic foreign body removal: comparison of sevoflurane with propofol for anaesthesia supplementation for bronchoscope insertion. ( Li, B; Wang, Y; Zhang, J; Zhang, W, 2010)
"Upper airway obstruction occurred more frequently (68."2.73Removal of the laryngeal tube in children: anaesthetized compared with awake. ( Kim, C; Kim, H; Kim, J; Kim, S; Lee, J; Yoon, T, 2007)
"Isoflurane was compared with sevoflurane in terms of rapidity, efficacy, safety and acceptability of induction."2.69Single vital capacity inhalational anaesthetic induction in adults--isoflurane vs sevoflurane. ( Lee, TL; Pua, HL; Ti, LK, 1998)
"Sevoflurane is a volatile anesthetic agent, which combines rapid, smooth inhalational induction of anesthesia with rapid recovery, making it particularly suitable for day case anesthesia."2.69Propofol or sevoflurane for laryngeal mask airway insertion. ( Buggy, DJ; Molloy, ME; Scanlon, P, 1999)
"Sevoflurane has a non-pungent odour and provides smooth induction of anaesthesia."2.69End-tidal sevoflurane concentration for tracheal extubation (MACEX) in adults: comparison with isoflurane. ( Inomata, S; Taguchi, M; Toyooka, H; Yaguchi, Y, 1999)
"Sevoflurane patients were less likely to have complications during induction (P < 0."2.68Sevoflurane versus isoflurane: induction and recovery characteristics with single-breath inhaled inductions of anesthesia. ( Conard, PF; Gross, JB; Karsunky, PK; Sloan, MH, 1996)

Research

Studies (44)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's9 (20.45)18.2507
2000's10 (22.73)29.6817
2010's24 (54.55)24.3611
2020's1 (2.27)2.80

Authors

AuthorsStudies
Kim, HY1
Choi, JB1
Lee, EA1
Kwon, SH1
Kim, JE1
Lee, SY2
Lsakov, AV1
Paponov, ON1
Aaavelvan, EG1
Stenanenko, SM1
Lai, HC1
Huang, TW1
Tseng, WC1
Lin, WL1
Chang, H1
Wu, ZF1
Kwon, JH1
Shin, YH1
Gil, NS1
Park, J1
Chung, YJ1
Hahm, TS1
Jeong, JS1
de Oliveira, GS2
Girao, W1
Fitzgerald, PC2
McCarthy, RJ2
Ahmad, S1
Marcus, RJ1
Chen, L1
Yu, L1
Fan, Y1
Manyande, A1
Pokkinen, SM1
Yli-Hankala, A1
Kalliomäki, ML1
Lee, JH2
Choi, SH4
Choi, YS2
Lee, B1
Yang, SJ1
Lee, JR4
Lee, JS1
Kang, YR1
Kim, Y1
Shim, YH2
Stevanovic, A1
Rossaint, R1
Fritz, HG1
Froeba, G1
Heine, J1
Puehringer, FK1
Tonner, PH1
Coburn, M1
Sukhupragarn, W1
Leurcharusmee, P1
Sotthisopha, T1
Cui, XL1
Ma, MJ1
Wang, L1
Yu, XR1
Huang, YG1
Liu, JZ1
Zhao, J1
Zhang, YJ1
Yoo, JY1
Kim, JY2
Kim, DH2
Lee, JD1
Rho, GU1
Park, H1
Park, SY1
Ozturk, T2
Acıkel, A1
Yılmaz, O1
Topçu, I1
Çevıkkalp, E1
Yuksel, H2
Hans, P1
Marechal, H1
Bonhomme, V1
Erbuyun, K1
Keles, GT1
Ozer, M1
Tok, D1
Ramachandran, SK1
White, PF1
Tang, J1
Wender, RH1
Yumul, R1
Stokes, OJ1
Sloninsky, A1
Naruse, R1
Kariger, R1
Norel, E1
Mandel, S1
Webb, T1
Zaentz, A1
Lema, FE1
Tafur, LA1
Giraldo, C1
Delgado, MA1
Inomata, S2
Maeda, T1
Shimizu, T1
Satsumae, T1
Tanaka, M1
Jun, NH1
Lee, JW1
Song, JW1
Koh, JC1
Park, WS1
Zhang, J1
Wang, Y1
Li, B1
Zhang, W1
Yoo, YC1
Na, S1
Jeong, JJ1
Choi, EM2
Moon, BE1
Park, WK1
Soh, S1
Lili, X1
Jianjun, S1
Haiyan, Z1
Cho, HB1
Kim, DW1
Chae, YJ1
Kim, H2
Kim, NO1
Wild, MR1
Gornall, CB1
Griffiths, DE1
Curran, J1
McKay, RE1
Bostrom, A1
Balea, MC1
McKay, WR1
Lee, J1
Kim, J1
Kim, S1
Kim, C1
Yoon, T1
Hohlrieder, M1
Tiefenthaler, W1
Klaus, H1
Gabl, M1
Kavakebi, P1
Keller, C1
Benzer, A1
Martin-Castro, C1
Montero, A1
Doi, M1
Ikeda, K1
Sloan, MH1
Conard, PF1
Karsunky, PK1
Gross, JB1
Ip-Yam, PC1
Board, P1
Ti, LK1
Pua, HL1
Lee, TL1
Molloy, ME1
Buggy, DJ1
Scanlon, P1
Goto, T1
Nakata, Y1
Uezono, S1
Niimi, Y1
Uchiyama, M1
Morita, S1
Philip, BK1
Lombard, LL1
Roaf, ER1
Drager, LR1
Calalang, I1
Philip, JH1
Yaguchi, Y1
Taguchi, M1
Toyooka, H1
Smith, I1

