sevoflurane has been researched along with Age-Related Memory Disorders in 55 studies
Sevoflurane: A non-explosive inhalation anesthetic used in the induction and maintenance of general anesthesia. It does not cause respiratory irritation and may also prevent PLATELET AGGREGATION.
sevoflurane : An ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Objective We compared the effects of sevoflurane and isoflurane on systemic inflammation, sepsis-associated encephalopathy, and memory impairment in a rat sepsis model of cecal ligation and puncture (CLP)-induced polymicrobial peritonitis." | 7.88 | Sevoflurane exerts brain-protective effects against sepsis-associated encephalopathy and memory impairment through caspase 3/9 and Bax/Bcl signaling pathway in a rat model of sepsis. ( Bagriacik, EU; Bedirli, A; Bedirli, N; Cavunt Bayraktar, A; Kavutçu, M; Ozkose, Z; Yilmaz, G, 2018) |
| "Although preoperative sleep deprivation is known to be an independent risk factor for postoperative cognitive dysfunction (POCD) after inhalation anesthesia, the circadian mechanisms involved are currently unclear." | 5.51 | REM sleep deprivation-induced circadian clock gene abnormalities participate in hippocampal-dependent memory impairment by enhancing inflammation in rats undergoing sevoflurane inhalation. ( Hou, J; Shen, Q; Wan, X; Wu, Y; Xia, Z; Zhao, B, 2019) |
| "Sevoflurane has been shown to stimulate or depress memory in adult rats; however, the cellular mechanism of this bidirectional effect has not been fully investigated." | 5.48 | Different doses of sevoflurane facilitate and impair learning and memory function through activation of the ERK pathway and synthesis of ARC protein in the rat hippocampus. ( Luo, Y; Xue, QS; Yu, BW; Zhang, FJ; Zhu, QL, 2018) |
| "Treatment with tetrandrine reduced the expression levels of COX‑2, IL‑1β, TNF‑α, NF‑κB, iNOS and caspase‑3, and increased the Bcl‑2 protein expression in sevoflurane‑treated aged rats." | 5.43 | Tetrandrine ameliorates sevoflurane‑induced cognitive impairment via the suppression of inflammation and apoptosis in aged rats. ( Li, X; Ma, H; Pang, L; Yao, L; Yao, Q, 2016) |
| "Focal cerebral ischemia was performed via 1h of middle cerebral artery occlusion (MCAO) followed by reperfusion." | 5.39 | Preconditioning with sevoflurane ameliorates spatial learning and memory deficit after focal cerebral ischemia-reperfusion in rats. ( Hu, X; Li, W; Li, Y; Liu, J; Zhang, Y, 2013) |
| "Objective We compared the effects of sevoflurane and isoflurane on systemic inflammation, sepsis-associated encephalopathy, and memory impairment in a rat sepsis model of cecal ligation and puncture (CLP)-induced polymicrobial peritonitis." | 3.88 | Sevoflurane exerts brain-protective effects against sepsis-associated encephalopathy and memory impairment through caspase 3/9 and Bax/Bcl signaling pathway in a rat model of sepsis. ( Bagriacik, EU; Bedirli, A; Bedirli, N; Cavunt Bayraktar, A; Kavutçu, M; Ozkose, Z; Yilmaz, G, 2018) |
