Page last updated: 2024-08-24

sertindole and Long QT Syndrome

sertindole has been researched along with Long QT Syndrome in 13 studies

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (7.69)18.2507
2000's8 (61.54)29.6817
2010's4 (30.77)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chen, XL; Kang, J; Kongsamut, S; Rampe, D; Roehr, J1
Cavalli, A; De Ponti, F; Poluzzi, E; Recanatini, M1
Pearlstein, R; Rampe, D; Vaz, R1
Bruno, A; Micali Bellinghieri, P; Muscatello, MR; Pandolfo, G; Zoccali, RA1
Graff, C; Kanters, JK; Matz, J; Mittoux, A; Nielsen, J; Polcwiartek, C; Struijk, JJ; Toft, E1
Hansen, K; Lançon, C; Sapin, C; Toumi, M1
Hale, A; Kasper, S; Möller, HJ1
Andersen, MP; Dybbro, J; Graff, C; Hardahl, T; Kanters, JK; Meyer, JM; Nielsen, J; Struijk, JJ; Toft, E1
Hale, AS1
Barnas, C; Kasper, S; Küfferle, B; Moertl, D; Pezawas, L; Quiner, S; Tauscher, J; Wolf, R1
Cox, BF; Gintant, GA; Limberis, JT; McDermott, JS; Wegner, CD1
Heeley, EL; Pickering, RM; Shakir, SA; Wilton, LV1
Breithardt, G; Eckardt, L; Haverkamp, W1

Reviews

3 review(s) available for sertindole and Long QT Syndrome

ArticleYear
Understanding the structure-activity relationship of the human ether-a-go-go-related gene cardiac K+ channel. A model for bad behavior.
    Journal of medicinal chemistry, 2003, May-22, Volume: 46, Issue:11

    Topics: Cation Transport Proteins; DNA-Binding Proteins; Drug-Related Side Effects and Adverse Reactions; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Long QT Syndrome; Models, Molecular; Pharmaceutical Preparations; Potassium Channels; Potassium Channels, Voltage-Gated; Structure-Activity Relationship; Torsades de Pointes; Trans-Activators; Transcriptional Regulator ERG

2003
Sertindole in schizophrenia: efficacy and safety issues.
    Expert opinion on pharmacotherapy, 2014, Volume: 15, Issue:13

    Topics: Antipsychotic Agents; Clinical Trials as Topic; Cost-Benefit Analysis; Drug Interactions; Humans; Imidazoles; Indoles; Long QT Syndrome; Recurrence; Schizophrenia; Schizophrenic Psychology; Secondary Prevention

2014
A review of the safety and tolerability of sertindole.
    International clinical psychopharmacology, 1998, Volume: 13 Suppl 3

    Topics: Antipsychotic Agents; Basal Ganglia Diseases; Clinical Trials as Topic; Humans; Imidazoles; Indoles; Long QT Syndrome; Neurologic Examination; Risk Factors; Schizophrenia

1998

Trials

2 trial(s) available for sertindole and Long QT Syndrome

ArticleYear
Cardiac effects of sertindole and quetiapine: analysis of ECGs from a randomized double-blind study in patients with schizophrenia.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2015, Volume: 25, Issue:3

    Topics: Antipsychotic Agents; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; Follow-Up Studies; Heart Rate; Humans; Imidazoles; Indoles; Long QT Syndrome; Male; Principal Component Analysis; Quetiapine Fumarate; Schizophrenia

2015
The European post-marketing observational sertindole study: an investigation of the safety of antipsychotic drug treatment.
    European archives of psychiatry and clinical neuroscience, 2010, Volume: 260, Issue:1

    Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Antipsychotic Agents; Electrocardiography; Europe; Female; Follow-Up Studies; Humans; Imidazoles; Indoles; Long QT Syndrome; Male; Middle Aged; Patient Compliance; Product Surveillance, Postmarketing; Psychiatric Status Rating Scales; Safety; Schizophrenia; Severity of Illness Index; Treatment Outcome; Young Adult

