serine has been researched along with TDP-43 Proteinopathies in 3 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
TDP-43 Proteinopathies: Diseases characterized by the presence of abnormally phosphorylated, ubiquitinated, and cleaved DNA-binding protein TDP-43 in affected brain and spinal cord. Inclusions of the pathologic protein in neurons and glia, without the presence of AMYLOID, is the major feature of these conditions, thus making these proteinopathies distinct from most other neurogenerative disorders in which protein misfolding leads to brain amyloidosis. Both frontotemporal lobar degeneration and AMYOTROPHIC LATERAL SCLEROSIS exhibit this common method of pathogenesis and thus they may represent two extremes of a continuous clinicopathological spectrum of one disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study investigated the expression of abnormal serine phosphorylation of insulin receptor substrate 1 (IRS1) in 157 human brain autopsy cases that included AD, tauopathies, α-synucleinopathies, TDP-43 proteinopathies, and normal aging." | 7.80 | Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer's disease and tauopathies. ( Arnold, SE; Arvanitakis, Z; Han, LY; Kazi, H; Kim, SF; Lee, EB; Lee, VM; Louneva, N; Toledo, JB; Trojanowski, JQ; Yarchoan, M, 2014) |
| " This study investigated the expression of abnormal serine phosphorylation of insulin receptor substrate 1 (IRS1) in 157 human brain autopsy cases that included AD, tauopathies, α-synucleinopathies, TDP-43 proteinopathies, and normal aging." | 3.80 | Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer's disease and tauopathies. ( Arnold, SE; Arvanitakis, Z; Han, LY; Kazi, H; Kim, SF; Lee, EB; Lee, VM; Louneva, N; Toledo, JB; Trojanowski, JQ; Yarchoan, M, 2014) |
| " Hyperphosphorylated TDP-43 was found within the inclusion bodies in disease lesions; however, the role of hyperphosphorylation and the toxic species are still ambiguous." | 1.72 | Hyperphosphorylation-Mimetic TDP-43 Drives Amyloid Formation and Possesses Neuronal Toxicity at the Oligomeric Stage. ( Chang, LY; Chen, YR; Chiang, WC; Chou, SC; Fang, YS; Ganesan, K; Huang, SH; Lye, YS; Weng, TY, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Chiang, WC | 1 |
| Fang, YS | 1 |
| Lye, YS | 1 |
| Weng, TY | 1 |
| Ganesan, K | 1 |
| Huang, SH | 1 |
| Chang, LY | 1 |
| Chou, SC | 1 |
| Chen, YR | 1 |
| Liachko, NF | 1 |
| McMillan, PJ | 1 |
| Guthrie, CR | 1 |
| Bird, TD | 1 |
| Leverenz, JB | 1 |
| Kraemer, BC | 1 |
| Yarchoan, M | 1 |
| Toledo, JB | 1 |
| Lee, EB | 1 |
| Arvanitakis, Z | 1 |
| Kazi, H | 1 |
| Han, LY | 1 |
| Louneva, N | 1 |
| Lee, VM | 1 |
| Kim, SF | 1 |
| Trojanowski, JQ | 1 |
| Arnold, SE | 1 |
3 other studies available for serine and TDP-43 Proteinopathies
| Article | Year |
|---|---|
Hyperphosphorylation-Mimetic TDP-43 Drives Amyloid Formation and Possesses Neuronal Toxicity at the Oligomeric Stage.
Topics: Amyloid; Amyloidogenic Proteins; Amyloidosis; Amyotrophic Lateral Sclerosis; DNA-Binding Proteins; H | 2022 |
CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration.
Topics: Animals; Animals, Genetically Modified; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cel | 2013 |
Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer's disease and tauopathies.
Topics: Age Factors; Aged; Aged, 80 and over; alpha-Synuclein; Alzheimer Disease; Analysis of Variance; Anim | 2014 |