serine and Uremia
serine has been researched along with Uremia in 15 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Uremia: A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hepatocytes isolated from livers of rats with various models of acute uremia (binephrectomy, ureter ligation, uranyl nitrate-induced, or ischemic ARF) were incubated with glucagon, adrenalin, or cyclic AMP using serine as a substrate." | 7.66 | Effect of serine on gluconeogenic ability of hepatocytes in acute uremia. ( Heidland, A; Hörl, WH; Münchmeyer, M; Riegel, W; Stepinski, J, 1983) |
| "Hepatocytes isolated from livers of rats with various models of acute uremia (binephrectomy, ureter ligation, uranyl nitrate-induced, or ischemic ARF) were incubated with glucagon, adrenalin, or cyclic AMP using serine as a substrate." | 3.66 | Effect of serine on gluconeogenic ability of hepatocytes in acute uremia. ( Heidland, A; Hörl, WH; Münchmeyer, M; Riegel, W; Stepinski, J, 1983) |
| " From a stimulation of endogenous hepatic proteolysis, acceleration of amino acid transport into the liver cell, and activation of L-serine-dehydratase and other key enzymes of amino acid metabolism, an increased supply of substrate for gluconeogenesis can be expected, thus leading to enhanced formation of glucose by the liver in acute uremia." | 3.66 | [Stimulation of hepatic gluconeogenesis from amino acids in acute uremia]. ( Fröhlich, J, 1978) |
| "Uremia is characterized by a specific intracellular amino acid (AA) pattern in muscle, which is not consistently reflected by that in plasma." | 2.65 | Intracellular amino acids in uremia. ( Alvestrand, A; Bergström, J; Fürst, P, 1983) |
| "Glycogen was increased in the presence of serine in the perfusion medium, the value being 1." | 1.27 | Glycogen synthesis from serine in isolated perfused hindquarters of acutely uraemic rats. ( Djovkar, A; Heidland, A; Hörl, WH, 1983) |
Research
Studies (15)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (86.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Levine, S | 1 |
| Saltzman, A | 1 |
| Riegel, W | 1 |
| Stepinski, J | 2 |
| Münchmeyer, M | 1 |
| Heidland, A | 5 |
| Hörl, WH | 5 |
| Djovkar, A | 1 |
| Alvestrand, A | 1 |
| Fürst, P | 1 |
| Bergström, J | 1 |
| Schäfer, RM | 1 |
| Nohara, Y | 1 |
| Suzuki, J | 1 |
| Kinoshita, T | 1 |
| Watanabe, M | 1 |
| Fröhlich, J | 1 |
| Jontofsohn, R | 1 |
| Trivisas, G | 1 |
| Katz, N | 1 |
| Kluthe, R | 1 |
| Klim, RA | 1 |
| Albajar, M | 1 |
| Hems, R | 1 |
| Williamson, DH | 1 |
| Wolfson, M | 1 |
| Kopple, JD | 1 |
| Matsuda, Y | 1 |
| Takahara, K | 1 |
| Nakanishi, S | 1 |
| Natelson, S | 1 |
| Lacy, WW | 1 |
Reviews
1 review available for serine and Uremia
| Article | Year |
|---|---|
[Regulation of synthesis of uric acid as the final stage of nitrogen metabolism].
Topics: Animals; Chickens; Glutamate-Ammonia Ligase; Glutamates; Glutaminase; Glutamine; Glycine; Humans; Hy | 1972 |
Trials
1 trial available for serine and Uremia
| Article | Year |
|---|---|
Intracellular amino acids in uremia.
Topics: Adolescent; Adult; Aged; Amino Acids; Amino Acids, Branched-Chain; Amino Acids, Essential; Body Flui | 1983 |
Other Studies
13 other studies available for serine and Uremia
| Article | Year |
|---|---|
Hydropic degeneration of the anterior pituitary gland (adenohypophysis) in uremic rats.
Topics: Animals; Body Water; Body Weight; Diet; Hyponatremia; Kidney Tubular Necrosis, Acute; Male; Mercuric | 2004 |
Effect of serine on gluconeogenic ability of hepatocytes in acute uremia.
Topics: Acute Disease; Adenosine Triphosphate; Animals; Bucladesine; Dihydroxyacetone; Epinephrine; Female; | 1983 |
Glycogen synthesis from serine in isolated perfused hindquarters of acutely uraemic rats.
Topics: Acute Disease; Animals; Female; Glycogen; Hindlimb; Muscles; Perfusion; Rats; Rats, Inbred Strains; | 1983 |
Glycogen metabolism in muscle in uremia.
Topics: Acute Disease; Animals; Dietary Proteins; Enzyme Activation; Fasting; Glycogen; Glycogen Synthase; I | 1980 |
Isolation of protein-glycogen complexes from rat skeletal muscle in acute uremia: role of serine.
Topics: Acute Disease; Animals; Diet; Female; Glycogen; Glycogen Synthase; Phosphorylases; Protein Binding; | 1982 |
The gluconeogenetic ability of hepatocytes in various types of acute uraemia.
Topics: Acute Disease; Acute Kidney Injury; Animals; Dihydroxyacetone; Female; Fructose; Gluconeogenesis; Gl | 1982 |
Creatinine inhibits D-amino acid oxidase.
Topics: Alanine; Alanine Transaminase; Creatinine; D-Amino-Acid Oxidase; Enzyme Activation; Flavin-Adenine D | 2002 |
[Stimulation of hepatic gluconeogenesis from amino acids in acute uremia].
Topics: Adrenal Cortex Hormones; Amino Acids; Animals; Gluconeogenesis; L-Serine Dehydratase; Liver; Liver G | 1978 |
Amino acid content of erythrocytes in uremia.
Topics: Alanine; Amino Acids; Erythrocytes; Histidine; Humans; Renal Dialysis; Serine; Tyrosine; Uremia | 1978 |
Effects of chronic uraemia on the formation of glucose and urea plus ammonia from L-alanine, L-glutamine and L-serine in isolated rat hepatocytes.
Topics: Acidosis; Alanine; Amino Acids; Ammonia; Animals; Gluconeogenesis; Glutaminase; Glutamine; In Vitro | 1986 |
The effects of vitamin B-6 deficiency in chronically azotemic and sham-operated rats.
Topics: Alanine; Animals; Asparagine; Aspartate Aminotransferases; Chronic Disease; Creatinine; Erythrocytes | 1987 |
Cleavage of canavaninosuccinic acid by human liver to form guanidinosuccinic acid, a substance found in the urine of uremic patients.
Topics: Animals; Breast; Canavanine; Electrophoresis; Female; Guanidines; Humans; Hydrogen-Ion Concentration | 1969 |
Uptake of individual amino acids by perfused rat liver: effect of acute uremia.
Topics: Amino Acids; Animals; Fasting; Female; Glutamates; Isoleucine; Leucine; Liver; Lysine; Perfusion; Pr | 1970 |