Clinical Trials (13)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effect of Desflurane vs Sevoflurane on Perioperative Respiratory Complications in Laryngeal Mask Airway Anesthesia: A Prospective Randomized Double-blinded Control Study[NCT03006250]Phase 4220 participants (Anticipated)Interventional2016-08-31Recruiting
The Quality of Recovery After General Anesthesia With Desflurane and Sevoflurane in Endoscopic Ureteral Lithotripsy[NCT04712162]60 participants (Actual)Interventional2019-11-19Completed
Effect of Single-dose Dexmedetomidine on Airway Reflex in Adult With Oral Intubation After Thyroidectomy[NCT01774305]Phase 4141 participants (Actual)Interventional2012-12-31Completed
The Effects of Remifentanil and Remifentanil-Alfentanil Administration on Emergence Agitation After Brief Ophthalmic Surgery in Children[NCT02486926]102 participants (Actual)Interventional2012-11-30Completed
Comparing the Efficacy Between Desflurane and Sevoflurane in Miantainance of Spontaneous General Anaesthesia Using Ambu Aura Gain in Paediatrics Patients[NCT04771962]Phase 1/Phase 280 participants (Actual)Interventional2020-01-01Completed
Effect of Two Plasma Concentrations of Remifentanil Through Target Controlled Anesthesia on Frequency and Intensity of Coughing During Extubation: Randomized Controlled Clinical Trial[NCT02711904]Phase 4110 participants (Actual)Interventional2011-01-31Completed
A Comparison of Desflurane vs. Sevoflurane on Time to Awakening and the Incidence and Severity of Cough After Ambulatory Surgery Using Laryngeal Mask Airway[NCT01202162]85 participants (Actual)Interventional2010-02-28Completed
Can Propofol Reduce Respiratory Adverse Events During Extubation in Children With Tonsillectomy? A Prospective Randomized Controlled Study[NCT05769842]240 participants (Anticipated)Interventional2023-11-01Not yet recruiting
Efficiency of Intravenous Lidocaine to Reduce Coughing and the Hemodynamic Changes Associated to Tracheal Extubation[NCT03731429]Phase 4144 participants (Anticipated)Interventional2019-04-05Recruiting
Low Dose Fentanyl/Midazolam Improves Sevoflurane Induction in Adults[NCT00723164]80 participants (Actual)Interventional2005-10-31Completed
Evaluation of the Effectiveness and Safety of Endotracheal Intubation for Inhalational Anesthesia Without the Use of Muscle Relaxants or Analgesics[NCT03112564]91 participants (Actual)Interventional2013-03-01Completed
Comparison of Propofol and Sevoflurane Anesthesia on the Quality of Recovery After Ambulatory Surgery for Anal Fistula in Obese Patients: A Prospective, Randomized, Single-blinded, Controlled Clinical Trial[NCT05529875]0 participants (Actual)Interventional2022-10-31Withdrawn (stopped due to In the early stage of the research, this research was limited by the application permission of research drugs and instruments, and the research will have to be interrupted, which is extremely regrettable.)
Which is the Better Choice for Extubation in Pediatric Patients: Proactive or Passive?[NCT04432701]60 participants (Anticipated)Interventional2020-07-10Enrolling by invitation
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Coughing Grade

