sevoflurane has been researched along with Cognitive Dysfunction in 136 studies
Sevoflurane: A non-explosive inhalation anesthetic used in the induction and maintenance of general anesthesia. It does not cause respiratory irritation and may also prevent PLATELET AGGREGATION.
sevoflurane : An ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups.
Cognitive Dysfunction: Diminished or impaired mental and/or intellectual function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Elderly patients undergoing laparoscopic cholecystectomy were randomly assigned to receive propofol, sevoflurane, or isoflurane anesthesia." | 9.24 | Effect of propofol, sevoflurane, and isoflurane on postoperative cognitive dysfunction following laparoscopic cholecystectomy in elderly patients: A randomized controlled trial. ( Geng, YJ; Wu, QH; Zhang, RQ, 2017) |
| "To determine the prophylactic effect of rHsp70 in sevoflurane-induced cognitive dysfunction, aged mice were pretreated with different concentrations of rHsp70 (29." | 8.31 | Exogenous recombinant Hsp70 attenuates sevoflurane anesthesia-induced cognitive dysfunction in aged mice. ( Chen, Y; Huang, J; Xie, Y, 2023) |
| "Postoperative cognitive dysfunction (POCD) is regularly observed in patients postsurgery due to the usage of anesthetics, including Sevoflurane." | 8.31 | Effects of miR-190a-3p on Sevoflurane-induced postoperative cognitive dysfunction (POCD). ( Guo, LL; Song, S; Wang, HY; Wang, Y; Zhang, J, 2023) |
| " The aim and objective of the current experimental study was to access the neuroprotective effect of sevoflurane against isoflurane induced cognitive dysfunction in rats." | 8.31 | Neuroprotective potential of sevoflurane against isoflurane induced cognitive dysfunction in rats via anti-inflammatory and antioxidant effect. ( Chen, Y; Gong, Y; Kang, P; Wang, J; Wei, Z, 2023) |
| "We aimed to explore the effects of hypercholesterolemia on sevoflurane-induced cognitive impairment in aged rats and the underlying mechanism(s)." | 8.12 | Hypercholesterolemia aggravates sevoflurane-induced cognitive impairment in aged rats by inducing neurological inflammation and apoptosis. ( Liu, L; Long, B; Wang, C; Wu, X; Zhang, X, 2022) |
| "To study the dynamics of markers of brain damage, determine their role in postoperative cognitive dysfunction (POCD) and evaluate the effectiveness of therapeutic correction of POCD in patients undergoing laparoscopic cholecystectomy under inhalation anesthesia with sevoflurane." | 8.12 | [Correction of cognitive dysfunction after laparoscopic cholecystectomy under inhalation anesthesia with sevoflurane]. ( Nazarchuk, EA; Neimark, MI; Rakhmonov, AA; Shmelev, VV, 2022) |
| " We recently found that the anaesthetization of aging C57BL/6 J mice (14-16 months) with sevoflurane (3%, two hours each day for three consecutive days) can induce cognitive dysfunction and synaptic plasticity deficits." | 8.12 | Sevoflurane inhibits histone acetylation and contributes to cognitive dysfunction by enhancing the expression of ANP32A in aging mice. ( Chai, G; Fang, R; Jiang, Z; Liu, Y; Nie, Y; Wang, X; Wu, J; Yi, H; Zhang, D; Zhang, J; Zhao, P; Zhou, J, 2022) |
| "This research aimed to explore the influence of TLR deletion on sevoflurane-induced postoperative cognitive dysfunction in neonatal mice." | 8.12 | TLR3 deletion inhibits programmed necrosis of brain cells in neonatal mice with sevoflurane-induced cognitive dysfunction. ( Guo, J; Li, Y; Wang, Q; Yin, C; Yu, J; Zhang, Q; Zhao, J, 2022) |
| " In this study, we investigated whether cucurbitacin E could alleviate sevoflurane-induced cognitive dysfunction in rats." | 8.12 | Cucurbitacin E reduces the cognitive dysfunction induced by sevoflurane in rats by regulating NF-κB pathway. ( Feng, Y; Li, X; Shi, B; Yuan, H; Zheng, S, 2022) |
| "Sevoflurane anesthesia enhanced ApoE mRNA, total ApoE, full-length ApoE, ApoE fragments, Tau phosphorylation (AT8 and PHF1), and cognitive impairment in young mice, but not in adult mice." | 8.12 | Effects of toxic apolipoprotein E fragments on Tau phosphorylation and cognitive impairment in neonatal mice under sevoflurane anesthesia. ( Pan, J; Yang, M; Yu, Y; Zhao, Y; Zhuang, X, 2022) |
| "The objective of this study was to discuss the possible mechanism and effect of miR-182-5p delivered by plasma exosomes on sevoflurane-induced neuroinflammation and cognitive disorder in aged rats with postoperative cognitive dysfunction (POCD)." | 8.12 | miR-182-5p Delivered by Plasma Exosomes Promotes Sevoflurane-Induced Neuroinflammation and Cognitive Dysfunction in Aged Rats with Postoperative Cognitive Dysfunction by Targeting Brain-Derived Neurotrophic Factor and Activating NF-κB Pathway. ( Chen, SB; Huang, YL; Rao, MW; Wei, FS; Wu, YQ; Yang, L, 2022) |
| "Studies have shown that long-term exposure to sevoflurane (SEV) may cause postoperative cognitive dysfunction." | 8.12 | Resveratrol ameliorates neuronal apoptosis and cognitive impairment by activating the SIRT1/RhoA pathway in rats after anesthesia with sevoflurane. ( Deng, Y; Hu, X; Xu, Y; Zhou, Q, 2022) |
| "The involvement of Dexmedetomidine (Dex) has been indicated in postoperative cognitive dysfunction (POCD), while the mechanism is not well characterized." | 8.02 | Protective role of dexmedetomidine against sevoflurane-induced postoperative cognitive dysfunction via the microRNA-129/TLR4 axis. ( Chen, S; He, S; Sun, Z; Wei, W; Zhang, W, 2021) |
| "Cdk5/CRMP2 and GSK-3β/CRMP2 pathways participate in sevoflurane-induced dendritic development abnormalities and cognitive dysfunction in developing rats." | 8.02 | Regulation of CRMP2 by Cdk5 and GSK-3β participates in sevoflurane-induced dendritic development abnormalities and cognitive dysfunction in developing rats. ( Huang, Z; Li, H; Li, J; Li, Y; Liao, Z; Liu, Y; Miao, L; Xu, Y; Zhang, J, 2021) |
| " Sevoflurane anesthesia is linked to cognitive dysfunction correlated to the expression of miRNA levels." | 8.02 | MiR-124 protects against cognitive dysfunction induced by sevoflurane anesthesia in vivo and in vitro through targeting calpain small subunit 1 via NF-κB signaling pathway. ( Li, Y; Ma, L; Tai, Y; Wang, Q; Wang, Y; Zhang, Q; Zhao, Z, 2021) |
| "RAGE over-expression in the hippocampal vascular endothelial cells possibly resulted in the excessive transport of the plasma Aβ1-40 into the brain after treatment with sevoflurane, which was associated with sevoflurane-induced cognitive dysfunction in aged mice." | 7.96 | Plasma amyloid beta level changes in aged mice with cognitive dysfunction following sevoflurane exposure. ( Han, Y; Liang, R; Ou, S; Xu, J; Zhou, S, 2020) |
| "This study aimed to investigate the protective effects and underlying mechanisms of cistanche on sevoflurane-induced aged cognitive dysfunction rat model." | 7.96 | Cistanches alleviates sevoflurane-induced cognitive dysfunction by regulating PPAR-γ-dependent antioxidant and anti-inflammatory in rats. ( Li, P; Liu, C; Liu, P; Lu, W; Peng, S; Wang, J; Yan, H; Zhou, Y, 2020) |
| " Our previous studies verified that cyclin-dependent kinase 5 (CDK5) plays a role in sevoflurane-induced cognitive dysfunction." | 7.96 | Downregulation of CDK5 Restores Sevoflurane-Induced Cognitive Dysfunction by Promoting SIRT1-Mediated Autophagy. ( Fu, S; Liu, J; Liu, S; Wu, H; Yang, J; Yang, X; Zhang, W; Zhang, X; Zhao, Y, 2020) |
| "To investigate the effects of C1q/tumor necrosis factor-related protein-3 (CTRP3) on postoperative cognitive dysfunction (POCD) and elucidate the potential regulatory mechanism in sevoflurane anesthesia-induced aged rats." | 7.96 | Neuroprotective effect of CTRP3 overexpression against sevoflurane anesthesia-induced cognitive dysfunction in aged rats through activating AMPK/SIRT1 and PI3K/AKT signaling pathways. ( Xu, YC; Yang, LH; Zhang, W, 2020) |
| " However, little is known about whether TLR4 is associated with sevoflurane-induced cognitive decline." | 7.96 | Sevoflurane-induced cognitive decline in aged mice: Involvement of toll-like receptors 4. ( Dong, N; Fei, X; Sheng, ZY; Wang, JX; Wu, Y, 2020) |
| "The present study was aimed to observe the protective effect of rapamycin on cognitive dysfunction induced by sevoflurane in aged rats and its effect on autophagy‑related proteins, and to investigate the regulatory mechanism of the Toll‑like receptor 4/myeloid differentiation primary response 88/nuclear factor‑κB (TLR4/MyD88/NF‑κB) signaling pathway." | 7.91 | Rapamycin improves sevoflurane‑induced cognitive dysfunction in aged rats by mediating autophagy through the TLR4/MyD88/NF‑κB signaling pathway. ( Li, Y; Liu, L; Tian, Y; Zhang, J, 2019) |
| "Adult C57BL/6 mice received a laparotomy under sevoflurane anesthesia and HNK or SIRT3 inhibitor (3-TYP) treatment." | 7.91 | SIRT3 activator honokiol ameliorates surgery/anesthesia-induced cognitive decline in mice through anti-oxidative stress and anti-inflammatory in hippocampus. ( Chen, L; Lei, SQ; Lu, YY; Peng, M; Xia, ZY; Ye, JS, 2019) |
| "Sevoflurane anesthesia impaired cognitive functions, as well as metabotropic glutamate receptor-dependent long-term depression, through elevated surface expression of small conductance calcium-activated potassium type 2 channels." | 7.91 | Sevoflurane anesthesia impairs metabotropic glutamate receptor-dependent long-term depression and cognitive functions in senile mice. ( Shi, J; Yu, X; Zhang, F, 2019) |
