Page last updated: 2024-11-04

sevoflurane and Aging

sevoflurane has been researched along with Aging in 95 studies

Sevoflurane: A non-explosive inhalation anesthetic used in the induction and maintenance of general anesthesia. It does not cause respiratory irritation and may also prevent PLATELET AGGREGATION.
sevoflurane : An ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"We set up to determine the incidence and duration of postoperative delirium in older patients who had surgery under the intravenous anesthetic propofol or the inhalational anesthetic sevoflurane."9.34The Effects of Propofol and Sevoflurane on Postoperative Delirium in Older Patients: A Randomized Clinical Trial Study. ( Li, C; Ma, X; Marcantonio, E; Mei, X; Shen, Y; Xie, Z; Zheng, H; Zheng, HL, 2020)
"During the first 10 min after sevoflurane administration, A (sev) in the hyperventilation group was the highest and differed significantly from those in the normal ventilation group, followed by those in the hypoventilation group."9.17Hyperventilation accelerates rise in arterial blood concentrations of sevoflurane in gynecologic patients. ( Chen, RM; Chen, TL; Ho, ST; Hsu, CH; Ku, CH; Lin, TC; Lu, CC; Yu, MH, 2013)
" We recently found that the anaesthetization of aging C57BL/6 J mice (14-16 months) with sevoflurane (3%, two hours each day for three consecutive days) can induce cognitive dysfunction and synaptic plasticity deficits."8.12Sevoflurane inhibits histone acetylation and contributes to cognitive dysfunction by enhancing the expression of ANP32A in aging mice. ( Chai, G; Fang, R; Jiang, Z; Liu, Y; Nie, Y; Wang, X; Wu, J; Yi, H; Zhang, D; Zhang, J; Zhao, P; Zhou, J, 2022)
"To investigate the effects of C1q/tumor necrosis factor-related protein-3 (CTRP3) on postoperative cognitive dysfunction (POCD) and elucidate the potential regulatory mechanism in sevoflurane anesthesia-induced aged rats."7.96Neuroprotective effect of CTRP3 overexpression against sevoflurane anesthesia-induced cognitive dysfunction in aged rats through activating AMPK/SIRT1 and PI3K/AKT signaling pathways. ( Xu, YC; Yang, LH; Zhang, W, 2020)
" However, little is known about whether TLR4 is associated with sevoflurane-induced cognitive decline."7.96Sevoflurane-induced cognitive decline in aged mice: Involvement of toll-like receptors 4. ( Dong, N; Fei, X; Sheng, ZY; Wang, JX; Wu, Y, 2020)
"The present study was aimed to observe the protective effect of rapamycin on cognitive dysfunction induced by sevoflurane in aged rats and its effect on autophagy‑related proteins, and to investigate the regulatory mechanism of the Toll‑like receptor 4/myeloid differentiation primary response 88/nuclear factor‑κB (TLR4/MyD88/NF‑κB) signaling pathway."7.91Rapamycin improves sevoflurane‑induced cognitive dysfunction in aged rats by mediating autophagy through the TLR4/MyD88/NF‑κB signaling pathway. ( Li, Y; Liu, L; Tian, Y; Zhang, J, 2019)
"Sevoflurane anesthesia impaired cognitive functions, as well as metabotropic glutamate receptor-dependent long-term depression, through elevated surface expression of small conductance calcium-activated potassium type 2 channels."7.91Sevoflurane anesthesia impairs metabotropic glutamate receptor-dependent long-term depression and cognitive functions in senile mice. ( Shi, J; Yu, X; Zhang, F, 2019)
"We set up to determine the incidence and duration of postoperative delirium in older patients who had surgery under the intravenous anesthetic propofol or the inhalational anesthetic sevoflurane."5.34The Effects of Propofol and Sevoflurane on Postoperative Delirium in Older Patients: A Randomized Clinical Trial Study. ( Li, C; Ma, X; Marcantonio, E; Mei, X; Shen, Y; Xie, Z; Zheng, H; Zheng, HL, 2020)
"During the first 10 min after sevoflurane administration, A (sev) in the hyperventilation group was the highest and differed significantly from those in the normal ventilation group, followed by those in the hypoventilation group."5.17Hyperventilation accelerates rise in arterial blood concentrations of sevoflurane in gynecologic patients. ( Chen, RM; Chen, TL; Ho, ST; Hsu, CH; Ku, CH; Lin, TC; Lu, CC; Yu, MH, 2013)
"Sevoflurane is a new volatile anesthetic with physical properties that should make it suitable for anesthesia (MAC of sevoflurane on oxygen alone and in 60% nitrous oxide, (MAC) of sevoflurane in oxygen alone and in 60% nitrous oxide, the hemodynamic, induction and emergence responses to sevoflurane and the metabolism to inorganic fluoride were studied in 90 ASA physical status 1 or 2 neonates, infants, and children."5.07The pharmacology of sevoflurane in infants and children. ( Kleinman, S; Lerman, J; Sikich, N; Yentis, S, 1994)
" We recently found that the anaesthetization of aging C57BL/6 J mice (14-16 months) with sevoflurane (3%, two hours each day for three consecutive days) can induce cognitive dysfunction and synaptic plasticity deficits."4.12Sevoflurane inhibits histone acetylation and contributes to cognitive dysfunction by enhancing the expression of ANP32A in aging mice. ( Chai, G; Fang, R; Jiang, Z; Liu, Y; Nie, Y; Wang, X; Wu, J; Yi, H; Zhang, D; Zhang, J; Zhao, P; Zhou, J, 2022)
"To investigate the effects of C1q/tumor necrosis factor-related protein-3 (CTRP3) on postoperative cognitive dysfunction (POCD) and elucidate the potential regulatory mechanism in sevoflurane anesthesia-induced aged rats."3.96Neuroprotective effect of CTRP3 overexpression against sevoflurane anesthesia-induced cognitive dysfunction in aged rats through activating AMPK/SIRT1 and PI3K/AKT signaling pathways. ( Xu, YC; Yang, LH; Zhang, W, 2020)
" However, little is known about whether TLR4 is associated with sevoflurane-induced cognitive decline."3.96Sevoflurane-induced cognitive decline in aged mice: Involvement of toll-like receptors 4. ( Dong, N; Fei, X; Sheng, ZY; Wang, JX; Wu, Y, 2020)
"The present study was aimed to observe the protective effect of rapamycin on cognitive dysfunction induced by sevoflurane in aged rats and its effect on autophagy‑related proteins, and to investigate the regulatory mechanism of the Toll‑like receptor 4/myeloid differentiation primary response 88/nuclear factor‑κB (TLR4/MyD88/NF‑κB) signaling pathway."3.91Rapamycin improves sevoflurane‑induced cognitive dysfunction in aged rats by mediating autophagy through the TLR4/MyD88/NF‑κB signaling pathway. ( Li, Y; Liu, L; Tian, Y; Zhang, J, 2019)
"Sevoflurane anesthesia impaired cognitive functions, as well as metabotropic glutamate receptor-dependent long-term depression, through elevated surface expression of small conductance calcium-activated potassium type 2 channels."3.91Sevoflurane anesthesia impairs metabotropic glutamate receptor-dependent long-term depression and cognitive functions in senile mice. ( Shi, J; Yu, X; Zhang, F, 2019)
"Objective This study aimed to evaluate the role of the hippocampal 5-hydroxytryptamine-1A (5-HT1A)-mediated cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) signalling pathway in sevoflurane-induced cognitive dysfunction in aged rats."3.88Role of the hippocampal 5-HT1A receptor-mediated cAMP/PKA signalling pathway in sevoflurane-induced cognitivedysfunction in aged rats. ( Qiu, Y; Wang, C; Wang, X; Wang, Y; Xia, ZY, 2018)
"Additionally, trisomy 21 (P = 0."2.76Factors affecting the decision to defer endotracheal extubation after surgery for congenital heart disease: a prospective observational study. ( Bodian, C; Chakravarti, S; Hollinger, I; Hossain, S; Kin, N; Krol, M; Mittnacht, AJ; Nguyen, K; Srivastava, S; Weismann, C, 2011)
"Sevoflurane was administered to achieve steady-state end-tidal sevoflurane concentrations (ET(sevo)) of 2."2.71Correlation of bispectral index with end-tidal sevoflurane concentration and age in infants and children. ( Kim, CS; Kim, HS; Kim, JH; Kim, SD; Oh, AY; Seo, KS, 2005)
"Fentanyl was administered at predicted plasma concentrations of 1 and 2 ng mg-1 using a computer-controlled continuous infusion and plasma concentrations of fentanyl were measured at the time of MAC-awake measurements."2.67Effect of fentanyl on awakening concentration of sevoflurane. ( Ikeda, K; Katoh, T; Uchiyama, T, 1994)
"Lovastatin treatment also inhibited the increased expressions of β-secretase 1 (BACE1) and γ-secretase in hippocampal neurons under sevoflurane exposure in vitro."1.62Lovastatin attenuates sevoflurane-induced cognitive disorder in aged rats via reducing Aβ accumulation. ( Chu, H; Dong, Y; Jiang, Q; Tian, Y; Wang, C; Xu, Y, 2021)
"Sevoflurane anesthesia has been implicated in both postoperative cognitive dysfunction and neurotoxicity."1.56Sevoflurane anesthesia-mediated oxidative stress and cognitive impairment in hippocampal neurons of old rats can be ameliorated by expression of brain derived neurotrophic factor. ( Qian, B; Xu, Z, 2020)
" The authors used the ND23 mutant for testing the hypothesis that anesthetics have toxic potential in carriers of mitochondrial mutations."1.56Mitochondrial Complex I Mutations Predispose Drosophila to Isoflurane Neurotoxicity. ( Ganetzky, B; Olufs, ZPG; Perouansky, M; Wassarman, DA, 2020)
"Sevoflurane has been found to increase apoptosis and pathologic markers associated with Alzheimer disease, provoking concern over their potential contribution to postoperative cognitive dysfunction."1.43Sevoflurane anesthesia induces neither contextual fear memory impairment nor alterations in local population connectivity of medial prefrontal cortex local field potentials networks in aged rats. ( Tian, X; Wang, G; Xu, X; Zhang, Q, 2016)
"Increasingly more aged people with Alzheimer's disease (AD) must undergo surgery with general anesthesia for various reasons."1.40Smaller sized inhaled anesthetics have more potency on senescence-accelerated prone-8 mice compared with senescence-resistant-1 mice. ( Deng, Y; He, Z; Lu, B; Qi, B; Su, D; Tian, J; Wang, X; Xu, H; Zheng, B, 2014)
"Sevoflurane is a commonly used anesthetic in children."1.40Sevoflurane induces tau phosphorylation and glycogen synthase kinase 3β activation in young mice. ( Crosby, G; Culley, DJ; Dong, Y; Tao, G; Xie, Z; Yu, B; Zhang, J; Zhang, L; Zhang, Y, 2014)
"Patients with Alzheimer's disease (AD) exhibit a failure in the clearance of amyloid β peptides (Aβ) from the central nervous system."1.39Sevoflurane alters the expression of receptors and enzymes involved in Aβ clearance in rats. ( Gao, M; Liu, Y; Ma, L; Pan, N; Zhang, L, 2013)
"Sevoflurane was administered at 2 % volume inspiratory concentration, 6 L."1.38Oxidative stress and antioxidant activity of female rat liver tissue after sevoflurane anaesthesia: young versus old. ( Arslan, M; Isik, B; Kavutcu, M; Kurtipek, O, 2012)
"Sevoflurane was vaporized in sealed roller culture vials to produce a continuous saturating dose (0."1.29Biotransformation of sevoflurane by rat neonate liver slices. ( Brendel, K; Gandolfi, AJ; Morgan, SE; Payne, AK, 1995)

