serine and Sterility, Male
serine has been researched along with Sterility, Male in 8 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"In a pilot study with 14 HSAN1 patients, L-serine supplementation similarly reduced dSL levels." | 2.76 | Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1. ( Brown, RH; Eichler, FS; Frosch, MP; Garofalo, K; Hornemann, T; Lee, HJ; Penno, A; Schmidt, BP; von Eckardstein, A, 2011) |
"Genic male sterility is an essential trait in the utilization of heterosis and hybrid seed production for wheat." | 1.91 | Identification and validation of major-effect quantitative trait locus QMS-5B associated with male sterility in photo-thermo-sensitive genic male sterile wheat. ( Bai, J; Li, Y; Liu, Y; Liu, Z; Niu, F; Song, X; Yuan, S; Zhang, F; Zhang, H; Zhang, L; Zhao, C, 2023) |
Research
Studies (8)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (12.50) | 29.6817 |
2010's | 4 (50.00) | 24.3611 |
2020's | 3 (37.50) | 2.80 |
Authors
Authors | Studies |
---|---|
Zhan, P | 1 |
Hao, T | 1 |
Yang, X | 1 |
Zhang, Y | 1 |
Niu, F | 1 |
Liu, Z | 1 |
Zhang, F | 1 |
Yuan, S | 1 |
Bai, J | 1 |
Liu, Y | 1 |
Li, Y | 1 |
Zhang, H | 2 |
Zhao, C | 1 |
Song, X | 1 |
Zhang, L | 1 |
Capoano, CA | 1 |
Ortiz-Laquintana, LA | 1 |
Rodríguez-Casuriaga, R | 1 |
Schlapp, G | 1 |
Meikle, MN | 1 |
Mulet, AP | 1 |
Crispo, M | 1 |
Benavente, R | 1 |
Geisinger, A | 1 |
Shen, YR | 1 |
Wang, HY | 1 |
Kuo, YC | 1 |
Shih, SC | 1 |
Hsu, CH | 1 |
Chen, YR | 1 |
Wu, SR | 1 |
Wang, CY | 1 |
Kuo, PL | 1 |
Ingold, I | 1 |
Aichler, M | 1 |
Yefremova, E | 1 |
Roveri, A | 1 |
Buday, K | 1 |
Doll, S | 1 |
Tasdemir, A | 1 |
Hoffard, N | 1 |
Wurst, W | 1 |
Walch, A | 1 |
Ursini, F | 1 |
Friedmann Angeli, JP | 1 |
Conrad, M | 1 |
Hashad, D | 1 |
Mohamed, N | 1 |
Hashad, MM | 1 |
Garofalo, K | 1 |
Penno, A | 1 |
Schmidt, BP | 1 |
Lee, HJ | 1 |
Frosch, MP | 1 |
von Eckardstein, A | 1 |
Brown, RH | 1 |
Hornemann, T | 1 |
Eichler, FS | 1 |
Olesen, C | 1 |
Silber, J | 1 |
Eiberg, H | 1 |
Ernst, E | 1 |
Petersen, K | 1 |
Lindenberg, S | 1 |
Tommerup, N | 1 |
Clinical Trials (2)
Trial Overview
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of L-Serine in Subjects With Hereditary Sensory Neuropathy Type 1[NCT01733407] | Phase 1/Phase 2 | 18 participants (Actual) | Interventional | 2013-09-30 | Completed | ||
Tolerability and Efficacy of L-Serine in Patients With Amyotrophic Lateral Sclerosis: A Phase IIa Study[NCT03580616] | Phase 2 | 43 participants (Actual) | Interventional | 2018-10-24 | Terminated (stopped due to Study was terminated by the IRB due to continued noncompliance.) | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Trial Outcomes
1-deoxy-sphinganine
Plasma levels of the deoxysphingoid lipid 1-deoxy-sphinganine measured by liquid chromatography/mass spectrometry after hydrolyzing the N-acyl and O-linked headgroups (NCT01733407)
Timeframe: 48 Weeks
Intervention | micromole per liter (Mean) |
---|---|
Sugar Pill | 0.338 |
L-serine | 0.112 |
1-deoxy-sphingosine
Plasma levels of the deoxysphingoid lipid 1-deoxy-sphingosine measured by liquid chromatography/mass spectrometry after hydrolyzing the N-acyl and O-linked headgroups (NCT01733407)
Timeframe: 48 weeks
Intervention | micromole per liter (Mean) |
---|---|
Sugar Pill | 0.698 |
L-serine | 0.337 |
Autonomic Function Testing (AFT) Composite Autonomic Severity Score (CASS)
Autonomic Function Testing (AFT) tests the effectiveness of your autonomic nervous system which regulates important functions such as blood pressure, heart rate, and respiration. AFT results are quantified using the composite autonomic severity score scale (CASS) which is a scale from 0 to 10 that is the sum of three sub scores (cardiovagal, adrenergic, and sudomotor). Cardiovagal is scored from 0 to 3, sudomotor is scored from 0 to 3, and adrenergic is scored from 0 to 4. The tests include deep breathing, Valsalva maneuver, head-up tilt, and a sweat test. The three subscores are then summed. This total represents the CASS which classifies autonomic function as normal functioning (total score 0), mild (total score 1-3), moderate (total score 4-6), or severe (total score 7-10). (NCT01733407)
Timeframe: 48 Weeks
Intervention | scores on a scale (Mean) |
---|---|
Sugar Pill | 3.56 |
L-serine | 2.22 |
Charcot Marie Tooth Neuropathy Score