| " The authors investigated whether exposure of neonatal mice to inhaled sevoflurane causes deficits in social behavior as well as learning disabilities." | 3.75 | Neonatal exposure to sevoflurane induces abnormal social behaviors and deficits in fear conditioning in mice. ( Imaki, J; Ito, M; Miyao, H; Satoh, Y; Satomoto, M; Takishima, K; Terui, K, 2009) |
| "Although preoperative sleep deprivation is known to be an independent risk factor for postoperative cognitive dysfunction (POCD) after inhalation anesthesia, the circadian mechanisms involved are currently unclear." | 1.51 | REM sleep deprivation-induced circadian clock gene abnormalities participate in hippocampal-dependent memory impairment by enhancing inflammation in rats undergoing sevoflurane inhalation. ( Hou, J; Shen, Q; Wan, X; Wu, Y; Xia, Z; Zhao, B, 2019) |
| "Sevoflurane has been shown to stimulate or depress memory in adult rats; however, the cellular mechanism of this bidirectional effect has not been fully investigated." | 1.48 | Different doses of sevoflurane facilitate and impair learning and memory function through activation of the ERK pathway and synthesis of ARC protein in the rat hippocampus. ( Luo, Y; Xue, QS; Yu, BW; Zhang, FJ; Zhu, QL, 2018) |
| "Sevoflurane is a general anesthetic, which has been found to cause cognitive and memory deficit in elderly." | 1.48 | Autophagy induction by hispidulin provides protection against sevoflurane-induced neuronal apoptosis in aged rats. ( Huang, K; Huang, L; Ning, H, 2018) |
| "Sevoflurane has been found to increase apoptosis and pathologic markers associated with Alzheimer disease, provoking concern over their potential contribution to postoperative cognitive dysfunction." | 1.48 | Sevoflurane reduced functional connectivity of excitatory neurons in prefrontal cortex during working memory performance of aged rats. ( Tian, X; Wang, G; Xu, X, 2018) |
| "Sevoflurane has been found to increase apoptosis and pathologic markers associated with Alzheimer disease, provoking concern over their potential contribution to postoperative cognitive dysfunction." | 1.43 | Sevoflurane anesthesia induces neither contextual fear memory impairment nor alterations in local population connectivity of medial prefrontal cortex local field potentials networks in aged rats. ( Tian, X; Wang, G; Xu, X; Zhang, Q, 2016) |
| "Treatment with tetrandrine reduced the expression levels of COX‑2, IL‑1β, TNF‑α, NF‑κB, iNOS and caspase‑3, and increased the Bcl‑2 protein expression in sevoflurane‑treated aged rats." | 1.43 | Tetrandrine ameliorates sevoflurane‑induced cognitive impairment via the suppression of inflammation and apoptosis in aged rats. ( Li, X; Ma, H; Pang, L; Yao, L; Yao, Q, 2016) |
| "The corticosterone level was significantly increased immediately after repeated neonatal sevoflurane exposures." | 1.43 | Heightened stress response and cognitive impairment after repeated neonatal sevoflurane exposures might be linked to excessive GABAAR-mediated depolarization. ( Li, F; Liu, G; Qian, B; Qian, W; Zhang, A; Zhu, T, 2016) |
| "Sevoflurane exposures were demonstrated to induce neurotoxicity in the developing brain in both human and animal studies." | 1.43 | Docosahexaenoic Acid Rescues Synaptogenesis Impairment and Long-Term Memory Deficits Caused by Postnatal Multiple Sevoflurane Exposures. ( Li, G; Luo, Y; Tan, Y; Tao, G; Xiao, J; Xue, Q; Yu, B, 2016) |