Research

Studies (95)

TimeframeStudies, this research(%)All Research%
pre-19902 (2.11)18.7374
1990's11 (11.58)18.2507
2000's24 (25.26)29.6817
2010's40 (42.11)24.3611
2020's18 (18.95)2.80

Authors

AuthorsStudies
Yang, S1
Liu, Y3
Huang, S1
Jin, F1
Qi, F1
Hao, C1
Duan, X1
Yang, X1
Huang, Z1
Li, F1
Yang, J2
Chai, G1
Wu, J1
Fang, R1
Wang, X4
Zhang, J3
Zhou, J1
Jiang, Z1
Yi, H1
Nie, Y1
Zhao, P1
Zhang, D1
Li, Y2
Liu, L2
Tian, Y4
Yang, Y1
Wu, ZY1
Lin, XF1
Zhang, C1
Zhu, ZQ1
Zhu, J2
Zhang, Z2
Jia, J2
Wang, L2
Yang, Q1
Wang, Y2
Chen, C2
Xu, Z1
Qian, B1
Kreuzer, M1
Stern, MA1
Hight, D1
Berger, S1
Schneider, G1
Sleigh, JW1
García, PS1
Yang, LH1
Xu, YC1
Zhang, W1
Schiffman, HJ1
Olufs, ZPG2
Lasarev, MR1
Wassarman, DA2
Perouansky, M2
Yang, XY1
Li, QJ1
Zhang, WC1
Zheng, SQ1
Qu, ZJ1
Xi, Y1
Wang, G3
Mei, X1
Zheng, HL1
Li, C2
Ma, X1
Zheng, H1
Marcantonio, E1
Xie, Z2
Shen, Y1
Ganetzky, B1
Fei, X1
Wang, JX1
Wu, Y1
Dong, N1
Sheng, ZY1
Qu, Y1
Li, H3
Shi, C1
Qian, M1
Yang, N1
Gao, X1
Ni, C1
Chen, Q1
Chu, W1
Sheng, R1
Song, S1
Ji, F1
Jin, X1
Pei, W1
Fu, L1
Li, SQ1
Yu, Y2
Fang, P1
Zheng, F1
Chen, T1
Chang, J1
Xie, L1
Fang, Q2
Wei, X1
Zhou, L1
Wang, S1
Xu, Y1
Dong, Y3
Wang, C7
Jiang, Q2
Chu, H1
Huang, L1
Huang, K1
Ning, H1
Guo, S2
Qiu, Y1
Xia, ZY1
Cornelissen, L1
Kim, SE1
Lee, JM1
Brown, EN2
Purdon, PL2
Berde, CB1
Yu, X1
Zhang, F1
Shi, J1
Chen, G2
Gong, M2
Yan, M2
Zhang, X2
Gao, M1
Ma, L2
Zhang, L4
Pan, N1
Zhou, C1
Chen, D1
Fang, N1
Yao, Y1
Li, L2
Xu, H1
Lu, B1
Zheng, B1
Tian, J1
Qi, B1
Deng, Y1
He, Z1
Su, D1
Sury, MR1
Worley, A1
Boyd, SG1
McKeever, S1
Johnston, L1
Davidson, AJ2
Wang, ZH1
Ni, XL1
Li, JN1
Xiao, ZY1
Zhang, LN1
Tong, L1
Dong, HL1
Rhondali, O1
Juhel, S1
Mathews, S1
Cellier, Q1
Desgranges, FP1
Mahr, A1
De Queiroz, M1
Pouyau, A1
Rhzioual-Berrada, K1
Chassard, D1
Tao, G1
Yu, B1
Crosby, G1
Culley, DJ1
Zhang, Y3
Dong, P1
Zhao, J1
Dong, J1
Li, D1
Yang, B1
Lei, W1
Schwartz, D1
Begley, A1
Gibson, C1
Visintainer, P1
Connelly, NR1
Wu, X1
Zhao, X1
Acharya, NK1
Goldwaser, EL1
Forsberg, MM1
Godsey, GA1
Johnson, CA1
Sarkar, A1
DeMarshall, C1
Kosciuk, MC1
Dash, JM1
Hale, CP1
Leonard, DM1
Appelt, DM1
Nagele, RG1
Hu, N1
Wang, M1
Xie, K1
Wang, H1
Pavone, KJ1
Akeju, O1
Smith, AC1
Sampson, AL1
Lee, J1
Zhou, DW1
Solt, K1
Jiang, JJ1
Lin, ZH1
Fu, BJ1
Zeng, YM1
Xu, X1
Zhang, Q1
Tian, X1
Fang, F1
Lin, W1
Ling, X1
Song, R1
Liu, Q1
Lai, B1
Cang, J1
Osthaus, WA1
Cortínez, LI1
Trocóniz, IF1
Fuentes, R1
Gambús, P1
Hsu, YW1
Altermatt, F1
Muñoz, HR2
Matsuura, T2
Oda, Y2
Tanaka, K1
Mori, T1
Nishikawa, K2
Asada, A2
Wiklund, A1
Granon, S1
Faure, P1
Sundman, E1
Changeux, JP1
Eriksson, LI1
YAMASHITA, K1
IWASAKI, Y1
UMAR, MA1
ITAMI, T1
Mordhorst, C1
Latz, B1
Kerz, T1
Wisser, G1
Schmidt, A1
Schneider, A1
Jahn-Eimermacher, A1
Werner, C1
Engelhard, K1
Peng, S1
Sun, DP1
Zhang, DX1
Li, GJ1
Siriussawakul, A1
Sharma, D1
Sookplung, P1
Armstead, W1
Vavilala, MS2
Kin, N1
Weismann, C1
Srivastava, S1
Chakravarti, S1
Bodian, C1
Hossain, S1
Krol, M1
Hollinger, I1
Nguyen, K1
Mittnacht, AJ1
Fudickar, A1
Voss, D1
Serocki, G1
Jeckström, W1
Ambrosch, P1
Steinfath, M1
Bein, B1
Kohjitani, A1
Miyata, M1
Iwase, Y1
Sugiyama, K1
Jeong, CW1
Ju, J1
Lee, DW1
Lee, SH1
Yoon, MH1
Zhang, XM1
Xu, LH1
Wang, HM1
Schöffmann, G1
Vettorato, E1
Burke, JG1
Gibson, AJ1
Clutton, ER1
Hayashi, K1
Shigemi, K1
Sawa, T1
Constant, I2
Sabourdin, N1
Kimura-Kuroiwa, K1
Adachi, YU1
Mimuro, S1
Obata, Y1
Kawamata, M1
Sato, S2
Matsuda, N1
Lu, CC1
Lin, TC1
Hsu, CH1
Yu, MH1
Ku, CH1
Chen, TL1
Chen, RM1
Ho, ST1
Arslan, M1
Isik, B1
Kavutcu, M1
Kurtipek, O1
Soltész, S1
Silomon, M1
Mencke, T1
Schlaich, N1
Fuchs-Buder, T1
Chaves, AA1
Dech, SJ1
Nakayama, T1
Hamlin, RL1
Bauer, JA1
Carnes, CA1
Lee, LA1
Lee, M1
Graham, A1
Visco, E1
Lam, AM1
Nickalls, RW1
Mapleson, WW1
Ibacache, ME1
Brandes, V1
Morales, AL1
Sniecinski, R1
Liu, H1
Fernandez, M1
Lejus, C1
Rivault, O1
Bazin, V1
Le Roux, C1
Bizouarn, P1
Pinaud, M1
Wodey, E1
Tirel, O1
Bansard, JY1
Terrier, A1
Chanavaz, C1
Harris, R1
Ecoffey, C1
Senhadji, L1
Kim, HS1
Oh, AY1
Kim, CS1
Kim, SD1
Seo, KS1
Kim, JH1
Huang, GH1
Rebmann, CS1
Ellery, C1
Nghe, MC1
Boudet, L1
Berniere, J1
Schrayer, S1
Seeman, R1
Murat, I1
Lewis, MC1
Gerenstein, RI1
Chidiac, G1
Kuczkowski, KM1
Ikeshita, K1
Ito, K1
Raghavendran, S1
Brown, KA1
Buu, N1
Payne, AK1
Morgan, SE1
Gandolfi, AJ1
Brendel, K1
Kitajima, T1
Ishii, K1
Ogata, H1
Katoh, T4
Uchiyama, T1
Ikeda, K3
Lerman, J1
Sikich, N1
Kleinman, S1
Yentis, S1
Suguro, Y2
Ikeda, T1
Kazama, T2
Fragen, RJ1
Dunn, KL1
Nishiyama, T1
Sugai, N1
Hanaoka, K1
Thiel, A1
Schindler, E1
Dyckmans, D1
Hempelmann, G1
Ozaki, M1
Sessler, DI1
Matsukawa, T1
Ozaki, K1
Atarashi, K1
Negishi, C1
Suzuki, H1
Kashimoto, S1
Furuya, A1
Nonaka, A1
Oguchi, T1
Koshimizu, M1
Kumazawa, T1
Bito, H1
Prakash, YS1
Cody, MJ1
Hannon, JD1
Housmans, PR1
Sieck, GC1
Melloni, C1
Antolini, F1
Tanaka, M1
Nishikawa, T1
Kudoh, A1
Katagai, H1
Takazawa, T1
Matsuki, A1
Nakajima, R1
Yasuda, N1
Targ, AG1
Eger, EI2
Strum, DP1

