serine and Starvation
serine has been researched along with Starvation in 25 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Starvation: Lengthy and continuous deprivation of food. (Stedman, 25th ed)
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study examined the effects of starvation and of feeding to rats diets that contain varying protein, carbohydrate and fat levels on serine metabolism in isolated hepatocytes." | 7.66 | Effect of starvation and diet composition on two pathways of L-serine metabolism in isolated rat hepatocytes. ( Beliveau, GP; Freedland, RA, 1982) |
| "Here we show that human cancer cells rapidly use exogenous serine and that serine deprivation triggered activation of the serine synthesis pathway and rapidly suppressed aerobic glycolysis, resulting in an increased flux to the tricarboxylic acid cycle." | 5.39 | Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. ( Berkers, CR; Blyth, K; Gottlieb, E; Maddocks, OD; Mason, SM; Vousden, KH; Zheng, L, 2013) |
| " Phosphorylation at serine 1108 (Ser¹¹⁰⁸) of eIF4G, which is associated with enhanced protein translation, is promoted by insulin-like growth factor 1 and inhibited by rapamycin or starvation, suggesting that phosphorylation of this residue is regulated by mTOR." | 3.78 | MNK2 inhibits eIF4G activation through a pathway involving serine-arginine-rich protein kinase in skeletal muscle. ( Chen, A; Chin, S; Cruz, J; Glass, DJ; Hu, SI; Ibebunjo, C; Katz, M; Qi, X; Zhao, S, 2012) |
| "This study examined the effects of starvation and of feeding to rats diets that contain varying protein, carbohydrate and fat levels on serine metabolism in isolated hepatocytes." | 3.66 | Effect of starvation and diet composition on two pathways of L-serine metabolism in isolated rat hepatocytes. ( Beliveau, GP; Freedland, RA, 1982) |
| " The effect of pregnancy on the glycemic response to exogenous alanine administration during starvation was also investigated." | 3.65 | Amino acid metabolism during starvation in human pregnancy. ( Felig, P; Hendler, R; Kim, YJ; Lynch, V, 1972) |
| "Here we show that human cancer cells rapidly use exogenous serine and that serine deprivation triggered activation of the serine synthesis pathway and rapidly suppressed aerobic glycolysis, resulting in an increased flux to the tricarboxylic acid cycle." | 1.39 | Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. ( Berkers, CR; Blyth, K; Gottlieb, E; Maddocks, OD; Mason, SM; Vousden, KH; Zheng, L, 2013) |
| " The effects on the amino acids are not due to a change in the food intake caused by dosing with arsenate." | 1.26 | The effects of sodium arsenate on the free amino acid levels in erythrocytes and plasma in rats. ( Kilroe-Smith, TA; McLoughlin, JL, 1979) |
| "3." | 1.25 | Concentrations of free glucogenic amino acids in livers of rats subjected to various metabolic stresses. ( Lopes-Vieira, O; Walker, B; Williamson, DH, 1967) |
Research
Studies (25)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (80.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Fathy, M | 1 |
| Awale, S | 1 |
| Nikaido, T | 1 |
| Moloughney, JG | 1 |
| Vega-Cotto, NM | 1 |
| Liu, S | 1 |
| Patel, C | 1 |
| Kim, PK | 1 |
| Wu, CC | 1 |
| Albaciete, D | 1 |
| Magaway, C | 1 |