| "Sevoflurane-treated animals had a deficit in early long-term memory, and isoflurane-treated animals had a deficit in both short-term and early long-term memory." | 1.39 | Distinct long-term neurocognitive outcomes after equipotent sevoflurane or isoflurane anaesthesia in immature rats. ( Alvi, RS; Barbour, KC; Ben-Tzur, D; Chang, FL; Di Geronimo, RT; Elphick, SA; Huang, P; Kang, H; Kong, CL; McCreery, MS; Park, A; Quitoriano, GR; Ramage, TM; Rau, V; Rossi, MJ; Sall, JW; Shih, J; Stratmann, G; Tantoco, NK; Uy, J; Zhao, C, 2013) |
| "Focal cerebral ischemia was performed via 1h of middle cerebral artery occlusion (MCAO) followed by reperfusion." | 1.39 | Preconditioning with sevoflurane ameliorates spatial learning and memory deficit after focal cerebral ischemia-reperfusion in rats. ( Hu, X; Li, W; Li, Y; Liu, J; Zhang, Y, 2013) |
| "Sevoflurane is a general anesthetic commonly used in the pediatric setting because it is sweet-smelling, nonflammable, fast acting and has a very short recovery time." | 1.39 | Early life exposure to sevoflurane impairs adulthood spatial memory in the rat. ( Guo, X; Liu, Y; Shen, R; Shen, X; Wang, F; Xu, S; Zhao, Q, 2013) |
| "Sevoflurane-treated rats had a greater escape latency when the delay between memory acquisition and memory retrieval was increased from 1 min to 1 h, indicating that short-term memory was impaired." | 1.38 | Delayed environmental enrichment reverses sevoflurane-induced memory impairment in rats. ( Alvi, RS; Bickler, PE; Carlston, CM; Gonzalez, HE; Guggenheim, JN; Kang, H; Lalchandani, GR; Lee, EW; May, LD; Mendoza, MV; Rau, V; Rowe, AM; Sall, JW; Schaefer, M; Shih, J; Stratmann, G; Wilk, AJ; Woodward, E; Yusupova, M, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (7.27) | 29.6817 |
| 2010's | 41 (74.55) | 24.3611 |
| 2020's | 10 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Wali, B | 1 |
| Sayeed, I | 1 |
| Stein, DG | 1 |
| Raper, J | 1 |
| Zhao, W | 1 |
| Song, S | 1 |
| Chu, W | 1 |
| Li, Y | 3 |
| Chen, S | 1 |
| Ji, Y | 1 |
| Chen, Q | 2 |
| Jin, X | 1 |
| Ji, F | 1 |
| Wang, Y | 3 |
| Li, H | 1 |
| Zhao, Y | 3 |
| Qin, F | 1 |
| Wang, L | 2 |
| Jiang, L | 1 |
| Wang, X | 2 |
| Chen, R | 1 |
| He, Y | 1 |
| Wei, Q | 1 |
| Li, S | 1 |
| Chen, Y | 1 |
| Xiao, Y | 1 |
| Dai, Y | 1 |
| Bu, Q | 1 |
| Tian, J | 1 |
| Wang, H | 2 |
| Cen, X | 1 |
| Song, XY | 1 |
| Liu, XW | 1 |
| Wang, J | 3 |
| Jimenez-Tellez, N | 1 |
| Pehar, M | 1 |
| Visser, F | 1 |
| Casas-Ortiz, A | 1 |
| Rice, T | 1 |
| Syed, NI | 1 |
| Tian, Y | 3 |
| Song, M | 1 |
| Wu, Z | 1 |
| Zhang, Y | 6 |
| Zhao, P | 2 |
| Zhu, J | 1 |
| Zhang, Z | 1 |
| Jia, J | 1 |
| Yang, Q | 1 |
| Chen, C | 1 |
| Xu, L | 1 |
| Xu, Q | 1 |
| Xu, F | 1 |
| Zhang, W | 1 |
| Wu, H | 1 |
| Chen, X | 1 |
| Sun, H | 1 |
| Hu, H | 1 |
| Xu, X | 3 |
| Tao, T | 1 |
| Liang, Z | 1 |
| Dong, Y | 3 |
| Hong, W | 1 |
| Tang, Z | 1 |
| Gao, Y | 2 |
| Wu, X | 4 |
| Liu, H | 2 |
| Alvarado, MC | 1 |
| Murphy, KL | 1 |
| Baxter, MG | 1 |
