sevoflurane has been researched along with Aging in 95 studies
Sevoflurane: A non-explosive inhalation anesthetic used in the induction and maintenance of general anesthesia. It does not cause respiratory irritation and may also prevent PLATELET AGGREGATION.
sevoflurane : An ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We set up to determine the incidence and duration of postoperative delirium in older patients who had surgery under the intravenous anesthetic propofol or the inhalational anesthetic sevoflurane." | 9.34 | The Effects of Propofol and Sevoflurane on Postoperative Delirium in Older Patients: A Randomized Clinical Trial Study. ( Li, C; Ma, X; Marcantonio, E; Mei, X; Shen, Y; Xie, Z; Zheng, H; Zheng, HL, 2020) |
| "During the first 10 min after sevoflurane administration, A (sev) in the hyperventilation group was the highest and differed significantly from those in the normal ventilation group, followed by those in the hypoventilation group." | 9.17 | Hyperventilation accelerates rise in arterial blood concentrations of sevoflurane in gynecologic patients. ( Chen, RM; Chen, TL; Ho, ST; Hsu, CH; Ku, CH; Lin, TC; Lu, CC; Yu, MH, 2013) |
| " We recently found that the anaesthetization of aging C57BL/6 J mice (14-16 months) with sevoflurane (3%, two hours each day for three consecutive days) can induce cognitive dysfunction and synaptic plasticity deficits." | 8.12 | Sevoflurane inhibits histone acetylation and contributes to cognitive dysfunction by enhancing the expression of ANP32A in aging mice. ( Chai, G; Fang, R; Jiang, Z; Liu, Y; Nie, Y; Wang, X; Wu, J; Yi, H; Zhang, D; Zhang, J; Zhao, P; Zhou, J, 2022) |
| "To investigate the effects of C1q/tumor necrosis factor-related protein-3 (CTRP3) on postoperative cognitive dysfunction (POCD) and elucidate the potential regulatory mechanism in sevoflurane anesthesia-induced aged rats." | 7.96 | Neuroprotective effect of CTRP3 overexpression against sevoflurane anesthesia-induced cognitive dysfunction in aged rats through activating AMPK/SIRT1 and PI3K/AKT signaling pathways. ( Xu, YC; Yang, LH; Zhang, W, 2020) |
| " However, little is known about whether TLR4 is associated with sevoflurane-induced cognitive decline." | 7.96 | Sevoflurane-induced cognitive decline in aged mice: Involvement of toll-like receptors 4. ( Dong, N; Fei, X; Sheng, ZY; Wang, JX; Wu, Y, 2020) |
| "The present study was aimed to observe the protective effect of rapamycin on cognitive dysfunction induced by sevoflurane in aged rats and its effect on autophagy‑related proteins, and to investigate the regulatory mechanism of the Toll‑like receptor 4/myeloid differentiation primary response 88/nuclear factor‑κB (TLR4/MyD88/NF‑κB) signaling pathway." | 7.91 | Rapamycin improves sevoflurane‑induced cognitive dysfunction in aged rats by mediating autophagy through the TLR4/MyD88/NF‑κB signaling pathway. ( Li, Y; Liu, L; Tian, Y; Zhang, J, 2019) |
| "Sevoflurane anesthesia impaired cognitive functions, as well as metabotropic glutamate receptor-dependent long-term depression, through elevated surface expression of small conductance calcium-activated potassium type 2 channels." | 7.91 | Sevoflurane anesthesia impairs metabotropic glutamate receptor-dependent long-term depression and cognitive functions in senile mice. ( Shi, J; Yu, X; Zhang, F, 2019) |
| "We set up to determine the incidence and duration of postoperative delirium in older patients who had surgery under the intravenous anesthetic propofol or the inhalational anesthetic sevoflurane." | 5.34 | The Effects of Propofol and Sevoflurane on Postoperative Delirium in Older Patients: A Randomized Clinical Trial Study. ( Li, C; Ma, X; Marcantonio, E; Mei, X; Shen, Y; Xie, Z; Zheng, H; Zheng, HL, 2020) |
| "During the first 10 min after sevoflurane administration, A (sev) in the hyperventilation group was the highest and differed significantly from those in the normal ventilation group, followed by those in the hypoventilation group." | 5.17 | Hyperventilation accelerates rise in arterial blood concentrations of sevoflurane in gynecologic patients. ( Chen, RM; Chen, TL; Ho, ST; Hsu, CH; Ku, CH; Lin, TC; Lu, CC; Yu, MH, 2013) |
| "Sevoflurane is a new volatile anesthetic with physical properties that should make it suitable for anesthesia (MAC of sevoflurane on oxygen alone and in 60% nitrous oxide, (MAC) of sevoflurane in oxygen alone and in 60% nitrous oxide, the hemodynamic, induction and emergence responses to sevoflurane and the metabolism to inorganic fluoride were studied in 90 ASA physical status 1 or 2 neonates, infants, and children." | 5.07 | The pharmacology of sevoflurane in infants and children. ( Kleinman, S; Lerman, J; Sikich, N; Yentis, S, 1994) |
| " We recently found that the anaesthetization of aging C57BL/6 J mice (14-16 months) with sevoflurane (3%, two hours each day for three consecutive days) can induce cognitive dysfunction and synaptic plasticity deficits." | 4.12 | Sevoflurane inhibits histone acetylation and contributes to cognitive dysfunction by enhancing the expression of ANP32A in aging mice. ( Chai, G; Fang, R; Jiang, Z; Liu, Y; Nie, Y; Wang, X; Wu, J; Yi, H; Zhang, D; Zhang, J; Zhao, P; Zhou, J, 2022) |
| "To investigate the effects of C1q/tumor necrosis factor-related protein-3 (CTRP3) on postoperative cognitive dysfunction (POCD) and elucidate the potential regulatory mechanism in sevoflurane anesthesia-induced aged rats." | 3.96 | Neuroprotective effect of CTRP3 overexpression against sevoflurane anesthesia-induced cognitive dysfunction in aged rats through activating AMPK/SIRT1 and PI3K/AKT signaling pathways. ( Xu, YC; Yang, LH; Zhang, W, 2020) |
| " However, little is known about whether TLR4 is associated with sevoflurane-induced cognitive decline." | 3.96 | Sevoflurane-induced cognitive decline in aged mice: Involvement of toll-like receptors 4. ( Dong, N; Fei, X; Sheng, ZY; Wang, JX; Wu, Y, 2020) |
| "The present study was aimed to observe the protective effect of rapamycin on cognitive dysfunction induced by sevoflurane in aged rats and its effect on autophagy‑related proteins, and to investigate the regulatory mechanism of the Toll‑like receptor 4/myeloid differentiation primary response 88/nuclear factor‑κB (TLR4/MyD88/NF‑κB) signaling pathway." | 3.91 | Rapamycin improves sevoflurane‑induced cognitive dysfunction in aged rats by mediating autophagy through the TLR4/MyD88/NF‑κB signaling pathway. ( Li, Y; Liu, L; Tian, Y; Zhang, J, 2019) |
