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serine and Starvation

serine has been researched along with Starvation in 25 studies

Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.

Starvation: Lengthy and continuous deprivation of food. (Stedman, 25th ed)

Research Excerpts

ExcerptRelevanceReference
"This study examined the effects of starvation and of feeding to rats diets that contain varying protein, carbohydrate and fat levels on serine metabolism in isolated hepatocytes."7.66Effect of starvation and diet composition on two pathways of L-serine metabolism in isolated rat hepatocytes. ( Beliveau, GP; Freedland, RA, 1982)
"Here we show that human cancer cells rapidly use exogenous serine and that serine deprivation triggered activation of the serine synthesis pathway and rapidly suppressed aerobic glycolysis, resulting in an increased flux to the tricarboxylic acid cycle."5.39Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. ( Berkers, CR; Blyth, K; Gottlieb, E; Maddocks, OD; Mason, SM; Vousden, KH; Zheng, L, 2013)
" Phosphorylation at serine 1108 (Ser¹¹⁰⁸) of eIF4G, which is associated with enhanced protein translation, is promoted by insulin-like growth factor 1 and inhibited by rapamycin or starvation, suggesting that phosphorylation of this residue is regulated by mTOR."3.78MNK2 inhibits eIF4G activation through a pathway involving serine-arginine-rich protein kinase in skeletal muscle. ( Chen, A; Chin, S; Cruz, J; Glass, DJ; Hu, SI; Ibebunjo, C; Katz, M; Qi, X; Zhao, S, 2012)
"This study examined the effects of starvation and of feeding to rats diets that contain varying protein, carbohydrate and fat levels on serine metabolism in isolated hepatocytes."3.66Effect of starvation and diet composition on two pathways of L-serine metabolism in isolated rat hepatocytes. ( Beliveau, GP; Freedland, RA, 1982)
" The effect of pregnancy on the glycemic response to exogenous alanine administration during starvation was also investigated."3.65Amino acid metabolism during starvation in human pregnancy. ( Felig, P; Hendler, R; Kim, YJ; Lynch, V, 1972)
"Here we show that human cancer cells rapidly use exogenous serine and that serine deprivation triggered activation of the serine synthesis pathway and rapidly suppressed aerobic glycolysis, resulting in an increased flux to the tricarboxylic acid cycle."1.39Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. ( Berkers, CR; Blyth, K; Gottlieb, E; Maddocks, OD; Mason, SM; Vousden, KH; Zheng, L, 2013)
" The effects on the amino acids are not due to a change in the food intake caused by dosing with arsenate."1.26The effects of sodium arsenate on the free amino acid levels in erythrocytes and plasma in rats. ( Kilroe-Smith, TA; McLoughlin, JL, 1979)
"3."1.25Concentrations of free glucogenic amino acids in livers of rats subjected to various metabolic stresses. ( Lopes-Vieira, O; Walker, B; Williamson, DH, 1967)

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-199020 (80.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fathy, M1
Awale, S1
Nikaido, T1
Moloughney, JG1
Vega-Cotto, NM1
Liu, S1
Patel, C1
Kim, PK1
Wu, CC1
Albaciete, D1
Magaway, C1
Chang, A1
Rajput, S1
Su, X1
Werlen, G1
Jacinto, E1
Russell, RC1
Tian, Y1
Yuan, H1
Park, HW1
Chang, YY1
Kim, J1
Kim, H1
Neufeld, TP1
Dillin, A1
Guan, KL1
Hu, SI1
Katz, M1
Chin, S1
Qi, X1
Cruz, J1
Ibebunjo, C1
Zhao, S1
Chen, A1
Glass, DJ1
Maddocks, OD1
Berkers, CR1
Mason, SM1
Zheng, L1
Blyth, K1
Gottlieb, E1
Vousden, KH1
ISHIKAWA, E1
NINAGAWA, T1
SUDA, M1
Williamson, DH2
Lopes-Vieira, O1
Walker, B1
Remesy, C1
Fafournoux, P1
Demigne, C1
Beliveau, GP1
Freedland, RA2
Müller, L1
Ohnesorge, FK1
Kilroe-Smith, TA1
McLoughlin, JL1
Whitton, PD3
Hems, DA3
Pozefsky, T1
Tancredi, RG1
Moxley, RT1
Dupre, J1
Tobin, JD1
Bentley, CM1
Dawes, EA2
Baird, GD1
Heitzman, RJ1
Hibbitt, KG1
Reynolds, RD1
Potter, VR1
Metz, T1
Nogaj, U1
Kröner, H1
Staib, W1
Taylor, EA1
Toback, FG1
Mayers, AM1
Lowenstein, LM1
Montague, MD1
Lee, DJ1
Felig, P1
Kim, YJ1
Lynch, V1
Hendler, R1
Chan, TM1
Bojanowska, K1