| Shi, Y | 1 |
| Wang, G | 4 |
| Li, J | 2 |
| Yu, W | 1 |
| Zhu, QL | 1 |
| Luo, Y | 2 |
| Xue, QS | 2 |
| Zhang, FJ | 1 |
| Yu, BW | 2 |
| Huang, L | 2 |
| Huang, K | 2 |
| Ning, H | 2 |
| Guo, S | 2 |
| Liu, L | 1 |
| Wang, C | 1 |
| Jiang, Q | 1 |
| Tang, X | 1 |
| Ao, J | 1 |
| Ding, L | 1 |
| Liu, Y | 2 |
| Yuan, Y | 1 |
| Wang, Z | 1 |
| Yin, S | 1 |
| Xue, H | 1 |
| Yang, Y | 2 |
| Zhang, N | 1 |
| Bedirli, N | 1 |
| Bagriacik, EU | 1 |
| Yilmaz, G | 1 |
| Ozkose, Z | 1 |
| Kavutçu, M | 1 |
| Cavunt Bayraktar, A | 1 |
| Bedirli, A | 1 |
| Huang, C | 1 |
| Irwin, MG | 1 |
| Wong, GTC | 1 |
| Chang, RCC | 1 |
| Hu, X | 3 |
| Zhang, L | 3 |
| Zhang, Q | 3 |
| Duan, X | 2 |
| Tian, X | 2 |
| Hou, J | 1 |
| Shen, Q | 1 |
| Wan, X | 1 |
| Zhao, B | 1 |
| Wu, Y | 1 |
| Xia, Z | 1 |
| Goyagi, T | 1 |
| Sun, GY | 1 |
| Xie, K | 1 |
| Sun, ZY | 1 |
| Sun, MY | 1 |
| Li, N | 1 |
| Yang, F | 1 |
| Shan, Y | 1 |
| Wang, WY | 2 |
| Yang, R | 1 |
| Hu, SF | 2 |
| Ma, ZW | 1 |
| Lu, Y | 1 |
| Ramage, TM | 1 |
| Chang, FL | 1 |
| Shih, J | 2 |
| Alvi, RS | 2 |
| Quitoriano, GR | 1 |
| Rau, V | 2 |
| Barbour, KC | 1 |
| Elphick, SA | 1 |
| Kong, CL | 1 |
| Tantoco, NK | 1 |
| Ben-Tzur, D | 1 |
| Kang, H | 2 |
| McCreery, MS | 1 |
| Huang, P | 1 |
| Park, A | 1 |
| Uy, J | 1 |
| Rossi, MJ | 1 |
| Zhao, C | 1 |
| Di Geronimo, RT | 1 |
| Stratmann, G | 2 |
| Sall, JW | 2 |
| Li, W | 1 |
| Liu, J | 2 |
| Wang, SQ | 1 |
| Fang, F | 1 |
| Xue, ZG | 1 |
| Cang, J | 1 |
| Zhang, XG | 1 |
| Shen, X | 2 |
| Xu, S | 1 |
| Zhao, Q | 1 |
| Guo, X | 1 |
| Shen, R | 1 |
| Wang, F | 1 |
| Yin, J | 1 |
| Wang, SL | 1 |
| Liu, XB | 1 |
| Lin, XF | 1 |
| Han, YQ | 1 |
| Li, HL | 1 |
| Zhao, YP | 1 |
| Fei, XJ | 1 |
| Sheng, JX | 1 |
| Lu, HH | 1 |
| Liu, S | 1 |
| Ma, L | 1 |
| Zhao, X | 1 |
| Chen, K | 1 |
| Liu, X | 1 |
| Song, X | 1 |
| Yuan, T | 1 |
| He, J | 1 |
| Wang, Q | 1 |
| Wu, XM | 1 |
| Jia, LJ | 1 |
| Zhang, HH | 1 |
| Cai, F | 1 |
| Mao, H | 1 |
| Xu, WC | 1 |
| Chen, L | 1 |
| Zhang, J | 1 |
| Ma, H | 1 |
| Yao, L | 1 |
| Pang, L | 1 |
| Li, X | 1 |
| Yao, Q | 1 |
| Liu, G | 1 |
| Zhu, T | 1 |
| Zhang, A | 1 |
| Li, F | 1 |
| Qian, W | 1 |
| Qian, B | 1 |
| Tian, D | 1 |
| Tian, M | 1 |
| Ma, Z | 1 |
| Cui, Y | 1 |
| Tao, G | 1 |
| Xue, Q | 1 |
| Li, G | 1 |
| Tan, Y | 1 |
| Xiao, J | 1 |
| Yu, B | 1 |
| Chen, Z | 1 |
| Jiang, J | 1 |
| Lv, X | 1 |
| Jiang, H | 1 |
| Satomoto, M | 1 |
| Satoh, Y | 2 |
| Terui, K | 1 |
| Miyao, H | 1 |
| Takishima, K | 1 |
| Ito, M | 1 |
| Imaki, J | 1 |
| Li, Q | 1 |
| Liu, XS | 1 |
| Zeng, QW | 1 |
| Cao, XH | 1 |
| Ren, Y | 1 |
| Davidson, AJ | 1 |
| May, LD | 1 |
| Gonzalez, HE | 1 |
| Lee, EW | 1 |
| Bickler, PE | 1 |
| Lalchandani, GR | 1 |
| Yusupova, M | 1 |
| Woodward, E | 1 |
| Wilk, AJ | 1 |
| Carlston, CM | 1 |
| Mendoza, MV | 1 |
| Guggenheim, JN | 1 |
| Schaefer, M | 1 |
| Rowe, AM | 1 |
| Gong, M | 1 |
| Chen, G | 1 |
| Zhang, XM | 1 |
| Xu, LH | 1 |
| Wang, HM | 1 |
| Yan, M | 1 |
| Yang, T | 1 |
| Zhuang, L | 1 |
| Rei Fidalgo, AM | 1 |
| Petrides, E | 1 |
| Terrando, N | 1 |
| Sanders, RD | 1 |
| Robertson, NJ | 1 |
| Johnson, MR | 1 |