| "Sevoflurane anesthesia impaired cognitive functions, as well as metabotropic glutamate receptor-dependent long-term depression, through elevated surface expression of small conductance calcium-activated potassium type 2 channels." | 3.91 | Sevoflurane anesthesia impairs metabotropic glutamate receptor-dependent long-term depression and cognitive functions in senile mice. ( Shi, J; Yu, X; Zhang, F, 2019) |
| "Objective This study aimed to evaluate the role of the hippocampal 5-hydroxytryptamine-1A (5-HT1A)-mediated cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) signalling pathway in sevoflurane-induced cognitive dysfunction in aged rats." | 3.88 | Role of the hippocampal 5-HT1A receptor-mediated cAMP/PKA signalling pathway in sevoflurane-induced cognitivedysfunction in aged rats. ( Qiu, Y; Wang, C; Wang, X; Wang, Y; Xia, ZY, 2018) |
| "Additionally, trisomy 21 (P = 0." | 2.76 | Factors affecting the decision to defer endotracheal extubation after surgery for congenital heart disease: a prospective observational study. ( Bodian, C; Chakravarti, S; Hollinger, I; Hossain, S; Kin, N; Krol, M; Mittnacht, AJ; Nguyen, K; Srivastava, S; Weismann, C, 2011) |
| "Sevoflurane was administered to achieve steady-state end-tidal sevoflurane concentrations (ET(sevo)) of 2." | 2.71 | Correlation of bispectral index with end-tidal sevoflurane concentration and age in infants and children. ( Kim, CS; Kim, HS; Kim, JH; Kim, SD; Oh, AY; Seo, KS, 2005) |
| "Fentanyl was administered at predicted plasma concentrations of 1 and 2 ng mg-1 using a computer-controlled continuous infusion and plasma concentrations of fentanyl were measured at the time of MAC-awake measurements." | 2.67 | Effect of fentanyl on awakening concentration of sevoflurane. ( Ikeda, K; Katoh, T; Uchiyama, T, 1994) |
| "Lovastatin treatment also inhibited the increased expressions of β-secretase 1 (BACE1) and γ-secretase in hippocampal neurons under sevoflurane exposure in vitro." | 1.62 | Lovastatin attenuates sevoflurane-induced cognitive disorder in aged rats via reducing Aβ accumulation. ( Chu, H; Dong, Y; Jiang, Q; Tian, Y; Wang, C; Xu, Y, 2021) |
| "Sevoflurane anesthesia has been implicated in both postoperative cognitive dysfunction and neurotoxicity." | 1.56 | Sevoflurane anesthesia-mediated oxidative stress and cognitive impairment in hippocampal neurons of old rats can be ameliorated by expression of brain derived neurotrophic factor. ( Qian, B; Xu, Z, 2020) |
| " The authors used the ND23 mutant for testing the hypothesis that anesthetics have toxic potential in carriers of mitochondrial mutations." | 1.56 | Mitochondrial Complex I Mutations Predispose Drosophila to Isoflurane Neurotoxicity. ( Ganetzky, B; Olufs, ZPG; Perouansky, M; Wassarman, DA, 2020) |
| "Sevoflurane has been found to increase apoptosis and pathologic markers associated with Alzheimer disease, provoking concern over their potential contribution to postoperative cognitive dysfunction." | 1.43 | Sevoflurane anesthesia induces neither contextual fear memory impairment nor alterations in local population connectivity of medial prefrontal cortex local field potentials networks in aged rats. ( Tian, X; Wang, G; Xu, X; Zhang, Q, 2016) |
| "Increasingly more aged people with Alzheimer's disease (AD) must undergo surgery with general anesthesia for various reasons." | 1.40 | Smaller sized inhaled anesthetics have more potency on senescence-accelerated prone-8 mice compared with senescence-resistant-1 mice. ( Deng, Y; He, Z; Lu, B; Qi, B; Su, D; Tian, J; Wang, X; Xu, H; Zheng, B, 2014) |
| "Sevoflurane is a commonly used anesthetic in children." | 1.40 | Sevoflurane induces tau phosphorylation and glycogen synthase kinase 3β activation in young mice. ( Crosby, G; Culley, DJ; Dong, Y; Tao, G; Xie, Z; Yu, B; Zhang, J; Zhang, L; Zhang, Y, 2014) |
| "Patients with Alzheimer's disease (AD) exhibit a failure in the clearance of amyloid β peptides (Aβ) from the central nervous system." | 1.39 | Sevoflurane alters the expression of receptors and enzymes involved in Aβ clearance in rats. ( Gao, M; Liu, Y; Ma, L; Pan, N; Zhang, L, 2013) |
| "Sevoflurane was administered at 2 % volume inspiratory concentration, 6 L." | 1.38 | Oxidative stress and antioxidant activity of female rat liver tissue after sevoflurane anaesthesia: young versus old. ( Arslan, M; Isik, B; Kavutcu, M; Kurtipek, O, 2012) |
| "Sevoflurane was vaporized in sealed roller culture vials to produce a continuous saturating dose (0." | 1.29 | Biotransformation of sevoflurane by rat neonate liver slices. ( Brendel, K; Gandolfi, AJ; Morgan, SE; Payne, AK, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (2.11) | 18.7374 |
| 1990's | 11 (11.58) | 18.2507 |
| 2000's | 24 (25.26) | 29.6817 |
| 2010's | 40 (42.11) | 24.3611 |
| 2020's | 18 (18.95) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, S | 1 |
| Liu, Y | 3 |
| Huang, S | 1 |
| Jin, F | 1 |
| Qi, F | 1 |
| Hao, C | 1 |
| Duan, X | 1 |
| Yang, X | 1 |
| Huang, Z | 1 |
| Li, F | 1 |
| Yang, J | 2 |
| Chai, G | 1 |
| Wu, J | 1 |
| Fang, R | 1 |
| Wang, X | 4 |
| Zhang, J | 3 |
| Zhou, J | 1 |
| Jiang, Z | 1 |
| Yi, H | 1 |
| Nie, Y | 1 |
| Zhao, P | 1 |
| Zhang, D | 1 |
| Li, Y | 2 |
| Liu, L | 2 |
| Tian, Y | 4 |
| Yang, Y | 1 |
| Wu, ZY | 1 |
| Lin, XF | 1 |
| Zhang, C | 1 |
| Zhu, ZQ | 1 |
| Zhu, J | 2 |
| Zhang, Z | 2 |
| Jia, J | 2 |
| Wang, L | 2 |
| Yang, Q | 1 |
| Wang, Y | 2 |
| Chen, C | 2 |
| Xu, Z | 1 |
| Qian, B | 1 |
| Kreuzer, M | 1 |
| Stern, MA | 1 |
| Hight, D | 1 |
| Berger, S | 1 |
| Schneider, G | 1 |
| Sleigh, JW | 1 |
| García, PS | 1 |
| Yang, LH | 1 |
| Xu, YC | 1 |
| Zhang, W | 1 |
| Schiffman, HJ | 1 |
| Olufs, ZPG | 2 |
| Lasarev, MR | 1 |
| Wassarman, DA | 2 |
| Perouansky, M | 2 |
| Yang, XY | 1 |
| Li, QJ | 1 |
| Zhang, WC | 1 |
| Zheng, SQ | 1 |
| Qu, ZJ | 1 |
| Xi, Y | 1 |
| Wang, G | 3 |
| Mei, X | 1 |
| Zheng, HL | 1 |
| Li, C | 2 |
| Ma, X | 1 |
| Zheng, H | 1 |
| Marcantonio, E | 1 |
| Xie, Z | 2 |
| Shen, Y | 1 |
| Ganetzky, B | 1 |
| Fei, X | 1 |
| Wang, JX | 1 |
| Wu, Y | 1 |
| Dong, N | 1 |
| Sheng, ZY | 1 |
| Qu, Y | 1 |
| Li, H | 3 |
| Shi, C | 1 |
| Qian, M | 1 |
| Yang, N | 1 |
| Gao, X | 1 |
| Ni, C | 1 |
| Chen, Q | 1 |
| Chu, W | 1 |
| Sheng, R | 1 |
| Song, S | 1 |
| Ji, F | 1 |
| Jin, X | 1 |
| Pei, W | 1 |
| Fu, L | 1 |
| Li, SQ | 1 |
| Yu, Y | 2 |
| Fang, P | 1 |
| Zheng, F | 1 |
| Chen, T | 1 |
| Chang, J | 1 |
| Xie, L | 1 |
| Fang, Q | 2 |
| Wei, X | 1 |
| Zhou, L | 1 |
| Wang, S | 1 |
| Xu, Y | 1 |
| Dong, Y | 3 |
| Wang, C | 7 |
| Jiang, Q | 2 |
| Chu, H | 1 |
| Huang, L | 1 |
| Huang, K | 1 |
| Ning, H | 1 |
| Guo, S | 2 |
| Qiu, Y | 1 |
| Xia, ZY | 1 |
| Cornelissen, L | 1 |
| Kim, SE | 1 |
| Lee, JM | 1 |
| Brown, EN | 2 |
| Purdon, PL | 2 |
| Berde, CB | 1 |
| Yu, X | 1 |
| Zhang, F | 1 |
| Shi, J | 1 |
| Chen, G | 2 |
| Gong, M | 2 |
| Yan, M | 2 |
| Zhang, X | 2 |