The coughing incidence and severity will be measured at extubation. Especially from the time of eye opening to 5 min after extubation. The coughing grade was assessed by the following cough grading system: Grade 0, no cough or single, mild cough at extubation; Grade 1, multiple, not sustained cough with mild severity; Grade 2, cough persistence less than 5 s with moderate severity; Grade 3, severe, persistent cough for more than 5 s (bucking). (NCT01774305)
Timeframe: from the time of eye opening to 5 min after extubation

Interventionunits on a scale (Mean)
Dexmedetomidine0.6
Saline1.4

Emergence Time

The emergence time will be recorded as the time from sevoflurane discontinuation to eye opening on command. (NCT01774305)
Timeframe: from sevoflurane discontinuation, up to the time of eye opening (estimated time : from 5 min to 10 min)

Interventionsec (Mean)
Dexmedetomidine492
Saline355

Number of Participants Who Coughed

(NCT01202162)
Timeframe: Perioperative

Interventionparticipants (Number)
Desflurane4
Sevoflurane7

Quality of Recovery 40

Survey completion at 24 hours post surgery of the Quality of Recovery 40 questionnaire.This questionnaire asks 40 questions in 5 categories of recovery. The scores are combined from each group and are used as a composite score. The scores range from a low of 40 to a high of 200. A score of 40 would indicate a poor quality of recovery where as a score of 200 would be a good quality of recovery at 24 hours postoperative. (NCT01202162)
Timeframe: 1 day

Interventionscore (between 40 low-200 high) (Median)
Desflurane188
Sevoflurane182

Time to Awakening

(NCT01202162)
Timeframe: Time inhalational agent is turned off to time of patient awakening

InterventionElapsed time in minutes (Median)
Desflurane6.8
Sevoflurane11.8

Reviews

2 reviews available for sevoflurane and Cough

ArticleYear
The effect of sevoflurane versus desflurane on the incidence of upper respiratory morbidity in patients undergoing general anesthesia with a Laryngeal Mask Airway: a meta-analysis of randomized controlled trials.
    Journal of clinical anesthesia, 2013, Volume: 25, Issue:6

    Topics: Anesthesia, General; Anesthetics, Inhalation; Cough; Desflurane; Humans; Incidence; Isoflurane; Lary

2013
Airway reactions and emergence times in general laryngeal mask airway anaesthesia: a meta-analysis.
    European journal of anaesthesiology, 2015, Volume: 32, Issue:2

    Topics: Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Inhalation; Cough; Desflurane; Humans;

2015

Trials

33 trials available for sevoflurane and Cough

ArticleYear
Sevoflurane is an effective adjuvant to propofol-based total intravenous anesthesia for attenuating cough reflex in nonintubated video-assisted thoracoscopic surgery.
    Medicine, 2018, Volume: 97, Issue:42

    Topics: Adult; Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Cough; Female; Humans; Male; Methyl

2018
Effect-site concentration of remifentanil for smooth emergence from sevoflurane anesthesia in patients undergoing endovascular neurointervention.
    PloS one, 2019, Volume: 14, Issue:6