Clinical Trials (26)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Study on the Influencing Factors of Electroencephalogram Parameters Under Anesthesia[NCT04760028]Phase 480 participants (Actual)Interventional2021-03-01Completed
The Impact of Electroencephalogram (EEG) - Guided Inhalational Anesthetic Control on the Occurrence of EEG Discontinuity in Infants: A Prospective Randomized Controlled Trial[NCT05906225]78 participants (Anticipated)Interventional2023-06-20Not yet recruiting
Study of an Intraoperative Frontal Electroencephalographic Marker of Preoperative Frailty in Patients Over 65 Years of Age for Elective Non-cardiac Surgery.[NCT04783662]60 participants (Actual)Observational2021-05-13Completed
Cognitive Outcomes and Neuroimages Associated With Anesthesia-Related EEG Signatures[NCT03442179]24 participants (Actual)Observational2019-02-13Active, not recruiting
The Role of Brain Wave Monitoring in Reducing the Incidence of Postoperative Cognitive Dysfunction[NCT04189861]100 participants (Anticipated)Observational2020-01-24Recruiting
Development of a Pharmacodynamic Model for Propofol in Older Adults (Development phaRmacodynamic mOdel Propofol oLdEr adulTs: DROPLET)[NCT05790720]60 participants (Anticipated)Interventional2023-12-01Not yet recruiting
Relationship Between Bispectral Index, EEG Features, and Propofol Effect-site Concentration in Young and Elderly Patients.[NCT04774120]30 participants (Actual)Observational2020-12-11Completed
The Effect of Chronic Opioid Use on Minimum Alveolar Concentration of Sevoflurane for Maintaining Bispectral(BIS) Index Below 50 ; Prospective, Blind Study[NCT02582437]20 participants (Anticipated)Interventional2015-06-30Recruiting
Effect of Two Plasma Concentrations of Remifentanil Through Target Controlled Anesthesia on Frequency and Intensity of Coughing During Extubation: Randomized Controlled Clinical Trial[NCT02711904]Phase 4110 participants (Actual)Interventional2011-01-31Completed
Effective and Safe Morphine Dose for Patient Controlled Anesthesia in Supratentorial Craniotomies[NCT04313374]Phase 490 participants (Actual)Interventional2016-08-01Completed
Pre-emptive Scalp Infiltration With Dexamethasone Plus Ropivacaine vs. Ropivacaine for Relief of Postoperative Pain After Craniotomy in Adults[NCT03618264]Phase 4140 participants (Actual)Interventional2019-04-04Completed
Pre-emptive Topical Lidocaine 5% Plaster for Prevention of Post-craniotomy Pain : a Protocol for a Randomized, Triple Blind, Placebo-controlled Trail[NCT04169854]Phase 3180 participants (Anticipated)Interventional2020-10-15Recruiting
Evaluation of a Peri-Operative Continuous Bilateral Erector Spinae Plane (ESP) Continuous Catheter After Open Cardiac Surgery in Adults[NCT03901612]Phase 40 participants (Actual)Interventional2019-01-05Withdrawn (stopped due to covid and surgeon left)
Bilateral Erector Spinae Plane (ESP) Catheters Versus Single Shot ESP Block for Open Heart Surgery in Infants[NCT03593642]40 participants (Actual)Interventional2018-10-01Completed
Core Temperature Variations During Midazolam vs Propofol Sedation for Neuraxial Anesthesia[NCT02502877]27 participants (Actual)Interventional2015-07-31Completed
EEG to Monitor Propofol Anesthetic Depth in Infants and Toddlers[NCT05701748]120 participants (Anticipated)Interventional2023-02-03Recruiting
EEG-based Depth of Anesthesia-monitoring During General Anesthesia - Effects on Time to Wake-up and Post-operative Cognition[NCT04529304]100 participants (Anticipated)Interventional2021-01-08Recruiting
Use of Dexmedetomidine for Emergence Delirium in Children Undergoing General Anesthesia for Endovascular Interventional Neuroradiologic Procedures[NCT00857727]Phase 333 participants (Actual)Interventional2009-08-31Completed
Effect of Dexmedetomidine on Outcomes During Emergence From Retroperitoneal Laparoscopic Surgery[NCT02316236]66 participants (Actual)Interventional2014-12-10Completed
An Intraoperative Infusion of Dexmedetomidine Reduces the Opioid Requirements for Pediatric Patients Undergoing Hypospadias Surgery[NCT00926705]Phase 348 participants (Actual)Interventional2008-06-30Completed
Effect of Increasing Depth of Dexmedetomidine and Propofol Anesthesia on Upper Airway Morphology in Children With History of Obstructive Sleep Apnea[NCT01344759]Phase 460 participants (Actual)Interventional2009-06-30Completed
Personalizing Perioperative Morphine Analgesia for Adolescents Undergoing Major Spine Surgeries[NCT01839461]137 participants (Actual)Observational2009-07-31Completed
Evaluation of Pupillary Distension Reflexes, as a Tool for the Monitoring of Analgesia for Patients in Intensive Care.[NCT02843893]51 participants (Actual)Interventional2012-04-30Completed
Optimal Positive End-expiratory Pressure (PEEP) in Prone Position During Spine Surgery. A Prospective Observational Study[NCT04024410]20 participants (Actual)Observational2019-06-03Completed
A Prospective Randomized Clinical Trial Evaluating the Effect of Convective Pre-warming on Intra-operative Thermoregulatory Capabilities in Patients Enrolled in the TIGER Anesthesia Perioperative Protocol[NCT03876808]10 participants (Actual)Interventional2017-10-26Terminated (stopped due to Poor participant recruitment)
Neuromodulation With Percutaneous Electrical Nerve Field Stimulation for Adults With COVID-19[NCT04514627]100 participants (Anticipated)Interventional2020-07-13Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Length of Anesthesia