| Gao, M | 1 |
| Ma, L | 2 |
| Zhang, L | 4 |
| Pan, N | 1 |
| Zhou, C | 1 |
| Chen, D | 1 |
| Fang, N | 1 |
| Yao, Y | 1 |
| Li, L | 2 |
| Xu, H | 1 |
| Lu, B | 1 |
| Zheng, B | 1 |
| Tian, J | 1 |
| Qi, B | 1 |
| Deng, Y | 1 |
| He, Z | 1 |
| Su, D | 1 |
| Sury, MR | 1 |
| Worley, A | 1 |
| Boyd, SG | 1 |
| McKeever, S | 1 |
| Johnston, L | 1 |
| Davidson, AJ | 2 |
| Wang, ZH | 1 |
| Ni, XL | 1 |
| Li, JN | 1 |
| Xiao, ZY | 1 |
| Zhang, LN | 1 |
| Tong, L | 1 |
| Dong, HL | 1 |
| Rhondali, O | 1 |
| Juhel, S | 1 |
| Mathews, S | 1 |
| Cellier, Q | 1 |
| Desgranges, FP | 1 |
| Mahr, A | 1 |
| De Queiroz, M | 1 |
| Pouyau, A | 1 |
| Rhzioual-Berrada, K | 1 |
| Chassard, D | 1 |
| Tao, G | 1 |
| Yu, B | 1 |
| Crosby, G | 1 |
| Culley, DJ | 1 |
| Zhang, Y | 3 |
| Dong, P | 1 |
| Zhao, J | 1 |
| Dong, J | 1 |
| Li, D | 1 |
| Yang, B | 1 |
| Lei, W | 1 |
| Schwartz, D | 1 |
| Begley, A | 1 |
| Gibson, C | 1 |
| Visintainer, P | 1 |
| Connelly, NR | 1 |
| Wu, X | 1 |
| Zhao, X | 1 |
| Acharya, NK | 1 |
| Goldwaser, EL | 1 |
| Forsberg, MM | 1 |
| Godsey, GA | 1 |
| Johnson, CA | 1 |
| Sarkar, A | 1 |
| DeMarshall, C | 1 |
| Kosciuk, MC | 1 |
| Dash, JM | 1 |
| Hale, CP | 1 |
| Leonard, DM | 1 |
| Appelt, DM | 1 |
| Nagele, RG | 1 |
| Hu, N | 1 |
| Wang, M | 1 |
| Xie, K | 1 |
| Wang, H | 1 |
| Pavone, KJ | 1 |
| Akeju, O | 1 |
| Smith, AC | 1 |
| Sampson, AL | 1 |
| Lee, J | 1 |
| Zhou, DW | 1 |
| Solt, K | 1 |
| Jiang, JJ | 1 |
| Lin, ZH | 1 |
| Fu, BJ | 1 |
| Zeng, YM | 1 |
| Xu, X | 1 |
| Zhang, Q | 1 |
| Tian, X | 1 |
| Fang, F | 1 |
| Lin, W | 1 |
| Ling, X | 1 |
| Song, R | 1 |
| Liu, Q | 1 |
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| Osthaus, WA | 1 |
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| Trocóniz, IF | 1 |
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| Hsu, YW | 1 |
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| Muñoz, HR | 2 |
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| Tanaka, K | 1 |
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| Nishikawa, K | 2 |
| Asada, A | 2 |
| Wiklund, A | 1 |
| Granon, S | 1 |
| Faure, P | 1 |
| Sundman, E | 1 |
| Changeux, JP | 1 |
| Eriksson, LI | 1 |
| YAMASHITA, K | 1 |
| IWASAKI, Y | 1 |
| UMAR, MA | 1 |
| ITAMI, T | 1 |
| Mordhorst, C | 1 |
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| Li, GJ | 1 |
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| Armstead, W | 1 |
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| Weismann, C | 1 |
| Srivastava, S | 1 |
| Chakravarti, S | 1 |
| Bodian, C | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Study on the Influencing Factors of Electroencephalogram Parameters Under Anesthesia[NCT04760028] | Phase 4 | 80 participants (Actual) | Interventional | 2021-03-01 | Completed | ||
| The Impact of Electroencephalogram (EEG) - Guided Inhalational Anesthetic Control on the Occurrence of EEG Discontinuity in Infants: A Prospective Randomized Controlled Trial[NCT05906225] | 78 participants (Anticipated) | Interventional | 2023-06-20 | Not yet recruiting | |||
| Study of an Intraoperative Frontal Electroencephalographic Marker of Preoperative Frailty in Patients Over 65 Years of Age for Elective Non-cardiac Surgery.[NCT04783662] | 60 participants (Actual) | Observational | 2021-05-13 | Completed | |||
| Cognitive Outcomes and Neuroimages Associated With Anesthesia-Related EEG Signatures[NCT03442179] | 24 participants (Actual) | Observational | 2019-02-13 | Active, not recruiting | |||
| The Role of Brain Wave Monitoring in Reducing the Incidence of Postoperative Cognitive Dysfunction[NCT04189861] | 100 participants (Anticipated) | Observational | 2020-01-24 | Recruiting | |||
| Development of a Pharmacodynamic Model for Propofol in Older Adults (Development phaRmacodynamic mOdel Propofol oLdEr adulTs: DROPLET)[NCT05790720] | 60 participants (Anticipated) | Interventional | 2023-12-01 | Not yet recruiting | |||
| Relationship Between Bispectral Index, EEG Features, and Propofol Effect-site Concentration in Young and Elderly Patients.[NCT04774120] | 30 participants (Actual) | Observational | 2020-12-11 | Completed | |||
| The Effect of Chronic Opioid Use on Minimum Alveolar Concentration of Sevoflurane for Maintaining Bispectral(BIS) Index Below 50 ; Prospective, Blind Study[NCT02582437] | 20 participants (Anticipated) | Interventional | 2015-06-30 | Recruiting | |||
| Effect of Two Plasma Concentrations of Remifentanil Through Target Controlled Anesthesia on Frequency and Intensity of Coughing During Extubation: Randomized Controlled Clinical Trial[NCT02711904] | Phase 4 | 110 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| Effective and Safe Morphine Dose for Patient Controlled Anesthesia in Supratentorial Craniotomies[NCT04313374] | Phase 4 | 90 participants (Actual) | Interventional | 2016-08-01 | Completed | ||
| Pre-emptive Scalp Infiltration With Dexamethasone Plus Ropivacaine vs. Ropivacaine for Relief of Postoperative Pain After Craniotomy in Adults[NCT03618264] | Phase 4 | 140 participants (Actual) | Interventional | 2019-04-04 | Completed | ||
| Pre-emptive Topical Lidocaine 5% Plaster for Prevention of Post-craniotomy Pain : a Protocol for a Randomized, Triple Blind, Placebo-controlled Trail[NCT04169854] | Phase 3 | 180 participants (Anticipated) | Interventional | 2020-10-15 | Recruiting | ||
| Evaluation of a Peri-Operative Continuous Bilateral Erector Spinae Plane (ESP) Continuous Catheter After Open Cardiac Surgery in Adults[NCT03901612] | Phase 4 | 0 participants (Actual) | Interventional | 2019-01-05 | Withdrawn (stopped due to covid and surgeon left) | ||
| Bilateral Erector Spinae Plane (ESP) Catheters Versus Single Shot ESP Block for Open Heart Surgery in Infants[NCT03593642] | 40 participants (Actual) | Interventional | 2018-10-01 | Completed | |||
| Core Temperature Variations During Midazolam vs Propofol Sedation for Neuraxial Anesthesia[NCT02502877] | 27 participants (Actual) | Interventional | 2015-07-31 | Completed | |||
| EEG to Monitor Propofol Anesthetic Depth in Infants and Toddlers[NCT05701748] | 120 participants (Anticipated) | Interventional | 2023-02-03 | Recruiting | |||
| EEG-based Depth of Anesthesia-monitoring During General Anesthesia - Effects on Time to Wake-up and Post-operative Cognition[NCT04529304] | 100 participants (Anticipated) | Interventional | 2021-01-08 | Recruiting | |||
| Use of Dexmedetomidine for Emergence Delirium in Children Undergoing General Anesthesia for Endovascular Interventional Neuroradiologic Procedures[NCT00857727] | Phase 3 | 33 participants (Actual) | Interventional | 2009-08-31 | Completed | ||