    Topics: Adult; Aged; Anesthesia Recovery Period; Cough; Endovascular Procedures; Female; Humans; Intubation,

2019
Desflurane/fentanyl compared with sevoflurane/fentanyl on awakening and quality of recovery in outpatient surgery using a laryngeal mask airway: a randomized, double-blinded controlled trial.
    Journal of clinical anesthesia, 2013, Volume: 25, Issue:8

    Topics: Adult; Ambulatory Surgical Procedures; Analgesics, Opioid; Anesthesia Recovery Period; Anesthetics,

2013
Desflurane/fentanyl compared with sevoflurane/fentanyl on awakening and quality of recovery in outpatient surgery using a laryngeal mask airway: a randomized, double-blinded controlled trial.
    Journal of clinical anesthesia, 2013, Volume: 25, Issue:8

    Topics: Adult; Ambulatory Surgical Procedures; Analgesics, Opioid; Anesthesia Recovery Period; Anesthetics,

2013
Desflurane/fentanyl compared with sevoflurane/fentanyl on awakening and quality of recovery in outpatient surgery using a laryngeal mask airway: a randomized, double-blinded controlled trial.
    Journal of clinical anesthesia, 2013, Volume: 25, Issue:8

    Topics: Adult; Ambulatory Surgical Procedures; Analgesics, Opioid; Anesthesia Recovery Period; Anesthetics,

2013
Desflurane/fentanyl compared with sevoflurane/fentanyl on awakening and quality of recovery in outpatient surgery using a laryngeal mask airway: a randomized, double-blinded controlled trial.
    Journal of clinical anesthesia, 2013, Volume: 25, Issue:8

    Topics: Adult; Ambulatory Surgical Procedures; Analgesics, Opioid; Anesthesia Recovery Period; Anesthetics,

2013
A comparison between total intravenous anaesthesia using propofol plus remifentanil and volatile induction/ maintenance of anaesthesia using sevoflurane in children undergoing flexible fibreoptic bronchoscopy.
    Anaesthesia and intensive care, 2013, Volume: 41, Issue:6

    Topics: Anesthesia Recovery Period; Anesthetics, Inhalation; Anesthetics, Intravenous; Biomarkers; Blood Glu

2013
The effects of propofol vs. sevoflurane on post-operative pain and need of opioid.
    Acta anaesthesiologica Scandinavica, 2014, Volume: 58, Issue:8

    Topics: Aged; Analgesia, Patient-Controlled; Anesthetics, Combined; Anesthetics, General; Anesthetics, Inhal

2014
Does the type of anesthetic agent affect remifentanil effect-site concentration for preventing endotracheal tube-induced cough during anesthetic emergence? Comparison of propofol, sevoflurane, and desflurane.
    Journal of clinical anesthesia, 2014, Volume: 26, Issue:6

    Topics: Adult; Aged; Anesthesia Recovery Period; Anesthetics, General; Antitussive Agents; Cough; Desflurane

2014
Efficacy of a single dose of dexmedetomidine for cough suppression during anesthetic emergence: a randomized controlled trial.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2015, Volume: 62, Issue:4

    Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Airway Extubation; Anesthesia Recovery Period; Anesthes

2015
Cardiovascular effects of volatile induction and maintenance of anesthesia (VIMA) and total intravenous anesthesia (TIVA) for laryngeal mask airway (LMA) anesthesia: a comparison study.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2015, Volume: 98, Issue:4

    Topics: Adolescent; Adult; Anesthesia; Anesthesia, Intravenous; Blood Pressure; Cough; Female; Heart Rate; H

2015
[Comparison of jaw thrust and trapezius squeezing test as indicators for laryngeal mask airway insertion in infants and young children].
    Zhonghua yi xue za zhi, 2016, Volume: 96, Issue:6

    Topics: Anesthesia; Anesthetics, Inhalation; Blood Pressure; Child, Preschool; Cough; Eye Movements; Heart R