| " In the present study, it was examined whether treatment with PPAR‑γ agonist pioglitazone (PIO) is beneficial in counteracting SEV‑induced neuroinflammation and cognitive decline in a rat model of CIH." | 7.91 | Pioglitazone prevents sevoflurane‑induced neuroinflammation and cognitive decline in a rat model of chronic intermittent hypoxia by upregulating hippocampal PPAR‑γ. ( Dong, P; Fei, J; Li, D; Li, L; Li, N; Lin, Q; Lu, L; Yang, B; Zhang, X, 2019) |
| " Sevoflurane anesthesia has been found to lead to CD and microRNAs (miRNAs) were reported to affect cognitive function." | 7.91 | Neuroprotective effect of miR-410-3p against sevoflurane anesthesia-induced cognitive dysfunction in rats through PI3K/Akt signaling pathway via targeting C-X-C motif chemokine receptor 5. ( Feng, C; Su, R; Sun, P; Xiao, W; Zhang, D; Zhong, L, 2019) |
| "To investigate the role of IL-17A in the neuroinflammation and cognitive function of aged rats anaesthetized with sevoflurane through NF-κB pathway." | 7.88 | IL-17A promotes the neuroinflammation and cognitive function in sevoflurane anesthetized aged rats via activation of NF-κB signaling pathway. ( Yang, ZY; Yuan, CX, 2018) |
| "Sevoflurane anesthesia is a high-risk factor for postoperative cognitive dysfunction (POCD) in elderly patients." | 7.88 | Role of dexmedetomidine in reducing the incidence of postoperative cognitive dysfunction caused by sevoflurane inhalation anesthesia in elderly patients with esophageal carcinoma. ( Qiao, Y; Wu, Z; Zhang, H; Zhao, X, 2018) |
| "Our findings suggested that sevoflurane can induce neuroapoptosis and cognitive dysfunction in adolescent rats that received repeated sevoflurane (2% for 1 h) during the postnatal period." | 7.85 | Repeated 2% sevoflurane administration in 7‑ and 60-day-old rats : Neurotoxicity and neurocognitive dysfunction. ( Chen, J; Huang, H; Jin, WJ; Liu, CM; Sun, J; Wu, YQ, 2017) |
| "Inhibiting CDK5 with roscovitine has neuroprotective effects against neuronal injury and cognitive dysfunction caused by sevoflurane anesthesia that are exerted via modulation of Tau/GSK3β and ERK/PPARγ/CREB signaling." | 7.85 | Roscovitine, a CDK5 Inhibitor, Alleviates Sevoflurane-Induced Cognitive Dysfunction via Regulation Tau/GSK3β and ERK/PPARγ/CREB Signaling. ( Cai, L; Guo, G; Liu, J; Wu, H; Xu, Y; Yang, J; Zhang, X; Zhao, Y, 2017) |
| "This study was designed to explore the effect of 3-methyladenine (3-MA) on sevoflurane anesthesia-induced cognitive dysfunction." | 7.85 | The autophagy inhibitor 3-methyladenine restores sevoflurane anesthesiainduced cognitive dysfunction and neurons apoptosis. ( Bu, J; Hou, B; Li, G; Liang, Z; Xiao, X; Yang, L; Zhu, Y, 2017) |
| "This study aimed to explore the role of NF-κB/P65 signaling pathway in postoperative cognitive dysfunction (POCD) after sevoflurane anesthesia." | 7.85 | NF-κB/P65 signaling pathway: a potential therapeutic target in postoperative cognitive dysfunction after sevoflurane anesthesia. ( Chen, JP; Li, XY; Lu, B; Meng, B; Wu, GR; Zheng, JW, 2017) |
| "Isovitexin (IVX) is a trihydroxyl flavonoid that is a naturally bioactive ingredient found in various medicinal plants and has antioxidant, anti‑inflammatory and neuroprotective properties." | 5.72 | Isovitexin restores sevoflurane‑induced cognitive dysfunction by mediating autophagy through activation of the PGC‑1α/FNDC5 signaling pathway. ( Chen, Q; Guo, Y; Sun, L; Wu, B, 2022) |
| "Sevoflurane (Sev) might cause neurotoxicity in elderly rats." | 5.72 | Lin28A Reduced Sevoflurane-Induced Nerve Injury and Cognitive Dysfunction by Inhibiting Tau Acetylation and Phosphorylation via Activating SIRT1 in Elderly Rats. ( Wang, J; Wang, Q; Zhang, M; Zhu, Y, 2022) |
| "Sevoflurane treatment induced cognitive dysfunction and motor impairment in aged WT mice." | 5.72 | Pleiotrophin Potentiates Sevoflurane Anesthesia-induced Learning Deficits in Mice. ( Mao, S; Wang, L; Yu, J; Zhu, C, 2022) |
| "Postoperative cognitive dysfunction is a common complication in elderly patients after surgeries involving anesthesia, but the underlying mechanisms are poorly understood." | 5.56 | Lithium chloride ameliorates cognition dysfunction induced by sevoflurane anesthesia in rats. ( An, X; Liu, J; Wang, J; Wang, Y; Yang, Z; Zhang, X, 2020) |
| "Sevoflurane is an experimental potent yet volatile anesthesia agent characterized by a low blood/gas partition coefficient." | 5.51 | MicroRNA-96 is responsible for sevoflurane-induced cognitive dysfunction in neonatal rats via inhibiting IGF1R. ( Niu, JJ; Wei, YS; Xu, C; Zhou, JF, 2019) |
| "Sevoflurane is a widely used volatile anesthetic in the clinical setting." | 5.48 | Sevoflurane exaggerates cognitive decline in a rat model of chronic intermittent hypoxia by aggravating microglia-mediated neuroinflammation via downregulation of PPAR-γ in the hippocampus. ( Dong, P; Li, D; Li, L; Li, N; Lu, L; Yang, B; Zhang, L; Zhang, X; Zhao, J, 2018) |
| "Treatment with tetrandrine reduced the expression levels of COX‑2, IL‑1β, TNF‑α, NF‑κB, iNOS and caspase‑3, and increased the Bcl‑2 protein expression in sevoflurane‑treated aged rats." | 5.43 | Tetrandrine ameliorates sevoflurane‑induced cognitive impairment via the suppression of inflammation and apoptosis in aged rats. ( Li, X; Ma, H; Pang, L; Yao, L; Yao, Q, 2016) |
| "Elderly patients undergoing laparoscopic cholecystectomy were randomly assigned to receive propofol, sevoflurane, or isoflurane anesthesia." | 5.24 | Effect of propofol, sevoflurane, and isoflurane on postoperative cognitive dysfunction following laparoscopic cholecystectomy in elderly patients: A randomized controlled trial. ( Geng, YJ; Wu, QH; Zhang, RQ, 2017) |
| "To determine the effect of choice of inhalational anaesthetic (sevoflurane vs propofol) on the incidence and severity of postoperative cognitive dysfunction (POCD) in elderly patients (aged ≥ 60 years) with mild cognitive impairment (MCI)." | 5.19 | Effect of inhalational anaesthetic on postoperative cognitive dysfunction following radical rectal resection in elderly patients with mild cognitive impairment. ( Bai, Y; Liu, Y; Ou, C; Tang, N; Zuo, Y, 2014) |
| "To determine the prophylactic effect of rHsp70 in sevoflurane-induced cognitive dysfunction, aged mice were pretreated with different concentrations of rHsp70 (29." | 4.31 | Exogenous recombinant Hsp70 attenuates sevoflurane anesthesia-induced cognitive dysfunction in aged mice. ( Chen, Y; Huang, J; Xie, Y, 2023) |
| "Prolonged anesthesia with sevoflurane was used to establish the sevoflurane-induced neurotoxicity (SIN) animal model." | 4.31 | Prolonged anesthesia induces neuroinflammation and complement-mediated microglial synaptic elimination involved in neurocognitive dysfunction and anxiety-like behaviors. ( Chen, X; Deng, D; Ding, Y; Han, L; Ma, L; Wang, Y; Xu, F; Zhang, Q; Zhao, S, 2023) |
| "Postoperative cognitive dysfunction may be associated with neuroinflammation, and sevoflurane suppresses surgery-induced inflammation." | 4.31 | Influence of Different Sevoflurane Concentrations on Postoperative Cognitive Function in Aged Rats. ( Kimura, T; Niiyama, Y; Yamamoto, N, 2023) |
| " Both pyroptosis inhibition and ROS scavenging might be potential approaches to ameliorate sevoflurane-induced neurocognitive dysfunction." | 4.31 | Microglial pyroptosis in hippocampus mediates sevolfurane-induced cognitive impairment in aged mice via ROS-NLRP3 inflammasome pathway. ( Chen, G; Chen, Y; Wang, H; Zhang, X; Zhang, Y; Zhou, Y, 2023) |
| "Postoperative cognitive dysfunction (POCD) is regularly observed in patients postsurgery due to the usage of anesthetics, including Sevoflurane." | 4.31 | Effects of miR-190a-3p on Sevoflurane-induced postoperative cognitive dysfunction (POCD). ( Guo, LL; Song, S; Wang, HY; Wang, Y; Zhang, J, 2023) |
| "Sevoflurane (SEV), usually causing neuronal damage and cognitive dysfunction, is one of the most commonly used anesthetics in clinical practice." | 4.31 | Knocking down Trim47 ameliorated sevoflurane-induced neuronal cell injury and cognitive impairment in rats. ( Wang, J; Wang, Q; Zhang, M; Zhu, Y, 2023) |
| "Inhibition of C/EBPα promotes the M2 polarization of microglia and reduces the production of pro-inflammatory cytokines to alleviate the cognitive dysfunction of sevoflurane-induced elderly rats by HDAC1/STAT3 pathway." | 4.31 | C/EBPα involvement in microglial polarization via HDAC1/STAT3 pathway aggravated sevoflurane-induced cognitive impairment in aged rats. ( Xu, Z; Yao, B; Yao, X; Zhao, Y, 2023) |
| "Sevoflurane is one of the most widely used anesthetics in surgery which is the main cause of postoperative cognitive dysfunction (POCD)." | 4.31 | The m ( Huang, Y; Liu, Z; Wei, F; Yang, Y; Ye, C, 2023) |
| " The aim and objective of the current experimental study was to access the neuroprotective effect of sevoflurane against isoflurane induced cognitive dysfunction in rats." | 4.31 | Neuroprotective potential of sevoflurane against isoflurane induced cognitive dysfunction in rats via anti-inflammatory and antioxidant effect. ( Chen, Y; Gong, Y; Kang, P; Wang, J; Wei, Z, 2023) |
| "We aimed to explore the effects of hypercholesterolemia on sevoflurane-induced cognitive impairment in aged rats and the underlying mechanism(s)." | 4.12 | Hypercholesterolemia aggravates sevoflurane-induced cognitive impairment in aged rats by inducing neurological inflammation and apoptosis. ( Liu, L; Long, B; Wang, C; Wu, X; Zhang, X, 2022) |
| "To study the dynamics of markers of brain damage, determine their role in postoperative cognitive dysfunction (POCD) and evaluate the effectiveness of therapeutic correction of POCD in patients undergoing laparoscopic cholecystectomy under inhalation anesthesia with sevoflurane." | 4.12 | [Correction of cognitive dysfunction after laparoscopic cholecystectomy under inhalation anesthesia with sevoflurane]. ( Nazarchuk, EA; Neimark, MI; Rakhmonov, AA; Shmelev, VV, 2022) |