| Effect of Dexmedetomidine on Outcomes During Emergence From Retroperitoneal Laparoscopic Surgery[NCT02316236] | 66 participants (Actual) | Interventional | 2014-12-10 | Completed | |||
| An Intraoperative Infusion of Dexmedetomidine Reduces the Opioid Requirements for Pediatric Patients Undergoing Hypospadias Surgery[NCT00926705] | Phase 3 | 48 participants (Actual) | Interventional | 2008-06-30 | Completed | ||
| Effect of Increasing Depth of Dexmedetomidine and Propofol Anesthesia on Upper Airway Morphology in Children With History of Obstructive Sleep Apnea[NCT01344759] | Phase 4 | 60 participants (Actual) | Interventional | 2009-06-30 | Completed | ||
| Personalizing Perioperative Morphine Analgesia for Adolescents Undergoing Major Spine Surgeries[NCT01839461] | 137 participants (Actual) | Observational | 2009-07-31 | Completed | |||
| Evaluation of Pupillary Distension Reflexes, as a Tool for the Monitoring of Analgesia for Patients in Intensive Care.[NCT02843893] | 51 participants (Actual) | Interventional | 2012-04-30 | Completed | |||
| Optimal Positive End-expiratory Pressure (PEEP) in Prone Position During Spine Surgery. A Prospective Observational Study[NCT04024410] | 20 participants (Actual) | Observational | 2019-06-03 | Completed | |||
| A Prospective Randomized Clinical Trial Evaluating the Effect of Convective Pre-warming on Intra-operative Thermoregulatory Capabilities in Patients Enrolled in the TIGER Anesthesia Perioperative Protocol[NCT03876808] | 10 participants (Actual) | Interventional | 2017-10-26 | Terminated (stopped due to Poor participant recruitment) | |||
| Neuromodulation With Percutaneous Electrical Nerve Field Stimulation for Adults With COVID-19[NCT04514627] | 100 participants (Anticipated) | Interventional | 2020-07-13 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00857727)
Timeframe: Day 1
| Intervention | minutes (Mean) |
|---|---|
| Drug | 199 |
| Control | 215 |
(NCT00857727)
Timeframe: Day 1
| Intervention | minutes (Mean) |
|---|---|
| Drug | 58 |
| Control | 86 |
Total Drug used (NCT00857727)
Timeframe: Day 1
| Intervention | mcg/kg (Mean) |
|---|---|
| Drug | 2.33 |
| Control | 2.36 |
Total Drug used (NCT00857727)
Timeframe: Day 1
| Intervention | mg/kg (Mean) |
|---|---|
| Drug | 2.11 |
| Control | 2.41 |
Total Drug used (NCT00857727)
Timeframe: Day 1
| Intervention | ml/kg (Mean) |
|---|---|
| Drug | 3.67 |
| Control | 6.80 |
Total Study Drug used (NCT00857727)
Timeframe: Day 1
| Intervention | mcg/kg (Mean) |
|---|---|
| Drug | 1.55 |
| Control | 1.43 |
(NCT00857727)
Timeframe: Baseline
| Intervention | kg (Mean) |
|---|---|
| Drug | 21.8 |
| Control | 18.5 |
Emergence Delirium (ED) during the 15-45min. post-op period as assessed by the Cole Score. (Cole Score 3-5 = ED). The Cole Scale is an ordinal ranking of ED (1=sleeping; 2=awake, calm; 3=irritable, crying; 4=inconsolable, crying; 5=severe restlessness, disorientation). (NCT00857727)
Timeframe: 15-45 minutes post-op
| Intervention | participants (Number) | |
|---|---|---|
| ED | No ED | |
| Control | 7 | 7 |
| Drug | 1 | 13 |
This is the count of the number of patients who needed an artificial airway. (NCT01344759)
Timeframe: During MRI and until recovery room discharge - approximately 30-250 minutes
| Intervention | Number of artifical airway events (Number) |
|---|---|
| Mild OSA and Dexmedetomidine | 0 |
| Mild OSA and Propofol | 1 |
| Moderate OSA and Dexmedetomidine | 1 |
| Moderate OSA and Propofol | 1 |
| Severe OSA and Dexmedetomidine | 2 |
| Severe OSA and Propofol | 5 |
The Obstructive Index is a count of the obstructive apnea events per hour of sleep (NCT01344759)
Timeframe: During MRI and until recovery room discharge - approximately 30-250 minutes
| Intervention | Apnea events/hour of sleep (Mean) |
|---|---|
| Mild OSA and Dexmedetomidine | 4.2 |
| Mild OSA and Propofol | 3.0 |
| Moderate OSA and Dexmedetomidine | 8.0 |
| Moderate OSA and Propofol | 8.0 |
| Severe OSA and Dexmedetomidine | 16.7 |
| Severe OSA and Propofol | 17.1 |
The respiratory disturbance index is a count of respiratory disturbance events per hour of sleep. (NCT01344759)
Timeframe: During MRI and until recovery room discharge - approximately 30-250 minutes
| Intervention | respir.disturbance events/hr of sleep (Mean) |
|---|---|
| Mild OSA and Dexmedetomidine | 5.1 |
| Mild OSA and Propofol | 3.2 |
| Moderate OSA and Dexmedetomidine | 8.8 |
| Moderate OSA and Propofol | 7.1 |
| Severe OSA and Dexmedetomidine | 16.6 |
| Severe OSA and Propofol | 25.2 |
The patient's oxygen saturation on room air. (NCT01344759)
Timeframe: During MRI and until recovery room discharge - approximately 30-250 minutes
| Intervention | percentage of SpO2 (Mean) |
|---|---|
| Mild OSA and Dexmedetomidine | 87.2 |
| Mild OSA and Propofol | 88.0 |
| Moderate OSA and Dexmedetomidine | 86.3 |
| Moderate OSA and Propofol | 89.0 |
| Severe OSA and Dexmedetomidine | 84.0 |
| Severe OSA and Propofol | 88.0 |
The primary outcome measures will be the cross sectional area of the pharyngeal airway of the patients measured at two levels soft palate (nasopharyngeal) and base of the tongue (retroglossal). Magnetic resonance images of the airway were obtained during low (1 mcg/kg/hr) and high (3 mcg/kg/hr) doses of DEX or low (100 mcg/kg/m) and high (200 mcg/kg/m) doses of Propofol. All were administered through an intravenous (IV) catheter. (NCT01344759)
Timeframe: during MRI within first 10 minutes of scanning
| Intervention | mm^2 (Median) | |||
|---|---|---|---|---|
| Low Dose Sedative, Nasopharyngeal measurement | High Dose Sedative, Nasopharyngeal measurement | Low Dose Sedative, Retroglossal measurement | High dose sedative, Retroglossal measurement | |
| Dexmedetomidine | 178.5 | 235.4 | 120.9 | 120.5 |
| Propofol | 239.9 | 201.6 | 115.1 | 108.1 |
Change in core temperature between induction of anesthesia and end of skin preparation (NCT03876808)
Timeframe: Day 1
| Intervention | Degrees Celsius (Mean) |
|---|---|
| Convective Pre-warming | -0.95 |
| Standard of Care | -0.53 |
Core body temperature measured intraoperatively (NCT03876808)
Timeframe: Day 1
| Intervention | Degrees Celsius (Mean) |
|---|---|
| Convective Pre-warming | 36.0 |
| Standard of Care | 35.7 |
Change in skin temperature between arrival to the holding area and departure to the operating room, and arrival to the PACU (NCT03876808)
Timeframe: Day 1
| Intervention | Degrees Celsius (Mean) | |
|---|---|---|
| Holding area to operating room departure | Holding area to arrival in PACU | |
| Convective Pre-warming | -0.03 | -0.07 |
| Standard of Care | 0.08 | -0.48 |
Differences in temperature changes between elderly (≥ 65 years) and younger patients (< 65 years). (NCT03876808)
Timeframe: Day 1