2016
Optimal effect-site concentration of remifentanil for preventing cough during removal of the double-lumen endotracheal tube from sevoflurane-remifentanil anesthesia: A prospective clinical trial.
    Medicine, 2016, Volume: 95, Issue:24

    Topics: Adult; Aged; Airway Extubation; Analgesics, Opioid; Anesthetics, Inhalation; Cough; Dose-Response Re

2016
Effects of low-dose propofol vs ketamine on emergence cough in children undergoing flexible bronchoscopy with sevoflurane-remifentanil anesthesia: a randomized, double-blind, placebo-controlled trial.
    Journal of clinical anesthesia, 2016, Volume: 35

    Topics: Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous;

2016
Effect of propofol and sevoflurane on coughing in smokers and non-smokers awakening from general anaesthesia at the end of a cervical spine surgery.
    British journal of anaesthesia, 2008, Volume: 101, Issue:5

    Topics: Adult; Anesthesia Recovery Period; Anesthetics, Inhalation; Anesthetics, Intravenous; Cervical Verte

2008
The effect of remifentanil on the emergence characteristics of children undergoing FBO for bronchoalveolar lavage with sevoflurane anaesthesia.
    European journal of anaesthesiology, 2009, Volume: 26, Issue:4

    Topics: Analgesics, Opioid; Anesthesia Recovery Period; Anesthetics, Inhalation; Bronchoalveolar Lavage; Bro

2009
Desflurane versus sevoflurane for maintenance of outpatient anesthesia: the effect on early versus late recovery and perioperative coughing.
    Anesthesia and analgesia, 2009, Volume: 109, Issue:2

    Topics: Activities of Daily Living; Adult; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anest

2009
Desflurane versus sevoflurane for maintenance of outpatient anesthesia: the effect on early versus late recovery and perioperative coughing.
    Anesthesia and analgesia, 2009, Volume: 109, Issue:2

    Topics: Activities of Daily Living; Adult; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anest

2009
Desflurane versus sevoflurane for maintenance of outpatient anesthesia: the effect on early versus late recovery and perioperative coughing.
    Anesthesia and analgesia, 2009, Volume: 109, Issue:2

    Topics: Activities of Daily Living; Adult; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anest

2009
Desflurane versus sevoflurane for maintenance of outpatient anesthesia: the effect on early versus late recovery and perioperative coughing.
    Anesthesia and analgesia, 2009, Volume: 109, Issue:2

    Topics: Activities of Daily Living; Adult; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anest

2009
[Incidence of cough after desflurane and sevoflurane administration through a laryngeal mask: a controlled clinical trial].
    Revista espanola de anestesiologia y reanimacion, 2010, Volume: 57, Issue:3

    Topics: Adolescent; Adult; Aged; Anesthetics, Inhalation; Cough; Desflurane; Double-Blind Method; Female; Hu

2010
Effects of fentanyl infusion on tracheal intubation and emergence agitation in preschool children anaesthetized with sevoflurane.
    British journal of anaesthesia, 2010, Volume: 105, Issue:3

    Topics: Adjuvants, Anesthesia; Akathisia, Drug-Induced; Anesthesia Recovery Period; Anesthetics, Inhalation;

2010
Optimal effect-site concentration of remifentanil for preventing cough during emergence from sevoflurane-remifentanil anaesthesia.
    Anaesthesia, 2010, Volume: 65, Issue:9

    Topics: Adult; Aged; Analgesics, Opioid; Anesthesia Recovery Period; Anesthetics, Combined; Anesthetics, Inh

2010
Remifentail infusion for paediatric bronchoscopic foreign body removal: comparison of sevoflurane with propofol for anaesthesia supplementation for bronchoscope insertion.
    Anaesthesia and intensive care, 2010, Volume: 38, Issue:5

    Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Apnea; Blood Pressure; Bronchoscopy; Child, Presc

2010
Dose-dependent attenuation by fentanyl on cough during emergence from general anesthesia.
    Acta anaesthesiologica Scandinavica, 2011, Volume: 55, Issue:10

