Page last updated: 2024-11-08

serine and Sterility, Male

serine has been researched along with Sterility, Male in 8 studies

Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.

Research Excerpts

ExcerptRelevanceReference
"In a pilot study with 14 HSAN1 patients, L-serine supplementation similarly reduced dSL levels."2.76Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1. ( Brown, RH; Eichler, FS; Frosch, MP; Garofalo, K; Hornemann, T; Lee, HJ; Penno, A; Schmidt, BP; von Eckardstein, A, 2011)
"Genic male sterility is an essential trait in the utilization of heterosis and hybrid seed production for wheat."1.91Identification and validation of major-effect quantitative trait locus QMS-5B associated with male sterility in photo-thermo-sensitive genic male sterile wheat. ( Bai, J; Li, Y; Liu, Y; Liu, Z; Niu, F; Song, X; Yuan, S; Zhang, F; Zhang, H; Zhang, L; Zhao, C, 2023)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (12.50)29.6817
2010's4 (50.00)24.3611
2020's3 (37.50)2.80

Authors

AuthorsStudies
Zhan, P1
Hao, T1
Yang, X1
Zhang, Y1
Niu, F1
Liu, Z1
Zhang, F1
Yuan, S1
Bai, J1
Liu, Y1
Li, Y1
Zhang, H2
Zhao, C1
Song, X1
Zhang, L1
Capoano, CA1
Ortiz-Laquintana, LA1
Rodríguez-Casuriaga, R1
Schlapp, G1
Meikle, MN1
Mulet, AP1
Crispo, M1
Benavente, R1
Geisinger, A1
Shen, YR1
Wang, HY1
Kuo, YC1
Shih, SC1
Hsu, CH1
Chen, YR1
Wu, SR1
Wang, CY1
Kuo, PL1
Ingold, I1
Aichler, M1
Yefremova, E1
Roveri, A1
Buday, K1
Doll, S1
Tasdemir, A1
Hoffard, N1
Wurst, W1
Walch, A1
Ursini, F1
Friedmann Angeli, JP1
Conrad, M1
Hashad, D1
Mohamed, N1
Hashad, MM1
Garofalo, K1
Penno, A1
Schmidt, BP1
Lee, HJ1
Frosch, MP1
von Eckardstein, A1
Brown, RH1
Hornemann, T1
Eichler, FS1
Olesen, C1
Silber, J1
Eiberg, H1
Ernst, E1
Petersen, K1
Lindenberg, S1
Tommerup, N1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of L-Serine in Subjects With Hereditary Sensory Neuropathy Type 1[NCT01733407]Phase 1/Phase 218 participants (Actual)Interventional2013-09-30Completed
Tolerability and Efficacy of L-Serine in Patients With Amyotrophic Lateral Sclerosis: A Phase IIa Study[NCT03580616]Phase 243 participants (Actual)Interventional2018-10-24Terminated (stopped due to Study was terminated by the IRB due to continued noncompliance.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

1-deoxy-sphinganine

Plasma levels of the deoxysphingoid lipid 1-deoxy-sphinganine measured by liquid chromatography/mass spectrometry after hydrolyzing the N-acyl and O-linked headgroups (NCT01733407)
Timeframe: 48 Weeks

Interventionmicromole per liter (Mean)
Sugar Pill0.338
L-serine0.112

1-deoxy-sphingosine

Plasma levels of the deoxysphingoid lipid 1-deoxy-sphingosine measured by liquid chromatography/mass spectrometry after hydrolyzing the N-acyl and O-linked headgroups (NCT01733407)
Timeframe: 48 weeks

Interventionmicromole per liter (Mean)
Sugar Pill0.698
L-serine0.337

Autonomic Function Testing (AFT) Composite Autonomic Severity Score (CASS)

Autonomic Function Testing (AFT) tests the effectiveness of your autonomic nervous system which regulates important functions such as blood pressure, heart rate, and respiration. AFT results are quantified using the composite autonomic severity score scale (CASS) which is a scale from 0 to 10 that is the sum of three sub scores (cardiovagal, adrenergic, and sudomotor). Cardiovagal is scored from 0 to 3, sudomotor is scored from 0 to 3, and adrenergic is scored from 0 to 4. The tests include deep breathing, Valsalva maneuver, head-up tilt, and a sweat test. The three subscores are then summed. This total represents the CASS which classifies autonomic function as normal functioning (total score 0), mild (total score 1-3), moderate (total score 4-6), or severe (total score 7-10). (NCT01733407)
Timeframe: 48 Weeks