| Maze, M | 1 |
| Ma, D | 1 |
| Yonamine, R | 1 |
| Kodama, M | 1 |
| Araki, Y | 1 |
| Kazama, T | 1 |
| Nishikawa, K | 1 |
| Rinaldi, S | 1 |
| Consales, G | 1 |
| Gallerani, E | 1 |
| Ortolani, O | 1 |
| De Gaudio, AR | 1 |
| Millar, K | 1 |
| Asbury, AJ | 1 |
| Bowman, AW | 1 |
| Hosey, MT | 1 |
| Musiello, T | 1 |
| Welbury, RR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Neurodevelopment Outcomes After Pediatric Dental Caries Treatment Under General Anaesthesia[NCT03002792] | 360 participants (Anticipated) | Observational | 2017-01-31 | Not yet recruiting | |||
| Evaluation of Neurotoxic Effect of Sevoflurane-Based Anaesthesia Guided by Significant Short-Term Olfactory Identification Impairment in Old Age[NCT03726580] | 600 participants (Actual) | Observational [Patient Registry] | 2017-03-01 | Completed | |||
| Effect of Sevoflurane on the Success of External Cephalic Version for Breech Presentation[NCT04346823] | Phase 4 | 40 participants (Anticipated) | Interventional | 2020-05-25 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for sevoflurane and Age-Related Memory Disorders
| Article | Year |
|---|---|
[Volatile anesthetics and synaptic transmission in the central nervous system].
Topics: Anesthetics, Inhalation; Animals; Hippocampus; Humans; Isoflurane; Long-Term Potentiation; Memory; M | 2004 |
4 trials available for sevoflurane and Age-Related Memory Disorders
| Article | Year |
|---|---|
Disruption of hippocampal P2RX2/CaMKII/NF-κB signaling contributes to learning and memory impairment in C57BL/6 mice induced by surgery plus anesthesia in neonatal period.
Topics: Anesthesia; Animals; Animals, Newborn; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Hippocamp | 2022 |
The effects of general anaesthesia on memory in children: a comparison between propofol and sevoflurane.
Topics: Adolescent; Anesthetics, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Child; Female; | 2014 |
A-line autoregression index monitoring to titrate inhalational anaesthesia: effects on sevoflurane consumption, emergence time and memory.
Topics: Abdomen; Adult; Aged; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; E | 2005 |
The effects of brief sevoflurane-nitrous oxide anaesthesia upon children's postoperative cognition and behaviour.
Topics: Ambulatory Surgical Procedures; Anesthetics, Combined; Anesthetics, Inhalation; Child; Child Behavio | 2006 |
50 other studies available for sevoflurane and Age-Related Memory Disorders
| Article | Year |
|---|---|
Prophylactic progesterone prevents adverse behavioural and neurocognitive effects of neonatal anaesthesia exposure in rat.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Behavior, Animal; Cognitive Dysfunction; Female; | 2022 |
Neonatal exposure to sevoflurane induces adolescent neurobehavioral dysfunction by interfering with hippocampal glycerophoslipid metabolism in rats.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Hippocampus; Maze Learning; Memory Disorders; Ph | 2023 |
Suberoylanilide hydroxamic acid (SAHA) attenuates memory impairment in the offspring of rats exposed to sevoflurane anesthesia.