2010

Other Studies

8 other study(ies) available for sertindole and Long QT Syndrome

ArticleYear
A comparison of the receptor binding and HERG channel affinities for a series of antipsychotic drugs.
    European journal of pharmacology, 2002, Aug-16, Volume: 450, Issue:1

    Topics: Animals; Antipsychotic Agents; Cation Transport Proteins; Cell Line; Clinical Trials as Topic; Cricetinae; DNA-Binding Proteins; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Long QT Syndrome; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Radioligand Assay; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D2; Receptors, Serotonin; Trans-Activators; Transcriptional Regulator ERG

2002
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers.
    Journal of medicinal chemistry, 2002, Aug-29, Volume: 45, Issue:18

    Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go-Go Potassium Channels; Long QT Syndrome; Models, Molecular; Molecular Conformation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship

2002
The Sertindole Safety Survey: a retrospective analysis under a named patient use programme in Europe.
    BMC psychiatry, 2008, Jul-18, Volume: 8

    Topics: Adult; Antipsychotic Agents; Brain Diseases; Chronic Disease; Europe; Female; Humans; Imidazoles; Indoles; Long QT Syndrome; Male; Program Development; Prospective Studies; Psychotic Disorders; Retrospective Studies; Schizophrenia; Severity of Illness Index; Surveys and Questionnaires; Survival Rate

2008
The effect of sertindole on QTD and TPTE.
    Acta psychiatrica Scandinavica, 2010, Volume: 121, Issue:5

    Topics: Adult; Antipsychotic Agents; Denmark; Electrocardiography; Female; Heart Rate; Humans; Imidazoles; Indoles; Long QT Syndrome; Male; Middle Aged; Prospective Studies; Safety-Based Drug Withdrawals; Schizophrenia; Signal Processing, Computer-Assisted; Torsades de Pointes

2010
Efficacy, cardiac safety and tolerability of sertindole: a drug surveillance.
    International clinical psychopharmacology, 2000, Volume: 15, Issue:4

    Topics: Adult; Adverse Drug Reaction Reporting Systems; Aged; Antipsychotic Agents; Drug Monitoring; Electrocardiography; Female; Humans; Imidazoles; Indoles; Long QT Syndrome; Male; Middle Aged; Psychiatric Status Rating Scales; Psychotic Disorders; Treatment Outcome

2000
The canine Purkinje fiber: an in vitro model system for acquired long QT syndrome and drug-induced arrhythmogenesis.
    Journal of cardiovascular pharmacology, 2001, Volume: 37, Issue:5

    Topics: Action Potentials; Animals; Anti-Infective Agents; Arrhythmias, Cardiac; Aza Compounds; Cisapride; Dogs; Erythromycin; Female; Fluoroquinolones; Imidazoles; In Vitro Techniques; Indoles; Long QT Syndrome; Male; Models, Biological; Moxifloxacin; Perfusion; Piperazines; Purkinje Fibers; Quinolines; Sotalol; Swine; Torsades de Pointes

2001
Comparative study of mortality rates and cardiac dysrhythmias in post-marketing surveillance studies of sertindole and two other atypical antipsychotic drugs, risperidone and olanzapine.
    Journal of psychopharmacology (Oxford, England), 2001, Volume: 15, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antipsychotic Agents; Arrhythmias, Cardiac; Benzodiazepines; Cohort Studies; Death, Sudden; Electrocardiography; European Union; Female; Humans; Imidazoles; Indoles; Long QT Syndrome; Male; Middle Aged; Olanzapine; Pirenzepine; Product Surveillance, Postmarketing; Risperidone; Sex Factors

2001
Electrophysiologic characterization of the antipsychotic drug sertindole in a rabbit heart model of torsade de pointes: low torsadogenic potential despite QT prolongation.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 300, Issue:1

    Topics: Animals; Anti-Arrhythmia Agents; Antipsychotic Agents; Arrhythmias, Cardiac; Electrocardiography; Electrophysiology; Heart; Heart Rate; Heart Ventricles; Imidazoles; In Vitro Techniques; Indoles; Long QT Syndrome; Rabbits; Sotalol; Torsades de Pointes; Ventricular Premature Complexes

2002