| Intervention | Degrees Celcius (Mean) |
|---|---|
| Temperature before prewarming - Patients >65 years of age | |
| Standard of Care | 36.5 |
Differences in temperature changes between elderly (≥ 65 years) and younger patients (< 65 years). (NCT03876808)
Timeframe: Day 1
| Intervention | Degrees Celcius (Mean) | |||
|---|---|---|---|---|
| Temperature before prewarming - Patients <65 years of age | Temperature before prewarming - Patients >65 years of age | Temperature after prewarming - Patients <65 years of age | Temperature after prewarming - Patients >65 years of age | |
| Convective Pre-warming | 36.5 | 36.6 | 36.5 | 36.4 |
1 review available for sevoflurane and Aging
| Article | Year |
|---|---|
The EEG signal: a window on the cortical brain activity.
Topics: Adult; Aging; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Cerebral Cortex; Child; | 2012 |
21 trials available for sevoflurane and Aging
| Article | Year |
|---|---|
The Effects of Propofol and Sevoflurane on Postoperative Delirium in Older Patients: A Randomized Clinical Trial Study.
Topics: Aged; Aged, 80 and over; Aging; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intra | 2020 |
Sevoflurane-induced changes in infants' quantifiable electroencephalogram parameters.
Topics: Aging; Anesthesia, Inhalation; Anesthetics, Inhalation; Child, Preschool; Consciousness Monitors; Cr | 2014 |
Advance of age decreases the minimum alveolar concentrations of isoflurane and sevoflurane for maintaining bispectral index below 50.
Topics: Adult; Aged; Aging; Anesthetics, Inhalation; Double-Blind Method; Drug Administration Schedule; Elec | 2009 |
Advance of age decreases the minimum alveolar concentrations of isoflurane and sevoflurane for maintaining bispectral index below 50.
Topics: Adult; Aged; Aging; Anesthetics, Inhalation; Double-Blind Method; Drug Administration Schedule; Elec | 2009 |
Advance of age decreases the minimum alveolar concentrations of isoflurane and sevoflurane for maintaining bispectral index below 50.
Topics: Adult; Aged; Aging; Anesthetics, Inhalation; Double-Blind Method; Drug Administration Schedule; Elec | 2009 |
Advance of age decreases the minimum alveolar concentrations of isoflurane and sevoflurane for maintaining bispectral index below 50.
Topics: Adult; Aged; Aging; Anesthetics, Inhalation; Double-Blind Method; Drug Administration Schedule; Elec | 2009 |
Factors affecting the decision to defer endotracheal extubation after surgery for congenital heart disease: a prospective observational study.
Topics: Adolescent; Aging; Analgesics, Opioid; Anesthesia, Inhalation; Anesthetics, Dissociative; Anesthetic | 2011 |
Factors affecting the decision to defer endotracheal extubation after surgery for congenital heart disease: a prospective observational study.
Topics: Adolescent; Aging; Analgesics, Opioid; Anesthesia, Inhalation; Anesthetics, Dissociative; Anesthetic | 2011 |
Factors affecting the decision to defer endotracheal extubation after surgery for congenital heart disease: a prospective observational study.
Topics: Adolescent; Aging; Analgesics, Opioid; Anesthesia, Inhalation; Anesthetics, Dissociative; Anesthetic | 2011 |
Factors affecting the decision to defer endotracheal extubation after surgery for congenital heart disease: a prospective observational study.
Topics: Adolescent; Aging; Analgesics, Opioid; Anesthesia, Inhalation; Anesthetics, Dissociative; Anesthetic | 2011 |
Lipid-emulsion propofol less attenuates the regulation of body temperature than micro-emulsion propofol or sevoflurane in the elderly.
Topics: Aged; Aging; Anesthesia, General; Anesthetics, Combined; Anesthetics, Inhalation; Anesthetics, Intra | 2012 |
The effects of age, isoflurane and sevoflurane on atracurium in lambs.
Topics: Aging; Anesthetics, Inhalation; Animals; Atracurium; Body Temperature; Dose-Response Relationship, D | 2012 |
Hyperventilation accelerates rise in arterial blood concentrations of sevoflurane in gynecologic patients.
Topics: Adult; Aging; Anesthesia, Inhalation; Anesthetics, Inhalation; Arteries; Carbon Dioxide; Chromatogra | 2013 |
[Neuromuscular blockade with cisatracurium in infants andchildren. Its course under sevoflurane anesthesia].
Topics: Aging; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intrav | 2002 |
Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children.
Topics: Aging; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure; | 2004 |
Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children.
Topics: Aging; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure; | 2004 |
Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children.
Topics: Aging; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure; | 2004 |
Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children.
Topics: Aging; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure; | 2004 |
Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children.
Topics: Aging; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure; | 2004 |
Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children.
Topics: Aging; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure; | 2004 |
Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children.
Topics: Aging; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure; | 2004 |
Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children.
Topics: Aging; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure; | 2004 |
Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children.
Topics: Aging; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure; | 2004 |
Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children.
Topics: Aging; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure; | 2004 |
Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children.
Topics: Aging; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure; | 2004 |
Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children.
Topics: Aging; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure; | 2004 |
Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children.
Topics: Aging; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure; | 2004 |
Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children.
Topics: Aging; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure; | 2004 |
Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children.
Topics: Aging; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure; | 2004 |
Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children.
Topics: Aging; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure; | 2004 |
Single-breath vital capacity rapid inhalation induction with sevoflurane: feasibility in children.