Topics: Anesthesia; Animals; Female; Hippocampus; Learning; Memory Disorders; MicroRNAs; Pregnancy; Rats; Se | 2023 |
Sevoflurane Exposure in Neonates Perturbs the Expression Patterns of Specific Genes That May Underly the Observed Learning and Memory Deficits.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Hippocampus; Learning; Maze Learning; Memory Dis | 2023 |
Sevoflurane Affects Memory Through Impairing Insulin-Like Growth Factor Receptor Signaling.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Computational Biology; Female; Maze Learning; Memory; M | 2019 |
Sirtuin 2 Inhibition Attenuates Sevoflurane-Induced Learning and Memory Deficits in Developing Rats via Modulating Microglial Activation.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Benzamides; Cognitive Dysfunction; Growth and De | 2020 |
Sevoflurane Induces Learning and Memory Impairment in Young Mice Through a Reduction in Neuronal Glucose Transporter 3.
Topics: Aging; Animals; Apoptosis; Brain; Cell Membrane; Cells, Cultured; Glucose; Glucose Transporter Type | 2020 |
MicroRNA-325-3p prevents sevoflurane-induced learning and memory impairment by inhibiting Nupr1 and C/EBPβ/IGFBP5 signaling in rats.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; CCAAT-Enh | 2020 |
Key miRNAs associated with memory and learning disorder upon exposure to sevoflurane determined by RNA sequencing.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Female; Hippocampus; Male; Maze Learning; Memory | 2020 |
Sevoflurane leads to learning and memory dysfunction via breaking the balance of tPA/PAI-1.
Topics: Anesthetics, Inhalation; Animals; Male; Maze Learning; Memory Disorders; Plasminogen Activator Inhib | 2020 |
Visual recognition memory is impaired in rhesus monkeys repeatedly exposed to sevoflurane in infancy.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Disease Models, Animal; Female; Macaca mulatta; | 2017 |
Hydrogen gas attenuates sevoflurane neurotoxicity through inhibiting nuclear factor κ-light-chain-enhancer of activated B cells signaling and proinflammatory cytokine release in neonatal rats.
Topics: Active Transport, Cell Nucleus; Anesthetics, Inhalation; Animals; Animals, Newborn; B-Lymphocytes; C | 2017 |
Different doses of sevoflurane facilitate and impair learning and memory function through activation of the ERK pathway and synthesis of ARC protein in the rat hippocampus.
Topics: AIDS-Related Complex; Anesthetics, Inhalation; Animals; Butadienes; Disease Models, Animal; Dose-Res | 2018 |
Hispidulin prevents sevoflurane- Induced memory dysfunction in aged rats.
Topics: Aging; Anesthetics, Inhalation; Animals; Apoptosis; Flavones; Male; Memory Disorders; Methyl Ethers; | 2018 |
Repeated exposure to sevoflurane impairs the learning and memory of older male rats.
Topics: Aging; Anesthetics, Inhalation; Animals; Apoptosis; Brain Chemistry; Brain-Derived Neurotrophic Fact | 2018 |
Autophagy induction by hispidulin provides protection against sevoflurane-induced neuronal apoptosis in aged rats.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Autophagy; Cell Line, Tumor; Flavones; Hippocampus; Hum | 2018 |
Role of α7nAChR-NMDAR in sevoflurane-induced memory deficits in the developing rat hippocampus.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Hippocampus; Memory Disorders; Methyl Ethers; Rats | 2018 |
Mid-gestational sevoflurane exposure inhibits fetal neural stem cell proliferation and impairs postnatal learning and memory function in a dose-dependent manner.
Topics: Anesthetics, Inhalation; Animals; Cell Division; Cyclin D1; Dose-Response Relationship, Drug; Female | 2018 |
Sevoflurane exerts brain-protective effects against sepsis-associated encephalopathy and memory impairment through caspase 3/9 and Bax/Bcl signaling pathway in a rat model of sepsis.
Topics: Anesthetics, Inhalation; Animals; Anti-Bacterial Agents; Apoptosis; bcl-2-Associated X Protein; Brai | 2018 |
Evidence of the impact of systemic inflammation on neuroinflammation from a non-bacterial endotoxin animal model.
