Page last updated: 2024-08-24

sertindole and Torsade de Pointes

sertindole has been researched along with Torsade de Pointes in 7 studies

Research

Studies (7)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (57.14)	29.6817
2010's	3 (42.86)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Pearlstein, R; Rampe, D; Vaz, R	1
Cooper, J; Cui, Y; Fink, M; Gavaghan, DJ; Heath, BM; McMahon, NC; Mirams, GR; Noble, D; Sher, A	1
Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS	1
Andersen, MP; Dybbro, J; Graff, C; Hardahl, T; Kanters, JK; Meyer, JM; Nielsen, J; Struijk, JJ; Toft, E	1
Beekman, JD; Matz, J; Thomsen, MB; Volders, PG; Vos, MA	1
Cox, BF; Gintant, GA; Limberis, JT; McDermott, JS; Wegner, CD	1
Breithardt, G; Eckardt, L; Haverkamp, W	1

Reviews

1 review(s) available for sertindole and Torsade de Pointes

Article	Year
Understanding the structure-activity relationship of the human ether-a-go-go-related gene cardiac K+ channel. A model for bad behavior. Journal of medicinal chemistry, 2003, May-22, Volume: 46, Issue:11 Topics: Cation Transport Proteins; DNA-Binding Proteins; Drug-Related Side Effects and Adverse Reactions; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Long QT Syndrome; Models, Molecular; Pharmaceutical Preparations; Potassium Channels; Potassium Channels, Voltage-Gated; Structure-Activity Relationship; Torsades de Pointes; Trans-Activators; Transcriptional Regulator ERG	2003

Article

Year

Understanding the structure-activity relationship of the human ether-a-go-go-related gene cardiac K+ channel. A model for bad behavior.

Journal of medicinal chemistry, 2003, May-22, Volume: 46, Issue:11

Topics: Cation Transport Proteins; DNA-Binding Proteins; Drug-Related Side Effects and Adverse Reactions; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Long QT Syndrome; Models, Molecular; Pharmaceutical Preparations; Potassium Channels; Potassium Channels, Voltage-Gated; Structure-Activity Relationship; Torsades de Pointes; Trans-Activators; Transcriptional Regulator ERG

2003

Other Studies

6 other study(ies) available for sertindole and Torsade de Pointes

Article	Year
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk. Cardiovascular research, 2011, Jul-01, Volume: 91, Issue:1 Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Computer Simulation; Dogs; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; HEK293 Cells; Humans; Ion Channels; Kinetics; Models, Cardiovascular; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Potassium Channel Blockers; Rabbits; Risk Assessment; Risk Factors; Sodium Channel Blockers; Sodium Channels; Torsades de Pointes; Transfection	2011
MICE models: superior to the HERG model in predicting Torsade de Pointes. Scientific reports, 2013, Volume: 3 Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes	2013
The effect of sertindole on QTD and TPTE. Acta psychiatrica Scandinavica, 2010, Volume: 121, Issue:5 Topics: Adult; Antipsychotic Agents; Denmark; Electrocardiography; Female; Heart Rate; Humans; Imidazoles; Indoles; Long QT Syndrome; Male; Middle Aged; Prospective Studies; Safety-Based Drug Withdrawals; Schizophrenia; Signal Processing, Computer-Assisted; Torsades de Pointes	2010
Beat-to-Beat variability of repolarization determines proarrhythmic outcome in dogs susceptible to drug-induced torsades de pointes. Journal of the American College of Cardiology, 2006, Sep-19, Volume: 48, Issue:6 Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Pacing, Artificial; Cromakalim; Disease Susceptibility; Dogs; Dose-Response Relationship, Drug; Heart Rate; Imidazoles; Indoles; Osmolar Concentration; Potassium; Potassium Channel Blockers; Potassium Channels; Potassium Chloride; Recurrence; Torsades de Pointes; Ventricular Function	2006
The canine Purkinje fiber: an in vitro model system for acquired long QT syndrome and drug-induced arrhythmogenesis. Journal of cardiovascular pharmacology, 2001, Volume: 37, Issue:5 Topics: Action Potentials; Animals; Anti-Infective Agents; Arrhythmias, Cardiac; Aza Compounds; Cisapride; Dogs; Erythromycin; Female; Fluoroquinolones; Imidazoles; In Vitro Techniques; Indoles; Long QT Syndrome; Male; Models, Biological; Moxifloxacin; Perfusion; Piperazines; Purkinje Fibers; Quinolines; Sotalol; Swine; Torsades de Pointes	2001
Electrophysiologic characterization of the antipsychotic drug sertindole in a rabbit heart model of torsade de pointes: low torsadogenic potential despite QT prolongation. The Journal of pharmacology and experimental therapeutics, 2002, Volume: 300, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Antipsychotic Agents; Arrhythmias, Cardiac; Electrocardiography; Electrophysiology; Heart; Heart Rate; Heart Ventricles; Imidazoles; In Vitro Techniques; Indoles; Long QT Syndrome; Rabbits; Sotalol; Torsades de Pointes; Ventricular Premature Complexes	2002