| Chang, A | 1 |
| Rajput, S | 1 |
| Su, X | 1 |
| Werlen, G | 1 |
| Jacinto, E | 1 |
| Russell, RC | 1 |
| Tian, Y | 1 |
| Yuan, H | 1 |
| Park, HW | 1 |
| Chang, YY | 1 |
| Kim, J | 1 |
| Kim, H | 1 |
| Neufeld, TP | 1 |
| Dillin, A | 1 |
| Guan, KL | 1 |
| Hu, SI | 1 |
| Katz, M | 1 |
| Chin, S | 1 |
| Qi, X | 1 |
| Cruz, J | 1 |
| Ibebunjo, C | 1 |
| Zhao, S | 1 |
| Chen, A | 1 |
| Glass, DJ | 1 |
| Maddocks, OD | 1 |
| Berkers, CR | 1 |
| Mason, SM | 1 |
| Zheng, L | 1 |
| Blyth, K | 1 |
| Gottlieb, E | 1 |
| Vousden, KH | 1 |
| ISHIKAWA, E | 1 |
| NINAGAWA, T | 1 |
| SUDA, M | 1 |
| Williamson, DH | 2 |
| Lopes-Vieira, O | 1 |
| Walker, B | 1 |
| Remesy, C | 1 |
| Fafournoux, P | 1 |
| Demigne, C | 1 |
| Beliveau, GP | 1 |
| Freedland, RA | 2 |
| Müller, L | 1 |
| Ohnesorge, FK | 1 |
| Kilroe-Smith, TA | 1 |
| McLoughlin, JL | 1 |
| Whitton, PD | 3 |
| Hems, DA | 3 |
| Pozefsky, T | 1 |
| Tancredi, RG | 1 |
| Moxley, RT | 1 |
| Dupre, J | 1 |
| Tobin, JD | 1 |
| Bentley, CM | 1 |
| Dawes, EA | 2 |
| Baird, GD | 1 |
| Heitzman, RJ | 1 |
| Hibbitt, KG | 1 |
| Reynolds, RD | 1 |
| Potter, VR | 1 |
| Metz, T | 1 |
| Nogaj, U | 1 |
| Kröner, H | 1 |
| Staib, W | 1 |
| Taylor, EA | 1 |
| Toback, FG | 1 |
| Mayers, AM | 1 |
| Lowenstein, LM | 1 |
| Montague, MD | 1 |
| Lee, DJ | 1 |
| Felig, P | 1 |
| Kim, YJ | 1 |
| Lynch, V | 1 |
| Hendler, R | 1 |
| Chan, TM | 1 |
| Bojanowska, K | 1 |
Other Studies
25 other studies available for serine and Starvation
| Article | Year |
|---|---|
Phosphorylated Akt Protein at Ser473 Enables HeLa Cells to Tolerate Nutrient-Deprived Conditions
Topics: Apoptosis; Cell Cycle; Cell Proliferation; Cell Survival; Food; HeLa Cells; Humans; Phosphorylation; | 2017 |
mTORC2 modulates the amplitude and duration of GFAT1 Ser-243 phosphorylation to maintain flux through the hexosamine pathway during starvation.
Topics: Acetylglucosamine; Animals; Biosynthetic Pathways; Glutamine-Fructose-6-Phosphate Transaminase (Isom | 2018 |
ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase.
Topics: Amino Acids; Animals; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein-1 Homolog; | 2013 |
MNK2 inhibits eIF4G activation through a pathway involving serine-arginine-rich protein kinase in skeletal muscle.
Topics: Animals; Arginine; Blotting, Western; Cell Line; Dexamethasone; Eukaryotic Initiation Factor-4G; Ins | 2012 |
Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells.
Topics: Aerobiosis; Animals; Antioxidants; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cel | 2013 |
HORMONAL AND DIETARY CONTROL OF SERINE DEHYDRATASE IN RAT LIVER.
Topics: Adrenalectomy; Amino Acids; Animals; Carbohydrate Metabolism; Dactinomycin; Diabetes Mellitus, Exper | 1965 |
Concentrations of free glucogenic amino acids in livers of rats subjected to various metabolic stresses.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Diabetes Mellitus, Experimental; Gluconeogenesis; Glut | 1967 |
Control of hepatic utilization of serine, glycine and threonine in fed and starved rats.
Topics: Alanine; Alanine Transaminase; Animals; Dietary Carbohydrates; Dietary Proteins; Gluconeogenesis; Gl | 1983 |
Effect of starvation and diet composition on two pathways of L-serine metabolism in isolated rat hepatocytes.