| " We recently found that the anaesthetization of aging C57BL/6 J mice (14-16 months) with sevoflurane (3%, two hours each day for three consecutive days) can induce cognitive dysfunction and synaptic plasticity deficits." | 4.12 | Sevoflurane inhibits histone acetylation and contributes to cognitive dysfunction by enhancing the expression of ANP32A in aging mice. ( Chai, G; Fang, R; Jiang, Z; Liu, Y; Nie, Y; Wang, X; Wu, J; Yi, H; Zhang, D; Zhang, J; Zhao, P; Zhou, J, 2022) |
| "This research aimed to explore the influence of TLR deletion on sevoflurane-induced postoperative cognitive dysfunction in neonatal mice." | 4.12 | TLR3 deletion inhibits programmed necrosis of brain cells in neonatal mice with sevoflurane-induced cognitive dysfunction. ( Guo, J; Li, Y; Wang, Q; Yin, C; Yu, J; Zhang, Q; Zhao, J, 2022) |
| " In this study, we investigated whether cucurbitacin E could alleviate sevoflurane-induced cognitive dysfunction in rats." | 4.12 | Cucurbitacin E reduces the cognitive dysfunction induced by sevoflurane in rats by regulating NF-κB pathway. ( Feng, Y; Li, X; Shi, B; Yuan, H; Zheng, S, 2022) |
| "Sevoflurane anesthesia enhanced ApoE mRNA, total ApoE, full-length ApoE, ApoE fragments, Tau phosphorylation (AT8 and PHF1), and cognitive impairment in young mice, but not in adult mice." | 4.12 | Effects of toxic apolipoprotein E fragments on Tau phosphorylation and cognitive impairment in neonatal mice under sevoflurane anesthesia. ( Pan, J; Yang, M; Yu, Y; Zhao, Y; Zhuang, X, 2022) |
| "Evidence has shown that suppression of the activation of NLRP3 inflammasome could ameliorate surgery/sevoflurane (SEV)-induced post-operative cognitive dysfunction (POCD)." | 4.12 | Knockdown of UAF1 alleviates sevoflurane-induced cognitive impairment and neurotoxicity in rats by inhibiting pro-inflammatory signaling and oxidative stress. ( Wang, J; Wang, Q; Zhang, M; Zhu, Y, 2022) |
| "The objective of this study was to discuss the possible mechanism and effect of miR-182-5p delivered by plasma exosomes on sevoflurane-induced neuroinflammation and cognitive disorder in aged rats with postoperative cognitive dysfunction (POCD)." | 4.12 | miR-182-5p Delivered by Plasma Exosomes Promotes Sevoflurane-Induced Neuroinflammation and Cognitive Dysfunction in Aged Rats with Postoperative Cognitive Dysfunction by Targeting Brain-Derived Neurotrophic Factor and Activating NF-κB Pathway. ( Chen, SB; Huang, YL; Rao, MW; Wei, FS; Wu, YQ; Yang, L, 2022) |
| "Studies have shown that long-term exposure to sevoflurane (SEV) may cause postoperative cognitive dysfunction." | 4.12 | Resveratrol ameliorates neuronal apoptosis and cognitive impairment by activating the SIRT1/RhoA pathway in rats after anesthesia with sevoflurane. ( Deng, Y; Hu, X; Xu, Y; Zhou, Q, 2022) |
| "The involvement of Dexmedetomidine (Dex) has been indicated in postoperative cognitive dysfunction (POCD), while the mechanism is not well characterized." | 4.02 | Protective role of dexmedetomidine against sevoflurane-induced postoperative cognitive dysfunction via the microRNA-129/TLR4 axis. ( Chen, S; He, S; Sun, Z; Wei, W; Zhang, W, 2021) |
| " However, it's not clear whether RhoA pathway is involved in inhaled general anesthetics sevoflurane-induced synaptic development abnormalities and long-term cognitive dysfunction." | 4.02 | Inhibition of RhoA Activity Does Not Rescue Synaptic Development Abnormalities and Long-Term Cognitive Impairment After Sevoflurane Exposure. ( Huang, W; Huang, Z; Li, J; Li, Y; Liao, Z; Liu, Y; Miao, L, 2021) |
| "Cdk5/CRMP2 and GSK-3β/CRMP2 pathways participate in sevoflurane-induced dendritic development abnormalities and cognitive dysfunction in developing rats." | 4.02 | Regulation of CRMP2 by Cdk5 and GSK-3β participates in sevoflurane-induced dendritic development abnormalities and cognitive dysfunction in developing rats. ( Huang, Z; Li, H; Li, J; Li, Y; Liao, Z; Liu, Y; Miao, L; Xu, Y; Zhang, J, 2021) |
| " Sevoflurane anesthesia is linked to cognitive dysfunction correlated to the expression of miRNA levels." | 4.02 | MiR-124 protects against cognitive dysfunction induced by sevoflurane anesthesia in vivo and in vitro through targeting calpain small subunit 1 via NF-κB signaling pathway. ( Li, Y; Ma, L; Tai, Y; Wang, Q; Wang, Y; Zhang, Q; Zhao, Z, 2021) |
| "RAGE over-expression in the hippocampal vascular endothelial cells possibly resulted in the excessive transport of the plasma Aβ1-40 into the brain after treatment with sevoflurane, which was associated with sevoflurane-induced cognitive dysfunction in aged mice." | 3.96 | Plasma amyloid beta level changes in aged mice with cognitive dysfunction following sevoflurane exposure. ( Han, Y; Liang, R; Ou, S; Xu, J; Zhou, S, 2020) |
| "This study aimed to investigate the protective effects and underlying mechanisms of cistanche on sevoflurane-induced aged cognitive dysfunction rat model." | 3.96 | Cistanches alleviates sevoflurane-induced cognitive dysfunction by regulating PPAR-γ-dependent antioxidant and anti-inflammatory in rats. ( Li, P; Liu, C; Liu, P; Lu, W; Peng, S; Wang, J; Yan, H; Zhou, Y, 2020) |
| " Our previous studies verified that cyclin-dependent kinase 5 (CDK5) plays a role in sevoflurane-induced cognitive dysfunction." | 3.96 | Downregulation of CDK5 Restores Sevoflurane-Induced Cognitive Dysfunction by Promoting SIRT1-Mediated Autophagy. ( Fu, S; Liu, J; Liu, S; Wu, H; Yang, J; Yang, X; Zhang, W; Zhang, X; Zhao, Y, 2020) |
| "The neuroprotective activity of ChIV against sevoflurane-induced cognitive dysfunction in aged rats was evaluated by Morris water maze, NOR test and Y-maze test, respectively." | 3.96 | Chikusetsu saponin IVa alleviated sevoflurane-induced neuroinflammation and cognitive impairment by blocking NLRP3/caspase-1 pathway. ( Fei, J; Feng, S; Shao, A; Weng, J, 2020) |
| "To investigate the effects of C1q/tumor necrosis factor-related protein-3 (CTRP3) on postoperative cognitive dysfunction (POCD) and elucidate the potential regulatory mechanism in sevoflurane anesthesia-induced aged rats." | 3.96 | Neuroprotective effect of CTRP3 overexpression against sevoflurane anesthesia-induced cognitive dysfunction in aged rats through activating AMPK/SIRT1 and PI3K/AKT signaling pathways. ( Xu, YC; Yang, LH; Zhang, W, 2020) |
| "Higher brain Tau concentrations and lower brain mitochondrial metabolism in neonatal compared with adult mice contribute to developmental stage-dependent cognitive dysfunction after sevoflurane anesthesia." | 3.96 | Tau Contributes to Sevoflurane-induced Neurocognitive Impairment in Neonatal Mice. ( Boukhali, M; Dong, Y; Haas, W; Hua, F; Khatri, A; Li, M; Liu, L; Tan, H; Xie, Z; Yang, G; Yang, Y; Yu, Y; Zhang, Y, 2020) |
| " However, little is known about whether TLR4 is associated with sevoflurane-induced cognitive decline." | 3.96 | Sevoflurane-induced cognitive decline in aged mice: Involvement of toll-like receptors 4. ( Dong, N; Fei, X; Sheng, ZY; Wang, JX; Wu, Y, 2020) |
| "The present study was aimed to observe the protective effect of rapamycin on cognitive dysfunction induced by sevoflurane in aged rats and its effect on autophagy‑related proteins, and to investigate the regulatory mechanism of the Toll‑like receptor 4/myeloid differentiation primary response 88/nuclear factor‑κB (TLR4/MyD88/NF‑κB) signaling pathway." | 3.91 | Rapamycin improves sevoflurane‑induced cognitive dysfunction in aged rats by mediating autophagy through the TLR4/MyD88/NF‑κB signaling pathway. ( Li, Y; Liu, L; Tian, Y; Zhang, J, 2019) |
| "Sevoflurane induced the cognitive dysfunction presenting with longer latency time and few platform crossings in rats." | 3.91 | MiR-125b-5p Inhibitor Might Protect Against Sevoflurane-induced Cognitive Impairments by Targeting LIMK1. ( Bao, Y; Liu, Z; Mu, F; Sun, Y; Wang, H; Xiong, J, 2019) |
| "Adult C57BL/6 mice received a laparotomy under sevoflurane anesthesia and HNK or SIRT3 inhibitor (3-TYP) treatment." | 3.91 | SIRT3 activator honokiol ameliorates surgery/anesthesia-induced cognitive decline in mice through anti-oxidative stress and anti-inflammatory in hippocampus. ( Chen, L; Lei, SQ; Lu, YY; Peng, M; Xia, ZY; Ye, JS, 2019) |
| "General anesthesia with sevoflurane is associated with an increased incidence of postoperative cognitive dysfunction." | 3.91 | Nerve growth factor metabolic dysfunction contributes to sevoflurane-induced cholinergic degeneration and cognitive impairments. ( Duan, L; Wang, Z; Xiong, L; Xu, W, 2019) |
| "Sevoflurane anesthesia impaired cognitive functions, as well as metabotropic glutamate receptor-dependent long-term depression, through elevated surface expression of small conductance calcium-activated potassium type 2 channels." | 3.91 | Sevoflurane anesthesia impairs metabotropic glutamate receptor-dependent long-term depression and cognitive functions in senile mice. ( Shi, J; Yu, X; Zhang, F, 2019) |
| " In the present study, it was examined whether treatment with PPAR‑γ agonist pioglitazone (PIO) is beneficial in counteracting SEV‑induced neuroinflammation and cognitive decline in a rat model of CIH." | 3.91 | Pioglitazone prevents sevoflurane‑induced neuroinflammation and cognitive decline in a rat model of chronic intermittent hypoxia by upregulating hippocampal PPAR‑γ. ( Dong, P; Fei, J; Li, D; Li, L; Li, N; Lin, Q; Lu, L; Yang, B; Zhang, X, 2019) |