(NCT00857727)
Timeframe: Day 1

Interventionminutes (Mean)
Drug199
Control215

Length of Surgery

(NCT00857727)
Timeframe: Day 1

Interventionminutes (Mean)
Drug58
Control86

Total Fentanyl

Total Drug used (NCT00857727)
Timeframe: Day 1

Interventionmcg/kg (Mean)
Drug2.33
Control2.36

Total Propofol

Total Drug used (NCT00857727)
Timeframe: Day 1

Interventionmg/kg (Mean)
Drug2.11
Control2.41

Total Sevoflurane

Total Drug used (NCT00857727)
Timeframe: Day 1

Interventionml/kg (Mean)
Drug3.67
Control6.80

Total Study Drug

Total Study Drug used (NCT00857727)
Timeframe: Day 1

Interventionmcg/kg (Mean)
Drug1.55
Control1.43

Weight

(NCT00857727)
Timeframe: Baseline

Interventionkg (Mean)
Drug21.8
Control18.5

Number of Participants With Emergence Delirium

Emergence Delirium (ED) during the 15-45min. post-op period as assessed by the Cole Score. (Cole Score 3-5 = ED). The Cole Scale is an ordinal ranking of ED (1=sleeping; 2=awake, calm; 3=irritable, crying; 4=inconsolable, crying; 5=severe restlessness, disorientation). (NCT00857727)
Timeframe: 15-45 minutes post-op

,
Interventionparticipants (Number)
EDNo ED
Control77
Drug113

Needed Artificial Airway

This is the count of the number of patients who needed an artificial airway. (NCT01344759)
Timeframe: During MRI and until recovery room discharge - approximately 30-250 minutes

InterventionNumber of artifical airway events (Number)
Mild OSA and Dexmedetomidine0
Mild OSA and Propofol1
Moderate OSA and Dexmedetomidine1
Moderate OSA and Propofol1
Severe OSA and Dexmedetomidine2
Severe OSA and Propofol5

Obstructive Index Until Recovery Room Discharge

The Obstructive Index is a count of the obstructive apnea events per hour of sleep (NCT01344759)
Timeframe: During MRI and until recovery room discharge - approximately 30-250 minutes

InterventionApnea events/hour of sleep (Mean)
Mild OSA and Dexmedetomidine4.2
Mild OSA and Propofol3.0
Moderate OSA and Dexmedetomidine8.0
Moderate OSA and Propofol8.0
Severe OSA and Dexmedetomidine16.7
Severe OSA and Propofol17.1

Respiratory Disturbance Index

The respiratory disturbance index is a count of respiratory disturbance events per hour of sleep. (NCT01344759)
Timeframe: During MRI and until recovery room discharge - approximately 30-250 minutes

Interventionrespir.disturbance events/hr of sleep (Mean)
Mild OSA and Dexmedetomidine5.1
Mild OSA and Propofol3.2
Moderate OSA and Dexmedetomidine8.8
Moderate OSA and Propofol7.1
Severe OSA and Dexmedetomidine16.6
Severe OSA and Propofol25.2

Room Air SpO2

The patient's oxygen saturation on room air. (NCT01344759)
Timeframe: During MRI and until recovery room discharge - approximately 30-250 minutes

Interventionpercentage of SpO2 (Mean)
Mild OSA and Dexmedetomidine87.2
Mild OSA and Propofol88.0
Moderate OSA and Dexmedetomidine86.3
Moderate OSA and Propofol89.0
Severe OSA and Dexmedetomidine84.0
Severe OSA and Propofol88.0

Cross Sectional Area of the Pharyngeal Airway

The primary outcome measures will be the cross sectional area of the pharyngeal airway of the patients measured at two levels soft palate (nasopharyngeal) and base of the tongue (retroglossal). Magnetic resonance images of the airway were obtained during low (1 mcg/kg/hr) and high (3 mcg/kg/hr) doses of DEX or low (100 mcg/kg/m) and high (200 mcg/kg/m) doses of Propofol. All were administered through an intravenous (IV) catheter. (NCT01344759)
Timeframe: during MRI within first 10 minutes of scanning

,
Interventionmm^2 (Median)
Low Dose Sedative, Nasopharyngeal measurementHigh Dose Sedative, Nasopharyngeal measurementLow Dose Sedative, Retroglossal measurementHigh dose sedative, Retroglossal measurement
Dexmedetomidine178.5235.4120.9120.5
Propofol239.9201.6115.1108.1

Core Body Temperature

Change in core temperature between induction of anesthesia and end of skin preparation (NCT03876808)
Timeframe: Day 1

InterventionDegrees Celsius (Mean)
Convective Pre-warming-0.95
Standard of Care-0.53

Intraoperative Temperatures

Core body temperature measured intraoperatively (NCT03876808)
Timeframe: Day 1

InterventionDegrees Celsius (Mean)
Convective Pre-warming36.0
Standard of Care35.7

Skin Temperature

Change in skin temperature between arrival to the holding area and departure to the operating room, and arrival to the PACU (NCT03876808)
Timeframe: Day 1

,
InterventionDegrees Celsius (Mean)
Holding area to operating room departureHolding area to arrival in PACU
Convective Pre-warming-0.03-0.07
Standard of Care0.08-0.48

Temperature Differences Between Different Age Groups

Differences in temperature changes between elderly (≥ 65 years) and younger patients (< 65 years). (NCT03876808)
Timeframe: Day 1

InterventionDegrees Celcius (Mean)
Temperature before prewarming - Patients >65 years of age
Standard of Care36.5

Temperature Differences Between Different Age Groups

Differences in temperature changes between elderly (≥ 65 years) and younger patients (< 65 years). (NCT03876808)
Timeframe: Day 1

InterventionDegrees Celcius (Mean)
Temperature before prewarming - Patients <65 years of ageTemperature before prewarming - Patients >65 years of ageTemperature after prewarming - Patients <65 years of ageTemperature after prewarming - Patients >65 years of age
Convective Pre-warming36.536.636.536.4

Reviews

1 review available for sevoflurane and Aging

ArticleYear
The EEG signal: a window on the cortical brain activity.
    Paediatric anaesthesia, 2012, Volume: 22, Issue:6

    Topics: Adult; Aging; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Cerebral Cortex; Child;

2012

Trials

21 trials available for sevoflurane and Aging

ArticleYear
The Effects of Propofol and Sevoflurane on Postoperative Delirium in Older Patients: A Randomized Clinical Trial Study.
    Journal of Alzheimer's disease : JAD, 2020, Volume: 76, Issue:4

    Topics: Aged; Aged, 80 and over; Aging; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intra

2020
Sevoflurane-induced changes in infants' quantifiable electroencephalogram parameters.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:7