Topics: Animals; Diet; Gluconeogenesis; Lactates; Lactic Acid; Liver; Male; Picolinic Acids; Quinolinic Acid | 1982 |
Different response of liver parenchymal cells from starved and fed rats to cadmium.
Topics: Animals; Cadmium; Digitonin; Female; Glutathione; In Vitro Techniques; Liver; Methionine; Rats; Rats | 1982 |
The effects of sodium arsenate on the free amino acid levels in erythrocytes and plasma in rats.
Topics: Amino Acids; Aminobutyrates; Animals; Arsenates; Arsenic; Aspartic Acid; Betaine; Circadian Rhythm; | 1979 |
Hepatic metabolism of glucose and glycogen in fed rats.
Topics: Animals; Glucose; Glycerol; Lactates; Liver; Liver Glycogen; Perfusion; Pyruvates; Rats; Serine; Sta | 1975 |
Metabolism of forearm tissues in man. Studies with glucagon.
Topics: Acetoacetates; Adipose Tissue; Adult; Fasting; Fatty Acids, Nonesterified; Forearm; Glucagon; Glucos | 1976 |
The energy-yielding reactions of Peptococcus prévotii, their behaviour on starvation and the role and regulation of threonine dehydratase.
Topics: Acyltransferases; Adenine Nucleotides; Adenosine Monophosphate; Adenosine Triphosphate; Anaerobiosis | 1974 |
Effects of starvation on intermediary metabolism in the lactating cow. A comparison with metabolic changes occurring during bovine ketosis.
Topics: Acidosis; Adenosine Triphosphate; Animals; Blood Glucose; Cattle; Cattle Diseases; Citrates; Fatty A | 1972 |
Neonatal rise of rat liver tyrosine aminotransferase and serine dehydratase activity associated with lack of food.
Topics: Animals; Animals, Newborn; Female; Hydro-Lyases; L-Serine Dehydratase; Liver; Male; Maternal Depriva | 1971 |
[Studies on regulation of serine gluconeogenesis under hormone and diet influence].
Topics: Animals; Betamethasone; Carboxy-Lyases; Dietary Proteins; Gluconeogenesis; In Vitro Techniques; Live | 1972 |
Glycogen synthesis in the perfused liver of the starved rat.
Topics: Animals; Carbon Isotopes; Gluconeogenesis; Glucose; Glycerol; In Vitro Techniques; Insulin; Liver; L | 1972 |
Alterations in renal and plasma amino acid concentrations during renal compensatory growth.
Topics: Alanine; Amino Acids; Animals; Kidney; Kidney Cortex; Leucine; Male; Methionine; Nephrectomy; Ornith | 1973 |
The survival of Peptococcus prévotii in relation to the adenylate energy charge.
Topics: Adenine Nucleotides; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Ammonia | 1974 |
The effect of a single oral dose of lysine or arginine on the excretion of free amino acids by the starved laying hen.
Topics: Administration, Oral; Amino Acid Metabolism, Inborn Errors; Amino Acids; Animals; Arginine; Chickens | 1972 |
Amino acid metabolism during starvation in human pregnancy.
Topics: Adolescent; Adult; Alanine; Amino Acids; Aminobutyrates; Amniotic Fluid; Blood Glucose; Female; Food | 1972 |
Glycogen synthesis in the perfused liver of starved rats.
Topics: Animals; Gluconeogenesis; Glucose; Glycerol; In Vitro Techniques; Liver; Liver Glycogen; Perfusion; | 1971 |
The role of L-serine dehydratase in the metabolism of L-serine in the perfused rat liver.
Topics: Animals; Aspartic Acid; Carboxy-Lyases; Chlorides; Freezing; Gluconeogenesis; Glutamates; Hydro-Lyas | 1971 |
Serine dehydratase activity in livers of phlorrhizin-treated rats and the hepatic serine plus threonine concentration.
Topics: Animals; Hydro-Lyases; Liver; Male; Phlorhizin; Rats; Serine; Starvation; Threonine | 1968 |