| " Sevoflurane anesthesia has been found to lead to CD and microRNAs (miRNAs) were reported to affect cognitive function." | 3.91 | Neuroprotective effect of miR-410-3p against sevoflurane anesthesia-induced cognitive dysfunction in rats through PI3K/Akt signaling pathway via targeting C-X-C motif chemokine receptor 5. ( Feng, C; Su, R; Sun, P; Xiao, W; Zhang, D; Zhong, L, 2019) |
| "Objective This study aimed to evaluate the role of the hippocampal 5-hydroxytryptamine-1A (5-HT1A)-mediated cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) signalling pathway in sevoflurane-induced cognitive dysfunction in aged rats." | 3.88 | Role of the hippocampal 5-HT1A receptor-mediated cAMP/PKA signalling pathway in sevoflurane-induced cognitivedysfunction in aged rats. ( Qiu, Y; Wang, C; Wang, X; Wang, Y; Xia, ZY, 2018) |
| "To investigate the role of IL-17A in the neuroinflammation and cognitive function of aged rats anaesthetized with sevoflurane through NF-κB pathway." | 3.88 | IL-17A promotes the neuroinflammation and cognitive function in sevoflurane anesthetized aged rats via activation of NF-κB signaling pathway. ( Yang, ZY; Yuan, CX, 2018) |
| "Sevoflurane anesthesia is a high-risk factor for postoperative cognitive dysfunction (POCD) in elderly patients." | 3.88 | Role of dexmedetomidine in reducing the incidence of postoperative cognitive dysfunction caused by sevoflurane inhalation anesthesia in elderly patients with esophageal carcinoma. ( Qiao, Y; Wu, Z; Zhang, H; Zhao, X, 2018) |
| "Our findings suggested that sevoflurane can induce neuroapoptosis and cognitive dysfunction in adolescent rats that received repeated sevoflurane (2% for 1 h) during the postnatal period." | 3.85 | Repeated 2% sevoflurane administration in 7‑ and 60-day-old rats : Neurotoxicity and neurocognitive dysfunction. ( Chen, J; Huang, H; Jin, WJ; Liu, CM; Sun, J; Wu, YQ, 2017) |
| "Inhibiting CDK5 with roscovitine has neuroprotective effects against neuronal injury and cognitive dysfunction caused by sevoflurane anesthesia that are exerted via modulation of Tau/GSK3β and ERK/PPARγ/CREB signaling." | 3.85 | Roscovitine, a CDK5 Inhibitor, Alleviates Sevoflurane-Induced Cognitive Dysfunction via Regulation Tau/GSK3β and ERK/PPARγ/CREB Signaling. ( Cai, L; Guo, G; Liu, J; Wu, H; Xu, Y; Yang, J; Zhang, X; Zhao, Y, 2017) |
| "This study was designed to explore the effect of 3-methyladenine (3-MA) on sevoflurane anesthesia-induced cognitive dysfunction." | 3.85 | The autophagy inhibitor 3-methyladenine restores sevoflurane anesthesiainduced cognitive dysfunction and neurons apoptosis. ( Bu, J; Hou, B; Li, G; Liang, Z; Xiao, X; Yang, L; Zhu, Y, 2017) |
| "This study aimed to explore the role of NF-κB/P65 signaling pathway in postoperative cognitive dysfunction (POCD) after sevoflurane anesthesia." | 3.85 | NF-κB/P65 signaling pathway: a potential therapeutic target in postoperative cognitive dysfunction after sevoflurane anesthesia. ( Chen, JP; Li, XY; Lu, B; Meng, B; Wu, GR; Zheng, JW, 2017) |
| "To explore the effect of general anesthesia combined with epidural anesthesia and patient-controlled epidural analgesia on the incidence of the post-operative cognitive dysfunction (POCD) in elderly patients." | 2.82 | [Incidence of the post-operative cognitive dysfunction in elderly patients with general anesthesia combined with epidural anesthesia and patient-controlled epidural analgesia]. ( Li, H; Liu, X; Wang, Y, 2016) |
| "Amnestic mild cognitive impairment (aMCI) is thought to be a transitional stage between normal aging and the development of Alzheimer's disease (AD)." | 2.78 | Inhaled sevoflurane may promote progression of amnestic mild cognitive impairment: a prospective, randomized parallel-group study. ( Gao, M; Guo, W; Li, H; Liu, G; Liu, Y; Ma, Y; Pan, N; Zhang, S; Zhou, J, 2013) |
| "Propofol has a more significant adverse effect on postoperative cognitive function in elderly patients with lung cancer than sevoflurane." | 2.61 | A systematic review: comparative analysis of the effects of propofol and sevoflurane on postoperative cognitive function in elderly patients with lung cancer. ( Ai, B; Kong, X; Lee, WT; Sun, H; Sun, L; Yan, T; Zhang, G; Zhang, H; Zheng, H, 2019) |
| "Sevoflurane is a widely used inhalational anesthetic in pediatric surgeries, which is considered reasonably safe and reversible upon withdrawal." | 2.61 | Role of the GABAA receptors in the long-term cognitive impairments caused by neonatal sevoflurane exposure. ( Huang, Z; Li, T; Tan, S; Wang, X; Zou, J, 2019) |
| "Sevoflurane (SEV) is a commonly used anesthetic in pediatric surgery." | 1.91 | Engeletin ameliorates sevoflurane-induced cognitive impairment by activating PPAR-gamma in neonatal mice. ( Jiang, S; Wang, X; Xiong, Y, 2023) |
| "Isovitexin (IVX) is a trihydroxyl flavonoid that is a naturally bioactive ingredient found in various medicinal plants and has antioxidant, anti‑inflammatory and neuroprotective properties." | 1.72 | Isovitexin restores sevoflurane‑induced cognitive dysfunction by mediating autophagy through activation of the PGC‑1α/FNDC5 signaling pathway. ( Chen, Q; Guo, Y; Sun, L; Wu, B, 2022) |
| "Sevoflurane (Sev) might cause neurotoxicity in elderly rats." | 1.72 | Lin28A Reduced Sevoflurane-Induced Nerve Injury and Cognitive Dysfunction by Inhibiting Tau Acetylation and Phosphorylation via Activating SIRT1 in Elderly Rats. ( Wang, J; Wang, Q; Zhang, M; Zhu, Y, 2022) |
| "Sevoflurane treatment induced cognitive dysfunction and motor impairment in aged WT mice." | 1.72 | Pleiotrophin Potentiates Sevoflurane Anesthesia-induced Learning Deficits in Mice. ( Mao, S; Wang, L; Yu, J; Zhu, C, 2022) |
| "We observed that preoperative hind limb muscle atrophy, indicated by TS, was associated with an increased occurrence of PND through the reduction in BDNF and neurogenesis after abdominal surgery in young adult rats." | 1.72 | Low Skeletal Muscle Mass Is Associated With Perioperative Neurocognitive Disorder Due To Decreased Neurogenesis in Rats. ( Goyagi, T; Nakagawasai, O; Nemoto, A; Nemoto, W; Niiyama, Y; Tan-No, K, 2022) |
| "Sevoflurane (Sev) is a commonly used anesthetic in hospitals that can cause neurotoxicity." | 1.62 | A new mechanism of POCD caused by sevoflurane in mice: cognitive impairment induced by cross-dysfunction of iron and glucose metabolism. ( Chang, Y; Gao, G; Ge, X; Li, X; Li, Y; Shi, Z; Thirupathi, A; Xie, J; Yu, P; Zhou, C; Zuo, Y, 2021) |
| "Accumulation and spread of tau in Alzheimer's disease and other tauopathies occur in a prion-like manner." | 1.62 | The anesthetic sevoflurane induces tau trafficking from neurons to microglia. ( Dong, Y; Fang, F; Huang, L; Liang, F; Quan, Q; Tanzi, RE; Xie, Z; Yang, G; Zhang, Y, 2021) |
| "Lovastatin treatment also inhibited the increased expressions of β-secretase 1 (BACE1) and γ-secretase in hippocampal neurons under sevoflurane exposure in vitro." | 1.62 | Lovastatin attenuates sevoflurane-induced cognitive disorder in aged rats via reducing Aβ accumulation. ( Chu, H; Dong, Y; Jiang, Q; Tian, Y; Wang, C; Xu, Y, 2021) |
| "Sevoflurane (Sev) is a rapidly acting, potent inhalation anesthetic with rapid uptake and elimination." | 1.62 | P300 Inhibition Improves Cell Apoptosis and Cognition Impairment Induced by Sevoflurane Through Regulating IL-17A Activation. ( Chen, A; Cheng, Y; Tan, B, 2021) |
| "Postoperative cognitive dysfunction is a common complication in elderly patients after surgeries involving anesthesia, but the underlying mechanisms are poorly understood." | 1.56 | Lithium chloride ameliorates cognition dysfunction induced by sevoflurane anesthesia in rats. ( An, X; Liu, J; Wang, J; Wang, Y; Yang, Z; Zhang, X, 2020) |
| "Sevoflurane anesthesia has been implicated in both postoperative cognitive dysfunction and neurotoxicity." | 1.56 | Sevoflurane anesthesia-mediated oxidative stress and cognitive impairment in hippocampal neurons of old rats can be ameliorated by expression of brain derived neurotrophic factor. ( Qian, B; Xu, Z, 2020) |
| "Sevoflurane is an experimental potent yet volatile anesthesia agent characterized by a low blood/gas partition coefficient." | 1.51 | MicroRNA-96 is responsible for sevoflurane-induced cognitive dysfunction in neonatal rats via inhibiting IGF1R. ( Niu, JJ; Wei, YS; Xu, C; Zhou, JF, 2019) |
| "Sevoflurane is a common anesthetic widely used in clinical practice." | 1.51 | Transcriptomic analysis reveals the molecular mechanism of Alzheimer-related neuropathology induced by sevoflurane in mice. ( Chang, YZ; Gao, G; Ge, X; Israr, M; Li, B; Shi, Z; Yu, P; Zhang, Y; Zuo, Y, 2019) |
| "Sevoflurane is a commonly used inhalation anesthetic." | 1.48 | MicroRNA-188-3p is involved in sevoflurane anesthesia-induced neuroapoptosis by targeting MDM2. ( Niu, Z; Wang, L; Wu, S; Zheng, M, 2018) |
| "Sevoflurane is a widely used volatile anesthetic in the clinical setting." | 1.48 | Sevoflurane exaggerates cognitive decline in a rat model of chronic intermittent hypoxia by aggravating microglia-mediated neuroinflammation via downregulation of PPAR-γ in the hippocampus. ( Dong, P; Li, D; Li, L; Li, N; Lu, L; Yang, B; Zhang, L; Zhang, X; Zhao, J, 2018) |
| "Treatment with tetrandrine reduced the expression levels of COX‑2, IL‑1β, TNF‑α, NF‑κB, iNOS and caspase‑3, and increased the Bcl‑2 protein expression in sevoflurane‑treated aged rats." | 1.43 | Tetrandrine ameliorates sevoflurane‑induced cognitive impairment via the suppression of inflammation and apoptosis in aged rats. ( Li, X; Ma, H; Pang, L; Yao, L; Yao, Q, 2016) |
| "The corticosterone level was significantly increased immediately after repeated neonatal sevoflurane exposures." | 1.43 | Heightened stress response and cognitive impairment after repeated neonatal sevoflurane exposures might be linked to excessive GABAAR-mediated depolarization. ( Li, F; Liu, G; Qian, B; Qian, W; Zhang, A; Zhu, T, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 42 (30.88) | 24.3611 |