    Topics: Aging; Anesthesia, Inhalation; Anesthetics, Inhalation; Child, Preschool; Consciousness Monitors; Cr

2014
Advance of age decreases the minimum alveolar concentrations of isoflurane and sevoflurane for maintaining bispectral index below 50.
    British journal of anaesthesia, 2009, Volume: 102, Issue:3

    Topics: Adult; Aged; Aging; Anesthetics, Inhalation; Double-Blind Method; Drug Administration Schedule; Elec

2009
Advance of age decreases the minimum alveolar concentrations of isoflurane and sevoflurane for maintaining bispectral index below 50.
    British journal of anaesthesia, 2009, Volume: 102, Issue:3

    Topics: Adult; Aged; Aging; Anesthetics, Inhalation; Double-Blind Method; Drug Administration Schedule; Elec

2009
Advance of age decreases the minimum alveolar concentrations of isoflurane and sevoflurane for maintaining bispectral index below 50.
    British journal of anaesthesia, 2009, Volume: 102, Issue:3

    Topics: Adult; Aged; Aging; Anesthetics, Inhalation; Double-Blind Method; Drug Administration Schedule; Elec

2009
Advance of age decreases the minimum alveolar concentrations of isoflurane and sevoflurane for maintaining bispectral index below 50.
    British journal of anaesthesia, 2009, Volume: 102, Issue:3

    Topics: Adult; Aged; Aging; Anesthetics, Inhalation; Double-Blind Method; Drug Administration Schedule; Elec

2009
Factors affecting the decision to defer endotracheal extubation after surgery for congenital heart disease: a prospective observational study.
    Anesthesia and analgesia, 2011, Volume: 113, Issue:2

    Topics: Adolescent; Aging; Analgesics, Opioid; Anesthesia, Inhalation; Anesthetics, Dissociative; Anesthetic

2011
Factors affecting the decision to defer endotracheal extubation after surgery for congenital heart disease: a prospective observational study.
    Anesthesia and analgesia, 2011, Volume: 113, Issue:2

    Topics: Adolescent; Aging; Analgesics, Opioid; Anesthesia, Inhalation; Anesthetics, Dissociative; Anesthetic

2011
Factors affecting the decision to defer endotracheal extubation after surgery for congenital heart disease: a prospective observational study.
    Anesthesia and analgesia, 2011, Volume: 113, Issue:2

    Topics: Adolescent; Aging; Analgesics, Opioid; Anesthesia, Inhalation; Anesthetics, Dissociative; Anesthetic

2011
Factors affecting the decision to defer endotracheal extubation after surgery for congenital heart disease: a prospective observational study.
    Anesthesia and analgesia, 2011, Volume: 113, Issue:2

    Topics: Adolescent; Aging; Analgesics, Opioid; Anesthesia, Inhalation; Anesthetics, Dissociative; Anesthetic

2011
Lipid-emulsion propofol less attenuates the regulation of body temperature than micro-emulsion propofol or sevoflurane in the elderly.
    Yonsei medical journal, 2012, Volume: 53, Issue:1

    Topics: Aged; Aging; Anesthesia, General; Anesthetics, Combined; Anesthetics, Inhalation; Anesthetics, Intra

2012
The effects of age, isoflurane and sevoflurane on atracurium in lambs.
    Veterinary anaesthesia and analgesia, 2012, Volume: 39, Issue:3

    Topics: Aging; Anesthetics, Inhalation; Animals; Atracurium; Body Temperature; Dose-Response Relationship, D

2012
Hyperventilation accelerates rise in arterial blood concentrations of sevoflurane in gynecologic patients.
    Journal of anesthesia, 2013, Volume: 27, Issue:1

    Topics: Adult; Aging; Anesthesia, Inhalation; Anesthetics, Inhalation; Arteries; Carbon Dioxide; Chromatogra

2013
[Neuromuscular blockade with cisatracurium in infants andchildren. Its course under sevoflurane anesthesia].
    Der Anaesthesist, 2002, Volume: 51, Issue:5

    Topics: Aging; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intrav

2002
Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:1

    Topics: Aging; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure;

2004
Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:1

    Topics: Aging; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure;

2004
Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:1

    Topics: Aging; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure;

2004
Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:1

    Topics: Aging; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure;

2004
Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:1

    Topics: Aging; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure;

2004
Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:1

    Topics: Aging; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure;

2004
Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:1

    Topics: Aging; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure;

2004
Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:1

    Topics: Aging; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure;

2004
Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:1

    Topics: Aging; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure;

2004
Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:1

    Topics: Aging; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure;

2004
Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:1

    Topics: Aging; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure;

2004
Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:1

    Topics: Aging; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure;

2004
Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:1

    Topics: Aging; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure;

2004
Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:1

    Topics: Aging; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure;

2004
Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:1

    Topics: Aging; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure;

2004
Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:1

    Topics: Aging; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure;

2004
Single-breath vital capacity rapid inhalation induction with sevoflurane: feasibility in children.
    Paediatric anaesthesia, 2005, Volume: 15, Issue:4

    Topics: Adjuvants, Anesthesia; Adolescent; Aging; Anesthesia, Inhalation; Anesthetics, Inhalation; Child; Ch

2005
Correlation of bispectral index with end-tidal sevoflurane concentration and age in infants and children.
    British journal of anaesthesia, 2005, Volume: 95, Issue:3

    Topics: Aging; Anesthetics, Inhalation; Blood Pressure; Child; Child, Preschool; Dose-Response Relationship,

2005
Differential electroencephalographic response to tracheal intubation between young and elderly during isoflurane and sevoflurane nitrous oxide anaesthesia.
    British journal of anaesthesia, 2007, Volume: 99, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Aging; Anesthetics, Combined; Anesthetics, Inhalation; Blood Pressur

2007
Edrophonium as an antagonist of vecuronium-induced neuromuscular block in the elderly.
    Anaesthesia, 1995, Volume: 50, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Aging; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressu

1995
Effect of fentanyl on awakening concentration of sevoflurane.
    British journal of anaesthesia, 1994, Volume: 73, Issue:3

    Topics: Adult; Aging; Anesthesia Recovery Period; Anesthesia, General; Anesthetics; Awareness; Dose-Response

1994
The pharmacology of sevoflurane in infants and children.
    Anesthesiology, 1994, Volume: 80, Issue:4

    Topics: Aging; Anesthesia; Anesthetics; Blood Pressure; Child; Child, Preschool; Dermatologic Surgical Proce

1994
The pharmacology of sevoflurane in infants and children.
    Anesthesiology, 1994, Volume: 80, Issue:4

    Topics: Aging; Anesthesia; Anesthetics; Blood Pressure; Child; Child, Preschool; Dermatologic Surgical Proce

1994
The pharmacology of sevoflurane in infants and children.
    Anesthesiology, 1994, Volume: 80, Issue:4

    Topics: Aging; Anesthesia; Anesthetics; Blood Pressure; Child; Child, Preschool; Dermatologic Surgical Proce

1994
The pharmacology of sevoflurane in infants and children.
    Anesthesiology, 1994, Volume: 80, Issue:4

    Topics: Aging; Anesthesia; Anesthetics; Blood Pressure; Child; Child, Preschool; Dermatologic Surgical Proce

1994
The minimum alveolar concentration (MAC) of sevoflurane with and without nitrous oxide in elderly versus young adults.
    Journal of clinical anesthesia, 1996, Volume: 8, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthetics, Inhalation; Cross-Over Studies; Dose

1996
Cerebrovascular CO2 reactivity in elderly and younger adult patients during sevoflurane anaesthesia.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1997, Volume: 44, Issue:2

    Topics: Adult; Aged; Aging; Anesthetics, Inhalation; Blood Flow Velocity; Carbon Dioxide; Cerebrovascular Ci

1997
[Transcranial doppler sonography. Effect of sevoflurane in comparison to isoflurane].
    Der Anaesthesist, 1997, Volume: 46, Issue:1

    Topics: Adolescent; Adult; Aging; Anesthesia, Inhalation; Anesthetics, Inhalation; Body Height; Body Weight;

1997
Influence of age on hypnotic requirement, bispectral index, and 95% spectral edge frequency associated with sedation induced by sevoflurane.
    Anesthesiology, 2000, Volume: 92, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Aging; Anesthetics, Inhalation; Conscious Sedation; Dose-Response Re

2000
Effective doses of cisatracurium. Potentiation by sevoflurane and increasing requirements with age.
    Minerva anestesiologica, 2000, Volume: 66, Issue:3