Topics: Anesthetics, Inhalation; Animals; Body Weight; Brain; Calcium-Binding Proteins; Cytokines; Disease M | 2018 |
Postconditioning with sevoflurane ameliorates spatial learning and memory deficit via attenuating endoplasmic reticulum stress induced neuron apoptosis in a rat model of hemorrhage shock and resuscitation.
Topics: Animals; Apoptosis; Brain Ischemia; CA1 Region, Hippocampal; Disease Models, Animal; Endoplasmic Ret | 2018 |
Sevoflurane reduced functional connectivity of excitatory neurons in prefrontal cortex during working memory performance of aged rats.
Topics: Action Potentials; Age Factors; Anesthetics, Inhalation; Animals; Behavior, Animal; Dose-Response Re | 2018 |
REM sleep deprivation-induced circadian clock gene abnormalities participate in hippocampal-dependent memory impairment by enhancing inflammation in rats undergoing sevoflurane inhalation.
Topics: Animals; Circadian Clocks; Cognition Disorders; Gene Expression; Gene Expression Regulation; Hippoca | 2019 |
Dexmedetomidine reduced sevoflurane-induced neurodegeneration and long-term memory deficits in neonatal rats.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Cognition; Conditioning, Classical; Dexmedetomid | 2019 |
Sevoflurane induces temporary spatial working memory deficits and synaptic ultrastructure impairments in the hippocampus of neonatal rats.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Female; Hippocampus; Male; Maze Learning; Memory | 2019 |
Neuroglobin protects offspring rats from neuronal damage induced by sevoflurane exposure to pregnant rats by inhibiting endogenous apoptosis.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Brain; Brain Chemistry; Cytochromes c; Female; Hemin; H | 2019 |
N-stearoyl-L-tyrosine ameliorates sevoflurane induced neuroapoptosis via MEK/ERK1/2 MAPK signaling pathway in the developing brain.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Brain; Cell Survival; Cells, Cultured; Embryo, Nonmamma | 2013 |
Distinct long-term neurocognitive outcomes after equipotent sevoflurane or isoflurane anaesthesia in immature rats.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Conditioning, Classical; Drug Administration Sch | 2013 |
Preconditioning with sevoflurane ameliorates spatial learning and memory deficit after focal cerebral ischemia-reperfusion in rats.
Topics: Animals; Brain Ischemia; Cholinergic Neurons; Hippocampus; Male; Maze Learning; Memory Disorders; Me | 2013 |
Neonatal sevoflurane anesthesia induces long-term memory impairment and decreases hippocampal PSD-95 expression without neuronal loss.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Disks Large Homolog 4 Protein; Hippocampus; Intr | 2013 |
Early life exposure to sevoflurane impairs adulthood spatial memory in the rat.
Topics: Age Factors; Analysis of Variance; Anesthetics, Inhalation; Animals; Animals, Newborn; Developmental | 2013 |
Early life exposure to sevoflurane impairs adulthood spatial memory in the rat.
Topics: Age Factors; Analysis of Variance; Anesthetics, Inhalation; Animals; Animals, Newborn; Developmental | 2013 |
Early life exposure to sevoflurane impairs adulthood spatial memory in the rat.
Topics: Age Factors; Analysis of Variance; Anesthetics, Inhalation; Animals; Animals, Newborn; Developmental | 2013 |
Early life exposure to sevoflurane impairs adulthood spatial memory in the rat.
Topics: Age Factors; Analysis of Variance; Anesthetics, Inhalation; Animals; Animals, Newborn; Developmental | 2013 |
SAHA attenuates sevoflurane-induced learning and memory impairments in fetal mice.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Histone Deacetylase Inhibitors; Hydroxamic Acids | 2014 |
Minocycline alleviates sevoflurane-induced cognitive impairment in aged rats.
Topics: Aging; Amyloid beta-Peptides; Animals; Apoptosis; Cognition Disorders; Hippocampus; Inflammation; Le | 2015 |
Environmental Enrichment Attenuated Sevoflurane-Induced Neurotoxicity through the PPAR-γ Signaling Pathway.