| 2020's | 94 (69.12) | 2.80 |
| Authors | Studies |
|---|---|
| Wei, W | 1 |
| Sun, Z | 2 |
| He, S | 1 |
| Zhang, W | 3 |
| Chen, S | 1 |
| Liu, Z | 5 |
| Yang, B | 3 |
| Chen, H | 2 |
| Chu, H | 2 |
| Jiang, Q | 2 |
| Wang, C | 5 |
| Tian, Y | 5 |
| Ge, X | 2 |
| Zuo, Y | 4 |
| Xie, J | 2 |
| Li, X | 6 |
| Li, Y | 8 |
| Thirupathi, A | 2 |
| Yu, P | 3 |
| Gao, G | 3 |
| Zhou, C | 2 |
| Chang, Y | 2 |
| Shi, Z | 3 |
| Shen, M | 1 |
| Lian, N | 1 |
| Song, C | 1 |
| Qin, C | 1 |
| Yu, Y | 7 |
| Yang, Y | 4 |
| Liang, F | 4 |
| Gao, J | 1 |
| Dong, Y | 7 |
| Zhang, Y | 19 |
| Yang, G | 4 |
| Soriano, SG | 3 |
| Feng, HJ | 1 |
| Xie, Z | 6 |
| Han, F | 1 |
| Zhao, J | 5 |
| Zhao, G | 1 |
| Weng, H | 1 |
| Liu, X | 3 |
| Ren, Y | 1 |
| Wali, B | 1 |
| Sayeed, I | 1 |
| Stein, DG | 1 |
| Raper, J | 1 |
| Yin, C | 3 |
| Zhang, Q | 6 |
| Yu, J | 3 |
| Li, W | 3 |
| Wang, Q | 7 |
| Yuan, H | 2 |
| Lu, B | 2 |
| Ji, Y | 1 |
| Meng, B | 2 |
| Wang, R | 1 |
| Sun, D | 1 |
| Liu, R | 1 |
| Zhai, X | 1 |
| Qin, J | 1 |
| Chen, J | 3 |
| Liu, L | 4 |
| Zhang, X | 11 |
| Wu, X | 2 |
| Long, B | 1 |
| Hao, C | 1 |
| Duan, X | 1 |
| Yang, X | 2 |
| Huang, Z | 4 |
| Li, F | 2 |
| Yang, J | 3 |
| Yang, H | 1 |
| Zhao, L | 4 |
| Li, Q | 2 |
| Zuo, C | 1 |
| Ma, J | 1 |
| Pan, Y | 1 |
| Zheng, D | 2 |
| Chen, C | 3 |
| Ruan, N | 1 |
| Su, Y | 1 |
| Nan, H | 1 |
| Lian, Q | 1 |
| Lin, H | 1 |
| Chen, YR | 1 |
| Zhang, SX | 1 |
| Fang, M | 1 |
| Zhang, P | 4 |
| Zhou, YF | 1 |
| Yu, X | 4 |
| Zhang, XN | 1 |
| Chen, G | 3 |
| Neimark, MI | 1 |
| Shmelev, VV | 1 |
| Rakhmonov, AA | 1 |
| Nazarchuk, EA | 1 |
| Jiang, Y | 1 |
| Zhang, J | 8 |
| Hu, Y | 1 |
| Chai, G | 2 |
| Wu, J | 2 |
| Fang, R | 1 |
| Liu, Y | 6 |
| Wang, X | 11 |
| Zhou, J | 5 |
| Jiang, Z | 1 |
| Yi, H | 1 |
| Nie, Y | 1 |
| Zhao, P | 3 |
| Zhang, D | 4 |
| Guo, J | 2 |
| Zheng, S | 1 |
| Shi, B | 1 |
| Feng, Y | 1 |
| Liu, P | 2 |
| Wang, J | 9 |
| Peng, S | 3 |
| Zhuang, L | 1 |
| Liu, C | 3 |
| Shi, X | 1 |
| Li, S | 1 |
| Teng, Y | 1 |
| Zhou, Y | 4 |
| Xiong, H | 1 |
| Feng, S | 2 |
| Li, L | 4 |
| Qiu, S | 1 |
| Jin, Y | 1 |
| Sun, Y | 4 |
| Zhong, Y | 1 |
| Zhang, C | 3 |
| Wang, Y | 9 |
| Tang, C | 1 |
| Ren, J | 1 |
| Wang, M | 1 |
| Liu, D | 1 |
| Zhu, Z | 2 |
| Yang, M | 1 |
| Zhuang, X | 1 |
| Pan, J | 2 |
| Zhao, Y | 6 |
| Zhu, Y | 4 |
| Zhang, M | 3 |
| Guo, Y | 1 |
| Chen, Q | 2 |
| Wu, B | 1 |
| Sun, L | 2 |
| Chen, Y | 5 |
| Xie, Y | 2 |
| Ni, H | 1 |
| Wei, FS | 1 |
| Rao, MW | 1 |
| Huang, YL | 1 |
| Chen, SB | 1 |
| Wu, YQ | 2 |
| Yang, L | 4 |
| Huang, J | 1 |
| Xu, F | 1 |
| Han, L | 1 |
| Deng, D | 1 |
| Ding, Y | 1 |
| Zhao, S | 1 |
| Ma, L | 2 |
| Chen, X | 2 |
| Lu, J | 1 |
| He, W | 1 |
| Zhang, L | 4 |
| Wang, H | 5 |
| Fang, X | 1 |
| Zhang, N | 1 |
| Yamamoto, N | 1 |
| Kimura, T | 1 |
| Niiyama, Y | 2 |
| Zhou, Q | 2 |
| Zheng, Z | 1 |
| Wang, L | 5 |
| Pan, X | 1 |
| Tang, Y | 1 |
| Wu, G | 1 |
| Li, M | 6 |
| Lv, JM | 1 |
| Zhang, LM | 1 |
| Wang, JX | 2 |
| Shao, JJ | 1 |
| Guo, XG | 1 |
| Wang, LY | 1 |
| Kang, LQ | 1 |
| Zheng, WC | 1 |
| Xin, Y | 1 |
| Song, RX | 1 |
| Guo, W | 2 |
| Zhang, DX | 1 |
| Yue, Y | 1 |
| Wu, A | 1 |
| Jiang, S | 1 |
| Xiong, Y | 2 |
| Guo, LL | 1 |
| Wang, HY | 1 |
| Song, S | 2 |
| Fan, P | 1 |
| Lu, Y | 1 |
| Wei, H | 1 |
| Wang, K | 1 |
| Jia, P | 1 |
| Wang, T | 1 |
| Zhang, S | 2 |
| Lu, H | 1 |
| Abdelkareem, E | 1 |
| Tayee, EM | 1 |
| Taha, AM | 1 |
| Abdelellatif, MS | 1 |
| Xu, Z | 3 |
| Yao, X | 1 |
| Yao, B | 1 |
| Xu, Y | 5 |
| Sun, F | 1 |
| Xu, M | 1 |
| McCann, ME | 1 |
| Wu, D | 1 |
| Li, D | 4 |
| Zhou, X | 1 |
| Fan, D | 1 |
| Huang, Y | 1 |
| Ye, C | 1 |
| Wei, F | 1 |
| Zhong, H | 1 |
| Ran, X | 1 |
| Chen, B | 1 |
| Luo, Y | 1 |
| Liu, J | 4 |
| Hong, Y | 1 |
| Meng, S | 1 |
| Zou, X | 1 |
| Qiang, T | 1 |
| Hu, X | 3 |
| Gong, Y | 1 |
| Kang, P | 1 |
| Wei, Z | 1 |
| Cao, G | 1 |
| Dong, X | 1 |
| Jiang, L | 1 |
| Xiong, J | 1 |
| Mu, F | 1 |
| Bao, Y | 1 |
| Liang, R | 1 |
| Ou, S | 1 |
| Han, Y | 1 |
| Xu, J | 1 |
| Zhou, S | 1 |
| Yin, J | 1 |
| Zhao, X | 2 |
| Xie, X | 1 |
| Geng, H | 1 |
| Zhan, X | 1 |
| Teng, J | 1 |
| Liang, L | 1 |
| Xie, R | 1 |
| Lu, R | 1 |
| Ma, R | 1 |
| Wang, F | 1 |
| Liu, B | 1 |
| Wu, S | 2 |
| Zhang, H | 5 |
| Wu, Z | 2 |
| Li, P | 1 |
| Yan, H | 1 |
| Lu, W | 1 |
| An, X | 1 |
| Yang, Z | 1 |
| Sun, H | 1 |
| Zhang, G | 1 |
| Ai, B | 1 |
| Kong, X | 1 |
| Lee, WT | 1 |
| Zheng, H | 1 |
| Yan, T | 1 |
| Wu, H | 2 |
| Fu, S | 1 |
| Liu, S | 2 |
| Zheng, F | 2 |
| Fang, P | 2 |
| Chang, J | 2 |
| Chen, M | 1 |
| Zhong, Q | 1 |
| Chen, T | 2 |
| Zhang, Z | 2 |
| Qian, B | 2 |
| Li, B | 2 |
| Ma, Z | 1 |
| Xu, H | 1 |
| Shao, A | 1 |
| Fei, J | 2 |
| Weng, J | 1 |
| Huang, H | 3 |
| Hu, C | 1 |
| Xu, L | 1 |
| Zhu, X | 2 |
| Min, J | 1 |
| Yang, LH | 1 |
| Xu, YC | 1 |
| Dai, CL | 1 |
| Li, H | 4 |
| Liu, F | 1 |
| Iqbal, K | 1 |
| Gong, CX | 1 |
| Zhou, HS | 1 |
| Cao, SM | 1 |
| Liao, HS | 1 |
| Huo, HY | 1 |
| Peng, Y | 1 |
| Tan, H | 1 |
| Boukhali, M | 1 |
| Khatri, A | 1 |
| Hua, F | 1 |
| Haas, W | 1 |
| Yu, Z | 1 |
| Cui, J | 1 |
| Fei, X | 1 |
| Wu, Y | 2 |
| Dong, N | 1 |
| Sheng, ZY | 1 |
| Cui, E | 1 |
| Yan, M | 1 |
| Sun, J | 3 |
| Sun, M | 1 |
| Fang, L | 1 |
| Liao, Z | 2 |
| Li, J | 2 |
| Miao, L | 2 |
| Huang, W | 1 |
| Tang, XL | 1 |
| Fang, G | 1 |
| Zhao, YL | 1 |
| Yan, J | 2 |
| Zhou, Z | 1 |
| Sun, R | 1 |
| Luo, AL | 1 |
| Li, SY | 1 |
| Li, C | 1 |
| Yu, TY | 1 |
| Gong, LR | 1 |
| Mu, R | 1 |
| Yu, JB | 1 |
| Jia, J | 1 |
| Zhu, J | 1 |
| Yuan, J | 1 |
| Huang, L | 1 |
| Fang, F | 2 |
| Tanzi, RE | 1 |
| Quan, Q | 1 |
| Zhao, Z | 1 |
| Tai, Y | 1 |
| Gong, H | 1 |
| Tuerhong, G | 1 |
| Xia, H | 1 |
| Liu, M | 1 |
| Chu, W | 1 |
| Ji, F | 1 |
| Deng, Y | 1 |
| Chen, A | 1 |
| Tan, B | 1 |
| Cheng, Y | 1 |
| Mao, S | 1 |
| Zhu, C | 1 |
| Nemoto, A | 1 |
| Goyagi, T | 1 |
| Nemoto, W | 1 |
| Nakagawasai, O | 1 |
| Tan-No, K | 1 |
| Dai, J | 1 |
| Gu, S | 1 |
| Dai, L | 1 |
| Fan, Y | 1 |
| Geng, YJ | 1 |
| Wu, QH | 1 |
| Zhang, RQ | 1 |
| Liu, CM | 1 |
| Jin, WJ | 1 |
| Guo, G | 1 |
| Cai, L | 1 |
| Satomoto, M | 1 |
| Adachi, YU | 1 |
| Kinoshita, H | 1 |
| Makita, K | 1 |
| Qiu, Y | 1 |
| Xia, ZY | 3 |
| Zheng, M | 1 |
| Niu, Z | 1 |
| Xiao, X | 1 |
| Bu, J | 1 |
| Li, G | 1 |
| Liang, Z | 1 |
| Hou, B | 1 |
| Dong, P | 2 |
| Li, N | 2 |
| Lu, L | 2 |
| Fan, CH | 1 |
| Peng, B | 1 |
| Zhang, FC | 1 |
| Shan, GJ | 1 |
| Zhang, YX | 1 |
| Cao, SJ | 1 |
| Zhu, SN | 1 |
| Li, HJ | 1 |
| Ma, D | 1 |
| Wang, DX | 1 |
| Zhang, F | 2 |
| Shi, J | 2 |
| Xu, C | 1 |
| Niu, JJ | 1 |
| Zhou, JF | 1 |
| Wei, YS | 1 |
| Alalawi, R | 1 |
| Yasmeen, N | 1 |
| Ye, JS | 2 |
| Chen, L | 2 |
| Lu, YY | 2 |
| Lei, SQ | 2 |
| Peng, M | 2 |
| Yang, ZY | 1 |
| Yuan, CX | 1 |
| Kletecka, J | 1 |
| Holeckova, I | 1 |
| Brenkus, P | 1 |
| Pouska, J | 1 |
| Benes, J | 1 |
| Chytra, I | 1 |
| Chen, KY | 1 |
| Liu, LD | 1 |
| Dong, YX | 1 |
| Guo, SB | 1 |
| Konishi, Y | 1 |
| Evered, LA | 1 |
| Scott, DA | 1 |
| Silbert, BS | 1 |
| Xiong, L | 1 |
| Duan, L | 1 |
| Xu, W | 1 |
| Wang, Z | 1 |
| Qiao, Y | 1 |
| Xue, B | 1 |
| You, J | 1 |
| Zhang, B | 1 |
| Gao, X | 1 |
| Ming, J | 1 |
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| Cang, J | 1 |
| Lin, Q | 1 |
| Li, T | 2 |
| Israr, M | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Brain Health & the Microbiome: A Proof-of-Concept Study in Patients With Mild Cognitive Impairment[NCT06039267] | 90 participants (Anticipated) | Observational | 2023-08-25 | Recruiting | |||
| Comparison of Propofol and Sevoflurane Anesthesia on the Quality of Recovery After Ambulatory Surgery for Anal Fistula in Obese Patients: A Prospective, Randomized, Single-blinded, Controlled Clinical Trial[NCT05529875] | 0 participants (Actual) | Interventional | 2022-10-31 | Withdrawn (stopped due to In the early stage of the research, this research was limited by the application permission of research drugs and instruments, and the research will have to be interrupted, which is extremely regrettable.) | |||
| Impact of Inhalational Versus Intravenous Anesthesia Maintenance Methods on Incidence of Postoperative Delirium in Elderly Patients After Cancer Surgery: An Open-label, Randomized Controlled Trial[NCT02662257] | 1,228 participants (Actual) | Interventional | 2015-04-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for sevoflurane and Cognitive Dysfunction
| Article | Year |
|---|---|
A systematic review: comparative analysis of the effects of propofol and sevoflurane on postoperative cognitive function in elderly patients with lung cancer.
Topics: Age Factors; Aged, 80 and over; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Cogni | 2019 |
Postoperative Cognitive Dysfunction in the Elderly: A Review Comparing the Effects of Desflurane and Sevflurane.
Topics: Aged; Anesthesia Recovery Period; Anesthetics, Inhalation; Cognitive Dysfunction; Desflurane; Humans | 2018 |
Role of the GABAA receptors in the long-term cognitive impairments caused by neonatal sevoflurane exposure.
Topics: Anesthetics, Inhalation; Animals; Brain; Cognitive Dysfunction; Humans; Neurogenesis; Receptors, GAB | 2019 |
6 trials available for sevoflurane and Cognitive Dysfunction
| Article | Year |
|---|---|
Effect of propofol, sevoflurane, and isoflurane on postoperative cognitive dysfunction following laparoscopic cholecystectomy in elderly patients: A randomized controlled trial.