    Topics: Aging; Anesthesia, General; Anesthetics, Inhalation; Atracurium; Drug Synergism; Female; Humans; Mal

2000
Aging reduces the efficacy of the simulated epidural test dose in anesthetized adults.
    Anesthesia and analgesia, 2000, Volume: 91, Issue:3

    Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Aging; Anesthesia, Epidural; Anesthesia, Inhalat

2000

Other Studies

73 other studies available for sevoflurane and Aging

ArticleYear
Sevoflurane and isoflurane inhibit KCl-induced, Rho kinase-mediated, and PI3K-participated vasoconstriction in aged diabetic rat aortas.
    BMC anesthesiology, 2021, 09-01, Volume: 21, Issue:1

    Topics: Aging; Amides; Anesthetics, Inhalation; Animals; Aorta; Chromones; Diabetes Mellitus, Experimental;

2021
Role of RGS2 in sevoflurane-induced cognitive dysfunction in aged rats.
    Pakistan journal of pharmaceutical sciences, 2022, Volume: 35, Issue:1

    Topics: Aging; Animals; bcl-2-Associated X Protein; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Typ

2022
Sevoflurane inhibits histone acetylation and contributes to cognitive dysfunction by enhancing the expression of ANP32A in aging mice.
    Behavioural brain research, 2022, 08-05, Volume: 431

    Topics: Acetylation; Aging; Animals; Cognitive Dysfunction; Histones; Mice; Mice, Inbred C57BL; Nuclear Prot

2022
Rapamycin improves sevoflurane‑induced cognitive dysfunction in aged rats by mediating autophagy through the TLR4/MyD88/NF‑κB signaling pathway.
    Molecular medicine reports, 2019, Volume: 20, Issue:4

    Topics: Aging; Animals; Autophagic Cell Death; Cognitive Dysfunction; Male; Myeloid Differentiation Factor 8

2019
[Effects of Sevoflurane on the Cognitive Function and Hippocampal Ultrastructure of Elderly Model Rats].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2019, Volume: 50, Issue:5

    Topics: Aging; Animals; Cognition; Hippocampus; Male; Maze Learning; Random Allocation; Rats; Rats, Sprague-

2019
Sevoflurane Induces Learning and Memory Impairment in Young Mice Through a Reduction in Neuronal Glucose Transporter 3.
    Cellular and molecular neurobiology, 2020, Volume: 40, Issue:6

    Topics: Aging; Animals; Apoptosis; Brain; Cell Membrane; Cells, Cultured; Glucose; Glucose Transporter Type

2020
Sevoflurane anesthesia-mediated oxidative stress and cognitive impairment in hippocampal neurons of old rats can be ameliorated by expression of brain derived neurotrophic factor.
    Neuroscience letters, 2020, 03-16, Volume: 721

    Topics: Administration, Inhalation; Aging; Anesthetics, Inhalation; Animals; Brain-Derived Neurotrophic Fact

2020
Spectral and Entropic Features Are Altered by Age in the Electroencephalogram in Patients under Sevoflurane Anesthesia.
    Anesthesiology, 2020, Volume: 132, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics, Inhalation; Ele

2020
Neuroprotective effect of CTRP3 overexpression against sevoflurane anesthesia-induced cognitive dysfunction in aged rats through activating AMPK/SIRT1 and PI3K/AKT signaling pathways.
    European review for medical and pharmacological sciences, 2020, Volume: 24, Issue:9

    Topics: Adipokines; Aging; AMP-Activated Protein Kinases; Anesthetics, Inhalation; Animals; Apoptosis; Cogni

2020
Ageing and genetic background influence anaesthetic effects in a D. melanogaster model of blunt trauma with brain injury
    British journal of anaesthesia, 2020, Volume: 125, Issue:1

    Topics: Aging; Anesthetics, Inhalation; Animals; Brain; Brain Injuries, Traumatic; Disease Models, Animal; D

2020
AMPK-SIRT1-PGC1α Signal Pathway Influences the Cognitive Function of Aged Rats in Sevoflurane-Induced Anesthesia.
    Journal of molecular neuroscience : MN, 2020, Volume: 70, Issue:12

    Topics: Aging; Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; Anesthetics, Inhalation; An

2020
Mitochondrial Complex I Mutations Predispose Drosophila to Isoflurane Neurotoxicity.
    Anesthesiology, 2020, 10-01, Volume: 133, Issue:4

    Topics: Aging; Anesthetics, Inhalation; Animals; Animals, Genetically Modified; Drosophila; Electron Transpo

2020
Sevoflurane-induced cognitive decline in aged mice: Involvement of toll-like receptors 4.
    Brain research bulletin, 2020, Volume: 165

    Topics: Aging; Anesthetics, Inhalation; Animals; Cognition; Cognitive Dysfunction; Cytokines; Hippocampus; M

2020
lncRNAs Are Involved in Sevoflurane Anesthesia-Related Brain Function Modulation through Affecting Mitochondrial Function and Aging Process.
    BioMed research international, 2020, Volume: 2020

    Topics: Aging; Anesthesia; Anesthetics; Animals; Brain; Brain Neoplasms; Cell Line, Tumor; Cognition Disorde

2020
Maternal anesthesia with sevoflurane during the mid-gestation induces social interaction deficits in offspring C57BL/6 mice.
    Biochemical and biophysical research communications, 2021, 05-14, Volume: 553

    Topics: Aging; Anesthetics, Inhalation; Animals; Brain; Female; Male; Mice; Mice, Inbred C57BL; Mothers; Pre

2021
Brain transcriptomics of nonhuman primates: A review.
    Neuroscience letters, 2021, 05-14, Volume: 753

    Topics: Aging; Animals; Brain; Brain Diseases; Disease Models, Animal; Ethanol; Humans; Methamphetamine; Neu

2021
NLRP3 inflammasome inhibition by histone acetylation ameliorates sevoflurane-induced cognitive impairment in aged mice by activating the autophagy pathway.
    Brain research bulletin, 2021, Volume: 172

    Topics: Acetylation; Aging; Animals; Autophagy; Cognitive Dysfunction; Hippocampus; Histone Deacetylase Inhi

2021
Exogenous insulin-like growth factor 1 attenuates sevoflurane anesthesia-induced cognitive dysfunction in aged rats.
    Journal of neurophysiology, 2021, 06-01, Volume: 125, Issue:6

    Topics: Aging; Anesthetics, Inhalation; Animals; Behavior, Animal; Disease Models, Animal; Down-Regulation;

2021
Lovastatin attenuates sevoflurane-induced cognitive disorder in aged rats via reducing Aβ accumulation.
    Neurochemistry international, 2021, Volume: 148

    Topics: Aging; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Cognition; Cog

2021
Hispidulin prevents sevoflurane- Induced memory dysfunction in aged rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 97

    Topics: Aging; Anesthetics, Inhalation; Animals; Apoptosis; Flavones; Male; Memory Disorders; Methyl Ethers;

2018
Repeated exposure to sevoflurane impairs the learning and memory of older male rats.
    Life sciences, 2018, Jan-01, Volume: 192

    Topics: Aging; Anesthetics, Inhalation; Animals; Apoptosis; Brain Chemistry; Brain-Derived Neurotrophic Fact

2018
Role of the hippocampal 5-HT1A receptor-mediated cAMP/PKA signalling pathway in sevoflurane-induced cognitivedysfunction in aged rats.
    The Journal of international medical research, 2018, Volume: 46, Issue:3

    Topics: Aging; Anesthetics, Inhalation; Animals; Cognitive Dysfunction; Cyclic AMP; Cyclic AMP Response Elem

2018
Electroencephalographic markers of brain development during sevoflurane anaesthesia in children up to 3 years old.
    British journal of anaesthesia, 2018, Volume: 120, Issue:6

    Topics: Aging; Anesthesia, General; Anesthetics, Inhalation; Brain; Brain Mapping; Child Development; Child,

2018
Sevoflurane anesthesia impairs metabotropic glutamate receptor-dependent long-term depression and cognitive functions in senile mice.
    Geriatrics & gerontology international, 2019, Volume: 19, Issue:4

    Topics: Aging; Anesthesia; Anesthetics, Inhalation; Animals; Cognition; Cognitive Dysfunction; Depression; E

2019
Sevoflurane induces endoplasmic reticulum stress mediated apoptosis in hippocampal neurons of aging rats.
    PloS one, 2013, Volume: 8, Issue:2