    Topics: Adult; Airway Extubation; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Inhalation;

2011
The application of dexmedetomidine in children undergoing vitreoretinal surgery.
    Journal of anesthesia, 2012, Volume: 26, Issue:4

    Topics: Airway Extubation; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Inhalation; Arteria

2012
Comparison of the optimal effect-site concentrations of remifentanil for preventing cough during emergence from desflurane or sevoflurane anaesthesia.
    The Journal of international medical research, 2012, Volume: 40, Issue:1

    Topics: Adult; Airway Extubation; Analgesics, Opioid; Anesthesia; Anesthesia Recovery Period; Anesthetics, I

2012
Comparison of the antitussive effect of remifentanil during recovery from propofol and sevoflurane anaesthesia.
    Anaesthesia, 2012, Volume: 67, Issue:7

    Topics: Adult; Aged; Anesthesia Recovery Period; Anesthetics, Inhalation; Anesthetics, Intravenous; Antituss

2012
Maintenance of anaesthesia with sevoflurane or isoflurane effects on adverse airway events in smokers.
    Anaesthesia, 2004, Volume: 59, Issue:9

    Topics: Adult; Aged; Anesthesia, General; Anesthetics, Inhalation; Cough; Female; Humans; Intraoperative Com

2004
Airway responses during desflurane versus sevoflurane administration via a laryngeal mask airway in smokers.
    Anesthesia and analgesia, 2006, Volume: 103, Issue:5

    Topics: Adult; Cough; Desflurane; Female; Humans; Isoflurane; Laryngeal Masks; Male; Methyl Ethers; Middle A

2006
Airway responses during desflurane versus sevoflurane administration via a laryngeal mask airway in smokers.
    Anesthesia and analgesia, 2006, Volume: 103, Issue:5

    Topics: Adult; Cough; Desflurane; Female; Humans; Isoflurane; Laryngeal Masks; Male; Methyl Ethers; Middle A

2006
Airway responses during desflurane versus sevoflurane administration via a laryngeal mask airway in smokers.
    Anesthesia and analgesia, 2006, Volume: 103, Issue:5

    Topics: Adult; Cough; Desflurane; Female; Humans; Isoflurane; Laryngeal Masks; Male; Methyl Ethers; Middle A

2006
Airway responses during desflurane versus sevoflurane administration via a laryngeal mask airway in smokers.
    Anesthesia and analgesia, 2006, Volume: 103, Issue:5

    Topics: Adult; Cough; Desflurane; Female; Humans; Isoflurane; Laryngeal Masks; Male; Methyl Ethers; Middle A

2006
Removal of the laryngeal tube in children: anaesthetized compared with awake.
    British journal of anaesthesia, 2007, Volume: 98, Issue:6

    Topics: Airway Obstruction; Anesthesia, Inhalation; Anesthetics, Inhalation; Awareness; Child; Child, Presch

2007
Effect of total intravenous anaesthesia and balanced anaesthesia on the frequency of coughing during emergence from the anaesthesia.
    British journal of anaesthesia, 2007, Volume: 99, Issue:4

    Topics: Adult; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inh

2007
Effect of total intravenous anaesthesia and balanced anaesthesia on the frequency of coughing during emergence from the anaesthesia.
    British journal of anaesthesia, 2007, Volume: 99, Issue:4

    Topics: Adult; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inh

2007
Effect of total intravenous anaesthesia and balanced anaesthesia on the frequency of coughing during emergence from the anaesthesia.
    British journal of anaesthesia, 2007, Volume: 99, Issue:4

    Topics: Adult; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inh

2007
Effect of total intravenous anaesthesia and balanced anaesthesia on the frequency of coughing during emergence from the anaesthesia.
    British journal of anaesthesia, 2007, Volume: 99, Issue:4

    Topics: Adult; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inh

2007
Effect of total intravenous anaesthesia and balanced anaesthesia on the frequency of coughing during emergence from the anaesthesia.
    British journal of anaesthesia, 2007, Volume: 99, Issue:4

