Page last updated: 2024-11-08

serine and Tauopathies

serine has been researched along with Tauopathies in 18 studies

Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.

Tauopathies: Neurodegenerative disorders involving deposition of abnormal tau protein isoforms (TAU PROTEINS) in neurons and glial cells in the brain. Pathological aggregations of tau proteins are associated with mutation of the tau gene on chromosome 17 in patients with ALZHEIMER DISEASE; DEMENTIA; PARKINSONIAN DISORDERS; progressive supranuclear palsy (SUPRANUCLEAR PALSY, PROGRESSIVE); and corticobasal degeneration.

Research Excerpts

ExcerptRelevanceReference
" This study investigated the expression of abnormal serine phosphorylation of insulin receptor substrate 1 (IRS1) in 157 human brain autopsy cases that included AD, tauopathies, α-synucleinopathies, TDP-43 proteinopathies, and normal aging."7.80Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer's disease and tauopathies. ( Arnold, SE; Arvanitakis, Z; Han, LY; Kazi, H; Kim, SF; Lee, EB; Lee, VM; Louneva, N; Toledo, JB; Trojanowski, JQ; Yarchoan, M, 2014)
" This study investigated the expression of abnormal serine phosphorylation of insulin receptor substrate 1 (IRS1) in 157 human brain autopsy cases that included AD, tauopathies, α-synucleinopathies, TDP-43 proteinopathies, and normal aging."3.80Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer's disease and tauopathies. ( Arnold, SE; Arvanitakis, Z; Han, LY; Kazi, H; Kim, SF; Lee, EB; Lee, VM; Louneva, N; Toledo, JB; Trojanowski, JQ; Yarchoan, M, 2014)
"Tau protein abnormally aggregates in tauopathies, a diverse group of neurologic diseases that includes Alzheimer's disease (AD)."1.56Tau Ser208 phosphorylation promotes aggregation and reveals neuropathologic diversity in Alzheimer's disease and other tauopathies. ( Bell, BM; Chakrabarty, P; Davies, P; Giasson, BI; Gorion, KM; Kim, JD; Manaois, AN; Prokop, S; Sorrentino, ZA; Xia, Y, 2020)
"A primary pathologic component of Alzheimer's disease (AD) is the formation of neurofibrillary tangles composed of hyperphosphorylated tau (p-tau)."1.34The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins. ( Ash, P; Bailey, RM; Burrows, F; Dickey, CA; Dickson, DW; Dunmore, J; Eckman, CB; Hutton, M; Kamal, A; Klosak, N; Lundgren, K; Nahman, NS; Patterson, C; Petrucelli, L; Shoraka, S; Zlatkovic, J, 2007)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (16.67)29.6817
2010's12 (66.67)24.3611
2020's3 (16.67)2.80

Authors

AuthorsStudies
Jacobsen, AM1
van de Merbel, NC1
Ditlevsen, DK1
Tvermosegaard, K1
Schalk, F1
Lambert, W1
Bundgaard, C1
Pedersen, JT1
Rosenqvist, N1
Xia, Y1
Prokop, S1
Gorion, KM1
Kim, JD1
Sorrentino, ZA1
Bell, BM1
Manaois, AN1
Chakrabarty, P1
Davies, P1
Giasson, BI1
Torres, AK1
Jara, C1
Olesen, MA1
Tapia-Rojas, C1
Antón-Fernández, A1
Merchán-Rubira, J1
Avila, J2
Hernández, F1
DeFelipe, J1
Muñoz, A1
Yarchoan, M1
Toledo, JB1
Lee, EB1
Arvanitakis, Z1
Kazi, H1
Han, LY1
Louneva, N1
Lee, VM1
Kim, SF1
Trojanowski, JQ1
Arnold, SE1
Loeffler, DA1
Smith, LM1
Klaver, AC1
Martić, S1
Joo, Y1
Schumacher, B1
Landrieu, I2
Bartel, M1
Smet-Nocca, C1
Jang, A1
Choi, HS1
Jeon, NL1
Chang, KA1
Kim, HS1
Ottmann, C1
Suh, YH1
Xu, L1
Ryu, J1
Nguyen, JV1
Arena, J1
Rha, E1
Vranis, P1
Hitt, D1
Marsh-Armstrong, N1
Koliatsos, VE1
Gasparini, L2
Crowther, RA1
Martin, KR1
Berg, N1
Coleman, M1
Goedert, M3
Spillantini, MG4
Scattoni, ML1
Alleva, E1
Calamandrei, G1
Hampton, DW1
Webber, DJ1
Bilican, B1
Chandran, S1
Iovino, M1
Vuono, R1
Combs, B1
Voss, K1
Gamblin, TC1
de Calignon, A1
Polydoro, M1
Suárez-Calvet, M1
William, C1
Adamowicz, DH1
Kopeikina, KJ1
Pitstick, R1
Sahara, N1
Ashe, KH1
Carlson, GA1
Spires-Jones, TL1
Hyman, BT1
Ando, K1
Dourlen, P1
Sambo, AV1
Bretteville, A1
Bélarbi, K1
Vingtdeux, V1
Eddarkaoui, S1
Drobecq, H1
Ghestem, A1
Bégard, S1
Demey-Thomas, E1
Melnyk, P1
Smet, C1
Lippens, G1
Maurage, CA1
Caillet-Boudin, ML1
Verdier, Y1
Vinh, J1
Galas, MC1
Blum, D1
Hamdane, M1
Sergeant, N1
Buée, L1
Pérez, M1
Ribe, E1
Rubio, A1
Lim, F1
Morán, MA1
Ramos, PG1
Ferrer, I1
Isla, MT1
Dickey, CA1
Kamal, A1
Lundgren, K1
Klosak, N1
Bailey, RM1
Dunmore, J1
Ash, P1
Shoraka, S1
Zlatkovic, J1
Eckman, CB1
Patterson, C1
Dickson, DW1
Nahman, NS1
Hutton, M1
Burrows, F1
Petrucelli, L1
Chun, W1
Waldo, GS1
Johnson, GV1