    Topics: Aging; Anesthetics, Inhalation; Animals; Apoptosis; Blood Gas Analysis; Caspase 12; Endoplasmic Reti

2013
Sevoflurane alters the expression of receptors and enzymes involved in Aβ clearance in rats.
    Acta anaesthesiologica Scandinavica, 2013, Volume: 57, Issue:7

    Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Anesthetics, Inhalation; Animals; Blood-Brain Barri

2013
Failure to protect against myocardial ischemia-reperfusion injury with sevoflurane postconditioning in old rats in vivo.
    Acta anaesthesiologica Scandinavica, 2013, Volume: 57, Issue:8

    Topics: Aging; Anesthetics, Inhalation; Animals; Blotting, Western; Enzyme Activation; Ischemic Postconditio

2013
Smaller sized inhaled anesthetics have more potency on senescence-accelerated prone-8 mice compared with senescence-resistant-1 mice.
    Journal of Alzheimer's disease : JAD, 2014, Volume: 39, Issue:1

    Topics: Aging; Alzheimer Disease; Analysis of Variance; Anesthetics, Inhalation; Animals; Desflurane; Diseas

2014
Age-related changes in EEG power spectra in infants during sevoflurane wash-out.
    British journal of anaesthesia, 2014, Volume: 112, Issue:4

    Topics: Aging; Anesthesia Recovery Period; Anesthetics, Inhalation; Electroencephalography; Female; Humans;

2014
Changes in plasma orexin-A levels in sevoflurane-remifentanil anesthesia in young and elderly patients undergoing elective lumbar surgery.
    Anesthesia and analgesia, 2014, Volume: 118, Issue:4

    Topics: Adult; Aged; Aging; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Inhalation; Anesth

2014
Impact of sevoflurane anesthesia on brain oxygenation in children younger than 2 years.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:7

    Topics: Aging; Anesthesia, Inhalation; Anesthetics, Inhalation; Arterial Pressure; Brain Chemistry; Female;

2014
Sevoflurane induces tau phosphorylation and glycogen synthase kinase 3β activation in young mice.
    Anesthesiology, 2014, Volume: 121, Issue:3

    Topics: Aging; Anesthetics, Inhalation; Animals; Cognition Disorders; Enzyme Activation; Escape Reaction; Fe

2014
Aging causes exacerbated ischemic brain injury and failure of sevoflurane post-conditioning: role of B-cell lymphoma-2.
    Neuroscience, 2014, Sep-05, Volume: 275

    Topics: Age Factors; Aging; Animals; Apoptosis; Brain; Brain Ischemia; Disease Models, Animal; Ischemic Post

2014
Laryngeal mask airway placement in children prior to an intravenous line utilizing heart rate as an indicator of anesthetic depth.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:10

    Topics: Aging; Anesthesia; Anesthetics, Inhalation; Blood Pressure; Catheterization, Peripheral; Child; Chil

2014
Minocycline alleviates sevoflurane-induced cognitive impairment in aged rats.
    Cellular and molecular neurobiology, 2015, Volume: 35, Issue:4

    Topics: Aging; Amyloid beta-Peptides; Animals; Apoptosis; Cognition Disorders; Hippocampus; Inflammation; Le

2015
Sevoflurane and Isoflurane induce structural changes in brain vascular endothelial cells and increase blood-brain barrier permeability: Possible link to postoperative delirium and cognitive decline.
    Brain research, 2015, Sep-16, Volume: 1620

    Topics: Aging; Anesthetics, Inhalation; Animals; Blood-Brain Barrier; Capillary Permeability; Cognition Diso

2015
Internalization of GluA2 and the underlying mechanisms of cognitive decline in aged rats following surgery and prolonged exposure to sevoflurane.
    Neurotoxicology, 2015, Volume: 49

    Topics: Aging; Anesthetics, Inhalation; Animals; Cognition Disorders; Conditioning, Psychological; Fear; Gen

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
Sevoflurane postconditioning affects post-ischaemic myocardial mitochondrial ATP-sensitive potassium channel function and apoptosis in ageing rats.
    Clinical and experimental pharmacology & physiology, 2016, Volume: 43, Issue:5

    Topics: Aging; Animals; Apoptosis; bcl-2-Associated X Protein; Coronary Circulation; Decanoic Acids; Hemodyn

2016
Sevoflurane anesthesia induces neither contextual fear memory impairment nor alterations in local population connectivity of medial prefrontal cortex local field potentials networks in aged rats.
    Fundamental & clinical pharmacology, 2016, Volume: 30, Issue:4

    Topics: Aging; Anesthetics, Inhalation; Animals; Conditioning, Psychological; Fear; Male; Memory; Memory Dis

2016
The hippocampal cyclin D1 expression is involved in postoperative cognitive dysfunction after sevoflurane exposure in aged mice.
    Life sciences, 2016, Sep-01, Volume: 160

    Topics: Aging; Anesthetics, Inhalation; Animals; Cognition Disorders; Cyclin D1; Hippocampus; Maze Learning;

2016
The ageing brain.
    British journal of anaesthesia, 2016, Volume: 117, Issue:5

    Topics: Aging; Anesthesia, General; Brain; Electroencephalography; Propofol; Sevoflurane

2016
The influence of age on the dynamic relationship between end-tidal sevoflurane concentrations and bispectral index.
    Anesthesia and analgesia, 2008, Volume: 107, Issue:5

    Topics: Adolescent; Adult; Aged; Aging; Anesthetics, Inhalation; Child; Child, Preschool; Drug Hypersensitiv

2008
Object memory in young and aged mice after sevoflurane anaesthesia.
    Neuroreport, 2009, Oct-28, Volume: 20, Issue:16

    Topics: Aging; Anesthetics, Inhalation; Animals; Discrimination Learning; Exploratory Behavior; Female; Male

2009
Effect of age on minimum alveolar concentration (MAC) of sevoflurane in dogs.
    The Journal of veterinary medical science, 2009, Volume: 71, Issue:11

    Topics: Aging; Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Dogs; Methyl Ethers; Pulmonary Alve

2009
Prospective assessment of postoperative pain after craniotomy.
    Journal of neurosurgical anesthesiology, 2010, Volume: 22, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Anesthesia, General; Anesthes

2010
Prospective assessment of postoperative pain after craniotomy.
    Journal of neurosurgical anesthesiology, 2010, Volume: 22, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Anesthesia, General; Anesthes

2010
Prospective assessment of postoperative pain after craniotomy.
    Journal of neurosurgical anesthesiology, 2010, Volume: 22, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Anesthesia, General; Anesthes

2010
Prospective assessment of postoperative pain after craniotomy.
    Journal of neurosurgical anesthesiology, 2010, Volume: 22, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Anesthesia, General; Anesthes

2010
Prospective assessment of postoperative pain after craniotomy.
    Journal of neurosurgical anesthesiology, 2010, Volume: 22, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Anesthesia, General; Anesthes

2010
Prospective assessment of postoperative pain after craniotomy.
    Journal of neurosurgical anesthesiology, 2010, Volume: 22, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Anesthesia, General; Anesthes

2010
Prospective assessment of postoperative pain after craniotomy.
    Journal of neurosurgical anesthesiology, 2010, Volume: 22, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Anesthesia, General; Anesthes

2010
Prospective assessment of postoperative pain after craniotomy.
    Journal of neurosurgical anesthesiology, 2010, Volume: 22, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Anesthesia, General; Anesthes

2010
Prospective assessment of postoperative pain after craniotomy.
    Journal of neurosurgical anesthesiology, 2010, Volume: 22, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Anesthesia, General; Anesthes

2010
The effect of sevoflurane anesthesia on cognitive function and the expression of Insulin-like Growth Factor-1 in CA1 region of hippocampus in old rats.
    Molecular biology reports, 2011, Volume: 38, Issue:2

    Topics: Aging; Anesthesia; Anesthetics, Inhalation; Animals; Cognition; Gene Expression Regulation; Hippocam

2011
Gender differences in cerebrovascular reactivity to carbon dioxide during sevoflurane anesthesia in children: preliminary findings.
    Paediatric anaesthesia, 2011, Volume: 21, Issue:2

    Topics: Adolescent; Aging; Anesthesia, Inhalation; Anesthetics, Inhalation; Carbon Dioxide; Cerebrovascular

2011
Clinically relevant asymmetry of bispectral index during recovery from anaesthesia for ear-nose-throat surgery in adults and children.
    Anaesthesia, 2011, Volume: 66, Issue:10