Other Studies

25 other studies available for serine and Starvation

ArticleYear
Phosphorylated Akt Protein at Ser473 Enables HeLa Cells to Tolerate Nutrient-Deprived Conditions
    Asian Pacific journal of cancer prevention : APJCP, 2017, Dec-29, Volume: 18, Issue:12

    Topics: Apoptosis; Cell Cycle; Cell Proliferation; Cell Survival; Food; HeLa Cells; Humans; Phosphorylation;

2017
mTORC2 modulates the amplitude and duration of GFAT1 Ser-243 phosphorylation to maintain flux through the hexosamine pathway during starvation.
    The Journal of biological chemistry, 2018, 10-19, Volume: 293, Issue:42

    Topics: Acetylglucosamine; Animals; Biosynthetic Pathways; Glutamine-Fructose-6-Phosphate Transaminase (Isom

2018
ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase.
    Nature cell biology, 2013, Volume: 15, Issue:7

    Topics: Amino Acids; Animals; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein-1 Homolog;

2013
MNK2 inhibits eIF4G activation through a pathway involving serine-arginine-rich protein kinase in skeletal muscle.
    Science signaling, 2012, Feb-14, Volume: 5, Issue:211

    Topics: Animals; Arginine; Blotting, Western; Cell Line; Dexamethasone; Eukaryotic Initiation Factor-4G; Ins

2012
Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells.
    Nature, 2013, Jan-24, Volume: 493, Issue:7433

    Topics: Aerobiosis; Animals; Antioxidants; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cel

2013
HORMONAL AND DIETARY CONTROL OF SERINE DEHYDRATASE IN RAT LIVER.
    Journal of biochemistry, 1965, Volume: 57

    Topics: Adrenalectomy; Amino Acids; Animals; Carbohydrate Metabolism; Dactinomycin; Diabetes Mellitus, Exper

1965
Concentrations of free glucogenic amino acids in livers of rats subjected to various metabolic stresses.
    The Biochemical journal, 1967, Volume: 104, Issue:2

    Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Diabetes Mellitus, Experimental; Gluconeogenesis; Glut

1967
Control of hepatic utilization of serine, glycine and threonine in fed and starved rats.
    The Journal of nutrition, 1983, Volume: 113, Issue:1

    Topics: Alanine; Alanine Transaminase; Animals; Dietary Carbohydrates; Dietary Proteins; Gluconeogenesis; Gl

1983
Effect of starvation and diet composition on two pathways of L-serine metabolism in isolated rat hepatocytes.
    The Journal of nutrition, 1982, Volume: 112, Issue:4

    Topics: Animals; Diet; Gluconeogenesis; Lactates; Lactic Acid; Liver; Male; Picolinic Acids; Quinolinic Acid

1982
Different response of liver parenchymal cells from starved and fed rats to cadmium.
    Toxicology, 1982, Volume: 25, Issue:2-3

    Topics: Animals; Cadmium; Digitonin; Female; Glutathione; In Vitro Techniques; Liver; Methionine; Rats; Rats

1982
The effects of sodium arsenate on the free amino acid levels in erythrocytes and plasma in rats.
    Chemico-biological interactions, 1979, Volume: 28, Issue:2-3

    Topics: Amino Acids; Aminobutyrates; Animals; Arsenates; Arsenic; Aspartic Acid; Betaine; Circadian Rhythm;

1979
Hepatic metabolism of glucose and glycogen in fed rats.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1975, Volume: 7, Issue:6