Topics: Aged; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Biomarkers; Cholecystectomy, La | 2017 |
Propofol compared with sevoflurane general anaesthesia is associated with decreased delayed neurocognitive recovery in older adults.
Topics: Aged; Aged, 80 and over; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Cog | 2018 |
Propofol versus sevoflurane anaesthesia: effect on cognitive decline and event-related potentials.
Topics: Adolescent; Adult; Aged; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Cognitive Dy | 2019 |
Effect of inhalational anaesthetic on postoperative cognitive dysfunction following radical rectal resection in elderly patients with mild cognitive impairment.
Topics: Administration, Inhalation; Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Cognition; Cogn | 2014 |
[Incidence of the post-operative cognitive dysfunction in elderly patients with general anesthesia combined with epidural anesthesia and patient-controlled epidural analgesia].
Topics: Analgesia, Epidural; Analgesia, Patient-Controlled; Anesthesia, Epidural; Anesthesia, General; Cogni | 2016 |
Inhaled sevoflurane may promote progression of amnestic mild cognitive impairment: a prospective, randomized parallel-group study.
Topics: Administration, Inhalation; Aged; Amnesia; Amyloid beta-Peptides; Biomarkers; Cognitive Dysfunction; | 2013 |
127 other studies available for sevoflurane and Cognitive Dysfunction
| Article | Year |
|---|---|
Protective role of dexmedetomidine against sevoflurane-induced postoperative cognitive dysfunction via the microRNA-129/TLR4 axis.
Topics: Animals; Cognitive Dysfunction; Dexmedetomidine; MicroRNAs; Postoperative Cognitive Complications; R | 2021 |
CTRP6(C1q/Tumor Necrosis Factor (TNF)-related protein-6) alleviated the sevoflurane induced injury of mice central nervous system by promoting the expression of p-Akt (phosphorylated Akt).
Topics: Adipokines; Animals; Cells, Cultured; Central Nervous System; Cognitive Dysfunction; Disease Models, | 2021 |
Irf6 participates in sevoflurane-induced perioperative neurocognitive disorder via modulating M2, but not M1 polarization of microglia.
Topics: Aged; Animals; Cognitive Dysfunction; Hippocampus; Humans; Interferon Regulatory Factors; Microglia; | 2021 |
A new mechanism of POCD caused by sevoflurane in mice: cognitive impairment induced by cross-dysfunction of iron and glucose metabolism.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Brain; Cognitive Dysfunction; Endothelial Cells; Glucos | 2021 |
Different Anesthetic Drugs Mediate Changes in Neuroplasticity During Cognitive Impairment in Sleep-Deprived Rats via Different Factors.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Cognitive Dysfunction; Disease Models, A | 2021 |
Testosterone attenuates sevoflurane-induced tau phosphorylation and cognitive impairment in neonatal male mice.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Cognitive Dysfunction; Disease Models, Animal; M | 2021 |
Prolonged Volatile Anesthetic Exposure Exacerbates Cognitive Impairment and Neuropathology in the 5xFAD Mouse Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Anesthetics, Inhalation; Animals; Cognitive Dysfunction; Disease Models, Animal; | 2021 |
Fingolimod loaded niosomes attenuates sevoflurane induced cognitive impairments.
Topics: Cognitive Dysfunction; Fingolimod Hydrochloride; Humans; Liposomes; Particle Size; Sevoflurane | 2021 |
Prophylactic progesterone prevents adverse behavioural and neurocognitive effects of neonatal anaesthesia exposure in rat.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Behavior, Animal; Cognitive Dysfunction; Female; | 2022 |
Necrostatin-1 Against Sevoflurane-Induced Cognitive Dysfunction Involves Activation of BDNF/TrkB Pathway and Inhibition of Necroptosis in Aged Rats.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cognitive Dysfunction; Hippocampus; Imidazoles; Indoles; | 2022 |
Role of P2X4/NLRP3 Pathway-Mediated Neuroinflammation in Perioperative Neurocognitive Disorders.
Topics: Animals; Cognitive Dysfunction; Male; Mice; Mice, Inbred C57BL; Microglia; Neurocognitive Disorders; | 2022 |
Hypercholesterolemia aggravates sevoflurane-induced cognitive impairment in aged rats by inducing neurological inflammation and apoptosis.
Topics: Animals; Apoptosis; Cognitive Dysfunction; Hypercholesterolemia; Inflammation; Rats; Rats, Sprague-D | 2022 |
Role of RGS2 in sevoflurane-induced cognitive dysfunction in aged rats.
Topics: Aging; Animals; bcl-2-Associated X Protein; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Typ | 2022 |
Echinacoside alleviates sevoflurane-induced cognitive dysfunction by activating FOXO1-mediated autophagy.
Topics: Animals; Autophagy; Cognitive Dysfunction; Forkhead Box Protein O1; Hippocampus; Mice; Sevoflurane | 2022 |
Isoflurane and Sevoflurane Induce Cognitive Impairment in Neonatal Rats by Inhibiting Neural Stem Cell Development Through Microglial Activation, Neuroinflammation, and Suppression of VEGFR2 Signaling Pathway.
Topics: Anesthetics; Anesthetics, Inhalation; Animals; Animals, Newborn; Cognitive Dysfunction; Hippocampus; | 2022 |
Egr2 contributes to age-dependent vulnerability to sevoflurane-induced cognitive deficits in mice.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Cognition; Cognitive Dysfunction; Early Growth R | 2022 |
[Correction of cognitive dysfunction after laparoscopic cholecystectomy under inhalation anesthesia with sevoflurane].
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Cholecystectomy, Laparoscopic; Cognitive Dysfunctio | 2022 |
GLP-1 Analog Alleviated Cognitive Dysfunction in Aged Rats Anaesthetized with Sevoflurane.
Topics: Aged; Anesthetics, Inhalation; Animals; Cognitive Dysfunction; Hippocampus; Humans; Liraglutide; Maz | 2022 |
Sevoflurane inhibits histone acetylation and contributes to cognitive dysfunction by enhancing the expression of ANP32A in aging mice.
Topics: Acetylation; Aging; Animals; Cognitive Dysfunction; Histones; Mice; Mice, Inbred C57BL; Nuclear Prot | 2022 |
TLR3 deletion inhibits programmed necrosis of brain cells in neonatal mice with sevoflurane-induced cognitive dysfunction.
Topics: Animals; Animals, Newborn; Apoptosis; Brain; Cognitive Dysfunction; Hippocampus; Methyl Ethers; Mice | 2022 |
Cucurbitacin E reduces the cognitive dysfunction induced by sevoflurane in rats by regulating NF-κB pathway.
Topics: Aged; Animals; Apoptosis; Cognitive Dysfunction; Cytokines; Hippocampus; Humans; Male; NF-kappa B; R | 2022 |
Suppression of phosphodiesterase IV enzyme by roflumilast ameliorates cognitive dysfunction in aged rats after sevoflurane anaesthesia via PKA-CREB and MEK/ERK pathways.
Topics: Aminopyridines; Anesthesia; Animals; Benzamides; Cognitive Dysfunction; Cyclic AMP Response Element- | 2022 |
Carnosol alleviates sevoflurane-induced cognitive dysfunction by mediating NF-κB pathway in aged rats.
Topics: Abietanes; Animals; Apoptosis; Cognitive Dysfunction; NF-kappa B; Rats; Rats, Sprague-Dawley; Sevofl | 2022 |
Protective role of trametenolic acid B against sevoflurane-induced cognitive impairments by its different regulatory modalities of mir-329-3p in neurons and microglia.
Topics: Animals; Cognitive Dysfunction; Microglia; MicroRNAs; Neurons; Neurotoxicity Syndromes; NF-kappa B; | 2022 |
Multiple exposures to sevoflurane across postnatal development may cause cognitive deficits in older age.
Topics: Anesthetics, Inhalation; Animals; Cognition; Cognitive Dysfunction; Hippocampus; Maze Learning; Meth | 2023 |
Effects of toxic apolipoprotein E fragments on Tau phosphorylation and cognitive impairment in neonatal mice under sevoflurane anesthesia.
Topics: Alzheimer Disease; Anesthesia; Animals; Animals, Newborn; Apolipoprotein E2; Apolipoprotein E3; Apol | 2022 |
Knockdown of UAF1 alleviates sevoflurane-induced cognitive impairment and neurotoxicity in rats by inhibiting pro-inflammatory signaling and oxidative stress.
Topics: Animals; Cognitive Dysfunction; Inflammasomes; Neurotoxicity Syndromes; NLR Family, Pyrin Domain-Con | 2022 |
Isovitexin restores sevoflurane‑induced cognitive dysfunction by mediating autophagy through activation of the PGC‑1α/FNDC5 signaling pathway.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apigenin; Apoptosis; Autophagy; Cognitive Dysfuncti | 2022 |
Effects of overexpression of Hsp70 in neural stem cells on neurotoxicity and cognitive dysfunction in neonatal mice under sevoflurane exposure.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Cognitive Dysfunction; Hippocampus; HSP70 Heat-S | 2022 |
miR-182-5p Delivered by Plasma Exosomes Promotes Sevoflurane-Induced Neuroinflammation and Cognitive Dysfunction in Aged Rats with Postoperative Cognitive Dysfunction by Targeting Brain-Derived Neurotrophic Factor and Activating NF-κB Pathway.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cognitive Dysfunction; Exosomes; Interleukin-6; MicroRNA | 2022 |
Lin28A Reduced Sevoflurane-Induced Nerve Injury and Cognitive Dysfunction by Inhibiting Tau Acetylation and Phosphorylation via Activating SIRT1 in Elderly Rats.
Topics: Acetylation; Animals; Apoptosis; Cognitive Dysfunction; Hippocampus; Neurotoxicity Syndromes; Phosph | 2022 |
Exogenous recombinant Hsp70 attenuates sevoflurane anesthesia-induced cognitive dysfunction in aged mice.
Topics: Aged; Anesthesia; Anesthetics, Inhalation; Animals; Cognitive Dysfunction; Hippocampus; HSP70 Heat-S | 2023 |
Prolonged anesthesia induces neuroinflammation and complement-mediated microglial synaptic elimination involved in neurocognitive dysfunction and anxiety-like behaviors.
Topics: Anesthesia; Animals; Anxiety; Cognitive Dysfunction; Complement C1q; Hippocampus; Microglia; Neuroin | 2023 |
FGF19 improves sevoflurane-induced cognitive dysfunction in rats through the PGC-1α/BDNF/FNDC5 pathway.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cognitive Dysfunction; Fibroblast Growth Factors; Hippoc | 2023 |
Ac-YVAD-cmk ameliorated sevoflurane-induced cognitive dysfunction and revised mitophagy impairment.
Topics: Animals; Caspase 1; Cognitive Dysfunction; Inflammasomes; Interleukin-18; Mice; Mitophagy; Neurodege | 2023 |
Activation of autophagy inhibits the activation of NLRP3 inflammasome and alleviates sevoflurane-induced cognitive dysfunction in elderly rats.
Topics: Animals; Autophagy; Carrier Proteins; Cognitive Dysfunction; Cytokines; Inflammasomes; NLR Family, P | 2023 |
Influence of Different Sevoflurane Concentrations on Postoperative Cognitive Function in Aged Rats.
Topics: Anesthetics, Inhalation; Animals; Cognition; Cognitive Dysfunction; Hippocampus; Male; Maze Learning | 2023 |
taVNS Alleviates Sevoflurane-Induced Cognitive Dysfunction in Aged Rats Via Activating Basal Forebrain Cholinergic Neurons.
Topics: Animals; Basal Forebrain; Cholinergic Agents; Cholinergic Neurons; Cognitive Dysfunction; Hippocampu | 2023 |
Long-term sevoflurane exposure resulted in temporary rather than lasting cognitive impairment in Drosophila.
Topics: Adenosine Triphosphate; Anesthetics, Inhalation; Animals; Cognitive Dysfunction; Drosophila melanoga | 2023 |
Abdominal surgery plus sevoflurane exposure induces abnormal emotional changes and cognitive dysfunction in aged rats.