The Charcot Marie Tooth Neuropathy Score (CMTNS) is a 0 to 36 point composite scoring assessment that is used to measure disease severity in Charcot Marie Tooth Neuropathy and other sensory and motor neuropathies. The CMTNS is composed of 9 items that evaluate functions related to disease progression. These 9 parameters include reviewing sensory symptoms, motor symptoms (arms and legs), pinprick sensibility, vibration, leg strength, arm strength, and nerve conduction tests. Each item is scored from 0 to 4, with the lower scores representing less severe symptoms and higher scores representing more severe symptoms.The 9 individual item scores are then totaled to provide a global measure of disease severity. For example the lowest possible total score is 0 which represents an asymptomatic individual and the highest score possible is a 36 which represents an individual with severe disease progression. There are sub scores that can be assessed but sub scores were not utilized in this study (NCT01733407)
Timeframe: 48 Weeks
Intervention | scores on a scale (Mean) |
---|---|
Sugar Pill | 25.67 |
L-serine | 20.22 |
Intraepidermal Nerve Fiber Density (IENFD)
Counts of nerve fibers per unit area in skin biopsies (NCT01733407)
Timeframe: 48 Weeks
Intervention | nerve fibers per micrometer^2 (Mean) | |
---|---|---|
Upper Thigh | Lower Calf | |
L-serine | 49.56 | 13.89 |
Sugar Pill | 34.67 | 0.89 |
Nerve Conduction Testing
Evaluates the functioning of electrical conduction of the motor and sensory nerves of the human body. (NCT01733407)
Timeframe: 48 Weeks
Intervention | microvolts (Mean) | ||||||||
---|---|---|---|---|---|---|---|---|---|
Sensrory Right Median Amplitude | Sensory Right Antebrach Amplitude | Sensory Right Superficial Radial Amplitude | Sensory Right Sural Amplitude | Sensory Right Superficial Peroneal Amplitude | Motor Right Median (Wrist) Amplitude | Motor Right Ulnar (Wrist) Amplitude | Motor Right Peroneal EDB (Ankle) Amplitude | Motor Right Peroneal Tib (Below) Amplitude | |
L-serine | 5.51 | 5.89 | 10.84 | 1.07 | 0.00 | 4.21 | 4.37 | 0.24 | 1.39 |
Sugar Pill | 1.34 | 2.31 | 4.56 | 0.52 | 0.00 | 3.34 | 2.49 | 0.54 | 0.29 |
Trials
1 trial available for serine and Sterility, Male
Article | Year |
---|---|
Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1.
Topics: Administration, Oral; Adult; Aged; Alanine; Animals; Depression, Chemical; Dose-Response Relationshi | 2011 |
Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1.
Topics: Administration, Oral; Adult; Aged; Alanine; Animals; Depression, Chemical; Dose-Response Relationshi | 2011 |
Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1.
Topics: Administration, Oral; Adult; Aged; Alanine; Animals; Depression, Chemical; Dose-Response Relationshi | 2011 |
Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1.
Topics: Administration, Oral; Adult; Aged; Alanine; Animals; Depression, Chemical; Dose-Response Relationshi | 2011 |
Other Studies
7 other studies available for serine and Sterility, Male
Article | Year |
---|---|
Association between chromosome 22q11.2 translocation and male oligozoospermia.
Topics: Chromosome Aberrations; Chromosomes; Humans; Infertility, Male; Male; Oligospermia; Protein Serine-T | 2022 |
Identification and validation of major-effect quantitative trait locus QMS-5B associated with male sterility in photo-thermo-sensitive genic male sterile wheat.
Topics: Humans; Infertility, Male; Male; Protein Serine-Threonine Kinases; Quantitative Trait Loci; Serine; | 2023 |
SPATS1 (spermatogenesis-associated, serine-rich 1) is not essential for spermatogenesis and fertility in mouse.
Topics: Amino Acid Sequence; Animals; Female; Fertility; Infertility, Male; Intracellular Signaling Peptides | 2021 |
SEPT12 phosphorylation results in loss of the septin ring/sperm annulus, defective sperm motility and poor male fertility.
Topics: Amino Acid Sequence; Animals; Blotting, Western; HEK293 Cells; Humans; Immunohistochemistry; Inferti | 2017 |
Expression of a Catalytically Inactive Mutant Form of Glutathione Peroxidase 4 (Gpx4) Confers a Dominant-negative Effect in Male Fertility.
Topics: Amino Acid Substitution; Animals; Catalytic Domain; Cells, Cultured; Embryo Loss; Female; Glutathion | 2015 |
Luteinising hormone β-subunit gene Gly102Ser variant and oxidative stress biomarkers in Egyptian infertile males.
Topics: Base Sequence; Biomarkers; DNA Primers; Egypt; Glycine; Humans; Infertility, Male; Luteinizing Hormo | 2012 |
Mutational analysis of the human FATE gene in 144 infertile men.
Topics: Adult; Alanine; Amino Acid Sequence; Animals; Arginine; Cysteine; DNA Mutational Analysis; DNA Prime | 2003 |