    Topics: Animals; Glucose; Glycerol; Lactates; Liver; Liver Glycogen; Perfusion; Pyruvates; Rats; Serine; Sta

1975
Metabolism of forearm tissues in man. Studies with glucagon.
    Diabetes, 1976, Volume: 25, Issue:2

    Topics: Acetoacetates; Adipose Tissue; Adult; Fasting; Fatty Acids, Nonesterified; Forearm; Glucagon; Glucos

1976
The energy-yielding reactions of Peptococcus prévotii, their behaviour on starvation and the role and regulation of threonine dehydratase.
    Archives of microbiology, 1974, Volume: 100, Issue:4

    Topics: Acyltransferases; Adenine Nucleotides; Adenosine Monophosphate; Adenosine Triphosphate; Anaerobiosis

1974
Effects of starvation on intermediary metabolism in the lactating cow. A comparison with metabolic changes occurring during bovine ketosis.
    The Biochemical journal, 1972, Volume: 128, Issue:5

    Topics: Acidosis; Adenosine Triphosphate; Animals; Blood Glucose; Cattle; Cattle Diseases; Citrates; Fatty A

1972
Neonatal rise of rat liver tyrosine aminotransferase and serine dehydratase activity associated with lack of food.
    Life sciences. Pt. 2: Biochemistry, general and molecular biology, 1971, Jan-08, Volume: 10, Issue:1

    Topics: Animals; Animals, Newborn; Female; Hydro-Lyases; L-Serine Dehydratase; Liver; Male; Maternal Depriva

1971
[Studies on regulation of serine gluconeogenesis under hormone and diet influence].
    Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 1972, Volume: 353, Issue:10

    Topics: Animals; Betamethasone; Carboxy-Lyases; Dietary Proteins; Gluconeogenesis; In Vitro Techniques; Live

1972
Glycogen synthesis in the perfused liver of the starved rat.
    The Biochemical journal, 1972, Volume: 129, Issue:3

    Topics: Animals; Carbon Isotopes; Gluconeogenesis; Glucose; Glycerol; In Vitro Techniques; Insulin; Liver; L

1972
Alterations in renal and plasma amino acid concentrations during renal compensatory growth.
    The American journal of physiology, 1973, Volume: 225, Issue:5

    Topics: Alanine; Amino Acids; Animals; Kidney; Kidney Cortex; Leucine; Male; Methionine; Nephrectomy; Ornith

1973
The survival of Peptococcus prévotii in relation to the adenylate energy charge.
    Journal of general microbiology, 1974, Volume: 80, Issue:1

    Topics: Adenine Nucleotides; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Ammonia

1974
The effect of a single oral dose of lysine or arginine on the excretion of free amino acids by the starved laying hen.
    British poultry science, 1972, Volume: 13, Issue:2

    Topics: Administration, Oral; Amino Acid Metabolism, Inborn Errors; Amino Acids; Animals; Arginine; Chickens

1972
Amino acid metabolism during starvation in human pregnancy.
    The Journal of clinical investigation, 1972, Volume: 51, Issue:5

    Topics: Adolescent; Adult; Alanine; Amino Acids; Aminobutyrates; Amniotic Fluid; Blood Glucose; Female; Food

1972
Glycogen synthesis in the perfused liver of starved rats.
    The Biochemical journal, 1971, Volume: 125, Issue:3

    Topics: Animals; Gluconeogenesis; Glucose; Glycerol; In Vitro Techniques; Liver; Liver Glycogen; Perfusion;

1971
The role of L-serine dehydratase in the metabolism of L-serine in the perfused rat liver.
    Biochimica et biophysica acta, 1971, Apr-20, Volume: 237, Issue:1

    Topics: Animals; Aspartic Acid; Carboxy-Lyases; Chlorides; Freezing; Gluconeogenesis; Glutamates; Hydro-Lyas

1971
Serine dehydratase activity in livers of phlorrhizin-treated rats and the hepatic serine plus threonine concentration.
    Biochimica et biophysica acta, 1968, Jul-09, Volume: 159, Issue:3

    Topics: Animals; Hydro-Lyases; Liver; Male; Phlorhizin; Rats; Serine; Starvation; Threonine

1968