    Topics: Adult; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inh

2007
Effect of total intravenous anaesthesia and balanced anaesthesia on the frequency of coughing during emergence from the anaesthesia.
    British journal of anaesthesia, 2007, Volume: 99, Issue:4

    Topics: Adult; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inh

2007
Effect of total intravenous anaesthesia and balanced anaesthesia on the frequency of coughing during emergence from the anaesthesia.
    British journal of anaesthesia, 2007, Volume: 99, Issue:4

    Topics: Adult; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inh

2007
Effect of total intravenous anaesthesia and balanced anaesthesia on the frequency of coughing during emergence from the anaesthesia.
    British journal of anaesthesia, 2007, Volume: 99, Issue:4

    Topics: Adult; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inh

2007
Effect of total intravenous anaesthesia and balanced anaesthesia on the frequency of coughing during emergence from the anaesthesia.
    British journal of anaesthesia, 2007, Volume: 99, Issue:4

    Topics: Adult; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inh

2007
Flexible laryngeal mask as an alternative to reinforced tracheal tube for upper chest, head and neck oncoplastic surgery.
    European journal of anaesthesiology, 2008, Volume: 25, Issue:4

    Topics: Adult; Aged; Anesthetics, Inhalation; Breast Neoplasms; Capnography; Cough; Female; Head and Neck Ne

2008
Sevoflurane versus isoflurane: induction and recovery characteristics with single-breath inhaled inductions of anesthesia.
    Anesthesia and analgesia, 1996, Volume: 82, Issue:3

    Topics: Adolescent; Adult; Aged; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anesthesia, Inh

1996
Single vital capacity inhalational anaesthetic induction in adults--isoflurane vs sevoflurane.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1998, Volume: 45, Issue:10

    Topics: Adolescent; Adult; Anesthesia, Closed-Circuit; Anesthesia, Inhalation; Anesthetics, Inhalation; Coug

1998
Propofol or sevoflurane for laryngeal mask airway insertion.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1999, Volume: 46, Issue:4

    Topics: Adolescent; Adult; Aged; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anesthetics, In

1999
Insertion of the cuffed oropharyngeal airway (COPA) with propofol or sevoflurane in adults.
    Journal of clinical anesthesia, 1999, Volume: 11, Issue:4

    Topics: Adult; Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Apnea; Chi-Square Distribution; Coug

1999
Comparison of vital capacity induction with sevoflurane to intravenous induction with propofol for adult ambulatory anesthesia.
    Anesthesia and analgesia, 1999, Volume: 89, Issue:3

    Topics: Adult; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anesthetics, Inhalation; Anesthet

1999
Comparison of vital capacity induction with sevoflurane to intravenous induction with propofol for adult ambulatory anesthesia.
    Anesthesia and analgesia, 1999, Volume: 89, Issue:3

    Topics: Adult; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anesthetics, Inhalation; Anesthet

1999
Comparison of vital capacity induction with sevoflurane to intravenous induction with propofol for adult ambulatory anesthesia.
    Anesthesia and analgesia, 1999, Volume: 89, Issue:3

    Topics: Adult; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anesthetics, Inhalation; Anesthet

1999
Comparison of vital capacity induction with sevoflurane to intravenous induction with propofol for adult ambulatory anesthesia.
    Anesthesia and analgesia, 1999, Volume: 89, Issue:3

    Topics: Adult; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anesthetics, Inhalation; Anesthet

1999
Comparison of vital capacity induction with sevoflurane to intravenous induction with propofol for adult ambulatory anesthesia.
    Anesthesia and analgesia, 1999, Volume: 89, Issue:3

    Topics: Adult; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anesthetics, Inhalation; Anesthet

1999
Comparison of vital capacity induction with sevoflurane to intravenous induction with propofol for adult ambulatory anesthesia.
    Anesthesia and analgesia, 1999, Volume: 89, Issue:3

    Topics: Adult; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anesthetics, Inhalation; Anesthet