Topics: Animals; Brain; Cognitive Dysfunction; Emotions; Hippocampus; Maze Learning; Rats; Rats, Sprague-Daw | 2023 |
Microglial pyroptosis in hippocampus mediates sevolfurane-induced cognitive impairment in aged mice via ROS-NLRP3 inflammasome pathway.
Topics: Animals; Caspase 1; Cognitive Dysfunction; Hippocampus; Inflammasomes; Mice; Microglia; NLR Family, | 2023 |
Luteoloside Prevents Sevoflurane-induced Cognitive Dysfunction in Aged Rats via Maintaining Mitochondrial Function and Dynamics in Hippocampal Neurons.
Topics: Animals; Cognitive Dysfunction; Hippocampus; Male; Mitochondria; Mitochondrial Dynamics; Neurons; Po | 2023 |
Engeletin ameliorates sevoflurane-induced cognitive impairment by activating PPAR-gamma in neonatal mice.
Topics: Animals; Animals, Newborn; Child; Cognitive Dysfunction; Hippocampus; Humans; Methyl Ethers; Mice; M | 2023 |
Effects of miR-190a-3p on Sevoflurane-induced postoperative cognitive dysfunction (POCD).
Topics: Animals; Cognitive Dysfunction; Inflammation; MicroRNAs; NF-E2-Related Factor 2; Postoperative Cogni | 2023 |
Knocking down Trim47 ameliorated sevoflurane-induced neuronal cell injury and cognitive impairment in rats.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Cognition; Cognitive Dysfunction; Disease Models, Anima | 2023 |
Metformin attenuates sevoflurane-induced neurogenesis damage and cognitive impairment: involvement of the Nrf2/G6PD pathway.
Topics: Animals; Animals, Newborn; Cognitive Dysfunction; Glucosephosphate Dehydrogenase; Hippocampus; Neuro | 2023 |
Effect of Sevoflurane and Isoflurane on Post-Anaesthesia Cognitive Dysfunction in Normal and Type II Diabetic Rats.
Topics: Anesthesia; Animals; Caspase 3; Cognitive Dysfunction; Diabetes Mellitus, Experimental; Diabetes Mel | 2023 |
C/EBPα involvement in microglial polarization via HDAC1/STAT3 pathway aggravated sevoflurane-induced cognitive impairment in aged rats.
Topics: Animals; CCAAT-Enhancer-Binding Proteins; Cognitive Dysfunction; Microglia; Postoperative Cognitive | 2023 |
Tbx2 knockdown alleviated sevoflurane-induced cognitive disorder and neuron damages in aged rats via suppressing oxidative stress and ferroptosis.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cognitive Dysfunction; Ferroptosis; Hippocampus; Neurons | 2023 |
Sevoflurane anaesthesia induces cognitive impairment in young mice through sequential tau phosphorylation.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Cognitive Dysfunction; Glycogen Synthase Kinase 3 beta | 2023 |
The role of PERK-eIF2α-ATF4-CHOP pathway in sevoflurane induced neuroapoptosis and cognitive dysfunction in aged mice.
Topics: Activating Transcription Factor 4; Animals; Apoptosis; Cognitive Dysfunction; eIF-2 Kinase; Endoplas | 2023 |
The m
Topics: Animals; Brain-Derived Neurotrophic Factor; Cognitive Dysfunction; Hippocampus; Neurons; Postoperati | 2023 |
Apamin, an SK2 Inhibitor, Attenuated Neonatal Sevoflurane Exposures Caused Cognitive Deficits in Mice through the Regulation of Hippocampal Neuroinflammation.
Topics: Animals; Apamin; Cognition; Cognitive Dysfunction; Hippocampus; Mice; Mice, Inbred C57BL; Neuroinfla | 2023 |
Sevoflurane-induced hypotension causes cognitive dysfunction and hippocampal inflammation in mice.
Topics: Animals; Cognitive Dysfunction; Hippocampus; Hypotension, Controlled; Inflammation; Mice; Sevofluran | 2023 |
Melatonin attenuates sevoflurane-induced hippocampal damage and cognitive deficits in neonatal mice by suppressing CypD in parvalbumin neurons.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Cognition; Cognitive Dysfunction; Hippocampus; M | 2023 |
Neuroprotective potential of sevoflurane against isoflurane induced cognitive dysfunction in rats via anti-inflammatory and antioxidant effect.
Topics: Acetylcholine; Amyloid beta-Peptides; Anesthetics, Inhalation; Animals; Anti-Inflammatory Agents; An | 2023 |
Rapamycin improves sevoflurane‑induced cognitive dysfunction in aged rats by mediating autophagy through the TLR4/MyD88/NF‑κB signaling pathway.
Topics: Aging; Animals; Autophagic Cell Death; Cognitive Dysfunction; Male; Myeloid Differentiation Factor 8 | 2019 |
Higher Circulating Trimethylamine N-oxide Sensitizes Sevoflurane-Induced Cognitive Dysfunction in Aged Rats Probably by Downregulating Hippocampal Methionine Sulfoxide Reductase A.
Topics: Animals; Cognitive Dysfunction; Down-Regulation; Fear; Hippocampus; Inflammation; Interleukin-1beta; | 2019 |
MiR-125b-5p Inhibitor Might Protect Against Sevoflurane-induced Cognitive Impairments by Targeting LIMK1.
Topics: Animals; Apoptosis; Cognitive Dysfunction; Hippocampus; Lim Kinases; Maze Learning; MicroRNAs; Sevof | 2019 |
Plasma amyloid beta level changes in aged mice with cognitive dysfunction following sevoflurane exposure.
Topics: Amyloid beta-Peptides; Anesthetics, Inhalation; Animals; Brain; Cognition; Cognitive Dysfunction; En | 2020 |
Sevoflurane-induced inflammation development: involvement of cholinergic anti-inflammatory pathway.
Topics: Acetylcholinesterase; alpha7 Nicotinic Acetylcholine Receptor; Anesthetics, Inhalation; Animals; Ben | 2019 |
Involvement of homodomain interacting protein kinase 2-c-Jun N-terminal kinase/c-Jun cascade in the long-term synaptic toxicity and cognition impairment induced by neonatal Sevoflurane exposure.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Cognitive Dysfunction; Hippocampus; JNK Mitogen- | 2020 |
Sirtuin 2 Inhibition Attenuates Sevoflurane-Induced Learning and Memory Deficits in Developing Rats via Modulating Microglial Activation.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Benzamides; Cognitive Dysfunction; Growth and De | 2020 |
Cistanches alleviates sevoflurane-induced cognitive dysfunction by regulating PPAR-γ-dependent antioxidant and anti-inflammatory in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Behavior, Animal; Cistanche; Cognitive D | 2020 |
Lithium chloride ameliorates cognition dysfunction induced by sevoflurane anesthesia in rats.
Topics: Anesthesia; Animals; Apoptosis; Cognition; Cognitive Dysfunction; Glycogen Synthase Kinase 3 beta; H | 2020 |
Downregulation of CDK5 Restores Sevoflurane-Induced Cognitive Dysfunction by Promoting SIRT1-Mediated Autophagy.
Topics: Animals; Apoptosis; Autophagy; Cells, Cultured; Cognitive Dysfunction; Cyclin-Dependent Kinase 5; Do | 2020 |
Methylene Blue Protects Against Sevoflurane-Induced Cognitive Dysfunction by Suppressing Drp1 deSUMOylation in Aged Mice.
Topics: Anesthetics, Inhalation; Animals; Cognitive Dysfunction; Cysteine Endopeptidases; Dynamins; Hippocam | 2020 |
Sevoflurane anesthesia-mediated oxidative stress and cognitive impairment in hippocampal neurons of old rats can be ameliorated by expression of brain derived neurotrophic factor.
Topics: Administration, Inhalation; Aging; Anesthetics, Inhalation; Animals; Brain-Derived Neurotrophic Fact | 2020 |
Sevoflurane anesthesia during pregnancy in mice induces cognitive impairment in the offspring by causing iron deficiency and inhibiting myelinogenesis.
Topics: Administration, Inhalation; Anemia, Iron-Deficiency; Anesthetics, Inhalation; Animals; Cognitive Dys | 2020 |
Chikusetsu saponin IVa alleviated sevoflurane-induced neuroinflammation and cognitive impairment by blocking NLRP3/caspase-1 pathway.
Topics: Anesthetics, Inhalation; Animals; Caspase 1; Caspase Inhibitors; Cognitive Dysfunction; Hippocampus; | 2020 |
The Effects of Hesperidin on Neuronal Apoptosis and Cognitive Impairment in the Sevoflurane Anesthetized Rat are Mediated Through the PI3/Akt/PTEN and Nuclear Factor-κB (NF-κB) Signaling Pathways.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Brain; Cognitive Dysfunction; Hesperidin; Male; Neurons | 2020 |
Neuroprotective effect of CTRP3 overexpression against sevoflurane anesthesia-induced cognitive dysfunction in aged rats through activating AMPK/SIRT1 and PI3K/AKT signaling pathways.
Topics: Adipokines; Aging; AMP-Activated Protein Kinases; Anesthetics, Inhalation; Animals; Apoptosis; Cogni | 2020 |
Neonatal Exposure to Anesthesia Leads to Cognitive Deficits in Old Age: Prevention with Intranasal Administration of Insulin in Mice.
Topics: Administration, Intranasal; Anesthesia, General; Anesthetics, Inhalation; Animals; Animals, Newborn; | 2020 |
Hirsutanol A exhibits neuroprotective activities against sevoflurane-induced neurotoxicity in aged rats.
Topics: Amyloid beta-Peptides; Anesthetics, Inhalation; Animals; Apoptosis; Cell Line, Tumor; Cognitive Dysf | 2021 |
Sevoflurane attenuates cognitive dysfunction and NLRP3-dependent caspase-1/11-GSDMD pathway-mediated pyroptosis in the hippocampus
Topics: Adaptor Proteins, Vesicular Transport; Animals; Caspase 1; Cognitive Dysfunction; Cytokines; Hippoca | 2022 |
Tau Contributes to Sevoflurane-induced Neurocognitive Impairment in Neonatal Mice.
Topics: Age Factors; Anesthetics, Inhalation; Animals; Animals, Newborn; Brain; Cognitive Dysfunction; Disea | 2020 |
Enriched environment improves sevoflurane-induced cognitive impairment during late-pregnancy via hippocampal histone acetylation.
Topics: Acetylation; Animals; Brain-Derived Neurotrophic Factor; Cognitive Dysfunction; Female; Hippocampus; | 2020 |
Sevoflurane-induced cognitive decline in aged mice: Involvement of toll-like receptors 4.
Topics: Aging; Anesthetics, Inhalation; Animals; Cognition; Cognitive Dysfunction; Cytokines; Hippocampus; M | 2020 |
Dexmedetomidine attenuates sevoflurane‑induced neurocognitive impairment through α2‑adrenoceptors.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Caspase 3; Cognitive Dysfunction; Dexmedetomidine; | 2021 |
Dexmedetomidine and Clonidine Attenuate Sevoflurane-Induced Tau Phosphorylation and Cognitive Impairment in Young Mice via α-2 Adrenergic Receptor.
Topics: Adrenergic alpha-2 Receptor Agonists; Age Factors; Animals; Behavior, Animal; Clonidine; Cognition; | 2021 |
AMPK‑SIRT1 pathway dysfunction contributes to neuron apoptosis and cognitive impairment induced by sevoflurane.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Apoptosis; Behavior, Animal; Cog | 2021 |
Inhibition of RhoA Activity Does Not Rescue Synaptic Development Abnormalities and Long-Term Cognitive Impairment After Sevoflurane Exposure.
Topics: Amides; Anesthetics, Inhalation; Animals; Animals, Newborn; Apoptosis; Cognitive Dysfunction; Dendri | 2021 |
Resveratrol ameliorates sevoflurane-induced cognitive impairment by activating the SIRT1/NF-κB pathway in neonatal mice.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Anti-Inflammatory Agents; Cognitive Dysfunction; | 2021 |
Regulation of CRMP2 by Cdk5 and GSK-3β participates in sevoflurane-induced dendritic development abnormalities and cognitive dysfunction in developing rats.