Topics: Animals; Apoptosis; Cognition Disorders; Down-Regulation; Environment; Male; Memory Disorders; Methy | 2015 |
Effects of calpain on sevoflurane-induced aged rats hippocampal neuronal apoptosis.
Topics: Animals; Apoptosis; Blotting, Western; Calpain; Hippocampus; Male; Maze Learning; Memory; Memory Dis | 2016 |
Beta-arrestin1 and 2 differently modulate metabotropic glutamate receptor 7 signaling in rat developmental sevoflurane-induced neuronal apoptosis.
Topics: Animals; Apoptosis; Arrestins; Benzhydryl Compounds; beta-Arrestin 1; beta-Arrestin 2; beta-Arrestin | 2016 |
Sevoflurane anesthesia induces neither contextual fear memory impairment nor alterations in local population connectivity of medial prefrontal cortex local field potentials networks in aged rats.
Topics: Aging; Anesthetics, Inhalation; Animals; Conditioning, Psychological; Fear; Male; Memory; Memory Dis | 2016 |
Tetrandrine ameliorates sevoflurane‑induced cognitive impairment via the suppression of inflammation and apoptosis in aged rats.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Benzylisoquinolines; Caspase 3; Cognitive Dysfunction; | 2016 |
Heightened stress response and cognitive impairment after repeated neonatal sevoflurane exposures might be linked to excessive GABAAR-mediated depolarization.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Bumetanide; Cognitive Dysfunction; Corticosteron | 2016 |
Voluntary exercise rescues sevoflurane-induced memory impairment in aged male mice.
Topics: Adaptor Proteins, Signal Transducing; Analysis of Variance; Anesthetics, Inhalation; Animals; Diseas | 2016 |
Docosahexaenoic Acid Rescues Synaptogenesis Impairment and Long-Term Memory Deficits Caused by Postnatal Multiple Sevoflurane Exposures.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Docosahexaenoic Acids; Drug Interactions; Female | 2016 |
Postconditioning with sevoflurane ameliorates spatial learning and memory deficit after hemorrhage shock and resuscitation in rats.
Topics: Animals; Biomarkers; Choline O-Acetyltransferase; Cholinergic Neurons; Hippocampus; Ischemic Postcon | 2016 |
Downregulation of circulating insulin-like growth factor 1 contributes to memory impairment in aged mice after sevoflurane anesthesia.
Topics: Anesthetics, Inhalation; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Reg | 2017 |
Neonatal exposure to sevoflurane induces abnormal social behaviors and deficits in fear conditioning in mice.
Topics: Animals; Animals, Newborn; Conditioning, Psychological; Fear; Learning Disabilities; Male; Memory Di | 2009 |
Post-training intra-basolateral amygdala infusions of norepinephrine block sevoflurane-induced impairment of memory consolidation and activity-regulated cytoskeletal protein expression inhibition in rat hippocampus.
Topics: Amygdala; Anesthetics, Inhalation; Animals; Avoidance Learning; Cytoskeletal Proteins; Dose-Response | 2011 |
Neurotoxicity and the need for anesthesia in the newborn: does the emperor have no clothes?
Topics: Animals; Housing, Animal; Male; Memory Disorders; Methyl Ethers; Sevoflurane | 2012 |
Delayed environmental enrichment reverses sevoflurane-induced memory impairment in rats.
Topics: Age Factors; Animals; Animals, Newborn; Housing, Animal; Male; Maze Learning; Memory Disorders; Meth | 2012 |
Parecoxib mitigates spatial memory impairment induced by sevoflurane anesthesia in aged rats.
Topics: Aging; Anesthetics, Intravenous; Animals; Blotting, Western; Cognition Disorders; Cyclooxygenase 2; | 2012 |
Xenon and sevoflurane provide analgesia during labor and fetal brain protection in a perinatal rat model of hypoxia-ischemia.
Topics: Analgesia; Animals; Animals, Newborn; Apoptosis; Brain; Caspase 3; Cell Survival; Cohort Studies; Fe | 2012 |
Coadministration of hydrogen gas as part of the carrier gas mixture suppresses neuronal apoptosis and subsequent behavioral deficits caused by neonatal exposure to sevoflurane in mice.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Blotting, Western; | 2013 |