1999
Comparison of vital capacity induction with sevoflurane to intravenous induction with propofol for adult ambulatory anesthesia.
    Anesthesia and analgesia, 1999, Volume: 89, Issue:3

    Topics: Adult; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anesthetics, Inhalation; Anesthet

1999
Comparison of vital capacity induction with sevoflurane to intravenous induction with propofol for adult ambulatory anesthesia.
    Anesthesia and analgesia, 1999, Volume: 89, Issue:3

    Topics: Adult; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anesthetics, Inhalation; Anesthet

1999
Comparison of vital capacity induction with sevoflurane to intravenous induction with propofol for adult ambulatory anesthesia.
    Anesthesia and analgesia, 1999, Volume: 89, Issue:3

    Topics: Adult; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anesthetics, Inhalation; Anesthet

1999
End-tidal sevoflurane concentration for tracheal extubation (MACEX) in adults: comparison with isoflurane.
    British journal of anaesthesia, 1999, Volume: 82, Issue:6

    Topics: Adult; Anesthetics, Inhalation; Cough; Dose-Response Relationship, Drug; Drug Administration Schedul

1999

Other Studies

9 other studies available for sevoflurane and Cough

ArticleYear
Effects of smoking on the optimal effect-site concentration of remifentanil required for preventing cough during anesthetic emergence in male patients undergoing laparoscopic or robotic cholecystectomy.
    Medicine, 2021, Apr-02, Volume: 100, Issue:13

    Topics: Adult; Aged; Anesthesia Recovery Period; Anesthesia, General; Antitussive Agents; Cholecystectomy; C

2021
COMPARISON OF EMERGENCE AND RECOVERY CHARACTERISTICS OF SEVOFLURANE AND DESFLURANE IN PEDIATRIC AMBULATORY SURGERY.
    Anesteziologiia i reanimatologiia, 2017, Volume: 62, Issue:1

    Topics: Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inh

2017
Influence of Sex on Remifentanil's Cough-prevention Effect during Anesthetic Emergence.
    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 2015, Volume: 37, Issue:3

    Topics: Airway Extubation; Anesthesia; Anesthesia Recovery Period; Anesthetics, Inhalation; Blood Pressure;

2015
Cough during emergence from anaesthesia.
    British journal of anaesthesia, 2009, Volume: 102, Issue:6

    Topics: Anesthesia Recovery Period; Anesthetics, Inhalation; Anesthetics, Intravenous; Cough; Humans; Methyl

2009
Smooth emergence in men undergoing nasal surgery: the effect site concentration of remifentanil for preventing cough after sevoflurane-balanced anaesthesia.
    Acta anaesthesiologica Scandinavica, 2012, Volume: 56, Issue:4

    Topics: Adolescent; Adult; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure; Cough; Heart Rat

2012
Airway irritation produced by volatile anaesthetics during brief inhalation: comparison of halothane, enflurane, isoflurane and sevoflurane.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1993, Volume: 40, Issue:2

    Topics: Administration, Inhalation; Adult; Anesthesia, Inhalation; Anesthetics; Cough; Enflurane; Ethers; Fu

1993
Sevoflurane for difficult tracheal intubation.
    British journal of anaesthesia, 1998, Volume: 81, Issue:1

    Topics: Anesthetics, Inhalation; Cough; Humans; Intubation, Intratracheal; Methyl Ethers; Movement; Sevoflur

1998
Sevoflurane for difficult tracheal intubation.
    British journal of anaesthesia, 1998, Volume: 81, Issue:1

    Topics: Anesthetics, Inhalation; Cough; Humans; Intubation, Intratracheal; Methyl Ethers; Sevoflurane

1998
Intravenous opioids reduce airway irritation during induction of anaesthesia with desflurane in adults.
    British journal of anaesthesia, 2001, Volume: 86, Issue:1

    Topics: Adult; Analgesics, Opioid; Anesthetics, Inhalation; Apnea; Cough; Desflurane; Humans; Isoflurane; Me

2001