Topics: Adjuvants, Anesthesia; Adolescent; Aging; Anesthesia, Inhalation; Anesthetics, Inhalation; Child; Ch | 2005 |
Correlation of bispectral index with end-tidal sevoflurane concentration and age in infants and children.
Topics: Aging; Anesthetics, Inhalation; Blood Pressure; Child; Child, Preschool; Dose-Response Relationship, | 2005 |
Differential electroencephalographic response to tracheal intubation between young and elderly during isoflurane and sevoflurane nitrous oxide anaesthesia.
Topics: Adult; Aged; Aged, 80 and over; Aging; Anesthetics, Combined; Anesthetics, Inhalation; Blood Pressur | 2007 |
Edrophonium as an antagonist of vecuronium-induced neuromuscular block in the elderly.
Topics: Adult; Aged; Aged, 80 and over; Aging; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressu | 1995 |
Effect of fentanyl on awakening concentration of sevoflurane.
Topics: Adult; Aging; Anesthesia Recovery Period; Anesthesia, General; Anesthetics; Awareness; Dose-Response | 1994 |
The pharmacology of sevoflurane in infants and children.
Topics: Aging; Anesthesia; Anesthetics; Blood Pressure; Child; Child, Preschool; Dermatologic Surgical Proce | 1994 |
The pharmacology of sevoflurane in infants and children.
Topics: Aging; Anesthesia; Anesthetics; Blood Pressure; Child; Child, Preschool; Dermatologic Surgical Proce | 1994 |
The pharmacology of sevoflurane in infants and children.
Topics: Aging; Anesthesia; Anesthetics; Blood Pressure; Child; Child, Preschool; Dermatologic Surgical Proce | 1994 |
The pharmacology of sevoflurane in infants and children.
Topics: Aging; Anesthesia; Anesthetics; Blood Pressure; Child; Child, Preschool; Dermatologic Surgical Proce | 1994 |
The minimum alveolar concentration (MAC) of sevoflurane with and without nitrous oxide in elderly versus young adults.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthetics, Inhalation; Cross-Over Studies; Dose | 1996 |
Cerebrovascular CO2 reactivity in elderly and younger adult patients during sevoflurane anaesthesia.
Topics: Adult; Aged; Aging; Anesthetics, Inhalation; Blood Flow Velocity; Carbon Dioxide; Cerebrovascular Ci | 1997 |
[Transcranial doppler sonography. Effect of sevoflurane in comparison to isoflurane].
Topics: Adolescent; Adult; Aging; Anesthesia, Inhalation; Anesthetics, Inhalation; Body Height; Body Weight; | 1997 |
Influence of age on hypnotic requirement, bispectral index, and 95% spectral edge frequency associated with sedation induced by sevoflurane.
Topics: Adult; Aged; Aged, 80 and over; Aging; Anesthetics, Inhalation; Conscious Sedation; Dose-Response Re | 2000 |
Effective doses of cisatracurium. Potentiation by sevoflurane and increasing requirements with age.
Topics: Aging; Anesthesia, General; Anesthetics, Inhalation; Atracurium; Drug Synergism; Female; Humans; Mal | 2000 |
Aging reduces the efficacy of the simulated epidural test dose in anesthetized adults.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Aging; Anesthesia, Epidural; Anesthesia, Inhalat | 2000 |
73 other studies available for sevoflurane and Aging
| Article | Year |
|---|---|
Sevoflurane and isoflurane inhibit KCl-induced, Rho kinase-mediated, and PI3K-participated vasoconstriction in aged diabetic rat aortas.
Topics: Aging; Amides; Anesthetics, Inhalation; Animals; Aorta; Chromones; Diabetes Mellitus, Experimental; | 2021 |
Role of RGS2 in sevoflurane-induced cognitive dysfunction in aged rats.
Topics: Aging; Animals; bcl-2-Associated X Protein; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Typ | 2022 |
Sevoflurane inhibits histone acetylation and contributes to cognitive dysfunction by enhancing the expression of ANP32A in aging mice.
Topics: Acetylation; Aging; Animals; Cognitive Dysfunction; Histones; Mice; Mice, Inbred C57BL; Nuclear Prot | 2022 |
Rapamycin improves sevoflurane‑induced cognitive dysfunction in aged rats by mediating autophagy through the TLR4/MyD88/NF‑κB signaling pathway.
Topics: Aging; Animals; Autophagic Cell Death; Cognitive Dysfunction; Male; Myeloid Differentiation Factor 8 | 2019 |
[Effects of Sevoflurane on the Cognitive Function and Hippocampal Ultrastructure of Elderly Model Rats].
Topics: Aging; Animals; Cognition; Hippocampus; Male; Maze Learning; Random Allocation; Rats; Rats, Sprague- | 2019 |
Sevoflurane Induces Learning and Memory Impairment in Young Mice Through a Reduction in Neuronal Glucose Transporter 3.
Topics: Aging; Animals; Apoptosis; Brain; Cell Membrane; Cells, Cultured; Glucose; Glucose Transporter Type | 2020 |
Sevoflurane anesthesia-mediated oxidative stress and cognitive impairment in hippocampal neurons of old rats can be ameliorated by expression of brain derived neurotrophic factor.
Topics: Administration, Inhalation; Aging; Anesthetics, Inhalation; Animals; Brain-Derived Neurotrophic Fact | 2020 |
Spectral and Entropic Features Are Altered by Age in the Electroencephalogram in Patients under Sevoflurane Anesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics, Inhalation; Ele | 2020 |
Neuroprotective effect of CTRP3 overexpression against sevoflurane anesthesia-induced cognitive dysfunction in aged rats through activating AMPK/SIRT1 and PI3K/AKT signaling pathways.
Topics: Adipokines; Aging; AMP-Activated Protein Kinases; Anesthetics, Inhalation; Animals; Apoptosis; Cogni | 2020 |
Ageing and genetic background influence anaesthetic effects in a D. melanogaster model of blunt trauma with brain injury
Topics: Aging; Anesthetics, Inhalation; Animals; Brain; Brain Injuries, Traumatic; Disease Models, Animal; D | 2020 |
AMPK-SIRT1-PGC1α Signal Pathway Influences the Cognitive Function of Aged Rats in Sevoflurane-Induced Anesthesia.
Topics: Aging; Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; Anesthetics, Inhalation; An | 2020 |
Mitochondrial Complex I Mutations Predispose Drosophila to Isoflurane Neurotoxicity.
Topics: Aging; Anesthetics, Inhalation; Animals; Animals, Genetically Modified; Drosophila; Electron Transpo | 2020 |
Sevoflurane-induced cognitive decline in aged mice: Involvement of toll-like receptors 4.
Topics: Aging; Anesthetics, Inhalation; Animals; Cognition; Cognitive Dysfunction; Cytokines; Hippocampus; M | 2020 |
lncRNAs Are Involved in Sevoflurane Anesthesia-Related Brain Function Modulation through Affecting Mitochondrial Function and Aging Process.
Topics: Aging; Anesthesia; Anesthetics; Animals; Brain; Brain Neoplasms; Cell Line, Tumor; Cognition Disorde | 2020 |
Maternal anesthesia with sevoflurane during the mid-gestation induces social interaction deficits in offspring C57BL/6 mice.
Topics: Aging; Anesthetics, Inhalation; Animals; Brain; Female; Male; Mice; Mice, Inbred C57BL; Mothers; Pre | 2021 |
Brain transcriptomics of nonhuman primates: A review.
Topics: Aging; Animals; Brain; Brain Diseases; Disease Models, Animal; Ethanol; Humans; Methamphetamine; Neu | 2021 |
NLRP3 inflammasome inhibition by histone acetylation ameliorates sevoflurane-induced cognitive impairment in aged mice by activating the autophagy pathway.