Other Studies

18 other studies available for serine and Tauopathies

ArticleYear
A Quantitative LC-MS/MS Method for Distinguishing the Tau Protein Forms Phosphorylated and Nonphosphorylated at Serine-396.
    Journal of the American Society for Mass Spectrometry, 2023, Mar-01, Volume: 34, Issue:3

    Topics: Alzheimer Disease; Animals; Biomarkers; Chromatography, Liquid; Humans; Mice; Phosphorylation; Serin

2023
Tau Ser208 phosphorylation promotes aggregation and reveals neuropathologic diversity in Alzheimer's disease and other tauopathies.
    Acta neuropathologica communications, 2020, 06-22, Volume: 8, Issue:1

    Topics: Alzheimer Disease; Animals; Cells, Cultured; Disease Models, Animal; HEK293 Cells; Humans; Mice, Inb

2020
Pathologically phosphorylated tau at S396/404 (PHF-1) is accumulated inside of hippocampal synaptic mitochondria of aged Wild-type mice.
    Scientific reports, 2021, 02-24, Volume: 11, Issue:1

    Topics: Aging; Animals; Cognitive Dysfunction; Hippocampus; Memory Disorders; Mice; Mice, Inbred C57BL; Mito

2021
Phospho-Tau Accumulation and Structural Alterations of the Golgi Apparatus of Cortical Pyramidal Neurons in the P301S Tauopathy Mouse Model.
    Journal of Alzheimer's disease : JAD, 2017, Volume: 60, Issue:2

    Topics: Animals; Carrier Proteins; Cerebral Cortex; Disease Models, Animal; Golgi Apparatus; Humans; Intrace

2017
Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer's disease and tauopathies.
    Acta neuropathologica, 2014, Volume: 128, Issue:5

    Topics: Age Factors; Aged; Aged, 80 and over; alpha-Synuclein; Alzheimer Disease; Analysis of Variance; Anim

2014
Effects of antibodies to phosphorylated and non-phosphorylated tau on in vitro tau phosphorylation at Serine-199: Preliminary report.
    Experimental gerontology, 2015, Volume: 67

    Topics: Animals; Antibodies, Monoclonal; Blotting, Western; In Vitro Techniques; Mice, Transgenic; Phosphory

2015
Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2015, Volume: 29, Issue:10

    Topics: 14-3-3 Proteins; Axons; Binding Sites; Biomarkers, Tumor; Blotting, Western; Cell Line, Tumor; Cells

2015
Evidence for accelerated tauopathy in the retina of transgenic P301S tau mice exposed to repetitive mild traumatic brain injury.
    Experimental neurology, 2015, Volume: 273

    Topics: Analysis of Variance; Animals; Brain Injuries; Cell Count; Cerebral Cortex; Disease Models, Animal;

2015
Tau inclusions in retinal ganglion cells of human P301S tau transgenic mice: effects on axonal viability.
    Neurobiology of aging, 2011, Volume: 32, Issue:3

    Topics: Analysis of Variance; Animals; Axons; Bacterial Proteins; Disease Models, Animal; Humans; Inclusion

2011
Early behavioural markers of disease in P301S tau transgenic mice.
    Behavioural brain research, 2010, Mar-17, Volume: 208, Issue:1

    Topics: Age Factors; Analysis of Variance; Animals; Behavior, Animal; Body Weight; Brain; Cues; Disease Mode

2010
Cell-mediated neuroprotection in a mouse model of human tauopathy.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, Jul-28, Volume: 30, Issue:30

    Topics: Age Factors; Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Differentiation; Cell Trans

2010
Release of growth factors by neuronal precursor cells as a treatment for diseases with tau pathology.
    Archives italiennes de biologie, 2011, Volume: 149, Issue:2

    Topics: Analysis of Variance; Animals; Brain-Derived Neurotrophic Factor; Cell Differentiation; Disease Mode

2011
Pseudohyperphosphorylation has differential effects on polymerization and function of tau isoforms.
    Biochemistry, 2011, Nov-08, Volume: 50, Issue:44

    Topics: Amino Acid Substitution; Arachidonic Acid; Aspartic Acid; Biopolymers; Glutamic Acid; Glycogen Synth

2011
Propagation of tau pathology in a model of early Alzheimer's disease.
    Neuron, 2012, Feb-23, Volume: 73, Issue:4

    Topics: Age Factors; Alzheimer Disease; Animals; Disease Models, Animal; Disease Progression; Entorhinal Cor

2012
Tau pathology modulates Pin1 post-translational modifications and may be relevant as biomarker.
    Neurobiology of aging, 2013, Volume: 34, Issue:3

    Topics: Acetylation; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Animals; Biomarkers; Brain; Cell Lin

2013
Characterization of a double (amyloid precursor protein-tau) transgenic: tau phosphorylation and aggregation.
    Neuroscience, 2005, Volume: 130, Issue:2

    Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Chromosomes, Human, Pair 17;

2005
The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins.
    The Journal of clinical investigation, 2007, Volume: 117, Issue:3

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Blood-Brain Barrier; Disease Models, Animal; DN

2007
Split GFP complementation assay: a novel approach to quantitatively measure aggregation of tau in situ: effects of GSK3beta activation and caspase 3 cleavage.
    Journal of neurochemistry, 2007, Volume: 103, Issue:6

    Topics: Binding Sites; Biological Assay; Brain; Caspase 3; Cell Line; Enzyme Activation; Fluorescence; Glyco

2007