    Topics: Adult; Aging; Anesthesia; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Inhalation;

2011
Responses of the second derivative of the finger photoplethysmogram indices and hemodynamic parameters to anesthesia induction.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2012, Volume: 35, Issue:2

    Topics: Adult; Aged; Aging; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Area Under Curve;

2012
Parecoxib mitigates spatial memory impairment induced by sevoflurane anesthesia in aged rats.
    Acta anaesthesiologica Scandinavica, 2012, Volume: 56, Issue:5

    Topics: Aging; Anesthetics, Intravenous; Animals; Blotting, Western; Cognition Disorders; Cyclooxygenase 2;

2012
Neonatal electroencephalography shows low sensitivity to anesthesia.
    Neuroscience letters, 2012, May-31, Volume: 517, Issue:2

    Topics: Aging; Analysis of Variance; Anesthesia; Anesthetics, Inhalation; Child, Preschool; Data Interpretat

2012
The effect of aging on dopamine release and metabolism during sevoflurane anesthesia in rat striatum: an in vivo microdialysis study.
    Brain research bulletin, 2012, Dec-01, Volume: 89, Issue:5-6

    Topics: Aging; Anesthetics, Inhalation; Animals; Corpus Striatum; Dopamine; Male; Methyl Ethers; Microdialys

2012
Oxidative stress and antioxidant activity of female rat liver tissue after sevoflurane anaesthesia: young versus old.
    Bratislavske lekarske listy, 2012, Volume: 113, Issue:12

    Topics: Aging; Anesthetics, Inhalation; Animals; Antioxidants; Female; Glutathione Transferase; Liver; Methy

2012
Age and anesthetic effects on murine electrocardiography.
    Life sciences, 2003, Apr-11, Volume: 72, Issue:21

    Topics: Aging; Anesthetics, Combined; Anesthetics, Inhalation; Animals; Disease Models, Animal; Electrocardi

2003
Cerebral autoregulation in children during sevoflurane anaesthesia.
    British journal of anaesthesia, 2003, Volume: 90, Issue:5

    Topics: Adolescent; Adult; Aging; Analysis of Variance; Anesthesia, General; Anesthetics, Inhalation; Blood

2003
Age-related iso-MAC charts for isoflurane, sevoflurane and desflurane in man.
    British journal of anaesthesia, 2003, Volume: 91, Issue:2

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Aging; Algorithms; Anesthetics, Inhalation;

2003
Reduced efficacy of volatile anesthetic preconditioning with advanced age in isolated rat myocardium.
    Anesthesiology, 2004, Volume: 100, Issue:3

    Topics: Adenosine Triphosphate; Aging; Anesthetics, Inhalation; Animals; Calcium; Creatine Kinase; Heart; He

2004
Impact of age on both BIS values and EEG bispectrum during anaesthesia with sevoflurane in children.
    British journal of anaesthesia, 2005, Volume: 94, Issue:6

    Topics: Adolescent; Aging; Anesthetics, Inhalation; Body Weight; Child; Child, Preschool; Dose-Response Rela

2005
Performance of entropy and Bispectral Index as measures of anaesthesia effect in children of different ages.
    British journal of anaesthesia, 2005, Volume: 95, Issue:5

    Topics: Aging; Anesthesia, Inhalation; Anesthetics, Inhalation; Child; Child, Preschool; Dose-Response Relat

2005
Reflex pupillary dilatation in response to skin incision and alfentanil in children anaesthetized with sevoflurane: a more sensitive measure of noxious stimulation than the commonly used variables.
    British journal of anaesthesia, 2006, Volume: 96, Issue:5

    Topics: Adolescent; Aging; Alfentanil; Analgesics, Opioid; Anesthesia, Inhalation; Anesthetics, Inhalation;

2006
Reflex pupillary dilatation in response to skin incision and alfentanil in children anaesthetized with sevoflurane: a more sensitive measure of noxious stimulation than the commonly used variables.
    British journal of anaesthesia, 2006, Volume: 96, Issue:5

    Topics: Adolescent; Aging; Alfentanil; Analgesics, Opioid; Anesthesia, Inhalation; Anesthetics, Inhalation;

2006
Reflex pupillary dilatation in response to skin incision and alfentanil in children anaesthetized with sevoflurane: a more sensitive measure of noxious stimulation than the commonly used variables.
    British journal of anaesthesia, 2006, Volume: 96, Issue:5

    Topics: Adolescent; Aging; Alfentanil; Analgesics, Opioid; Anesthesia, Inhalation; Anesthetics, Inhalation;

2006
Reflex pupillary dilatation in response to skin incision and alfentanil in children anaesthetized with sevoflurane: a more sensitive measure of noxious stimulation than the commonly used variables.
    British journal of anaesthesia, 2006, Volume: 96, Issue:5

    Topics: Adolescent; Aging; Alfentanil; Analgesics, Opioid; Anesthesia, Inhalation; Anesthetics, Inhalation;

2006
Onset time for sevoflurane/nitrous oxide induction in adults is prolonged with increasing age.
    Anesthesia and analgesia, 2006, Volume: 102, Issue:6

    Topics: Adult; Aged; Aging; Anesthesia, Inhalation; Anesthetics, Inhalation; Electroencephalography; Eyelash

2006
Anesthetic implications of botulinum toxin type A (Botox) injections for the treatment of 'the aging face' in the parturient.
    Acta anaesthesiologica Scandinavica, 2007, Volume: 51, Issue:4

    Topics: Adult; Aging; Anesthesia Recovery Period; Anesthesia, General; Anesthesia, Obstetrical; Anesthetics,

2007
Perioperative management of patients with Cockayne syndrome - recognition of accelerated aging with growth arrest.
    Paediatric anaesthesia, 2008, Volume: 18, Issue:4

    Topics: Adjuvants, Anesthesia; Adolescent; Aging; Anesthesia; Anesthetics, Inhalation; Cockayne Syndrome; Fe

2008
Biotransformation of sevoflurane by rat neonate liver slices.
    Drug metabolism and disposition: the biological fate of chemicals, 1995, Volume: 23, Issue:4

    Topics: 1-Propanol; Aging; Anesthetics; Animals; Animals, Newborn; Biotransformation; Ethers; Fluorides; Glu

1995
Influence of age on awakening concentrations of sevoflurane and isoflurane.
    Anesthesia and analgesia, 1993, Volume: 76, Issue:2

    Topics: Adult; Aging; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics; Ethers; Female; Human

1993
The threshold for thermoregulatory vasoconstriction during nitrous oxide/sevoflurane anesthesia is reduced in the elderly.
    Anesthesia and analgesia, 1997, Volume: 84, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Aging; Anesthetics, Combined; Anesthetics, Inhalation; Body Temperat

1997
The minimum alveolar concentration of sevoflurane in rats.
    European journal of anaesthesiology, 1997, Volume: 14, Issue:4

    Topics: Aging; Anesthetics, Inhalation; Animals; Blood Gas Analysis; Ethers; Male; Methyl Ethers; Pulmonary

1997
Comparison of volatile anesthetic effects on actin-myosin cross-bridge cycling in neonatal versus adult cardiac muscle.
    Anesthesiology, 2000, Volume: 92, Issue:4

    Topics: Actins; Aging; Algorithms; Anesthetics, Inhalation; Animals; Animals, Newborn; Halothane; Heart; In

2000
Plasma proinflammatory cytokine response to surgical stress in elderly patients.
    Cytokine, 2001, Sep-07, Volume: 15, Issue:5

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Anesthetics, Inhalation; Anesthetics, Intravenou

2001
Blood concentrations of sevoflurane and isoflurane on recovery from anaesthesia.
    British journal of anaesthesia, 1992, Volume: 69, Issue:3

    Topics: Adolescent; Adult; Aged; Aging; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics; Eth

1992
Solubility of I-653, sevoflurane, isoflurane, and halothane in human tissues.
    Anesthesia and analgesia, 1989, Volume: 69, Issue:3

    Topics: Aged; Aging; Anesthetics; Chromatography, Gas; Desflurane; Ethers; Halothane; Humans; Isoflurane; Me

1989
Partition coefficients for sevoflurane in human blood, saline, and olive oil.
    Anesthesia and analgesia, 1987, Volume: 66, Issue:7

    Topics: Adult; Aged; Aging; Anesthesia, Inhalation; Anesthetics; Chromatography, Gas; Ethers; Hemoglobins; H

1987