Topics: Acetylation; Aging; Animals; Autophagy; Cognitive Dysfunction; Hippocampus; Histone Deacetylase Inhi | 2021 |
Exogenous insulin-like growth factor 1 attenuates sevoflurane anesthesia-induced cognitive dysfunction in aged rats.
Topics: Aging; Anesthetics, Inhalation; Animals; Behavior, Animal; Disease Models, Animal; Down-Regulation; | 2021 |
Lovastatin attenuates sevoflurane-induced cognitive disorder in aged rats via reducing Aβ accumulation.
Topics: Aging; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Cognition; Cog | 2021 |
Hispidulin prevents sevoflurane- Induced memory dysfunction in aged rats.
Topics: Aging; Anesthetics, Inhalation; Animals; Apoptosis; Flavones; Male; Memory Disorders; Methyl Ethers; | 2018 |
Repeated exposure to sevoflurane impairs the learning and memory of older male rats.
Topics: Aging; Anesthetics, Inhalation; Animals; Apoptosis; Brain Chemistry; Brain-Derived Neurotrophic Fact | 2018 |
Role of the hippocampal 5-HT1A receptor-mediated cAMP/PKA signalling pathway in sevoflurane-induced cognitivedysfunction in aged rats.
Topics: Aging; Anesthetics, Inhalation; Animals; Cognitive Dysfunction; Cyclic AMP; Cyclic AMP Response Elem | 2018 |
Electroencephalographic markers of brain development during sevoflurane anaesthesia in children up to 3 years old.
Topics: Aging; Anesthesia, General; Anesthetics, Inhalation; Brain; Brain Mapping; Child Development; Child, | 2018 |
Sevoflurane anesthesia impairs metabotropic glutamate receptor-dependent long-term depression and cognitive functions in senile mice.
Topics: Aging; Anesthesia; Anesthetics, Inhalation; Animals; Cognition; Cognitive Dysfunction; Depression; E | 2019 |
Sevoflurane induces endoplasmic reticulum stress mediated apoptosis in hippocampal neurons of aging rats.
Topics: Aging; Anesthetics, Inhalation; Animals; Apoptosis; Blood Gas Analysis; Caspase 12; Endoplasmic Reti | 2013 |
Sevoflurane alters the expression of receptors and enzymes involved in Aβ clearance in rats.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Anesthetics, Inhalation; Animals; Blood-Brain Barri | 2013 |
Failure to protect against myocardial ischemia-reperfusion injury with sevoflurane postconditioning in old rats in vivo.
Topics: Aging; Anesthetics, Inhalation; Animals; Blotting, Western; Enzyme Activation; Ischemic Postconditio | 2013 |
Smaller sized inhaled anesthetics have more potency on senescence-accelerated prone-8 mice compared with senescence-resistant-1 mice.
Topics: Aging; Alzheimer Disease; Analysis of Variance; Anesthetics, Inhalation; Animals; Desflurane; Diseas | 2014 |
Age-related changes in EEG power spectra in infants during sevoflurane wash-out.
Topics: Aging; Anesthesia Recovery Period; Anesthetics, Inhalation; Electroencephalography; Female; Humans; | 2014 |
Changes in plasma orexin-A levels in sevoflurane-remifentanil anesthesia in young and elderly patients undergoing elective lumbar surgery.
Topics: Adult; Aged; Aging; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Inhalation; Anesth | 2014 |
Impact of sevoflurane anesthesia on brain oxygenation in children younger than 2 years.
Topics: Aging; Anesthesia, Inhalation; Anesthetics, Inhalation; Arterial Pressure; Brain Chemistry; Female; | 2014 |
Sevoflurane induces tau phosphorylation and glycogen synthase kinase 3β activation in young mice.
Topics: Aging; Anesthetics, Inhalation; Animals; Cognition Disorders; Enzyme Activation; Escape Reaction; Fe | 2014 |
Aging causes exacerbated ischemic brain injury and failure of sevoflurane post-conditioning: role of B-cell lymphoma-2.
Topics: Age Factors; Aging; Animals; Apoptosis; Brain; Brain Ischemia; Disease Models, Animal; Ischemic Post | 2014 |
Laryngeal mask airway placement in children prior to an intravenous line utilizing heart rate as an indicator of anesthetic depth.
Topics: Aging; Anesthesia; Anesthetics, Inhalation; Blood Pressure; Catheterization, Peripheral; Child; Chil | 2014 |
Minocycline alleviates sevoflurane-induced cognitive impairment in aged rats.
Topics: Aging; Amyloid beta-Peptides; Animals; Apoptosis; Cognition Disorders; Hippocampus; Inflammation; Le | 2015 |
Sevoflurane and Isoflurane induce structural changes in brain vascular endothelial cells and increase blood-brain barrier permeability: Possible link to postoperative delirium and cognitive decline.
Topics: Aging; Anesthetics, Inhalation; Animals; Blood-Brain Barrier; Capillary Permeability; Cognition Diso | 2015 |
Internalization of GluA2 and the underlying mechanisms of cognitive decline in aged rats following surgery and prolonged exposure to sevoflurane.
Topics: Aging; Anesthetics, Inhalation; Animals; Cognition Disorders; Conditioning, Psychological; Fear; Gen | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
Sevoflurane postconditioning affects post-ischaemic myocardial mitochondrial ATP-sensitive potassium channel function and apoptosis in ageing rats.
Topics: Aging; Animals; Apoptosis; bcl-2-Associated X Protein; Coronary Circulation; Decanoic Acids; Hemodyn | 2016 |
Sevoflurane anesthesia induces neither contextual fear memory impairment nor alterations in local population connectivity of medial prefrontal cortex local field potentials networks in aged rats.
Topics: Aging; Anesthetics, Inhalation; Animals; Conditioning, Psychological; Fear; Male; Memory; Memory Dis | 2016 |
The hippocampal cyclin D1 expression is involved in postoperative cognitive dysfunction after sevoflurane exposure in aged mice.
Topics: Aging; Anesthetics, Inhalation; Animals; Cognition Disorders; Cyclin D1; Hippocampus; Maze Learning; | 2016 |
The ageing brain.
Topics: Aging; Anesthesia, General; Brain; Electroencephalography; Propofol; Sevoflurane | 2016 |
The influence of age on the dynamic relationship between end-tidal sevoflurane concentrations and bispectral index.
Topics: Adolescent; Adult; Aged; Aging; Anesthetics, Inhalation; Child; Child, Preschool; Drug Hypersensitiv | 2008 |
Object memory in young and aged mice after sevoflurane anaesthesia.
Topics: Aging; Anesthetics, Inhalation; Animals; Discrimination Learning; Exploratory Behavior; Female; Male | 2009 |
Effect of age on minimum alveolar concentration (MAC) of sevoflurane in dogs.
Topics: Aging; Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Dogs; Methyl Ethers; Pulmonary Alve | 2009 |
Prospective assessment of postoperative pain after craniotomy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Anesthesia, General; Anesthes | 2010 |
Prospective assessment of postoperative pain after craniotomy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Anesthesia, General; Anesthes | 2010 |
Prospective assessment of postoperative pain after craniotomy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Anesthesia, General; Anesthes | 2010 |
Prospective assessment of postoperative pain after craniotomy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Anesthesia, General; Anesthes | 2010 |
Prospective assessment of postoperative pain after craniotomy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Anesthesia, General; Anesthes | 2010 |
Prospective assessment of postoperative pain after craniotomy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Anesthesia, General; Anesthes | 2010 |
Prospective assessment of postoperative pain after craniotomy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Anesthesia, General; Anesthes | 2010 |
Prospective assessment of postoperative pain after craniotomy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Anesthesia, General; Anesthes | 2010 |
Prospective assessment of postoperative pain after craniotomy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Anesthesia, General; Anesthes | 2010 |
The effect of sevoflurane anesthesia on cognitive function and the expression of Insulin-like Growth Factor-1 in CA1 region of hippocampus in old rats.
