serine has been researched along with Spinocerebellar Ataxias in 9 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Spinocerebellar Ataxias: A group of predominately late-onset, cerebellar ataxias which have been divided into multiple subtypes based on clinical features and genetic mapping. Progressive ataxia is a central feature of these conditions, and in certain subtypes POLYNEUROPATHY; DYSARTHRIA; visual loss; and other disorders may develop. (From Joynt, Clinical Neurology, 1997, Ch65, pp 12-17; J Neuropathol Exp Neurol 1998 Jun;57(6):531-43)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Spinocerebellar ataxia type 1 (SCA1) is an adult-onset neurodegenerative disorder characterized by motor incoordination, mild cognitive decline, respiratory dysfunction, and early lethality." | 1.62 | Modulation of ATXN1 S776 phosphorylation reveals the importance of allele-specific targeting in SCA1. ( Alcala, E; Coffin, SL; Dai, Y; El-Najjar, DB; Liu, Z; Nitschke, L; Orengo, JP; Orr, HT; Wan, YW; Xhako, E; Zoghbi, HY, 2021) |
| "Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant neurodegenerative disease resulting from an expanded CAG repeat in the SCA1 gene that leads to an expanded polyglutamine tract in the gene product." | 1.33 | Identification of a novel phosphorylation site in ataxin-1. ( Ferrington, DA; Orr, HT; Vierra-Green, CA; Zoghbi, HY, 2005) |
| "Spinocerebellar ataxia type 14 (SCA14) is an autosomal dominant neurodegenerative disorder characterized by cerebellar ataxia and intermittent axial myoclonus." | 1.33 | Identification of a new family of spinocerebellar ataxia type 14 in the Japanese spinocerebellar ataxia population by the screening of PRKCG exon 4. ( Hiramoto, K; Inoue, K; Kawakami, H; Kurisu, K; Maruyama, H; Matsumoto, M; Morino, H; Sakai, N; Seki, T, 2006) |
| "Spinocerebellar ataxia type 1 (SCA1) is one of several neurological disorders caused by a CAG repeat expansion." | 1.32 | Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1. ( Acevedo, SF; Aitken, A; Botas, J; Chen, HK; Fernandez, MH; Fernandez-Funez, P; Kaytor, MD; Lam, YC; Orr, HT; Skoulakis, EM; Zoghbi, HY, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 2 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, QW | 1 |
| Kapfhammer, JP | 1 |
| Nitschke, L | 1 |
| Coffin, SL | 1 |
| Xhako, E | 1 |
| El-Najjar, DB | 1 |
| Orengo, JP | 1 |
| Alcala, E | 1 |
| Dai, Y | 1 |
| Wan, YW | 1 |
| Liu, Z | 1 |
| Orr, HT | 5 |
| Zoghbi, HY | 5 |
| Caramins, M | 1 |
| Colebatch, JG | 1 |
| Bainbridge, MN | 1 |
| Scherer, SS | 1 |
| Abrams, CK | 1 |
| Hackett, EL | 1 |
| Freidin, MM | 1 |
| Jhangiani, SN | 1 |
| Wang, M | 1 |
| Wu, Y | 1 |
| Muzny, DM | 1 |
| Lindeman, R | 1 |
| Gibbs, RA | 1 |
| Tanabe, M | 1 |
| Nakano, T | 1 |
| Honda, M | 1 |
| Ono, H | 1 |
| Duvick, L | 1 |
| Barnes, J | 1 |
| Ebner, B | 1 |
| Agrawal, S | 1 |
| Andresen, M | 1 |
| Lim, J | 1 |
| Giesler, GJ | 1 |
| Emamian, ES | 1 |
| Kaytor, MD | 2 |
| Duvick, LA | 1 |
| Zu, T | 1 |
| Tousey, SK | 1 |
| Clark, HB | 1 |
| Chen, HK | 1 |
| Fernandez-Funez, P | 1 |
| Acevedo, SF | 1 |
| Lam, YC | 1 |
| Fernandez, MH | 1 |
| Aitken, A | 1 |
| Skoulakis, EM | 1 |
| Botas, J | 1 |
| Vierra-Green, CA | 1 |
| Ferrington, DA | 1 |
| Hiramoto, K | 1 |
| Kawakami, H | 1 |
| Inoue, K | 1 |
| Seki, T | 1 |
| Maruyama, H | 1 |
| Morino, H | 1 |
| Matsumoto, M | 1 |
| Kurisu, K | 1 |
| Sakai, N | 1 |
9 other studies available for serine and Spinocerebellar Ataxias
| Article | Year |
|---|---|
Serine/threonine kinase 17b (STK17B) signalling regulates Purkinje cell dendritic development and is altered in multiple spinocerebellar ataxias.
Topics: Animals; Apoptosis Regulatory Proteins; Cerebellum; Mice; Protein Kinase C; Protein Serine-Threonine | 2021 |
Modulation of ATXN1 S776 phosphorylation reveals the importance of allele-specific targeting in SCA1.
Topics: Alleles; Animals; Ataxin-1; Behavior, Animal; Brain; Disease Models, Animal; Humans; Mice; Mice, Inb | 2021 |
Exome sequencing identification of a GJB1 missense mutation in a kindred with X-linked spinocerebellar ataxia (SCA-X1).
Topics: Base Sequence; Chromosomes, Human, X; Connexins; Evolution, Molecular; Exome; Female; Gap Junction b | 2013 |
Glycine transporter blockade ameliorates motor ataxia in a mouse model of spinocerebellar atrophy.
Topics: Animals; Binding Sites; Cytarabine; Disease Models, Animal; Dose-Response Relationship, Drug; Glycin | 2009 |
SCA1-like disease in mice expressing wild-type ataxin-1 with a serine to aspartic acid replacement at residue 776.
Topics: Animals; Aspartic Acid; Ataxin-1; Ataxins; Calbindins; Cerebellum; Dendrites; Disease Models, Animal | 2010 |
Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice.
Topics: Amino Acid Sequence; Animals; Ataxin-1; Ataxins; Cell Nucleus; CHO Cells; COS Cells; Cricetinae; Dis | 2003 |
Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.
Topics: 14-3-3 Proteins; Amino Acid Motifs; Amino Acid Sequence; Animals; Ataxin-1; Ataxins; Cell Nucleus; C | 2003 |
Identification of a novel phosphorylation site in ataxin-1.
Topics: Amino Acid Sequence; Animals; Ataxin-1; Ataxins; COS Cells; Humans; Molecular Sequence Data; Mutatio | 2005 |
Identification of a new family of spinocerebellar ataxia type 14 in the Japanese spinocerebellar ataxia population by the screening of PRKCG exon 4.
Topics: Adult; Aged; Amino Acid Substitution; Brain; DNA Mutational Analysis; Exons; Female; Genetic Testing | 2006 |