Topics: Aminophenols; Animals; Cognitive Dysfunction; Cyclin-Dependent Kinase 5; Dendrites; Gene Expression | 2021 |
Involvement of Nrf-2/HO-1 pathway in sevoflurane-induced cognitive improvement in rats with traumatic brain injury.
Topics: Anesthetics, Inhalation; Animals; Behavior, Animal; Brain Injuries, Traumatic; Cognitive Dysfunction | 2021 |
NLRP3 inflammasome inhibition by histone acetylation ameliorates sevoflurane-induced cognitive impairment in aged mice by activating the autophagy pathway.
Topics: Acetylation; Aging; Animals; Autophagy; Cognitive Dysfunction; Hippocampus; Histone Deacetylase Inhi | 2021 |
[Dexmedetomidine-mediated Wnt Pathway Inhibits Sevoflurane-induced Cognitive Impairment in Neonatal Rats].
Topics: Animals; Animals, Newborn; beta Catenin; Cognitive Dysfunction; Dexmedetomidine; Glycogen Synthase K | 2021 |
The anesthetic sevoflurane induces tau trafficking from neurons to microglia.
Topics: Alzheimer Disease; Anesthetics, Inhalation; Animals; Brain; Cognitive Dysfunction; Extracellular Ves | 2021 |
Lovastatin attenuates sevoflurane-induced cognitive disorder in aged rats via reducing Aβ accumulation.
Topics: Aging; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Cognition; Cog | 2021 |
MiR-124 protects against cognitive dysfunction induced by sevoflurane anesthesia in vivo and in vitro through targeting calpain small subunit 1 via NF-κB signaling pathway.
Topics: Anesthesia; Animals; Apoptosis; Calpain; Cognitive Dysfunction; Humans; Mice; MicroRNAs; NF-kappa B; | 2021 |
Participation of Mind Bomb-2 in Sevoflurane Anesthesia Induces Cognitive Impairment in Aged Mice via Modulating Ferroptosis.
Topics: Aged; Anesthesia; Animals; Cognitive Dysfunction; Ferroptosis; Hippocampus; Humans; Male; Mice; Mice | 2021 |
Gut microbiota mediates cognitive impairment in young mice after multiple neonatal exposures to sevoflurane.
Topics: Anesthesia; Animals; Anti-Bacterial Agents; Behavior, Animal; Cognitive Dysfunction; Feces; Female; | 2021 |
Resveratrol ameliorates neuronal apoptosis and cognitive impairment by activating the SIRT1/RhoA pathway in rats after anesthesia with sevoflurane.
Topics: Anesthesia; Animals; Apoptosis; Cognitive Dysfunction; Male; Rats; Resveratrol; Sevoflurane; Sirtuin | 2022 |
P300 Inhibition Improves Cell Apoptosis and Cognition Impairment Induced by Sevoflurane Through Regulating IL-17A Activation.
Topics: Anesthetics, Inhalation; Apoptosis; Cell Line, Tumor; Cognitive Dysfunction; E1A-Associated p300 Pro | 2021 |
Pleiotrophin Potentiates Sevoflurane Anesthesia-induced Learning Deficits in Mice.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Carrier Proteins; Cognitive Dysfunction; Cytokines; Hi | 2022 |
Low Skeletal Muscle Mass Is Associated With Perioperative Neurocognitive Disorder Due To Decreased Neurogenesis in Rats.
Topics: Animals; Atrophy; Behavior, Animal; Blood Pressure; Cognition; Cognitive Dysfunction; Fear; Hippocam | 2022 |
Repeated neonatal sevoflurane induced neurocognitive impairment through NF-κB-mediated pyroptosis.
Topics: Anesthetics, Inhalation; Animals; Cell Survival; Cognitive Dysfunction; Hippocampus; Neuroinflammato | 2021 |
Repeated 2% sevoflurane administration in 7‑ and 60-day-old rats : Neurotoxicity and neurocognitive dysfunction.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Antigens, Nuclear; Apoptosis; Brain; Caspase 3; | 2017 |
Roscovitine, a CDK5 Inhibitor, Alleviates Sevoflurane-Induced Cognitive Dysfunction via Regulation Tau/GSK3β and ERK/PPARγ/CREB Signaling.
Topics: Animals; Apoptosis Regulatory Proteins; Butadienes; Caspase 3; Cells, Cultured; Cognitive Dysfunctio | 2017 |
Sevoflurane preconditioning ameliorates lipopolysaccharide-induced cognitive impairment in mice.
Topics: Amyloid beta-Peptides; Animals; Cognitive Dysfunction; Delirium; Disease Models, Animal; Inflammatio | 2018 |
Role of the hippocampal 5-HT1A receptor-mediated cAMP/PKA signalling pathway in sevoflurane-induced cognitivedysfunction in aged rats.
Topics: Aging; Anesthetics, Inhalation; Animals; Cognitive Dysfunction; Cyclic AMP; Cyclic AMP Response Elem | 2018 |
MicroRNA-188-3p is involved in sevoflurane anesthesia-induced neuroapoptosis by targeting MDM2.
Topics: Anesthetics, Inhalation; Animals; Antagomirs; Apoptosis; Benzothiazoles; Cell Line, Tumor; Cognitive | 2018 |
The autophagy inhibitor 3-methyladenine restores sevoflurane anesthesiainduced cognitive dysfunction and neurons apoptosis.
Topics: Adenine; Anesthetics, Inhalation; Animals; Apoptosis; Autophagy; Cognitive Dysfunction; Gene Express | 2017 |
Sevoflurane exaggerates cognitive decline in a rat model of chronic intermittent hypoxia by aggravating microglia-mediated neuroinflammation via downregulation of PPAR-γ in the hippocampus.
Topics: Anesthetics, Inhalation; Animals; Chronic Disease; Cognitive Dysfunction; Disease Models, Animal; Do | 2018 |
The postoperative effect of sevoflurane inhalational anesthesia on cognitive function and inflammatory response of pediatric patients.
Topics: Adolescent; Anesthesia, Inhalation; Child; Child, Preschool; Cognitive Dysfunction; Female; Humans; | 2018 |
Neonatal exposure to sevoflurane caused cognitive deficits by dysregulating SK2 channels and GluA2-lacking AMPA receptors in juvenile rat hippocampus.
Topics: Animals; Animals, Newborn; Apamin; Cognitive Dysfunction; Excitatory Postsynaptic Potentials; Hippoc | 2018 |
MicroRNA-96 is responsible for sevoflurane-induced cognitive dysfunction in neonatal rats via inhibiting IGF1R.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Apoptosis; Cognition; Cognitive Dysfunction; Fem | 2019 |
SIRT3 activator honokiol ameliorates surgery/anesthesia-induced cognitive decline in mice through anti-oxidative stress and anti-inflammatory in hippocampus.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Anti-Inflammatory Agents; Biphenyl Compounds; Cognitiv | 2019 |
IL-17A promotes the neuroinflammation and cognitive function in sevoflurane anesthetized aged rats via activation of NF-κB signaling pathway.
Topics: Age Factors; Anesthetics, Inhalation; Animals; Cognition; Cognitive Dysfunction; Enzyme-Linked Immun | 2018 |
Sevoflurane Exacerbates Cognitive Impairment Induced by A
Topics: Amyloid beta-Peptides; Animals; Apoptosis; bcl-X Protein; Brain-Derived Neurotrophic Factor; Calcium | 2018 |
Postoperative cognitive dysfunction after sevoflurane or propofol general anaesthesia in combination with spinal anaesthesia for hip arthroplasty.
Topics: Aged; Anesthesia, General; Anesthesia, Spinal; Anesthetics, Inhalation; Anesthetics, Intravenous; Ar | 2018 |
Nerve growth factor metabolic dysfunction contributes to sevoflurane-induced cholinergic degeneration and cognitive impairments.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Basal Forebrain; Choline O-Acetyltransferase; Choliner | 2019 |
Role of dexmedetomidine in reducing the incidence of postoperative cognitive dysfunction caused by sevoflurane inhalation anesthesia in elderly patients with esophageal carcinoma.
Topics: Age Factors; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anesthesia, General; Anesthetics, In | 2018 |
Suberoylanilide hydroxamic acid reversed cognitive and synaptic plasticity impairments induced by sevoflurane exposure in adult mice.
Topics: Anesthetics, Inhalation; Animals; Cognition; Cognitive Dysfunction; Histone Deacetylase Inhibitors; | 2019 |
Sevoflurane enhanced the clearance of Aβ1-40 in hippocampus under surgery via up-regulating AQP-4 expression in astrocyte.
Topics: Amyloid beta-Peptides; Animals; Aquaporin 4; Astrocytes; Brain; Central Nervous System; Cognitive Dy | 2019 |
Sevoflurane anesthesia impairs metabotropic glutamate receptor-dependent long-term depression and cognitive functions in senile mice.
Topics: Aging; Anesthesia; Anesthetics, Inhalation; Animals; Cognition; Cognitive Dysfunction; Depression; E | 2019 |
Pioglitazone prevents sevoflurane‑induced neuroinflammation and cognitive decline in a rat model of chronic intermittent hypoxia by upregulating hippocampal PPAR‑γ.
Topics: Animals; Chronic Disease; Cognitive Dysfunction; Disease Models, Animal; Hippocampus; Hypoglycemic A | 2019 |
Honokiol-Mediated Mitophagy Ameliorates Postoperative Cognitive Impairment Induced by Surgery/Sevoflurane via Inhibiting the Activation of NLRP3 Inflammasome in the Hippocampus.
Topics: Animals; Apoptosis; Autophagy; Biphenyl Compounds; Cognitive Dysfunction; Dentate Gyrus; Female; Hip | 2019 |
Sevoflurane induces cognitive impairment in young mice via autophagy.
Topics: Anesthesia, Inhalation; Animals; Autophagic Cell Death; Cognitive Dysfunction; Hippocampus; Maze Lea | 2019 |
Transcriptomic analysis reveals the molecular mechanism of Alzheimer-related neuropathology induced by sevoflurane in mice.
Topics: Alzheimer Disease; Anesthetics; Animals; Cognitive Dysfunction; Computational Biology; Disease Model | 2019 |
Overexpression of lncRNA Gm15621 alleviates apoptosis and inflammation response resulting from sevoflurane treatment through inhibiting miR-133a/Sox4.
Topics: Animals; Apoptosis; Cells, Cultured; Cognitive Dysfunction; Gene Expression Regulation; Hippocampus; | 2020 |
Neuroprotective effect of miR-410-3p against sevoflurane anesthesia-induced cognitive dysfunction in rats through PI3K/Akt signaling pathway via targeting C-X-C motif chemokine receptor 5.
Topics: Anesthesia; Animals; Apoptosis; Cognitive Dysfunction; Disease Models, Animal; Down-Regulation; Hipp | 2019 |
Tetrandrine ameliorates sevoflurane‑induced cognitive impairment via the suppression of inflammation and apoptosis in aged rats.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Benzylisoquinolines; Caspase 3; Cognitive Dysfunction; | 2016 |
Repeated Neonatal Sevoflurane Exposure-Induced Developmental Delays of Parvalbumin Interneurons and Cognitive Impairments Are Reversed by Environmental Enrichment.
Topics: Animals; Animals, Newborn; Brain; Cognitive Dysfunction; Environment; Interneurons; Male; Methyl Eth | 2017 |
Heightened stress response and cognitive impairment after repeated neonatal sevoflurane exposures might be linked to excessive GABAAR-mediated depolarization.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Bumetanide; Cognitive Dysfunction; Corticosteron | 2016 |
Sevoflurane induces cognitive impairments via the MiR-27b/LIMK1-signaling pathway in developing rats.
Topics: Anesthetics, Inhalation; Animals; Behavior, Animal; Cells, Cultured; Cognitive Dysfunction; Fear; Fe | 2016 |
NF-κB/P65 signaling pathway: a potential therapeutic target in postoperative cognitive dysfunction after sevoflurane anesthesia.
Topics: Anesthetics, Inhalation; Animals; Blood-Brain Barrier; Cognitive Dysfunction; Cytokines; Male; Methy | 2017 |