Interventionscores on a scale (Mean)
Sugar Pill3.56
L-serine2.22

Charcot Marie Tooth Neuropathy Score

The Charcot Marie Tooth Neuropathy Score (CMTNS) is a 0 to 36 point composite scoring assessment that is used to measure disease severity in Charcot Marie Tooth Neuropathy and other sensory and motor neuropathies. The CMTNS is composed of 9 items that evaluate functions related to disease progression. These 9 parameters include reviewing sensory symptoms, motor symptoms (arms and legs), pinprick sensibility, vibration, leg strength, arm strength, and nerve conduction tests. Each item is scored from 0 to 4, with the lower scores representing less severe symptoms and higher scores representing more severe symptoms.The 9 individual item scores are then totaled to provide a global measure of disease severity. For example the lowest possible total score is 0 which represents an asymptomatic individual and the highest score possible is a 36 which represents an individual with severe disease progression. There are sub scores that can be assessed but sub scores were not utilized in this study (NCT01733407)
Timeframe: 48 Weeks

Interventionscores on a scale (Mean)
Sugar Pill25.67
L-serine20.22

Intraepidermal Nerve Fiber Density (IENFD)

Counts of nerve fibers per unit area in skin biopsies (NCT01733407)
Timeframe: 48 Weeks

,
Interventionnerve fibers per micrometer^2 (Mean)
Upper ThighLower Calf
L-serine49.5613.89
Sugar Pill34.670.89

Nerve Conduction Testing

Evaluates the functioning of electrical conduction of the motor and sensory nerves of the human body. (NCT01733407)
Timeframe: 48 Weeks

,
Interventionmicrovolts (Mean)
Sensrory Right Median AmplitudeSensory Right Antebrach AmplitudeSensory Right Superficial Radial AmplitudeSensory Right Sural AmplitudeSensory Right Superficial Peroneal AmplitudeMotor Right Median (Wrist) AmplitudeMotor Right Ulnar (Wrist) AmplitudeMotor Right Peroneal EDB (Ankle) AmplitudeMotor Right Peroneal Tib (Below) Amplitude
L-serine5.515.8910.841.070.004.214.370.241.39
Sugar Pill1.342.314.560.520.003.342.490.540.29

Trials

1 trial available for serine and Sterility, Male

ArticleYear
Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1.
    The Journal of clinical investigation, 2011, Volume: 121, Issue:12

    Topics: Administration, Oral; Adult; Aged; Alanine; Animals; Depression, Chemical; Dose-Response Relationshi

2011
Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1.
    The Journal of clinical investigation, 2011, Volume: 121, Issue:12

    Topics: Administration, Oral; Adult; Aged; Alanine; Animals; Depression, Chemical; Dose-Response Relationshi

2011
Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1.
    The Journal of clinical investigation, 2011, Volume: 121, Issue:12

    Topics: Administration, Oral; Adult; Aged; Alanine; Animals; Depression, Chemical; Dose-Response Relationshi

2011
Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1.
    The Journal of clinical investigation, 2011, Volume: 121, Issue:12

    Topics: Administration, Oral; Adult; Aged; Alanine; Animals; Depression, Chemical; Dose-Response Relationshi

2011

Other Studies

7 other studies available for serine and Sterility, Male

ArticleYear
Association between chromosome 22q11.2 translocation and male oligozoospermia.
    Medicine, 2022, Sep-30, Volume: 101, Issue:39

    Topics: Chromosome Aberrations; Chromosomes; Humans; Infertility, Male; Male; Oligospermia; Protein Serine-T

2022
Identification and validation of major-effect quantitative trait locus QMS-5B associated with male sterility in photo-thermo-sensitive genic male sterile wheat.
    TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2023, Nov-28, Volume: 136, Issue:12

    Topics: Humans; Infertility, Male; Male; Protein Serine-Threonine Kinases; Quantitative Trait Loci; Serine;

2023
SPATS1 (spermatogenesis-associated, serine-rich 1) is not essential for spermatogenesis and fertility in mouse.
    PloS one, 2021, Volume: 16, Issue:5

    Topics: Amino Acid Sequence; Animals; Female; Fertility; Infertility, Male; Intracellular Signaling Peptides

2021
SEPT12 phosphorylation results in loss of the septin ring/sperm annulus, defective sperm motility and poor male fertility.
    PLoS genetics, 2017, Volume: 13, Issue:3

    Topics: Amino Acid Sequence; Animals; Blotting, Western; HEK293 Cells; Humans; Immunohistochemistry; Inferti

2017
Expression of a Catalytically Inactive Mutant Form of Glutathione Peroxidase 4 (Gpx4) Confers a Dominant-negative Effect in Male Fertility.
    The Journal of biological chemistry, 2015, Jun-05, Volume: 290, Issue:23

    Topics: Amino Acid Substitution; Animals; Catalytic Domain; Cells, Cultured; Embryo Loss; Female; Glutathion

2015
Luteinising hormone β-subunit gene Gly102Ser variant and oxidative stress biomarkers in Egyptian infertile males.
    Andrologia, 2012, Volume: 44 Suppl 1

    Topics: Base Sequence; Biomarkers; DNA Primers; Egypt; Glycine; Humans; Infertility, Male; Luteinizing Hormo

2012
Mutational analysis of the human FATE gene in 144 infertile men.
    Human genetics, 2003, Volume: 113, Issue:3

    Topics: Adult; Alanine; Amino Acid Sequence; Animals; Arginine; Cysteine; DNA Mutational Analysis; DNA Prime

2003
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