Topics: Aging; Anesthesia; Anesthetics, Inhalation; Animals; Cognition; Gene Expression Regulation; Hippocam | 2011 |
Gender differences in cerebrovascular reactivity to carbon dioxide during sevoflurane anesthesia in children: preliminary findings.
Topics: Adolescent; Aging; Anesthesia, Inhalation; Anesthetics, Inhalation; Carbon Dioxide; Cerebrovascular | 2011 |
Clinically relevant asymmetry of bispectral index during recovery from anaesthesia for ear-nose-throat surgery in adults and children.
Topics: Adult; Aging; Anesthesia; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Inhalation; | 2011 |
Responses of the second derivative of the finger photoplethysmogram indices and hemodynamic parameters to anesthesia induction.
Topics: Adult; Aged; Aging; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Area Under Curve; | 2012 |
Parecoxib mitigates spatial memory impairment induced by sevoflurane anesthesia in aged rats.
Topics: Aging; Anesthetics, Intravenous; Animals; Blotting, Western; Cognition Disorders; Cyclooxygenase 2; | 2012 |
Neonatal electroencephalography shows low sensitivity to anesthesia.
Topics: Aging; Analysis of Variance; Anesthesia; Anesthetics, Inhalation; Child, Preschool; Data Interpretat | 2012 |
The effect of aging on dopamine release and metabolism during sevoflurane anesthesia in rat striatum: an in vivo microdialysis study.
Topics: Aging; Anesthetics, Inhalation; Animals; Corpus Striatum; Dopamine; Male; Methyl Ethers; Microdialys | 2012 |
Oxidative stress and antioxidant activity of female rat liver tissue after sevoflurane anaesthesia: young versus old.
Topics: Aging; Anesthetics, Inhalation; Animals; Antioxidants; Female; Glutathione Transferase; Liver; Methy | 2012 |
Age and anesthetic effects on murine electrocardiography.
Topics: Aging; Anesthetics, Combined; Anesthetics, Inhalation; Animals; Disease Models, Animal; Electrocardi | 2003 |
Cerebral autoregulation in children during sevoflurane anaesthesia.
Topics: Adolescent; Adult; Aging; Analysis of Variance; Anesthesia, General; Anesthetics, Inhalation; Blood | 2003 |
Age-related iso-MAC charts for isoflurane, sevoflurane and desflurane in man.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Aging; Algorithms; Anesthetics, Inhalation; | 2003 |
Reduced efficacy of volatile anesthetic preconditioning with advanced age in isolated rat myocardium.
Topics: Adenosine Triphosphate; Aging; Anesthetics, Inhalation; Animals; Calcium; Creatine Kinase; Heart; He | 2004 |
Impact of age on both BIS values and EEG bispectrum during anaesthesia with sevoflurane in children.
Topics: Adolescent; Aging; Anesthetics, Inhalation; Body Weight; Child; Child, Preschool; Dose-Response Rela | 2005 |
Performance of entropy and Bispectral Index as measures of anaesthesia effect in children of different ages.
Topics: Aging; Anesthesia, Inhalation; Anesthetics, Inhalation; Child; Child, Preschool; Dose-Response Relat | 2005 |
Reflex pupillary dilatation in response to skin incision and alfentanil in children anaesthetized with sevoflurane: a more sensitive measure of noxious stimulation than the commonly used variables.
Topics: Adolescent; Aging; Alfentanil; Analgesics, Opioid; Anesthesia, Inhalation; Anesthetics, Inhalation; | 2006 |
Reflex pupillary dilatation in response to skin incision and alfentanil in children anaesthetized with sevoflurane: a more sensitive measure of noxious stimulation than the commonly used variables.
Topics: Adolescent; Aging; Alfentanil; Analgesics, Opioid; Anesthesia, Inhalation; Anesthetics, Inhalation; | 2006 |
Reflex pupillary dilatation in response to skin incision and alfentanil in children anaesthetized with sevoflurane: a more sensitive measure of noxious stimulation than the commonly used variables.
Topics: Adolescent; Aging; Alfentanil; Analgesics, Opioid; Anesthesia, Inhalation; Anesthetics, Inhalation; | 2006 |
Reflex pupillary dilatation in response to skin incision and alfentanil in children anaesthetized with sevoflurane: a more sensitive measure of noxious stimulation than the commonly used variables.
Topics: Adolescent; Aging; Alfentanil; Analgesics, Opioid; Anesthesia, Inhalation; Anesthetics, Inhalation; | 2006 |
Onset time for sevoflurane/nitrous oxide induction in adults is prolonged with increasing age.
Topics: Adult; Aged; Aging; Anesthesia, Inhalation; Anesthetics, Inhalation; Electroencephalography; Eyelash | 2006 |
Anesthetic implications of botulinum toxin type A (Botox) injections for the treatment of 'the aging face' in the parturient.
Topics: Adult; Aging; Anesthesia Recovery Period; Anesthesia, General; Anesthesia, Obstetrical; Anesthetics, | 2007 |
Perioperative management of patients with Cockayne syndrome - recognition of accelerated aging with growth arrest.
Topics: Adjuvants, Anesthesia; Adolescent; Aging; Anesthesia; Anesthetics, Inhalation; Cockayne Syndrome; Fe | 2008 |
Biotransformation of sevoflurane by rat neonate liver slices.
Topics: 1-Propanol; Aging; Anesthetics; Animals; Animals, Newborn; Biotransformation; Ethers; Fluorides; Glu | 1995 |
Influence of age on awakening concentrations of sevoflurane and isoflurane.
Topics: Adult; Aging; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics; Ethers; Female; Human | 1993 |
The threshold for thermoregulatory vasoconstriction during nitrous oxide/sevoflurane anesthesia is reduced in the elderly.
Topics: Adult; Aged; Aged, 80 and over; Aging; Anesthetics, Combined; Anesthetics, Inhalation; Body Temperat | 1997 |
The minimum alveolar concentration of sevoflurane in rats.
Topics: Aging; Anesthetics, Inhalation; Animals; Blood Gas Analysis; Ethers; Male; Methyl Ethers; Pulmonary | 1997 |
Comparison of volatile anesthetic effects on actin-myosin cross-bridge cycling in neonatal versus adult cardiac muscle.
Topics: Actins; Aging; Algorithms; Anesthetics, Inhalation; Animals; Animals, Newborn; Halothane; Heart; In | 2000 |
Plasma proinflammatory cytokine response to surgical stress in elderly patients.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Anesthetics, Inhalation; Anesthetics, Intravenou | 2001 |
Blood concentrations of sevoflurane and isoflurane on recovery from anaesthesia.
Topics: Adolescent; Adult; Aged; Aging; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics; Eth | 1992 |
Solubility of I-653, sevoflurane, isoflurane, and halothane in human tissues.
Topics: Aged; Aging; Anesthetics; Chromatography, Gas; Desflurane; Ethers; Halothane; Humans; Isoflurane; Me | 1989 |
Partition coefficients for sevoflurane in human blood, saline, and olive oil.
Topics: Adult; Aged; Aging; Anesthesia, Inhalation; Anesthetics; Chromatography, Gas; Ethers; Hemoglobins; H | 1987 |